Postweaning multisystemic wasting syndrome (PMWS), a new disease in Hungary, was recognized in a swine herd located in Southeast Hungary, during the early winter of 1999. The first clinical signs of paleness, anaemia, and leanness appeared immediately after weaning, at the age of 40-50 days. Pustules were frequently observed on the skin of the trunk, and signs of necrotic dermatitis were also visible. A syndrome of poor growth and wasting was characteristic of the affected pigs. A porcine circovirus (PCV), the suspected causative agent, was detected by polymerase chain reaction (PCR). Sequencing data and restriction endonuclease (RE) analysis of the PCR products suggested that the virus belonged to the PCV-II group where all the causative agents of PMWS are also grouped.
Allan, G. M., McNeilly, F., Meehan, B. M., Kennedy, S., Mackie, D. P., Ellis, J. A., Clark, E. G., Espuna, E., Saubi, N., Riera, P., Botner, A. and Charreyre, C. E. (1999): Isolation and characterisation of circoviruses from pigs with wasting syndromes in Spain, Denmark and Northern Ireland. Vet. Microbiol. 66, 115–123.
Allan, G. M., Meehan, B., Todd, D., Kennedy, S., McNeilly, F., Ellis, J., Clark, E. G., Harding, J., Espuna, E., Botner, A. and Charreyre, C. (1998) Novel porcine circoviruses from pigs with wasting disease syndromes. Vet. Rec. 142, 467–468.
Allan, G. M., Phenix, K. V., Todd, D. and McNulty, M. S. (1994): Some biological and physicochemical properties of porcine circovirus. J. Vet. Med. Ser. 41, 17–27.
Choi, C. and Chae, C. (1999): In-situ hybridization for the detection of porcine circovirus in pigs with postweaning multisystemic wasting syndrome. J. Comp. Pathol. 3, 265–270.
Clark, E. G. (1997): Post-weaning multisystemic wasting syndrome. Proc. Am. Ass. Swine. Pract. 10, 499–501.
Daft, B., Nordhausen, R. W., Latimer, K. S. and Niagro, F. D. (1996): Interstitial pneumonia and lymphadenopathy associated with circoviral infection in a 6-week-old pig. Proc. Am. Ass. Vet. Lab. Diagn. 39, 32.
Dulac, G. C. and Afshar, A. (1989): Porcine circovirus antigens in PK-15 cell line (ATCC CCL-33) and evidence of antibodies to circovirus in Canadian pigs. Can. J. Vet. Res. 53, 431–433.
Edwards, S. and Sands, S. S. (1994): Evidence of circovirus infection in British pigs. Vet. Rec. 134, 680–681.
Ellis, J., Hassard, L., Clark, E., Harding, J., Allan, G., Willson, P., Strokappe, J., Martin, K., McNeilly, F., Meehan, B., Todd, D. and Haines, D. (1998): Isolation of circovirus from lesions of pigs with multisystemic wasting syndrome. Can. Vet. J. 39, 44–51.
Horner, G. W. (1991): Pig circovirus antibodies present in New Zealand pigs. Surveillance-Wellington 18, 23.
Kennedy, S., Allan, G., McNeilly, F., Adair, B. M., Hughes, A. and Spillane, P. (1998): Porcine circovirus infection in Northern Ireland. Vet. Rec. 142, 495–496.
Kiss, I., Matiz, K., Bajmocy, E., Rusvai, M. and Harrach, B. (1996): Infectious canine hepatitis: detection of canine adenovirus type 1 by polymerase chain reaction. Acta Vet. Hung. 44, 253–258.
LeCann, P., Albina, E. and Medac, F. (1997): Piglet wasting disease. Vet. Rec. 141, 660.
Meehan, B. M., McNeilly, F., Todd, D., Kennedy, S., Jewhurst, V. A., Ellis, J. A., Hassard, L. E., Clark, E. G., Haines, D. M. and Allan, G. M. (1998): Characterization of novel circovirus DNAs associated with wasting syndromes in pigs. J. Gen. Virol. 79, 2171–2179.
Onuki, A., Abe, K., Togashi, K., Kawashima, K., Taneichi, A. and Tsunemitsu, H. (1999): Detection of porcine circovirus from lesions of a pig with wasting disease in Japan. J. Vet. Med. Sci. 10, 1119–1123.
Segalés, J., Sitjar, M., Domingo, M., Dee, S., Del Pozo, M., Noval, R., Sacristan, C., De las Heras, M., Ferro, A. and Latimer, S. (1997): First report of postweaning multisystemic wasting syndrome in pigs in Spain. Vet. Rec. 141, 600–601.
Spillane, P., Kennedy, S., Meehan, B. and Allan, G. (1998): Porcine circovirus infection in the Republic of Ireland. Vet. Rec. 142, 511–512.
Tischer, I., Bode, L., Peters, D., Pociali, S. and Germann, B. (1995): Distribution of antibodies to porcine circovirus in swine populations of different breeding farms. Arch. Virol. 140, 737–743.
Tischer, I., Gelderblom, H., Vetterman, W. and Koch, M. A. (1982): A very small porcine virus with a circular stranded DNA. Nature 295, 64–66.
Tischer, I., Mields, W., Wolff, D., Vagt, M. and Griem, W. (1986): Studies on the pathogenicity of porcine circovirus. Arch. Virol. 91, 271–276.
Tischer, I., Rasch, R. and Tochtermann, G. (1974): Characterization of papovavirus-and picornavirus-like particles in permanent pig kidney cell lines. Zbl. Bakteriol. A, 226, 153–167.