View More View Less
  • 1 Research Institute of Animal Breeding and Nutrition, H-2053 Herceghalom, Hungary
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $836.00

The intestinal absorption of trivalent and hexavalent chromium (Cr) given orally (experiment I) or infused in the intestine (experiment II) was investigated in rats. The nonabsorbable form of chromium (51Cr2O3) and water-soluble and more absorbable Na2 51CrO4 (the hexavalent form of Cr) were compared. Total retention of chromium given orally ranged around 15 percent of the dose, regardless of the chromium compounds applied. The absorption rate of chromic oxide, which is considered a nonabsorbable compound, was 14.4 as a percentage of chromium intake. This result indicates that some loss of chromium has to be taken into account in metabolic trials made by the indicator method. In isolated rat intestine, from the injected Cr 2.5% of chromic oxide and 43.2% of sodium chromate were absorbed during an hour (experiment II). The absorbed chromium was transferred to the liver where the liver tissue retained 10.9% of chromic oxide and 51.1% of sodium chromate. Radioactivity of v. cava caudalis following intestinal injection of Na2CrO4 was thirtyfold greater than after Na2CrO4 dosing. This phenomenon can be explained by the lower blood clearance of chromate. Different absorption rate of chromate depending on the route of administration could be due to the fact that the hexavalent form given orally was reduced to Cr3+ in the acidic environment of the stomach. When Na2CrO4 was infused directly in the intestine of rats, such reduction could not occur. This means that the acidic gastric juice might play a role in inhibiting the intestinal absorption of Na2CrO4 when this compound is given orally.

  • Donaldson, R. M. and Barreras, R. F. (1966). Intestinal absorption of trace quantities of chromium. J. Lab. Clin. Med. 68, 484493.

  • Dowling, H. J., Offenbacher, E. G. and Pi-Sunyer, F. X. (1989). Absorption of inorganic, trivalent chromium from the vascularly perfused rat small intestine. J. Nutr. 119, 11381145.

    • Search Google Scholar
    • Export Citation
  • Gabriel, J., Solomon, N., Fierst, S. and Sass, M. (1963). Evaluation of chromic oxide marker in the absorption of fat. Am. J. Digest. Dis. 8, 280.

    • Search Google Scholar
    • Export Citation
  • Hansky, J. and Connell, A. (1962). Measurement of gastrointestinal transit using radioactive chromium. Gut, 3, 187.

  • Hopkins, L. L. and Schwarz, K. (1964). Chromium(III) binding to serum proteins, specifically siderophilin. Biochim. Biophys. Acta 90, 484491.

    • Search Google Scholar
    • Export Citation
  • MacKenzie, R. D., Anwar, R. A., Byerrum, R. U. and Hoppert, C. A. (1959). Absorption and distribution of Cr51 in the albino rat. Arch. Biochem. Biophys. 79, 200205.

    • Search Google Scholar
    • Export Citation
  • Mertz, W. (1969). Chromium occurrence and function in biological systems. Phys. Rev. 49, 163239.

  • Mertz, W. and Roginski, E. E. (1971). Chromium metabolism: the glucose tolerance factor. In: Mertz, W. and Cornatzer, W. E. (eds) Newer Elements in Nutrition. Dekker Press, New York, pp. 123153.

    • Search Google Scholar
    • Export Citation
  • Mertz, W., Roginski, E. E. and Reba, R. C. (1965). Biological activity and fate of intravenous chromium(III) in the rat. Am. J. Physiol. 209, 489494.

    • Search Google Scholar
    • Export Citation
  • Underwood, J. E. (1977). Trace Elements in Human and Animal Nutrition. {pmAcademic Press,^New York}, 260. pp.

  • Visek, W. J., Whitney, I. B., Kuhn, U. S. G. and Comar, C. L. (1953). Metabolism of Cr51 by animals as influencedby chemical state. Proc. Soc. Exptl. Biol. Med. 84, 610615.

    • Search Google Scholar
    • Export Citation
  • Whitby, L. and Lang, D. (1960). Experience with the chromic oxide method of fecal marking in metabolic balance investigations onhumans. J. Clin. Invest. 39, 854.

    • Search Google Scholar
    • Export Citation

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Jun 2020 0 1 2
Jul 2020 2 0 0
Aug 2020 2 0 0
Sep 2020 6 0 0
Oct 2020 1 0 0
Nov 2020 26 0 0
Dec 2020 0 0 0