View More View Less
  • 1 IZINTA Trading Co. H-1121 Budapest, Konkoly Thege út 29-33, Hungary
  • | 2 Institute for Drug Research Budapest, Hungary
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $836.00

Cross Mark

The effects of cAMP-elevating compounds IBMX (3-isobutyl-1-methyl­xanthine) and isoproterenol, and that of rutin (an effective superoxide scavenger) were studied on orthovanadate- (a putative protein-phosphotyrosine phosphatase inhibitor) induced nitric oxide (NO) production in J774A.1 mouse macrophage cells. As we previously reported (Koncz and Horváth, 2000), rutin and sodium orthovanadate act synergistically to induce production of high amount of NO in J774A.1 cells. IBMX, an agent that can elevate cAMP level in the cells, can reduce the production of both the LPS- and rutin + orthovanadate-induced NO in macrophages. In contrast, isoproterenol, a non-selective ß-adrenergic receptor agonist, that reduced the LPS-induced NO production in macrophage cells, was unable to reduce the rutin + orthovanadate-induced NO production without negatively affecting cell viability. Moreover, isoproterenol dramatically enhanced the orthovanadate-induced NO synthesis in J774A.1 cells. Our previous study clarified that rutin and orthovanadate, in a specific concentration ratio of both, were able to produce hydrogen peroxide (H2O2). Using 2',7'-dichlorofluorescein-diacetate as a marker for H2O2, isoproterenol alone induced its oxidation but the rutin plus orthovanadate-induced H2O2 production was reduced by isoproterenol. These observations have revealed that, in some cases, H2O2 and superoxide (O2-) scavengers can act in a reverse mode on macrophage cells depending on the presence or absence of orthovanadate.

  • Meyer, M., Schreck, R. and Baeuerle, P. A. (1993): H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidantresponsive factor. EMBO J. 12, 2005-2015.

    'H2O2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidantresponsive factor. ' () 12 EMBO J. : 2005 -2015.

    • Search Google Scholar
  • Mietus-Snyder, M., Glass, C. K. and Pitas, R. E. (1998): Transcriptional activation of scavenger receptor expression in human smooth muscle cells requires AP-1/c-Jun and C/EBP. Both AP-1 binding and JNK activation are induced by phorbol esters and oxidative stress. Arterioscler. Thromb. Vasc. Biol. 18, 1440-1449.

    'Transcriptional activation of scavenger receptor expression in human smooth muscle cells requires AP-1/c-Jun and C/EBP. ' () 18 Both AP-1 binding and JNK activation are induced by phorbol esters and oxidative stress. Arterioscler. Thromb. Vasc. Biol. : 1440 -1449.

    • Search Google Scholar
  • Mooney, R. A., Bordwell, K. L., Luhowskyj, S. and Casnellie, J. E. (1989): The insulin-like effect of vanadate on lipolysis in rat adipocytes is not accompanied by an insulin-like effect on tyrosine phosphorylation. Endocrinology 124, 422-429.

    'The insulin-like effect of vanadate on lipolysis in rat adipocytes is not accompanied by an insulin-like effect on tyrosine phosphorylation. ' () 124 Endocrinology : 422 -429.

    • Search Google Scholar
  • Mustafa, S. B. and Olson, M. S. (1998): Expression of nitric-oxide synthase in rat Kupffer cells is regulated by cAMP. J. Biol. Chem. 273, 5073-5080.

    'Expression of nitric-oxide synthase in rat Kupffer cells is regulated by cAMP. ' () 273 J. Biol. Chem. : 5073 -5080.

    • Search Google Scholar
  • Nakaike, R., Shimokawa, H., Owada, M. K., Tokunaga, O., Yasutake, H., Kishimoto, T., Imada, C., Shiraishi, T., Egashira, K. and Takeshita, A. (1996): Vanadate causes synthesis of endothelium-derived NO via pertussis toxin-sensitive G protein in pigs. Am. J. Physiol. 271, H296-302.

    'Vanadate causes synthesis of endothelium-derived NO via pertussis toxin-sensitive G protein in pigs. ' () 271 Am. J. Physiol. : H296 -302.

    • Search Google Scholar
  • Nieder, G. L., Corder, C. N. and Culp, P. A. (1979): The effect of vanadate on human kidney potassium dependent phosphatase. Naunyn Schmiedebergs Arch. Pharmacol. 307, 191-197.

    'The effect of vanadate on human kidney potassium dependent phosphatase. ' () 307 Naunyn Schmiedebergs Arch. Pharmacol. : 191 -197.

    • Search Google Scholar
  • Novogrodsky, A., Vanichkin, A., Patya, M., Gazit, A., Osherov, N. and Levitzki, A. (1994): Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. Science 264, 1319-1322.

    'Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors. ' () 264 Science : 1319 -1322.

    • Search Google Scholar
  • Obrig, T. G., Culp, W. J., McKeehan, W. L. and Hardesty, B. (1971): The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes. J. Biol. Chem. 246, 174-181.

    'The mechanism by which cycloheximide and related glutarimide antibiotics inhibit peptide synthesis on reticulocyte ribosomes. ' () 246 J. Biol. Chem. : 174 -181.

    • Search Google Scholar
  • Olley, P. M., Kasserra, J., Kozak, R. and Lopaschuk, G. D. (1996): Synergism between prostaglandin E2 and isoproterenol in stimulating glucose oxidation in the heart. Can. J. Physiol. Pharmacol. 74, 590-597.

    'Synergism between prostaglandin E2 and isoproterenol in stimulating glucose oxidation in the heart. ' () 74 Can. J. Physiol. Pharmacol. : 590 -597.

    • Search Google Scholar
  • Olson, L. J., Knych, E. T. Jr., Herzig, T. C. and Drewett, J. G. (1997): Selective guanylyl cyclase inhibitor reverses nitric oxide-induced vasorelaxation. Hypertension 29, 254-261.

    'Selective guanylyl cyclase inhibitor reverses nitric oxide-induced vasorelaxation. ' () 29 Hypertension : 254 -261.

    • Search Google Scholar
  • Ozcelikay, A. T., Yidizoglu-Ari, N., Ozuari, A., Ozturk, Y. and Altan, V. M. (1993): The effect of vanadate on alloxan-diabetic rat atria. Diabetes Res. Clin. Pract. 19, 189-194.

    'The effect of vanadate on alloxan-diabetic rat atria. ' () 19 Diabetes Res. Clin. Pract. : 189 -194.

    • Search Google Scholar
  • Pandey, S. K., Anand-Srivastava, M. B. and Srivastava, A. K. (1998): Vanadyl sulfate-stimulated glycogen synthesis is associated with activation of phosphatidylinositol 3-kinase and is independent of insulin receptor tyrosine phosphorylation. Biochemistry 12, 987-996.

    'Vanadyl sulfate-stimulated glycogen synthesis is associated with activation of phosphatidylinositol 3-kinase and is independent of insulin receptor tyrosine phosphorylation. ' () 12 Biochemistry : 987 -996.

    • Search Google Scholar
  • Pang, L. and Hoult, J. R. (1997): Repression of inducible nitric oxide synthase and cyclooxygenase-2 by prostaglandin E2 and other cyclic AMP stimulants in J774 macrophages. Biochem. Pharmacol. 53, 493-500.

    'Repression of inducible nitric oxide synthase and cyclooxygenase-2 by prostaglandin E2 and other cyclic AMP stimulants in J774 macrophages. ' () 53 Biochem. Pharmacol. : 493 -500.

    • Search Google Scholar
  • Pearson, E. G. and Riebold, T. W. (1989): Comparison of bronchodilators in alleviating clinical signs in horses with chronic obstructive pulmonary disease. J. Am. Vet. Med. Assoc. 194, 1287-1291.

    'Comparison of bronchodilators in alleviating clinical signs in horses with chronic obstructive pulmonary disease. ' () 194 J. Am. Vet. Med. Assoc. : 1287 -1291.

    • Search Google Scholar
  • Persoon-Rothert, M., van der Valk-Kokshoorn, E. J., Egas-Kenniphaas, J. M., Mauve, I. and van der Laarse, A. (1989): Isoproterenol-induced cytotoxicity in neonatal rat heart cell cultures is mediated by free radical formation. J. Mol. Cell. Cardiol. 21, 1285-1291.

    'Isoproterenol-induced cytotoxicity in neonatal rat heart cell cultures is mediated by free radical formation. ' () 21 J. Mol. Cell. Cardiol. : 1285 -1291.

    • Search Google Scholar
  • Rathore, N., John, S., Kale, M. and Bhatnagar, D. (1998): Lipid peroxidation and antioxidant enzymes in isoproterenol induced oxidative stress in rat tissues. Pharmacol. Res. 38, 297-303.

    'Lipid peroxidation and antioxidant enzymes in isoproterenol induced oxidative stress in rat tissues. ' () 38 Pharmacol. Res. : 297 -303.

    • Search Google Scholar
  • Rathore, N., Kale, M., John, S. and Bhatnagar, D. (2000): Lipid peroxidation and antioxidant enzymes in isoproterenol induced oxidative stress in rat erythrocytes. Indian J. Physiol. Pharmacol. 44, 161-166.

    'Lipid peroxidation and antioxidant enzymes in isoproterenol induced oxidative stress in rat erythrocytes. ' () 44 Indian J. Physiol. Pharmacol. : 161 -166.

    • Search Google Scholar
  • Remiao, F., Carmo, H., Carvalho, F. D. and Bastos, M. L. (2000): Inhibition of glutathione reductase by isoproterenol oxidation products. J. Enzyme. Inhib. 15, 47-61.

    'Inhibition of glutathione reductase by isoproterenol oxidation products. ' () 15 J. Enzyme. Inhib. : 47 -61.

    • Search Google Scholar
  • Rona, G. (1985): Catecholamine cardiotoxicity. J. Mol. Cell. Cardiol. 17, 291-306.

    'Catecholamine cardiotoxicity. ' () 17 J. Mol. Cell. Cardiol. : 291 -306.

  • Rosa, L. F. (1997): Effect of adrenaline on lymphocyte metabolism and function. A mechanism involving cAMP and hydrogen peroxide. Cell Biochem. Funct. 15, 103-112.

    'Effect of adrenaline on lymphocyte metabolism and function. ' () 15 A mechanism involving cAMP and hydrogen peroxide. Cell Biochem. Funct. : 103 -112.

    • Search Google Scholar
  • Roy, S., Noda, Y., Eckert, V., Traber, M. G., Mori, A., Liburdy, R. and Packer, L. (1995): The phorbol 12-myristate 13-acetate (PMA)-induced oxidative burst in rat peritoneal neutrophils is increased by a 0.1 mT (60 Hz) magnetic field. FEBS Letters 376, 164-166.

    'The phorbol 12-myristate 13-acetate (PMA)-induced oxidative burst in rat peritoneal neutrophils is increased by a 0.1 mT (60 Hz) magnetic field ' () 376 FEBS Letters : 164 -166.

    • Search Google Scholar
  • Safrany, S. T. and Shears, S. B. (1998): Turnover of bis-diphosphoinositol tetrakisphosphate in a smooth muscle cell line is regulated by beta2-adrenergic receptors through a cAMP-mediated, A-kinase-independent mechanism. EMBO J. 17, 1710-1716.

    'Turnover of bis-diphosphoinositol tetrakisphosphate in a smooth muscle cell line is regulated by beta2-adrenergic receptors through a cAMP-mediated, A-kinase-independent mechanism. ' () 17 EMBO J. : 1710 -1716.

    • Search Google Scholar
  • Schmitt, A. S., Salvayre, R., Delchambre, J. and Négre-Salvayre, A. (1995): Prevention by alphatocopherol and rutin of glutathione and ATP depletion induced by oxidized LDL in cultured endothelial cells. Br. J. Pharmacol. 116, 1985-1990.

    'Prevention by alphatocopherol and rutin of glutathione and ATP depletion induced by oxidized LDL in cultured endothelial cells. ' () 116 Br. J. Pharmacol. : 1985 -1990.

    • Search Google Scholar
  • Schreck, R., Meyer, B., Männel, D. N., Dröge, W. and Baeuerle, P. A. (1992): Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells. J. Exp. Med. 175, 1181-1194.

    'Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells. ' () 175 J. Exp. Med. : 1181 -1194.

    • Search Google Scholar
  • Green, S. P., Hamilton, J. A. and Phillips, W. A. (1992): Zymosan-triggered tyrosine phosphorylation in mouse bone-marrow-derived macrophages is enhanced by respiratory-burst priming agents. Biochem. J. 288, 427-432.

    'Zymosan-triggered tyrosine phosphorylation in mouse bone-marrow-derived macrophages is enhanced by respiratory-burst priming agents. ' () 288 Biochem. J. : 427 -432.

    • Search Google Scholar
  • Gross, S. S., Stuehr, D. J., Aisaka, K., Jaffe, E. A., Levi, R. and Griffith, O. W. (1990): Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine. Biochem. Biophys. Res. Commun. 170, 96-103.

    'Macrophage and endothelial cell nitric oxide synthesis: cell-type selective inhibition by NG-aminoarginine, NG-nitroarginine and NG-methylarginine. ' () 170 Biochem. Biophys. Res. Commun. : 96 -103.

    • Search Google Scholar
  • Hansard, S. L. 2nd, Ammerman, C. B., Henry, P. R. and Simpson, C. F. (1982): Vanadium metabolism in sheep. I. Comparative and acute toxicity of vanadium compounds in sheep. J. Anim. Sci. 55, 344-349.

    'Vanadium metabolism in sheep. ' () 55 I. Comparative and acute toxicity of vanadium compounds in sheep. J. Anim. Sci. : 344 -349.

    • Search Google Scholar
  • Hasko, G., Nemeth, Z. H., Szabo, C., Zsilla, G., Salzman, A. L. and Vizi, E. S. (1998): Isoproterenol inhibits Il-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages. Brain Res. Bull. 45, 183-187.

    'Isoproterenol inhibits Il-10, TNF-alpha, and nitric oxide production in RAW 264.7 macrophages ' () 45 Brain Res. Bull. : 183 -187.

    • Search Google Scholar
  • Hibbs, J. B. Jr., Taintor, R. R., Vavrin, Z. and Rachlin, E. M. (1988): Nitric oxide: a cytotoxic activated macrophage effector molecule. Biochem. Biophys. Res. Commun. 157, 87-94.

    'Nitric oxide: a cytotoxic activated macrophage effector molecule. ' () 157 Biochem. Biophys. Res. Commun. : 87 -94.

    • Search Google Scholar
  • Hirono, O., Kubota, I., Minamihaba, O., Fatema, K., Kato, S., Nakamura, H. and Tomoike, H. (2001): Left ventricular diastolic dysfunction in patients with bronchial asthma with longterm oral beta2-adrenoceptor agonists. Am. Heart. J. 142, E11.

    'Left ventricular diastolic dysfunction in patients with bronchial asthma with longterm oral beta2-adrenoceptor agonists. ' () 142 Am. Heart. J. : E11.

    • Search Google Scholar
  • Hudgins, P. M. and Bond, G. H. (1979): Reversal of vanadate inhibition of NaK-ATPase by catecholamines. Res. Commun. Chem. Pathol. Pharmacol. 23, 313-326.

    'Reversal of vanadate inhibition of NaK-ATPase by catecholamines. ' () 23 Res. Commun. Chem. Pathol. Pharmacol. : 313 -326.

    • Search Google Scholar
  • Izeboud, C. A., Vermeulen, R. M., Zwart, A., Voss, H. P., van Miert, A. S. and Witkamp, R. F. (2000): Stereoselectivity at the beta2-adrenoceptor on macrophages is a major determinant of the anti-inflammatory effects of beta2-agonists. Naunyn Schmiedebergs Arch. Pharmacol. 362, 184-189.

    'Stereoselectivity at the beta2-adrenoceptor on macrophages is a major determinant of the anti-inflammatory effects of beta2-agonists. ' () 362 Naunyn Schmiedebergs Arch. Pharmacol. : 184 -189.

    • Search Google Scholar
  • Sherman, M. P., Aeberhard, E. E., Wong, V. Z., Griscavage, J. M. and Ignarro, L. J. (1993): Pyrrolidine dithiocarbamate inhibits induction of nitric oxide synthase activity in rat alveolar macrophages. Biochem. Biophys. Res. Commun. 191, 1301-1308.

    'Pyrrolidine dithiocarbamate inhibits induction of nitric oxide synthase activity in rat alveolar macrophages. ' () 191 Biochem. Biophys. Res. Commun. : 1301 -1308.

    • Search Google Scholar
  • Imbert, V., Rupec, R. A., Livolsi, A., Pahl, H. L., Traenckner, E. B., Mueller-Dieckmann, C., Farahifar, D., Rossi, B., Auberger, P., Baeuerle, P. A. and Peyron, J. F. (1996): Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha. Cell 86, 787-798.

    'Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha. ' () 86 Cell : 787 -798.

    • Search Google Scholar
  • Sims, C., Chiu, J. and Harvey, R. D. (2000): Tyrosine phosphatase inhibitors selectively antagonize beta-adrenergic receptor-dependent regulation of cardiac ion channels. Mol. Pharmacol. 58, 1213-1221.

    'Tyrosine phosphatase inhibitors selectively antagonize beta-adrenergic receptor-dependent regulation of cardiac ion channels. ' () 58 Mol. Pharmacol. : 1213 -1221.

    • Search Google Scholar
  • Singh, S. and Aggarwal, B. B. (1995): Protein-tyrosine phosphatase inhibitors block tumor necrosis factor-dependent activation of the nuclear transcription factor NF-kappa B. J. Biol. Chem. 270, 10631-10639.

    'Protein-tyrosine phosphatase inhibitors block tumor necrosis factor-dependent activation of the nuclear transcription factor NF-kappa B. ' () 270 J. Biol. Chem. : 10631 -10639.

    • Search Google Scholar
  • Thompson, M. S., Cohn, L. A. and Jordan, R. C. (1999): Use of rutin for medical management of idiopathic chylothorax in four cats. J. Am. Vet. Med. Assoc. 215, 345-348.

    'Use of rutin for medical management of idiopathic chylothorax in four cats. ' () 215 J. Am. Vet. Med. Assoc. : 345 -348.

    • Search Google Scholar
  • van Acker, S. A., Tromp, M. N., Haenen, G. R., van der Vijgh, W. J. and Bast, A. (1995): Flavonoids as scavengers of nitric oxide radical. Biochem. Biophys. Res. Commun. 214, 755-759.

    'Flavonoids as scavengers of nitric oxide radical. ' () 214 Biochem. Biophys. Res. Commun. : 755 -759.

    • Search Google Scholar
  • Sosunov, E. A., Gainullin, R. Z., Moise, N. S., Steinberg, S. F., Danilo, P. and Rosen, M. R. (2000): Beta(1) and beta(2)-adrenergic receptor subtype effects in German shepherd dogs with inherited lethal ventricular arrhythmias. Cardiovasc. Res. 48, 211-219.

    'Beta(1) and beta(2)-adrenergic receptor subtype effects in German shepherd dogs with inherited lethal ventricular arrhythmias. ' () 48 Cardiovasc. Res. : 211 -219.

    • Search Google Scholar
  • Tappia, P. S., Hata, T., Hozaima, L., Sandhu, M. S., Panagia, V. and Dhalla, N. S. (2001): Role of oxidative stress in catecholamine-induced changes in cardiac sarcolemmal Ca 2+ transport. Arch. Biochem. Biophys. 387, 85-92.

    'Role of oxidative stress in catecholamine-induced changes in cardiac sarcolemmal Ca 2+ transport. ' () 387 Arch. Biochem. Biophys. : 85 -92.

    • Search Google Scholar
  • Ungureanu-Longrois, D., Balligand, J. L., Okada, I., Simmons, W. W., Kobzik, L., Lowenstein, C. J., Kunkel, S. L., Michel, T., Kelly, R. A. and Smith, T. W. (1995): Contractile responsiveness of ventricular myocytes to isoproterenol is regulated by induction of nitric oxide synthase activity in cardiac microvascular endothelial cells in heterotypic primary culture. Circ. Res. 77, 486-493.

    'Contractile responsiveness of ventricular myocytes to isoproterenol is regulated by induction of nitric oxide synthase activity in cardiac microvascular endothelial cells in heterotypic primary culture. ' () 77 Circ. Res. : 486 -493.

    • Search Google Scholar
  • Walters, E. H. and Walters, J. (2000): Inhaled short acting beta2-agonist use in asthma: regular vs as needed treatment. Cochrane Database Syst. Rev. 4, CD001285.

    'Inhaled short acting beta2-agonist use in asthma: regular vs as needed treatment. ' () 4 Cochrane Database Syst. Rev. : CD001285.

    • Search Google Scholar
  • Wei, H., Bowen, R., Cai, Q., Barnes, S. and Wang, Y. (1995): Antioxidant and antipromotional effects of the soybean isoflavone genistein. Proc. Soc. Exp. Biol. Med. 208, 124-130.

    'Antioxidant and antipromotional effects of the soybean isoflavone genistein. ' () 208 Proc. Soc. Exp. Biol. Med. : 124 -130.

    • Search Google Scholar
  • Wei, H., Wei, L., Frenkel, K., Bowen, R. and Barnes, S. (1993): Inhibition of tumor promoter-induced hydrogen peroxide formation in vitro and in vivo by genistein. Nutr. Cancer 20, 1-12.

    'Inhibition of tumor promoter-induced hydrogen peroxide formation in vitro and in vivo by genistein. ' () 20 Nutr. Cancer : 1 -12.

    • Search Google Scholar
  • Welsh, N. (1994): A role for tyrosine kinase activation in interleukin-1 beta induced nitric oxide production in the insulin producing cell line RINm-5F. Biosci. Rep. 14, 43-50.

    'A role for tyrosine kinase activation in interleukin-1 beta induced nitric oxide production in the insulin producing cell line RINm-5F. ' () 14 Biosci. Rep. : 43 -50.

    • Search Google Scholar
  • Yin, X., Davison, A. J. and Tsang, S. S. (1992): Vanadate-induced gene expression in mouse C127 cells: roles of oxygen derived active species. Mol. Cell Biochem. 115, 85-96.

    'Vanadate-induced gene expression in mouse C127 cells: roles of oxygen derived active species. ' () 115 Mol. Cell Biochem. : 85 -96.

    • Search Google Scholar
  • Zhu, H., Bannenberg, G. L., Moldeus, P. and Shertzer, H. G. (1994): Oxidation pathways for the intracellular probe 2',7'-dichlorofluorescein. Arch. Toxicol. 68, 582-587.

    'Oxidation pathways for the intracellular probe 2',7'-dichlorofluorescein. ' () 68 Arch. Toxicol. : 582 -587.

    • Search Google Scholar
  • Zimmer, H. G., Ibel, H. and Suchner, U. (1990): Beta-adrenergic agonists stimulate the oxidative pentose phosphate pathway in the rat heart. Circ. Res. 67, 1525-1534.

    'Beta-adrenergic agonists stimulate the oxidative pentose phosphate pathway in the rat heart. ' () 67 Circ. Res. : 1525 -1534.

    • Search Google Scholar
  • Janatova, T., Pelouch, V., Ostadal, B. and Krause, E. G. (1986): The effect of oxidized isoprenaline on the chick embryonic heart. Can. J. Physiol. Pharmacol. 64, 897-903.

    'The effect of oxidized isoprenaline on the chick embryonic heart. ' () 64 Can. J. Physiol. Pharmacol. : 897 -903.

    • Search Google Scholar
  • Jenkins, K. J., Collins, F. W. and Hidiroglou, M. (1992): Research note: efficacy of various flavonoids and simple phenolics in prevention of nutritional myopathy in the chick. Poult. Sci. 71, 1577-1580.

    'Research note: efficacy of various flavonoids and simple phenolics in prevention of nutritional myopathy in the chick. ' () 71 Poult. Sci. : 1577 -1580.

    • Search Google Scholar
  • Kazazi, F., Koehler, J. K. and Klebanoff, S. J. (1996): Activation of the HIV long terminal repeat and viral production by H2O2-vanadate. Free Radic. Biol. Med. 20, 813-820.

    'Activation of the HIV long terminal repeat and viral production by H2O2-vanadate. ' () 20 Free Radic. Biol. Med. : 813 -820.

    • Search Google Scholar
  • Klatt, P., Cacho, J., Crespo, M. D., Herrera, E. and Ramos, P. (2000): Nitric oxide inhibits isoproterenol-stimulated adipocyte lipolysis through oxidative inactivation of the beta-agonist. Biochem. J. 351, 485-493.

    'Nitric oxide inhibits isoproterenol-stimulated adipocyte lipolysis through oxidative inactivation of the beta-agonist. ' () 351 Biochem. J. : 485 -493.

    • Search Google Scholar
  • Koncz, S. and Horváth, E. J. (2000): Synergistic action of rutin and orthovanadate on nitric oxide release from mouse macrophage cells. Acta Physiol. Hung. 87, 53-66.

    'Synergistic action of rutin and orthovanadate on nitric oxide release from mouse macrophage cells. ' () 87 Acta Physiol. Hung. : 53 -66.

    • Search Google Scholar
  • Kurosaki, K., Ikeda, U., Maeda, Y. and Shimada, K. (2000): Carvedilol stimulates nitric oxide synthesis in rat cardiac myocytes. J. Mol. Cell. Cardiol. 32, 333-339.

    'Carvedilol stimulates nitric oxide synthesis in rat cardiac myocytes. ' () 32 J. Mol. Cell. Cardiol. : 333 -339.

    • Search Google Scholar
  • Lebel, C. P., Ischiropoulos, H. and Bondy, S. C. (1992): Evaluation of the probe 2',7'-dichlorofluorescein as an indicator of reactive oxygen species formation and oxidative stress. Chem. Res. Toxicol. 5, 227-231.

    'Evaluation of the probe 2',7'-dichlorofluorescein as an indicator of reactive oxygen species formation and oxidative stress. ' () 5 Chem. Res. Toxicol. : 227 -231.

    • Search Google Scholar
  • Menon, S. D., Guy, G. R. and Tan, Y. H. (1995): Involvement of a putative protein-tyrosine phosphatase and I kappa B-alpha serine phosphorylation in nuclear factor kappa B activation by tumor necrosis factor. J. Biol. Chem. 270, 18881-18887.

    'Involvement of a putative protein-tyrosine phosphatase and I kappa B-alpha serine phosphorylation in nuclear factor kappa B activation by tumor necrosis factor. ' () 270 J. Biol. Chem. : 18881 -18887.

    • Search Google Scholar
  • Aebi, H. (1984): Catalase in vitro. Methods Enzymol. 105, 121-126.

    'Catalase in vitro. ' () 105 Methods Enzymol. : 121 -126.

  • Akiyama, M., Ishida, J., Nakagawa, S., Ogawara, H. and Watanabe, S. (1987): Genistein, a specific inhibitor of tyrosine-specific protein kinases. J. Biol. Chem. 262, 5592-5595.

    'Genistein, a specific inhibitor of tyrosine-specific protein kinases. ' () 262 J. Biol. Chem. : 5592 -5595.

    • Search Google Scholar
  • Barceloux, D. G. (1999): Vanadium. J. Toxicol. Clin. Toxicol. 37, 265-278.

    'Vanadium. ' () 37 J. Toxicol. Clin. Toxicol. : 265 -278.

  • Bassal, S., Liu, Y. S., Thomas, R. J. and Phillips, W. A. (1997): Phosphotyrosine phosphatase activity in the macrophage is enhanced by lipopolysaccharide, tumor necrosis factor alpha, and granulocyte/macrophage-colony stimulating factor: correlation with priming of the respiratory burst. Biochim. Biophys. Acta. 1355, 343-352.

    'Phosphotyrosine phosphatase activity in the macrophage is enhanced by lipopolysaccharide, tumor necrosis factor alpha, and granulocyte/macrophage-colony stimulating factor: correlation with priming of the respiratory burst. ' () 1355 Biochim. Biophys. Acta. : 343 -352.

    • Search Google Scholar
  • Beasley, R., Pearce, N., Crane, J. and Burgess, C. (1999): Beta-agonists: what is the evidence that their use increases the risk of asthma morbidity and mortality? J. Allergy Clin. Immunol. 104, S18-30.

    'Beta-agonists: what is the evidence that their use increases the risk of asthma morbidity and mortality? J. ' () 104 Allergy Clin. Immunol. : S18 -30.

    • Search Google Scholar
  • Li, J., Elberg, G., Sekar, N., Bin He, Z. and Shechter, Y. (1997): Antilipolytic actions of vanadate and insulin in rat adipocytes mediated by distinctly different mechanisms. Endocrinology 138, 2274-2279.

    'Antilipolytic actions of vanadate and insulin in rat adipocytes mediated by distinctly different mechanisms. ' () 138 Endocrinology : 2274 -2279.

    • Search Google Scholar
  • Mathew, S., Menon, P. V. and Kurup, P. A. (1986): Effect of administration of carnitine on the severity of myocardial infarction induced by isoproterenol in rats. Aust. J. Exp. Biol. Med. Sci. 64, 79-87.

    'Effect of administration of carnitine on the severity of myocardial infarction induced by isoproterenol in rats. ' () 64 Aust. J. Exp. Biol. Med. Sci. : 79 -87.

    • Search Google Scholar
  • Blasig, I. E., Zipper, J., Muschick, P., Modersohn, D. and Lowe, H. (1985): Absolute and relative myocardial ischemia by isoproterenol overdosage. Biomed. Biochim. Acta 44, 1641-1649.

    'Absolute and relative myocardial ischemia by isoproterenol overdosage. ' () 44 Biomed. Biochim. Acta : 1641 -1649.

    • Search Google Scholar
  • Castan, I., Wijkander, J. and Manganiello, V. (1999): Mechanisms of inhibition of lipolysis by insulin, vanadate and peroxovanadate in rat adipocytes. Biochem. J. 339, 281-289.

    'Mechanisms of inhibition of lipolysis by insulin, vanadate and peroxovanadate in rat adipocytes. ' () 339 Biochem. J. : 281 -289.

    • Search Google Scholar
  • Churchill, P. C. and Churchill, M. C. (1982): Isoproterenol-stimulated renin secretion in the rat: second messenger roles of Ca and cyclic AMP. Life Sci. 30, 1313-1319.

    'Isoproterenol-stimulated renin secretion in the rat: second messenger roles of Ca and cyclic AMP. ' () 30 Life Sci. : 1313 -1319.

    • Search Google Scholar
  • Cortijo, J., Villagrasa, V., Marti-Cabrera, M., Villar, V., Moreau, J., Advenier, C., Morcillo, E. J. and Small, R. C. (1997): The spasmogenic effects of vanadate in human isolated bronchus. Br. J. Pharmacol. 121, 1339-1349.

    'The spasmogenic effects of vanadate in human isolated bronchus. ' () 121 Br. J. Pharmacol. : 1339 -1349.

    • Search Google Scholar
  • Dackiw, P. B., Grinstein, S., Brisseau, G. F., McGilvray, I. D., Nathens, A. B., McGuire, J. A., Romanek, R., Cheung, P. Y. C. and Rotstein, O. D. (1997): The Role of tyrosine phosphorylation in lipopolysaccharide- and zymosan-induced procoagulant activity and tissue factor expression in macrophages. Infect. Immun. 65, 2362-2370.

    'The Role of tyrosine phosphorylation in lipopolysaccharide- and zymosan-induced procoagulant activity and tissue factor expression in macrophages. ' () 65 Infect. Immun. : 2362 -2370.

    • Search Google Scholar
  • Diez-Fraile, A., Meyer, E., Massart-Leen, A. M. and Burvenich, C. (2000): Effect of isoproterenol and dexamethasone on the lipopolysaccharide induced expression of CD11b on bovine neutrophils. Vet. Immunol. Immunopathol. 76, 151-156.

    'Effect of isoproterenol and dexamethasone on the lipopolysaccharide induced expression of CD11b on bovine neutrophils. ' () 76 Vet. Immunol. Immunopathol. : 151 -156.

    • Search Google Scholar
  • D'Ocon, M. P. (1989): Different effects of papaverine, isoprenaline and caffeine on rat uterine contractility in Ca-free medium. Arch. Int. Pharmacodyn. Ther. 302, 268-279.

    'Different effects of papaverine, isoprenaline and caffeine on rat uterine contractility in Ca-free medium. ' () 302 Arch. Int. Pharmacodyn. Ther. : 268 -279.

    • Search Google Scholar
  • Feinstein, D. L., Galea, E. and Reis, D. J. (1993): Norepinephrine suppresses inducible nitric oxide synthase activity in rat astroglial cultures. J. Neurochem. 60, 1945-1948.

    'Norepinephrine suppresses inducible nitric oxide synthase activity in rat astroglial cultures. ' () 60 J. Neurochem. : 1945 -1948.

    • Search Google Scholar
  • Ferlay, A., Charret, C., Galitzky, J., Berlan, M. and Chilliard, Y. (2001): Effects of the perfusion of beta-, beta2-, or beta3-adrenergic agonists or epinephrine on in situ adipose tissue lipolysis measured by microdialysis in underfed ewes. J. Anim. Sci. 79, 453-462.

    'Effects of the perfusion of beta-, beta2-, or beta3-adrenergic agonists or epinephrine on in situ adipose tissue lipolysis measured by microdialysis in underfed ewes. ' () 79 J. Anim. Sci. : 453 -462.

    • Search Google Scholar
  • Flohé, L. and Ötting, F. (1984): Superoxide dismutase assays. Methods Enzymol. 105, 93-104.

    'Superoxide dismutase assays. ' () 105 Methods Enzymol. : 93 -104.

  • Gillissen, A., Jaworska, M., Scharling, B., van Zwoll, D. and Schultze-Werninghaus, G. (1997): Beta-2-agonists have antioxidant function in vitro. 1. Inhibition of superoxide anion, hydrogen peroxide, hypochlorous acid and hydroxyl radical. Respiration 64, 16-22.

    'Beta-2-agonists have antioxidant function in vitro. ' () 64 1. Inhibition of superoxide anion, hydrogen peroxide, hypochlorous acid and hydroxyl radical. Respiration : 16 -22.

    • Search Google Scholar
  • Goeptar, A. R., Haenen, G. R., Timmerman, H. and Bast, A. (1988): The effects of beta-adrenergic receptor agonists on the H2O2 formation in alveolar macrophage suspensions are not mediated by beta-receptors. Agents Actions 25, 375-377.

    'The effects of beta-adrenergic receptor agonists on the H2O2 formation in alveolar macrophage suspensions are not mediated by beta-receptors. ' () 25 Agents Actions : 375 -377.

    • Search Google Scholar
  • Gordon, J. (1991): Use of vanadate as protein-phosphotyrosine phosphatase inhibitor. Methods Enzymol. 201, 477-482.

    'Use of vanadate as protein-phosphotyrosine phosphatase inhibitor. ' () 201 Methods Enzymol. : 477 -482.

    • Search Google Scholar
  • Green, L. C., Wagner, D. A., Glogowski, J., Skipper, P. L., Wishnok, J. S. and Tannenbaum, S. R. (1982): Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Analyt. Biochem. 126, 131-138.

    'Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. ' () 126 Analyt. Biochem. : 131 -138.

    • Search Google Scholar
  • Green, S. P. and Phillips, W. A. (1994): Activation of the macrophage respiratory burst by phorbol myristate acetate: evidence for both tyrosine-kinase-dependent and -independent pathways. Biochim. Biophys. Acta 1222, 241-248.

    'Activation of the macrophage respiratory burst by phorbol myristate acetate: evidence for both tyrosine-kinase-dependent and -independent pathways. ' () 1222 Biochim. Biophys. Acta : 241 -248.

    • Search Google Scholar
  • Mayer, A. M., Brenic, S., Stocker, R. and Glaser, K. B. (1995): Modulation of superoxide generation in in vivo lipopolysaccharide-primed rat alveolar macrophages by arachidonic acid and inhibitors of protein kinase C, phospholipase A2, protein serine-threonine phosphatase(s), protein tyrosine kinase(s) and phosphatase(s). J. Pharmacol. Exp. Ther. 274, 427-436.

    'Modulation of superoxide generation in in vivo lipopolysaccharide-primed rat alveolar macrophages by arachidonic acid and inhibitors of protein kinase C, phospholipase A2, protein serine-threonine phosphatase(s), protein tyrosine kinase(s) and phosphatase(s). ' () 274 J. Pharmacol. Exp. Ther. : 427 -436.

    • Search Google Scholar
  • McCall, T. B., Feelish, M., Palmer, R. M. J. and Moncada, S. (1991): Identification of N-iminoethyl-L-ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells. Br. J. Pharmacol. 102, 234-238.

    'Identification of N-iminoethyl-L-ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells. ' () 102 Br. J. Pharmacol. : 234 -238.

    • Search Google Scholar
All Time Past Year Past 30 Days
Abstract Views 38 38 0
Full Text Views 8 4 0
PDF Downloads 3 1 0