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  • 1 Department of the Physiology of Reproduction, Faculty of Veterinary Medicine, University of Liege Bvd de Colonster, 20-B41-P71- 4000 Sart-Tilman, Belgium
  • 2 University of Liege Faculty of Veterinary Medicine, Physiology of Reproduction Please ask the editor of the journal.
  • 3 University of Liege Faculty of Veterinary Medicine, Physiology of Reproduction Please ask the editor of the journal.
  • 4 Clinic for Large Animals, Faculty of Veterinary Science, Szent István University H-2225 Üllő, Dóra major, Hungary
  • 5 University of Liege Faculty of Veterinary Medicine, Physiology of Reproduction Please ask the editor of the journal.
  • 6 Department of the Physiology of Reproduction, Faculty of Veterinary Medicine, University of Liege Bvd de Colonster, 20-B41-P71- 4000 Sart-Tilman, Belgium
  • 7 University of Liege Faculty of Veterinary Medicine, Physiology of Reproduction Please ask the editor of the journal.
  • 8 University of Liege Faculty of Veterinary Medicine, Physiology of Reproduction Please ask the editor of the journal.
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The Pregnancy Associated Glycoproteins (PAGs) presented in this paper are largely expressed in the ruminant placenta. These proteins are classified as probably inactive members of the aspartic proteinase family. Pepsinogen, renin, cathepsin E & D and chymosine are typical members of this family, characterised by the presence of aspartic acids boarding the recognition sites. Secreted in the peripheral blood of the pregnant female from early pregnancy, these proteins can be used in serological tests for establishing different diagnoses. In the veterinary practice, these diagnoses are useful for both pregnancy confirmation and follow-up of trophoblastic function. The first aspect can help breeders in the management of reproduction, while the second one more specifically concerns clinicians and researchers wishing to establish a differential diagnosis of pathologic conditions affecting pregnancy.

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