Experimental vascular graft for liver transplantation

L. Kóbori; T. Németh; B. Nemes; G. Dallos; P. Sótonyi Jr.; I. Fehérvári; A. Patonai; M. J. H. Slooff; J. Járay; K. P. De Jong

doi:10.1556/avet.51.2003.4.11

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Acta Veterinaria Hungarica

Volume/Issue:: Volume 51: Issue 4

Experimental vascular graft for liver transplantation

Authors:

L. Kóbori

L. Kóbori Transplantation and Surgical Department, Semmelweis University H-1082 Budapest, Baross u. 23-25, Hungary

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T. Németh

T. Németh Department of Surgery and Ophthalmology, Faculty of Veterinary Science, Szent István University Budapest, Hungary

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B. Nemes

B. Nemes Transplantation and Surgical Department, Semmelweis University H-1082 Budapest, Baross u. 23-25, Hungary

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G. Dallos

G. Dallos Transplantation and Surgical Department, Semmelweis University H-1082 Budapest, Baross u. 23-25, Hungary

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P. Sótonyi Jr.

P. Sótonyi Jr. Transplantation and Surgical Department, Semmelweis University H-1082 Budapest, Baross u. 23-25, Hungary

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I. Fehérvári

I. Fehérvári Transplantation and Surgical Department, Semmelweis University H-1082 Budapest, Baross u. 23-25, Hungary

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A. Patonai

A. Patonai Transplantation and Surgical Department, Semmelweis University H-1082 Budapest, Baross u. 23-25, Hungary

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M. J. H. Slooff

M. J. H. Slooff Department of Hepatobiliary Surgery and Liver Transplantation, University Hospital Groningen Groningen, The Netherlands

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J. Járay

J. Járay Transplantation and Surgical Department, Semmelweis University H-1082 Budapest, Baross u. 23-25, Hungary

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K. P. De Jong

K. P. De Jong Department of Hepatobiliary Surgery and Liver Transplantation, University Hospital Groningen Groningen, The Netherlands

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Pages:: 529–537

Online Publication Date:: 22 Jul 2005

Publication Date:: 01 Oct 2003

Article Category:: Journal Article

DOI:: https://doi.org/10.1556/avet.51.2003.4.11

Keywords:: experimental vascular graft; experimental vascular graft; experimental vascular graft; liver transplantation; Rectus fascia sheath; mesothelial cells; endothelial cells

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Hepatic artery thrombosis is a major cause of graft failure in liver transplantation. Use of donor interponates are common, but results are controversial because of necrosis or thrombosis after rejection. Reperfusion injury, hypoxia and free radical production determinate the survival. The aim of the study was to create an 'ideal' arterial interponate. Autologous, tubular graft lined with mesothelial cells, prepared from the posterior rectus fascia sheath, was used for iliac artery replacement in eight mongrel dogs for six months under immunosuppression. Patency rate was followed by Doppler ultrasound. Eight grafts remained patent and another two are patent after one year. The patency rate was good (median Doppler flow: 370 cm/sec) and there was no necrosis, thrombosis or aneurysmatic formation. The grafts showed viable morphology with neoangiogenesis, appearance of elastin, smooth muscle and endothelial cells. Electron microscopy showed intact mitochondrial structures without signs of hypoxia. Tissue oxygenation was good in all cases with normal (< 30 ng/ml) myeloperoxidase production. In conclusion, this autologous graft presents good long-term patency rate. Viability, arterialisation and low thrombogenicity are prognostic factors indicating usability of the graft in the clinical practice without the risk of rejection. Further investigations such as cell cultures and standardisation are necessary.

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Acta Veterinaria Hungarica

Print ISSN:: 0236-6290

Online ISSN:: 1588-2705

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Mária BENKŐ (Acta Veterinaria Hungarica, Budapest, Hungary)
Gábor BODÓ (University of Veterinary Medicine, Budapest, Hungary)
Béla DÉNES (University of Veterinary Medicine, Budapest Hungary)
Edit ESZTERBAUER (Veterinary Medical Research Institute, Budapest, Hungary)
Hedvig FÉBEL (University of Veterinary Medicine, Budapest, Hungary)
László FODOR (University of Veterinary Medicine, Budapest, Hungary)
János GÁL (University of Veterinary Medicine, Budapest, Hungary)
Balázs HARRACH (Veterinary Medical Research Institute, Budapest, Hungary)
Peter MASSÁNYI (Slovak University of Agriculture in Nitra, Nitra, Slovak Republic)
Béla NAGY (Veterinary Medical Research Institute, Budapest, Hungary)
Tibor NÉMETH (University of Veterinary Medicine, Budapest, Hungary)
Zsuzsanna NEOGRÁDY (University of Veterinary Medicine, Budapest, Hungary)
Dušan PALIĆ (Ludwig Maximilian University, Munich, Germany)
Alessandra PELAGALLI (University of Naples Federico II, Naples, Italy)
Kurt PFISTER (Ludwig-Maximilians-University of Munich, Munich, Germany)
László SOLTI (University of Veterinary Medicine, Budapest, Hungary)
József SZABÓ (University of Veterinary Medicine, Budapest, Hungary)
Péter VAJDOVICH (University of Veterinary Medicine, Budapest, Hungary)
János VARGA (University of Veterinary Medicine, Budapest, Hungary)
Štefan VILČEK (University of Veterinary Medicine in Kosice, Kosice, Slovak Republic)
Károly VÖRÖS (University of Veterinary Medicine, Budapest, Hungary)
Herbert WEISSENBÖCK (University of Veterinary Medicine, Vienna, Austria)
Attila ZSARNOVSZKY (Szent István University, Gödöllő, Hungary)

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Acta Veterinaria Hungarica
Language	English
Size	A4
Year of Foundation	1951
Volumes per Year	1
Issues per Year	4
Founder	Magyar Tudományos Akadémia
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ISSN	0236-6290 (Print)
ISSN	1588-2705 (Online)