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  • 1 Semmelweis University 2nd Department of Pathology, Faculty of Medicine Budapest Hungary
  • 2 University of Pécs Department of Medical Microbiology and Immunology, Faculty of Medicine Pécs Hungary
  • 3 University of Kaposvár Department of Physiology, Faculty of Animal Science H-7401 Kaposvár P.O. Box 16 Hungary
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It is known that bacterial lipopolysaccharide (LPS) is not absorbed from the gastrointestinal tract in significant quantities. However, the question remained whether oral LPS modified the structure or function of the gut. In the present experiment Escherichia coli O83 LPS was administered to growing rats in repeated oral doses of 400 mg/kg body weight (b. w.), every 8 h. After three days of treatment, morphometric and histochemical examinations of the small intestine did not show significant differences between treated and control rats. It is concluded that repeated oral administration of high doses of E. coli O83 LPS had no demonstrable effect on intestinal structure and cell proliferation in a rat model.

  • Beatty, W. L. and Sansonetti, P. J. (1997): Role of lipopolysaccharide in signalling to subepithelial polymorphonuclear leucocytes. Infect. Immun. 65 , 4395–4404.

    Sansonetti P. J. , 'Role of lipopolysaccharide in signalling to subepithelial polymorphonuclear leucocytes ' (1997 ) 65 Infect. Immun. : 4395 -4404.

    • Search Google Scholar
  • Berczi, I., Bertók, L., Baintner, K. and Veress, B. (1968): Failure of oral E. coli endotoxin to induce either specific tolerance or toxic symptoms in rats. J. Path. Bact. 96 , 481–487.

    Veress B. , 'Failure of oral E. coli endotoxin to induce either specific tolerance or toxic symptoms in rats ' (1968 ) 96 J. Path. Bact. : 481 -487.

    • Search Google Scholar
  • Cario, E., Rosenberg, I. M., Brandwein, S. L., Beck, P. L., Reinecker, H.-C. and Podolsky, D. K. (2000): Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing toll-like receptors. J. Immunol. 164 , 966–972.

    Podolsky D. K. , 'Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing toll-like receptors ' (2000 ) 164 J. Immunol. : 966 -972.

    • Search Google Scholar
  • Kraehenbuhl, J.-P. and Corbett, M. (2004): Keeping the gut microflora at bay. Science 303 , 1624–1625.

    Corbett M. , 'Keeping the gut microflora at bay ' (2004 ) 303 Science : 1624 -1625.

  • Macpherson, A. J. and Uhr, T. (2004): Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria. Science 303 , 1662–1665.

    Uhr T. , 'Induction of protective IgA by intestinal dendritic cells carrying commensal bacteria ' (2004 ) 303 Science : 1662 -1665.

    • Search Google Scholar
  • Niess, J. H., Brand, S., Gu, X., Landsman, L., Jung, S., McCormick, B. A., Vyas, J. M., Boes, M., Ploegh, H. L., Fox, J. G., Littman, D. R. and Reinecker, H.-C. (2005): CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science 307 , 254–258.

    Reinecker H.-C. , 'CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance ' (2005 ) 307 Science : 254 -258.

    • Search Google Scholar
  • Owen, R. L. (1977): Sequential uptake of horseradish peroxidase by lymphoid follicle epithelium of Peyer’s patches in the normal unobstructed mouse intestine: an ultrastructural study. Gastroenterology 72 , 440–441.

    Owen R. L. , 'Sequential uptake of horseradish peroxidase by lymphoid follicle epithelium of Peyer’s patches in the normal unobstructed mouse intestine: an ultrastructural study ' (1977 ) 72 Gastroenterology : 440 -441.

    • Search Google Scholar
  • Westphal, O. and Jann, K. (1965): Bacterial lipopolysaccharides: extraction with phenol-water and further applications of the procedure. Methods Carbohydr. Chem. 5 , 83–91.

    Jann K. , 'Bacterial lipopolysaccharides: extraction with phenol-water and further applications of the procedure ' (1965 ) 5 Methods Carbohydr. Chem. : 83 -91.

    • Search Google Scholar

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