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  • 1 Department of Hormonal Action Mechanisms, Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences in Olsztyn 60-166 Poznań, ul. Grunwaldzka 250, Poland
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The effect of hypothyroidism on some oxidative stress parameters is reported. Moderate hypothyroid state was induced in two groups of female rabbits (3 and 12 months old) by giving 50 mg/kg body weight (BW) of propylthiouracil (PTU) per os for 6 days and 20 mg/kg BW of methimazole (MMI) for further 14 days. Serum T4 and T3 concentrations decreased by about 38-40 and 32-36%, respectively. The induced hypothyroidism resulted in a significant decrease in the serum concentration of the lipid peroxidation end-product malondialdehyde, as measured by the thiobarbituric-acid assay. Erythrocytes of hypothyroid animals exhibited higher resistance to oxidative stress, while submitted to free radicals generator 2,2'-azo-bis(2-amidinopropane) hydrochloride (AAPH) in vitro. Using two detector systems (phospholipid liposomes and deoxyribose), sensitive to either organic or inorganic oxygen radical damage, the ability of euthyroid and hypothyroid rabbit plasma to protect against oxygen radicals was evaluated. The plasma of hypothyroid animals showed about 20% higher ability to protect against iron-binding organic radicals, but about 50% lower chain-breaking antioxidant activity. The antioxidant capacity of plasma against inorganic radicals was not affected by hypothyroidism. In conclusion, the results show that thyroid hormones modulate the free-radical-induced oxidative damage of lipids and that hypothyroidism offers some protection against lipid peroxidation.

  • Ślebodziński, A. B., Brzezińska-Ślebodzińska, E. and Drews, R. (1982): Reciprocal changes in serum 3,3',5'-triiodothyronine concentration and the peripheral thyroxine inner ring monodeiodination during food restriction in the young pig. J. Endocrinol. 95, 349--355.

    'Reciprocal changes in serum 3,3',5'-triiodothyronine concentration and the peripheral thyroxine inner ring monodeiodination during food restriction in the young pig. ' () 95 J. Endocrinol. : 349 -355.

    • Search Google Scholar
  • Venditti, P., Balestrieri, M., Di-Meo, S. and De-Leo, T. (1997): Effect of thyroid state on lipid peroxidation, antioxidant defences, and susceptibility to oxidative stress in rat tissues. J. Endocrinol. 155, 151--157.

    'Effect of thyroid state on lipid peroxidation, antioxidant defences, and susceptibility to oxidative stress in rat tissues. ' () 155 J. Endocrinol. : 151 -157.

    • Search Google Scholar
  • Pamplona, R., Portero-Otin, M., Ruiz, C., Bellmunt, M. J., Reguena, J. R., Thorpe, S. R., Baynes, J. W., Romero, M., Lopez-Torres, M. and Barja, G. (1999): Thyroid status modulates glycoxidative and lipoxidative modification of tissue proteins. Free Radic. Biol. Med. 27, 901--910.

    'Thyroid status modulates glycoxidative and lipoxidative modification of tissue proteins. ' () 27 Free Radic. Biol. Med. : 901 -910.

    • Search Google Scholar
  • Stern, A. (1986): Red cell oxidative damage. In: Sies, H. (ed.) Oxidative Stress. Academic Press, London, UK, pp. 331--349.

    Oxidative Stress , () 331 -349.

  • Prem, P., Parihar, M. S., Malini, L. and Pradeep, K. G. (1998): Starvation induced hypothyroidism involves perturbations in thyroid superoxide-SOD system in pigeons. Biochem. Mol. Biol. Int. 45, 73--83.

    'Starvation induced hypothyroidism involves perturbations in thyroid superoxide-SOD system in pigeons. ' () 45 Biochem. Mol. Biol. Int. : 73 -83.

    • Search Google Scholar
  • Leonard, J. L. and Visser, T. J. (1986): Biochemistry of deiodination. In: Hennemann, G. (ed.) Thyroid Hormone Metabolism. Marcel Dekker, New York, pp. 189--229.

    Biochemistry of deiodination , () 189 -229.

  • Lopez-Torres, M., Romero, M. and Barja, G. (2000): Effect of thyroid hormones on mitochondrial oxygen free radical production and DNA oxidative damage in the rat heart. Mol. Cell Endocrinol. 168, 127--134.

    'Effect of thyroid hormones on mitochondrial oxygen free radical production and DNA oxidative damage in the rat heart. ' () 168 Mol. Cell Endocrinol. : 127 -134.

    • Search Google Scholar
  • Marzoev, A. I., Kozlov, A. V., Andryuschenko, A. P. and Vladimirov, Y. A. (1982a): Activation of lipid peroxidation in the liver mitochondria of hyperthyroid rabbits. Bull. Exp. Biol. Med. 93, 269--274.

    'Activation of lipid peroxidation in the liver mitochondria of hyperthyroid rabbits. ' () 93 Bull. Exp. Biol. Med. : 269 -274.

    • Search Google Scholar
  • Constantini, F., Pierdomenico, S. D., De-Cesare, D., De-Remigis, P., Bucciarelli, T., Bittolo-Bon, G., Cazzolato, G., Nubile, G., Guagnano, M. T., Sensi, S., Cuccurullo, F. and Mezzetti, A. (1998): Effect of thyroid function on LDL oxidation. Arterioscler. Thromb. Vasc. Biol. 18, 732--737.

    'Effect of thyroid function on LDL oxidation. ' () 18 Arterioscler. Thromb. Vasc. Biol. : 732 -737.

    • Search Google Scholar
  • Brzezińska-Ślebodzińska, E. (2001): Erythrocyte osmotic fragility test as the measure of defence against free radicals in rabbits of different age. Acta Vet. Hung. 49, 413--419.

    'Erythrocyte osmotic fragility test as the measure of defence against free radicals in rabbits of different age. ' () 49 Acta Vet. Hung. : 413 -419.

    • Search Google Scholar
  • Das, K. and Chainy, G. B. (2001): Modulation of rat liver mitochondrial antioxidant defense system by thyroid hormone. Biochim. Biophys. Acta 27, 1--13.

    'Modulation of rat liver mitochondrial antioxidant defense system by thyroid hormone. ' () 27 Biochim. Biophys. Acta : 1 -13.

    • Search Google Scholar
  • Dirican, M. and Tas, S. (1999): Effects of vitamin E and vitamin C supplementation on plasma lipid peroxidation and on oxidation of apolipoprotein B-containing lipoproteins in experimental hyperthyroidism. J. Med. Invest. 46, 29--33.

    'Effects of vitamin E and vitamin C supplementation on plasma lipid peroxidation and on oxidation of apolipoprotein B-containing lipoproteins in experimental hyperthyroidism. ' () 46 J. Med. Invest. : 29 -33.

    • Search Google Scholar
  • Galleano, M. and Puntarulo, S. (1995): Role of antioxidants on the erythrocytes resistance to lipid peroxidation after acute iron overloads in rats. Bioch. Biophys. Acta 1271, 321--326.

    'Role of antioxidants on the erythrocytes resistance to lipid peroxidation after acute iron overloads in rats. ' () 1271 Bioch. Biophys. Acta : 321 -326.

    • Search Google Scholar
  • Girodon, F., Blache, D., Monget, A-L., Lombart, M., Brunet-Lecompte, P., Arnaud, J., Richard, M-J. and Galan, P. (1997): Effect of a two-years supplementation with low doses of antioxidant vitamins and/or minerals in elderly subjects on levels of nutrients and antioxidant defense parameters. J. Am. Coll. Nutr. 16, 357--365.

    'Effect of a two-years supplementation with low doses of antioxidant vitamins and/or minerals in elderly subjects on levels of nutrients and antioxidant defense parameters. ' () 16 J. Am. Coll. Nutr. : 357 -365.

    • Search Google Scholar
  • Marzoev, A. I., Kozlov, A. V. and Vladimirov, Y. A. (1982b): Inhibition of lipid peroxidation in mitochondria isolated from the liver of hypothyroid rabbits. Bull. Exp. Biol. Med. 93, 275--280.

    'Inhibition of lipid peroxidation in mitochondria isolated from the liver of hypothyroid rabbits. ' () 93 Bull. Exp. Biol. Med. : 275 -280.

    • Search Google Scholar
  • Moreau, X., Lejeune, P. J. and Jeanningros, R. (1999): Kinetics of red blood cell T3 uptake in hypothyroidism with or without hormonal replacement in the rat. J. Endocrinol. Invest. 22, 257--261.

    'Kinetics of red blood cell T3 uptake in hypothyroidism with or without hormonal replacement in the rat. ' () 22 J. Endocrinol. Invest. : 257 -261.

    • Search Google Scholar
  • Shinohara, R., Mano, T., Nagasaka, A., Hayashi, R., Uchimura, K., Nakano, I., Watanabe, F., Tsugawa, T., Makino, M., Kakizawa, H., Nagata, M., Iwase, K., Ishizuki, Y. and Itoh, M. (2000): Lipid peroxidation levels in rat cardiac muscle are affected by age and thyroid status. J. Endocrinol. 164, 97--102.

    'Lipid peroxidation levels in rat cardiac muscle are affected by age and thyroid status. ' () 164 J. Endocrinol. : 97 -102.

    • Search Google Scholar
  • Rahaman, S. O., Ghosh, S., Mohanakumar, K. P., Das, S. and Sarkar, P. K. (2001): Hypothyroidism in the developing rat brain is associated with marked oxidative stress and aberrant intraneuronal accumulation of neurofilaments. Neurosci. Res. 40, 273--279.

    'Hypothyroidism in the developing rat brain is associated with marked oxidative stress and aberrant intraneuronal accumulation of neurofilaments. ' () 40 Neurosci. Res. : 273 -279.

    • Search Google Scholar
  • Bilgihan, K., Bilgihan, A., Diker, S., Ataoglu, O., Dolapci, M., Akata, F., Hasanreisoglu, B. and Turkozkan, N. (1996): Effects of hyper- and hypothyroidism on oxidative stress of the eye in experimental acute anterior uveitis. Acta Ophthalmol. Scand. 74, 41--43.

    'Effects of hyper- and hypothyroidism on oxidative stress of the eye in experimental acute anterior uveitis. ' () 74 Acta Ophthalmol. Scand. : 41 -43.

    • Search Google Scholar
  • Gredilla, R., Barja, G. and Lopez-Torres, M. (2001): Thyroid hormone-induced oxidative damage on lipids, glutathione and DNA in the mouse heart. Free Radic. Res. 35, 417--425.

    'Thyroid hormone-induced oxidative damage on lipids, glutathione and DNA in the mouse heart. ' () 35 Free Radic. Res. : 417 -425.

    • Search Google Scholar
  • Guerrero, A., Pamplona, R., Portero-Otin, M., Barja, G. and Lopez-Torres, M. (1999): Effect of thyroid status on lipid composition and peroxidation in the mouse liver. Free Radic. Biol. Med. 26, 73--80.

    'Effect of thyroid status on lipid composition and peroxidation in the mouse liver. ' () 26 Free Radic. Biol. Med. : 73 -80.

    • Search Google Scholar
  • Gutteridge, J. M. C. (1977): The measurement of malondialdehyde in peroxidised ox-brain phospholipid liposomes. Analyt. Biochem. 82, 76--82.

    'The measurement of malondialdehyde in peroxidised ox-brain phospholipid liposomes. ' () 82 Analyt. Biochem. : 76 -82.

    • Search Google Scholar
  • Gutteridge, J. M. C. (1986): Antioxidant properties of the proteins caeruloplasmin, albumin and transferrin. A study of their activity in serum and synovial fluid from patients with rheumatoid arthritis. Biochim. Biophys. Acta 969, 119--127.

    'Antioxidant properties of the proteins caeruloplasmin, albumin and transferrin. A study of their activity in serum and synovial fluid from patients with rheumatoid arthritis. ' () 969 Biochim. Biophys. Acta : 119 -127.

    • Search Google Scholar
  • Gutteridge, J. M. C. and Quinlan, G. J. (1992): Antioxidant protection against organic and inorganic oxygen radicals by normal human plasma: the important primary role for ironbinding and iron-oxidising proteins. Biochim. Biophys. Acta 1159, 248--254.

    'Antioxidant protection against organic and inorganic oxygen radicals by normal human plasma: the important primary role for ironbinding and iron-oxidising proteins. ' () 1159 Biochim. Biophys. Acta : 248 -254.

    • Search Google Scholar
  • Ledwożyw, A., Michalak, J., Stępień, A. and Kądziłka, A. (1986): The relationship between plasma triglycerides, cholesterol, total lipids and lipid peroxidation products during human atherosclerosis. Clin. Chim. Acta 155, 175--184.

    'The relationship between plasma triglycerides, cholesterol, total lipids and lipid peroxidation products during human atherosclerosis. ' () 155 Clin. Chim. Acta : 175 -184.

    • Search Google Scholar
  • Wagner, G. M., Lubin, B. H. and Chiu, D. T-Y. (1988): Oxidative damage to red blood cells. In: Chow, C. K. (ed.) Cellular Antioxidant Defense Mechanisms. CRC Press Inc., Boca Raton, USA, vol. 1, pp. 185--195.

    Cellular Antioxidant Defense Mechanisms , () 185 -195.

  • Kappus, H. (1985): Lipid peroxidation: mechanisms, analysis, enzymology and biological relevance. In: Sies, H. (ed.) Oxidative Stress. Academic Press, London, pp. 273--295.

    Lipid peroxidation: mechanisms, analysis, enzymology and biological relevance , () 273 -295.

    • Search Google Scholar
  • Konukoglu, D., Yelke, H. K., Hatemi, H. and Sabuncu, T. (2001): Effects of oxidative stress on the erythrocyte Na+, K+ ATPase activity in female hyperthyroid patients. J. Toxicol. Environ. Health A 63, 289--295.

    'Effects of oxidative stress on the erythrocyte Na+, K+ ATPase activity in female hyperthyroid patients. ' () 63 J. Toxicol. Environ. Health A : 289 -295.

    • Search Google Scholar
  • Gutteridge, J. M. C. and Stocks, J. (1981): Ceruloplasmin: physiological and pathological perspectives. CRC Crit. Rev. Clin. Lab. Med. 14, 257--329.

    'Ceruloplasmin: physiological and pathological perspectives. ' () 14 CRC Crit. Rev. Clin. Lab. Med. : 257 -329.

    • Search Google Scholar
  • Gutteridge, J. M. C., Paterson, S. K., Segal, A. W. and Halliwell, B. (1981): Inhibition of lipid peroxidation by the iron-binding protein lactoferrin. Biochem. J. 199, 259--261.

    'Inhibition of lipid peroxidation by the iron-binding protein lactoferrin. ' () 199 Biochem. J. : 259 -261.

    • Search Google Scholar
  • Halliwell, B. and Gutteridge, J. M. C. (1990): Role of free radicals and catalytic metal ions in human disease. In: Packer, L. and Glazer, A. N. (eds) Methods in Enzymology Vol. 186: Oxygen Radicals in Biological Systems Part B. Academic Press, New York, pp. 1--85.

    Role of free radicals and catalytic metal ions in human disease , () 1 -85.

  • Huh, K., Kwon, T. H., Kim, J. S. and Park, J. M. (1998): Role of hepatic xanthine oxidase in thyroid dysfunction: effect of thyroid hormones in oxidative stress in rat liver. Arch. Pharm. Res. 21, 236--240.

    'Role of hepatic xanthine oxidase in thyroid dysfunction: effect of thyroid hormones in oxidative stress in rat liver. ' () 21 Arch. Pharm. Res. : 236 -240.

    • Search Google Scholar

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