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  • 1 Faculty of Animal Science, University of Kaposvár H-7400 Kaposvár, Guba S. u. 40, Hungary
  • 2 Animal Breeding and Animal Hygiene Research Group of the Hungarian Academy of Sciences and the University of Kaposvár, Faculty of Animal Science, University of Kaposvár Kaposvár, Hungary
  • 3 Faculty of Veterinary Science, Szent István University Budapest, Hungary
  • 4 Faculty of Animal Science, Kaposvár University H-7400 Kaposvár, Guba S. u. 40, Hungary
  • 5 Plant Protection Institute, Hungarian Academy of Sciences H-1525 Budapest, P.O. Box 102, Hungary
  • 6 Boehringer Ingelheim Vetmedica GmbH, Research and Development, Biologicals Ingelheim, Germany
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Only few data are available on the effect of fumonisins on the immune response. The aim of the present study was to examine whether dietary fumonisin B1 (FB1) has any effect on the humoral and cellular immune response in weaned pigs, depending on the dose and the time of toxin exposure. Fusarium moniliforme fungal culture was added to the experimental animals' diet to ensure an FB1 intake of 1, 5 and 10 ppm (first experiment) or 100 mg per animal per day (second experiment). The control animals were fed a toxin-free diet. In order to determine the immune response, the animals were vaccinated against Aujeszky's disease with inactivated vaccine (Aujespig K, Phylaxia-Sanofi, Budapest, Hungary). Specific and nonspecific in vitro cellular immune response was measured by the lymphocyte stimulation test (LST) induced by PHA-P, Con A, LPS and inactivated suspension of the Aujeszky's disease virus. Humoral immune response, e.g. specific antibody titre, was measured by the virus neutralisation (VN) test. None of the immunological parameters examined showed significant differences between groups. It could be concluded that fumonisin B1 had no significant effect on the humoral and cellular specific and nonspecific immune response when fed in a high dose (100 mg/animal/day for 8 days) or in a low concentration even for a longer period (1, 5 and 10 ppm for 3-4 months).

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