Acta Veterinaria Hungarica
Volume/Issue:
Volume 53: Issue 4
Selective apoptotic behaviour of bovine herpesvirus 1 in an epithelial-like microenvironment
Authors: Yasemin Baskin 1 , Z. Yazici 2 , H. Baskin 3 , A. Ozkul 4 , Nur Olgun 1 , and I. H. Bahar 3
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  • 1 Oncology Institute, School of Medicine, Dokuz Eylul University Inciralti, 35340 Izmir, Turkey
  • 2 Department of Virology, Faculty of Veterinary Medicine, Ondokuz Mayis University Kurupelit, Samsun, Turkey
  • 3 Department of Microbiology and Clinical Microbiology, School of Medicine, Dokuz Eylul University Inciralti, 35340 Izmir, Turkey
  • 4 Department of Virology, Faculty of Veterinary Medicine, Ankara University Diskapi, Ankara, Turkey
DOI:
https://doi.org/10.1556/avet.53.2005.4.8
Page Count:
479–491
Publication Date:
01 Oct 2005
Online Publication Date:
07 Nov 2005
Article Category:
Research Article
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Apoptosis seems to play an important role in the pathogenic profile of bovine herpesvirus 1 (BHV-1) infection. Nitric oxide (NO) is also important as a signal molecule. In this study, apoptosis was selectively induced in HEp-2 cells in the early stage [1-3 h postinfection (PI)] of BHV-1 multiplication, and this apoptotic process was realised through the caspase-8, and partially through the caspase-3, pathway. BHV-1 infection inhibited staurosporine- (SS-) induced apoptosis only if the SS was added at 6 h PI. The results of this study showed that the 'NO-apoptosis' relation was realised through the caspase-8 pathway ('outer membrane receptor' pathway) at a later stage of infection in apoptosis induced by BHV-1 + SS. Our previous report (Yazici et al., 2004) and this study together showed that BHV-1 might induce and inhibit cell-type-specific pathways of apoptosis.

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Cover Acta Veterinaria Hungarica
Acta Veterinaria Hungarica
Print ISSN:
0236-6290
Online ISSN:
1588-2705

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