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  • 1 Oncology Institute, School of Medicine, Dokuz Eylul University Inciralti, 35340 Izmir, Turkey
  • | 2 Department of Virology, Faculty of Veterinary Medicine, Ondokuz Mayis University Kurupelit, Samsun, Turkey
  • | 3 Department of Microbiology and Clinical Microbiology, School of Medicine, Dokuz Eylul University Inciralti, 35340 Izmir, Turkey
  • | 4 Department of Virology, Faculty of Veterinary Medicine, Ankara University Diskapi, Ankara, Turkey
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Apoptosis seems to play an important role in the pathogenic profile of bovine herpesvirus 1 (BHV-1) infection. Nitric oxide (NO) is also important as a signal molecule. In this study, apoptosis was selectively induced in HEp-2 cells in the early stage [1-3 h postinfection (PI)] of BHV-1 multiplication, and this apoptotic process was realised through the caspase-8, and partially through the caspase-3, pathway. BHV-1 infection inhibited staurosporine- (SS-) induced apoptosis only if the SS was added at 6 h PI. The results of this study showed that the 'NO-apoptosis' relation was realised through the caspase-8 pathway ('outer membrane receptor' pathway) at a later stage of infection in apoptosis induced by BHV-1 + SS. Our previous report (Yazici et al., 2004) and this study together showed that BHV-1 might induce and inhibit cell-type-specific pathways of apoptosis.

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