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  • 1 Institute for Animal Breeding and Genetics, Veterinary University Veterinärplatz 1, A-1210 Vienna, Austria
  • 2 Institute for Pathology and Forensic Veterinary Research, Veterinary University Veterinärplatz 1, A-1210 Vienna, Austria
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Tumours localised in the large bowel of dogs were subjected to molecular genetic studies. Highly conserved regions of the tumour suppressor gene p53, including typical tumour hot spots (codons 175, 245, 248, 249, 273 and 282), were analysed. A mutation CGG ? TGG (arginine ? tryptophan) was present in codon 249 in an anaplastic carcinoma in the caecum.

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