View More View Less
  • 1 Szent István University, H-1400 Budapest, P.O. Box 2, Hungary
  • 2 Szent István University, H-1400 Budapest, P.O. Box 2, Hungary
  • 3 Szent István University, H-1400 Budapest, P.O. Box 2, Hungary
  • 4 Central Veterinary Institute, Budapest, Hungary
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $836.00

The effect of 10-day zearalenone administration starting 10 days after ovulation was studied in 6 cycling trotter mares in the summer period. After an entire oestrous cycle (Cycle 1), mares were given 7 mg purified zearalenone per os daily (1 mg/ml in ethyl alcohol) beginning on Day 10 of Cycle 2. Toxin exposure was continued until the subsequent ovulation. Luteal function and follicular activity were monitored daily by rectal palpation, ultrasonography and blood sampling for progesterone. During toxin exposure, all animals were in good physical condition. The toxin had no effect on the length of the interovulatory intervals, luteal and follicular phases. It did not influence significantly the plasma progesterone profiles (logistic curve parameters A1 to A6), the follicular activity (growth rate, maximum size of the ovulatory follicles, maximum number and the time of first increase in the number of large follicles) and the uterine oedema. It is concluded that in cyclic mares the methods used in this study could not detect any adverse effect of zearalenone (administered at a low dose similar to natural exposure) on reproduction.

  • Allen, W. R. and Cooper, M. J. (1993). Prostaglandins. In: McKinnon, A. O. and Voss, J. L. (eds) Equine Reproduction, {pmLea & Febiger,^Philadelphia}. pp. 6980.

    • Search Google Scholar
    • Export Citation
  • Bazer, F. W. and Thatcher, W. W. (1977). Theory of maternal recognition of pregnancy in swine based on estrogen-controlled endocrine versus exocrine secretion of prostaglandin F2a by the uterine endometrium. Prostaglandins 14, 397402.

    • Search Google Scholar
    • Export Citation
  • Berg, S. L. and Ginther, O. J. (1978). Effect of estrogens on uterine tone and life span of the corpus luteum in mares. J. Anim. Sci. 47, 203208.

    • Search Google Scholar
    • Export Citation
  • Blankenship, L. T., Dickey, J. F., Bodine, A. B. and Clemson, S. C. (1982). In vitro mycotoxin binding to bovine uterine steroid hormone receptors. Theriogenology 17, 325331.

    • Search Google Scholar
    • Export Citation
  • Bloomquist, C., Davidson, J. N. and Pearson, E. G. (1982). Zearalenone toxicosis in prepubertal dairy heifers. J. Am. Vet. Med. Assoc. 180, 164165.

    • Search Google Scholar
    • Export Citation
  • Christensen, C. M., Nelson, G. H. and Mirocha, C. J. (1965). Effect on the white rat uterus of a toxic substance isolated from Fusarium. Appl. Microbiol. 13, 653659.

    • Search Google Scholar
    • Export Citation
  • Coulombe, R. A. (1993). Biological action of mycotoxins. J. Dairy Sci. 76, 880891.

  • Csernus, V. (1982). Antibodies of high affinity and specificity for radioimmunological determination of progesterone, testosterone, estradiol-17β and cortisol. In: Görög, S. (ed.) Advances in SteroidAnalysis I. Akadémiai Kiado, Budapest. pp. 171177.

    • Search Google Scholar
    • Export Citation
  • Diekman, M. A. and Green, M. L. (1992). Mycotoxins and reproduction in domestic livestock. J. Anim. Sci. 70, 16151627.

  • Edwards, S., Cantley, T. C., Rottinghaus, G. E., Osweiler, G. D. and Day, B. N. (1987). The effect of zearalenone on reproduction in swine. I. The relationship between ingested zearalenone dose and anestrus in non-pregnant, sexually mature gilts. Theriogenology 28, 4349.

    • Search Google Scholar
    • Export Citation
  • Etienne, M. and Jemmali, M. (1982). Effects of zearalenone (F2) on estrous activity and reproduction in gilts. J. Anim. Sci. 55, 19.

  • Friend, D. W., Trenholm, H. L., Thompson, B. K., Hartin, K. E., Fiser, P. S., Asem, E. K. and Tsang, B. K. (1990). The reproductive efficiency of gilts fed very low levels of zearalenone. Can. J. Anim. Sci. 70, 635645.

    • Search Google Scholar
    • Export Citation
  • Ginther, O. J. (2000). Selection of the dominant follicle in cattle and horses. Anim. Reprod. Sci. 60–61, 6179.

  • Huszenicza, Gy., Szigeti, G., Fekete, S., Kulcsar, M., Cseh, S., Abavâryné, M. K. and Nagy, P. (1995). Ovarian malfunctions resulting in infertility and experimental studies on some of their possible reasons in inseminated dairy cattle. A survey of recent Hungarian investigations (in Hungarian, with English abstract). Magyar Allatorvosok Lapja 50, 819828.

    • Search Google Scholar
    • Export Citation
  • Juhasz, J., Nagy, P., Huszenicza, Gy., Szigeti, G., Reiczigel, J. and Kulcsar, M. (1997). Long term mycotoxin (T-2 Fusarium toxin) exposure failed to alter luteal function, follicular activity and embryo recovery in mares. Equine Vet. J., Suppl. 25, 1721.

    • Search Google Scholar
    • Export Citation
  • Kallela, K. and Ettala, E. (1984). The oestrogenic Fusarium toxin (zearalenone) in hay as a cause of early abortions in the cow. Nord. Vet. Med. 36, 305309.

    • Search Google Scholar
    • Export Citation
  • Katzenellenbogen, B. S., Katzenellenbogen, J. A. and Mordecia, D. (1979). Characterisation of the estrogenic potencies and receptor interactions of a series of fungal β-resorcylic acid lactones. Endocrinology 105, 3340.

    • Search Google Scholar
    • Export Citation
  • Koops, W. J. (1986). Multiphasic growth curve analysis. Growth 50, 169177.

  • Kurtz, H. J., Nairn, M. E., Nelson, G. H., Christensen, C. M. and Mirocha, C. J. (1969). Histological changes in the genital tracts of swine fed estrogenic mycotoxin. Am. J. Vet. Res. 30, 551556.

    • Search Google Scholar
    • Export Citation
  • Lindsay, D. G. (1985). Zeranol - A ‘nature-identical’ oestrogen? Food Chem. Toxicol. 23, 767774.

  • Long, G. G. and Diekman, M. A. (1984). Effect of purified zearalenone on early gestation in gilts. J. Anim. Sci. 59, 16621670.

  • Long, G. G., Diekman, M. A., Tuite, J. F., Shannon, G. M. and Vesonder, R. F. (1982). Effect of Fusarium roseum corn culture containing zearalenone on early pregnancy in swine. Am. J. Vet. Res. 43, 15991603.

    • Search Google Scholar
    • Export Citation
  • Matthews, J. N. S., Altman, D. G., Campbell, M. J. and Royston, P. (1990). Analysis of serial measurements in medical research. Brit. Med. J. 300, 230235.

    • Search Google Scholar
    • Export Citation
  • Mirocha, C. J., Harrison, J., Nichols, A. A. and McClintock, M. (1968). Detection of a fungal estrogen (F-2) in hay associated with infertility in dairy cattle. Appl. Microbiol. 16, 797798.

    • Search Google Scholar
    • Export Citation
  • Nagy, P., Solti, L., Kulcsar, M., Reiczigel, J., Huszenicza, Gy., Abavary, K. M. and Wölfling, A. (1998). Progesterone determination in equine plasma using different immunoassays. Acta Vet. Hung. 46, 501513.

    • Search Google Scholar
    • Export Citation
  • Nett, T. M. (1993). Estrogens. In: McKinnon, A. O. and Voss, J. L. (eds) Equine Reproduction. Lea & Febiger, Philadelphia, London. pp. 6568.

    • Search Google Scholar
    • Export Citation
  • Oldenburg, E., Valenta, H. and Sator, C. (2000). Risikoabschätzung und Vermeidungsstrategien bei der Futtermittelerzeugung. In: Dänicke, S. and Oldenburg, E. (eds) Risikofaktoren fur die Fusariumtoxinbildung in Futtermitteln und Vermeidungsstrategien bei der Futtermittelerzeugung und Futterung, Bundesforschungsanstalt fur Landwirtschaft, Braunschweig, pp. 534.

    • Search Google Scholar
    • Export Citation
  • Olsen, M., Malmlöf, M., Pettersson, H., Sandholm, K. and Kiessling, K.-H. (1985). Plasma and urinary levels of zearalenone and α-zearalenol in a prepubertal gilt fed zearalenone. Acta Pharmacol. Toxicol. 56, 239243.

    • Search Google Scholar
    • Export Citation
  • Pier, A. C., Richard, J. L. and Cysewski, S. J. (1980). Implications of mycotoxins in animal disease. J. Am. Vet. Med. Assoc. 176, 719724.

    • Search Google Scholar
    • Export Citation
  • Sharp, D. C. (1993). Maternal recognition of pregnancy. In: McKinnon, A. O. and Voss, J. L. (eds) Equine Reproduction. Lea & Febiger, Philadelphia, London. pp. 486494.

    • Search Google Scholar
    • Export Citation
  • Sirois, J., Ball, B. A. and Fortune, J. E. (1989). Patterns of growth and regression of ovarian follicles during the oestrous cycle and after hemiovariectomy in mares. Equine Vet. J., Suppl. 8, 4348.

    • Search Google Scholar
    • Export Citation
  • Smith, J. F., di Menna, M. E. and McGowan, L. T. (1990). Reproductive performance of Coopworth ewes following oral doses of zearalenone before and after mating. J. Reprod. Fertil. 89, 99106.

    • Search Google Scholar
    • Export Citation
  • Vanyi, A., Glavits, R. and Molnar, T. (1995). Reproductive disorders due to F-2 and T-2 toxins in large-scale pig farms (in Hungarian, with English abstract). Magyar Allatorvosok Lapja 50, 424430.

    • Search Google Scholar
    • Export Citation
  • Vanyi, A., Szemerédi, Gy., Quarini, L. and Romvary-Szailer, E. (1974). Fusariotoxicosis in a cattle herd (in Hungarian, with English abstract). Magyar Allatorvosok Lapja 29, 544546.

    • Search Google Scholar
    • Export Citation
  • Weaver, G. A., Kurtz, H. J., Behrens, J. C., Robinson, T. S., Seguin, B. E., Bates, F. Y. and Mirocha, C. J. (1986). Effect of zearalenone on the fertility of virgin dairy heifers. Am. J. Vet. Res. 47, 13951397.

    • Search Google Scholar
    • Export Citation
  • Woodley, S. L., Burns, P. J., Douglas, R. H. and Oxender, W. D. (1979). Prolonged interovulatory interval after estradiol treatment in mares. J. Reprod. Fertil., Suppl. 27, 205209.

    • Search Google Scholar
    • Export Citation
  • Young, L. G. and King, G. J. (1986). Low concentration of zearalenone in diets of mature gilts. J. Anim. Sci. 63, 11911196.

  • Zavy, M. T., Vernon, M. W., Sharp, D. C. and Bazer, F. W. (1984). Endocrine aspects of early pregnancy in pony mares: a comparison of uterine luminal and peripheral plasma levels of steroids during the estrous cycle and early pregnancy. Endocrinology 115, 214219.

    • Search Google Scholar
    • Export Citation

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Jun 2020 0 6 4
Jul 2020 3 0 0
Aug 2020 20 0 0
Sep 2020 4 0 0
Oct 2020 19 0 0
Nov 2020 4 1 1
Dec 2020 0 0 0