View More View Less
  • 1 Szent István University, H-1400 Budapest, P.O. Box 2, Hungary
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $836.00

The pharmacokinetics and the influence of food on the kinetic profile and bioavailability of doxycycline was studied after a single intravenous (i.v.) and oral dose of 10.0 mg/kg body weight in 7-week-old broiler chickens. Following i.v. administration the drug was rapidly distributed in the body with a distribution half-life of 0.21 ± 0.01 h. The elimination half-life of 6.78 ± 0.06 h was relatively long and resulted from both a low total body clearance of 0.139 ± 0.007 L/h·kg and a large volume of distribution of 1.36 ± 0.06 L/kg. After oral administration to fasted chickens, the absorption of doxycycline was quite fast and substantial as shown by the absorption half-life of 0.39 ± 0.03 h, the maximal plasma concentration of 4.47 ± 0.16 —g/mL and the time to reach the Cmax of 1.73 ± 0.06 h. The distribution and the final elimination of the drug were slower than after i.v. administration. The absolute bioavailability was 73.4 ± 2.5%. The presence of food in the intestinal tract reduced and extended the absorption (t1/2a = 1.23 ± 0.21 h; Cmax = 3.07 ± 0.23 µg/mL; tmax = 3.34 ± 0.21 h). The absolute bioavailability was reduced to 61.1% ± 4.4%.

  • Anadón, A., Martinez-Larranaga, M. R., Diaz, M. J., Bringas, P., Fernandez, M. C., Fernandez-Cruz, M. L., Iturbe, J. and Martinez, M. A. (1994): Pharmacokinetics of doxycycline in broiler chickens. Avian Pathol. 23, 7990.

    • Search Google Scholar
    • Export Citation
  • Aronson, A. L. (1980): Pharmacotherapeutics of the newer tetracyclines. JAVMA 176, 10611068.

  • Dorrestein, G. M., Bruijne, J. J. D. and Vulto, A. (1991): Bioavailability of doxycycline injectables in pigeons. Acta Vet. Scand. 87 (Suppl.) 291292.

    • Search Google Scholar
    • Export Citation
  • Küng, K. and Wanner, M. (1994): Pharmakokinetik von Doxycycline bei Puten und Vergleich der Futter und Trinkwassermedikation. Arch. Geflügelk. 58, 8488.

    • Search Google Scholar
    • Export Citation
  • Meijer, L. A., Ceyssens, K. G. F., de Greve, B. I. J. A. C. and de Bruijn, W. (1993): Pharmacokinetics and bioavailability of doxycycline hyclate after oral administration in calves. Vet. Quarterly 15, 15.

    • Search Google Scholar
    • Export Citation
  • Riond, I.-L., Vaden, S. L. and Riviere, J. E. (1990): Comparative pharmacokinetics of doxycycline in cats and dogs. J. Vet. Pharmacol. Therap. 13, 415424.

    • Search Google Scholar
    • Export Citation
  • Santos, M. D. F., Vermeersch, H., Remon, J. P., Schelkens, M., De Backer, P., Van Bree, H. I. I., Ducatelle, R. and Haesebrouck, F. (1996): Pharmacokinetics and bioavailability of doxycycline in turkeys. J. Vet. Pharmacol. Therap. 19, 274280.

    • Search Google Scholar
    • Export Citation
  • Santos, M. D. F., Vermeersch, H., Remon, J. P., Schelkens, M., De Backer, P., Ducatelle, R. and Haesebrouck, F. (1997): Administration of doxycycline hydrochloride via drinking water to turkeys under laboratory and field conditions. Poultry Sci. 76, 13421348.

    • Search Google Scholar
    • Export Citation
  • Shaw, D. H. and Rubin, S. I. (1986): Pharmacologic activity of doxycycline. JAVMA 189, 808810.

  • Varkonyi, P. (1983): A calculator package for pharmacokinetic application. Comp. Prog. Biomed. 17, 277282.

  • Welling, P. G., Koch, P. A. and Curtis, C. L. (1977): Bioavailability of tetracycline and doxycycline in fasted and nonfasted subjects. Antimicrob. Agents Chemother. 11, 462469.

    • Search Google Scholar
    • Export Citation

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Jun 2020 0 10 12
Jul 2020 10 1 2
Aug 2020 7 1 1
Sep 2020 14 0 0
Oct 2020 11 0 0
Nov 2020 11 0 0
Dec 2020 0 0 0