Effect of dietary fumonisin b1 on certain immune parameters of weaned pigs

G. Tornyos; Melinda Kovács; M. Rusvai; P. Horn; J. Fodor; F. Kovács

doi:10.1556/avet.51.2003.2.5

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Acta Veterinaria Hungarica

Volume/Issue:: Volume 51: Issue 2

Effect of dietary fumonisin b₁ on certain immune parameters of weaned pigs

Authors:

G. Tornyos

G. Tornyos Faculty of Animal Science, University of Kaposvár H-7400 Kaposvár, Guba S. u. 40, Hungary

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Melinda Kovács

Melinda Kovács Animal Breeding and Animal Hygiene Research Group of the Hungarian Academy of Sciences and the University of Kaposvár, Faculty of Animal Science, University of Kaposvár Kaposvár, Hungary

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M. Rusvai

M. Rusvai Faculty of Veterinary Science, Szent István University Budapest, Hungary

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P. Horn

P. Horn Faculty of Animal Science, Kaposvár University H-7400 Kaposvár, Guba S. u. 40, Hungary

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J. Fodor

J. Fodor Plant Protection Institute, Hungarian Academy of Sciences H-1525 Budapest, P.O. Box 102, Hungary

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F. Kovács

F. Kovács Boehringer Ingelheim Vetmedica GmbH, Research and Development, Biologicals Ingelheim, Germany

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Pages:: 171–179

Online Publication Date:: 22 Jul 2005

Publication Date:: 01 Mar 2003

Article Category:: Journal Article

DOI:: https://doi.org/10.1556/avet.51.2003.2.5

Keywords:: immune response; immune response; immune response; pig; Fumonisin B1; lymphocyte stimulation test

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Only few data are available on the effect of fumonisins on the immune response. The aim of the present study was to examine whether dietary fumonisin B₁ (FB₁) has any effect on the humoral and cellular immune response in weaned pigs, depending on the dose and the time of toxin exposure. Fusarium moniliforme fungal culture was added to the experimental animals' diet to ensure an FB₁ intake of 1, 5 and 10 ppm (first experiment) or 100 mg per animal per day (second experiment). The control animals were fed a toxin-free diet. In order to determine the immune response, the animals were vaccinated against Aujeszky's disease with inactivated vaccine (Aujespig K, Phylaxia-Sanofi, Budapest, Hungary). Specific and nonspecific in vitro cellular immune response was measured by the lymphocyte stimulation test (LST) induced by PHA-P, Con A, LPS and inactivated suspension of the Aujeszky's disease virus. Humoral immune response, e.g. specific antibody titre, was measured by the virus neutralisation (VN) test. None of the immunological parameters examined showed significant differences between groups. It could be concluded that fumonisin B₁ had no significant effect on the humoral and cellular specific and nonspecific immune response when fed in a high dose (100 mg/animal/day for 8 days) or in a low concentration even for a longer period (1, 5 and 10 ppm for 3-4 months).

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Acta Veterinaria Hungarica

Print ISSN:: 0236-6290

Online ISSN:: 1588-2705

Editorial Board

Mária BENKŐ (Acta Veterinaria Hungarica, Budapest, Hungary)
Gábor BODÓ (University of Veterinary Medicine, Budapest, Hungary)
Béla DÉNES (University of Veterinary Medicine, Budapest Hungary)
Edit ESZTERBAUER (Veterinary Medical Research Institute, Budapest, Hungary)
Hedvig FÉBEL (University of Veterinary Medicine, Budapest, Hungary)
László FODOR (University of Veterinary Medicine, Budapest, Hungary)
János GÁL (University of Veterinary Medicine, Budapest, Hungary)
Balázs HARRACH (Veterinary Medical Research Institute, Budapest, Hungary)
Peter MASSÁNYI (Slovak University of Agriculture in Nitra, Nitra, Slovak Republic)
Béla NAGY (Veterinary Medical Research Institute, Budapest, Hungary)
Tibor NÉMETH (University of Veterinary Medicine, Budapest, Hungary)
Zsuzsanna NEOGRÁDY (University of Veterinary Medicine, Budapest, Hungary)
Dušan PALIĆ (Ludwig Maximilian University, Munich, Germany)
Alessandra PELAGALLI (University of Naples Federico II, Naples, Italy)
Kurt PFISTER (Ludwig-Maximilians-University of Munich, Munich, Germany)
László SOLTI (University of Veterinary Medicine, Budapest, Hungary)
József SZABÓ (University of Veterinary Medicine, Budapest, Hungary)
Péter VAJDOVICH (University of Veterinary Medicine, Budapest, Hungary)
János VARGA (University of Veterinary Medicine, Budapest, Hungary)
Štefan VILČEK (University of Veterinary Medicine in Kosice, Kosice, Slovak Republic)
Károly VÖRÖS (University of Veterinary Medicine, Budapest, Hungary)
Herbert WEISSENBÖCK (University of Veterinary Medicine, Vienna, Austria)
Attila ZSARNOVSZKY (Szent István University, Gödöllő, Hungary)

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Acta Veterinaria Hungarica
Language	English
Size	A4
Year of Foundation	1951
Volumes per Year	1
Issues per Year	4
Founder	Magyar Tudományos Akadémia
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ISSN	0236-6290 (Print)
ISSN	1588-2705 (Online)