View More View Less
  • 1 Szent István University Department of Animal Breeding, Nutrition and Laboratory Animal Science, Faculty of Veterinary Science H-1400 Budapest P.O. Box 2 Hungary
  • | 2 Research Institute for Soil Science and Agricultural Chemistry of the Hungarian Academy of Sciences Budapest Hungary
  • | 3 Central Veterinary Institute Budapest Hungary
  • | 4 Research Institute of Animal Breeding and Nutrition Herceghalom Hungary
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $836.00

To study the effects of high dietary molybdenum (Mo) content, rabbits were fed with commercial pellets and carrots containing 39 mg Mo/kg dry matter (DM) [Experiment 1] and with a commercial diet supplemented with 40 mg Mo/kg DM [Experiment 2] for 14 days. The high dietary Mo contents failed to reduce the growth performance of rabbits. Moreover, supplemental Mo given in a dose of 40 mg/kg non-significantly decreased the apparent digestibility of crude protein (CP) and crude fibre (CF) compared to the control (73.63 ± 2.49 and 18.56 ± 5.10 vs. 74.31 ± 3.03 and 21.38 ± 6.48, respectively). Molybdenum ingested with feeds was mainly excreted (57%) via the urine. The highest Mo levels were found in kidney and liver samples (3.464 ± 0.872; 5.27 ± 0.95 mg/kg DM [Experiment 1] and 1.878 ± 0.283; 1.62 ± 0.16 mg/kg DM [Experiment 2], respectively), and Mo could also be detected in limb meat (0.336 ± 0.205 mg/kg DM). It was stated that the testes were more sensitive to Mo exposure than the female reproductive organs because the number of germ cells was reduced. Due to the high dietary Mo intake free radicals could be generated, resulting in a marked increase of creatine kinase (CK) activity.

  • Anke, M., Masaoka, T., Groppel, B., Zervas, G. and Arnhold, W. (1989): The influence of sulphur, molybdenum and cadmium exposure on the growth of goat, cattle and pigs. Arch. Anim. Nutr., Berlin, 1-2 , 221–228.

    Arnhold W. , 'The influence of sulphur, molybdenum and cadmium exposure on the growth of goat, cattle and pigs ' (1989 ) 1-2 Arch. Anim. Nutr., Berlin : 221 -228.

    • Search Google Scholar
  • AOAC (1990): Official Methods of Analysis (15th edition). Association of Official Analytical Chemists, Inc., Arlington, Virginia, USA.

    '', in Official Methods of Analysis , (1990 ) -.

  • Balogh, L., Jánoki, Gy. A., Bodó, K., Kerekes, A. and Kőrösi, L. (1998): Evaluation of a complex trace element composition (CTEC) bioutilization in dogs and rats using isotope techniques. In: Pais, I. (ed.) Proc. 8th Trace Element Symposium, Budapest. pp. 128–137.

  • Bersényi, A., Fekete, S., Hullár, I., Kádár, I., Glávits, R., Kulcsár, M., Mézes, M. and Zöldág, L. (1999): Study of the soil-plant (carrot)-animal cycle of nutritive and hazardous minerals in a rabbit model. Acta Vet. Hung. 47 , 181–190.

    Zöldág L. , 'Study of the soil-plant (carrot)-animal cycle of nutritive and hazardous minerals in a rabbit model ' (1999 ) 47 Acta Vet. Hung. : 181 -190.

    • Search Google Scholar
  • Cheeke, P. R. (1991): Feeding and nutrition of rabbits. In: Cheeke, P. R. (ed.) Applied Animal Nutrition — Feeds and Feeding. MacMillan, New York. pp. 425–430.

    Cheeke P. R. , '', in Applied Animal Nutrition — Feeds and Feeding , (1991 ) -.

  • Codex Alimentarius Hungaricus (1996): Magyar Élelmiszerkódex (in Hungarian). FM-MMI, Budapest.

    '', in Magyar Élelmiszerkódex (in Hungarian) , (1996 ) -.

  • Coppock, R. and Dziwenka, M. M. (2004): Molybdenum. In: Plumlee, K. H. (ed.) Clinical Veterinary Toxicology. Mosby, St. Louis, Missouri. pp. 211–214.

    Dziwenka M. M. , '', in Clinical Veterinary Toxicology , (2004 ) -.

  • Fekete, S. and Gippert, T. (1983): Suggestions for the standardisation of metabolic experiments with rabbits (in Hungarian). Agroinform, Budapest.

    Gippert T. , '', in Suggestions for the standardisation of metabolic experiments with rabbits (in Hungarian) , (1983 ) -.

  • Fekete, S. Gy., Bersényi, A., Kádár, I., Glávits, R., Koncz, J. and Zöldág, L. (2001): Study of the soil-plant (potato and beetroot)-animal cycle of nutritive and hazardous minerals in a rabbit model. Acta Vet. Hung. 49 , 301–310.

    Zöldág L. , 'Study of the soil-plant (potato and beetroot)-animal cycle of nutritive and hazardous minerals in a rabbit model ' (2001 ) 49 Acta Vet. Hung. : 301 -310.

    • Search Google Scholar
  • Fungwe, T. V., Budding, F., Demick, D. S., Lox, C. D., Yang, M. T. and Yang, S. P. (1990): The role of dietary molybdenum on estrus activity, fertility, reproduction and molybdenum and copper enzyme activities of female rats. Nutr. Res. 10 , 515–524.

    Yang S. P. , 'The role of dietary molybdenum on estrus activity, fertility, reproduction and molybdenum and copper enzyme activities of female rats ' (1990 ) 10 Nutr. Res. : 515 -524.

    • Search Google Scholar
  • FVM (2001): Regulation of the Ministry of Agriculture and Rural Development No. 43/2003. (IV. 26) on the Implementation of Act No. CXIX of 2001 on the Production, Marketing and Use of Feeds (in Hungarian). FVM Értesítő (FVM Gazette), Budapest. pp. 1506.

    '', in Regulation of the Ministry of Agriculture and Rural Development No. 43/2003. (IV. 26) on the Implementation of Act No. CXIX of 2001 on the Production, Marketing and Use of Feeds (in Hungarian) , (2001 ) -.

  • Galbraith, H., Chigwada, W., Scaife, J. R. and Humphrise, W. R. (1997): The effect of dietary molybdenum supplementation on tissue copper concentrations, mohair fibre and carcass characteristics of growing Angora goats. Anim. Feed Sci. Technol. 67 , 83–90.

    Humphrise W. R. , 'The effect of dietary molybdenum supplementation on tissue copper concentrations, mohair fibre and carcass characteristics of growing Angora goats ' (1997 ) 67 Anim. Feed Sci. Technol. : 83 -90.

    • Search Google Scholar
  • Gippert, T. (1984): Effect of fibre of agricultural by-products in meat rabbits’ nutrition (in Hungarian). Ph.D. Thesis, Budapest.

  • Gupta, U. C. and Lipsett, J. (1981): Molybdenum in soils, plants and animals. Adv. Agron. 34 , 73–115.

    Lipsett J. , 'Molybdenum in soils, plants and animals ' (1981 ) 34 Adv. Agron. : 73 -115.

  • Hewitt, C. D., Innes, D. J., Savory, J. and Wills, M. R. (1989): Normal biochemical and hematological values in New Zealand White rabbits. Clin. Chem. 35 , 1777–1779.

    Wills M. R. , 'Normal biochemical and hematological values in New Zealand White rabbits ' (1989 ) 35 Clin. Chem. : 1777 -1779.

    • Search Google Scholar
  • Hillyer, E. V. and Quesenberry, K. E. (1997): Rabbits. Basic approach to veterinary care. In: Hillyer, E. V. and Quesenberry, K. E. (eds) Ferrets, Rabbits, and Rodents. Clinical Medicine and Surgery. W. B. Saunders Co., Philadelphia. pp. 160–168.

    Quesenberry K. E. , '', in Ferrets, Rabbits, and Rodents. Clinical Medicine and Surgery , (1997 ) -.

  • Holzinger, S., Anke, M., Jaritz, M. and Röhrig, B. (1997): Molybdenum transfer in the food chain of humans. In: Pollet, S. (ed.) Proc. 1st Trace Element Symposium, Athens. pp. 209–223.

  • Horak, O., Wilhartitz, P., Krismer, R., Bildstein, H., Mohamad, S. and Rebler, R. (1993): Influence of fertilizer treatment on molybdenum uptake by pasture plants. In: Anke, M. et al. (eds) Trace Elements in Man and Animals — TEMA 8, Verlag Media Touristik, Gersdorf, Germany. pp. 480–481.

    Rebler R. , '', in Trace Elements in Man and Animals — TEMA 8 , (1993 ) -.

  • Kiersztan, A., Winiarska, K., Drozak, J., Przedlacka, M., Wegrzynowicz, M., Fraczyk, T. and Bryla, J. (2004): Differential effects of vanadium, tungsten and molybdenum on inhibition of glucose formation in renal tubules and hepatocytes of control and diabetic rabbits: Beneficial action of melatonin and N-acetylcysteine. Mol. Cell. Biochem. 261 , 9–21.

    Bryla J. , 'Differential effects of vanadium, tungsten and molybdenum on inhibition of glucose formation in renal tubules and hepatocytes of control and diabetic rabbits: Beneficial action of melatonin and N-acetylcysteine ' (2004 ) 261 Mol. Cell. Biochem. : 9 -21.

    • Search Google Scholar
  • Kleczkowski, M., Kluciński, W., Sitarska, E., Sikora, J., Dziekan, P. and Winnicka, A. (1997): Effect of Zn, Mo, and sulphates on Cu content in the liver of cattle as a food. In: Pollet, S. (ed.) Proc. 1st Trace Element Symposium, Athens. pp. 287–296.

  • Ladefoged, O. and Stürup, S. (1995): Copper deficiency in cattle, sheep and horses caused by excess molybdenum from fly ash: A case report. Vet. Hum. Toxicol. 37 , 63–65.

    Stürup S. , 'Copper deficiency in cattle, sheep and horses caused by excess molybdenum from fly ash: A case report ' (1995 ) 37 Vet. Hum. Toxicol. : 63 -65.

    • Search Google Scholar
  • Mason, J. (1981): Molybdenum-copper antagonism in ruminants: A review of the biochemical basis. Irish Vet. J. 35 , 221–229.

    Mason J. , 'Molybdenum-copper antagonism in ruminants: A review of the biochemical basis ' (1981 ) 35 Irish Vet. J. : 221 -229.

    • Search Google Scholar
  • Mills, C. F. and Davis, G. K. (1987): Molybdenum. In: Mertz, W. (ed.) Trace Elements in Human and Animal Nutrition. Academic Press, Inc., San Diego, Calif. 1 , 429–463.

    Davis G. K. , '', in Trace Elements in Human and Animal Nutrition , (1987 ) -.

  • Mills, C. F., Monty, K. J., Ichihara, A. and Pearson, P. B. (1958): Metabolic effects of molybdenum toxicity in the rat. J. Nutr. 65 , 129–142.

    Pearson P. B. , 'Metabolic effects of molybdenum toxicity in the rat ' (1958 ) 65 J. Nutr. : 129 -142.

    • Search Google Scholar
  • Norušis, M. J. (1988): SPSS/PC™ V3.0, Update Manual. SPSS Inc., Chicago, U.S.A.

    Norušis M. J. , '', in SPSS/PC™ V3.0, Update Manual , (1988 ) -.

  • Novotny, J. A. and Turnlund, J. R. (2007): Molybdenum intake influences molybdenum kinetics in men. J. Nutr. 137 , 37–42.

    Turnlund J. R. , 'Molybdenum intake influences molybdenum kinetics in men ' (2007 ) 137 J. Nutr. : 37 -42.

    • Search Google Scholar
  • NRC (1980): Molybdenum. In: National Research Council (ed.) Mineral Tolerance of Domestic Animals. NAS, Washington, D. C. pp. 328–341.

    '', in Mineral Tolerance of Domestic Animals , (1980 ) -.

  • Pais, I. (1998): Biological importance of molybdenum. In: Pais, I. (ed.) Biological Role of Microelements (in Hungarian). Mezőgazda Kiadó, Budapest. pp. 38–40.

    Pais I. , '', in Biological Role of Microelements (in Hungarian) , (1998 ) -.

  • Pennington, J. A. T. and Jones, J. W. (1987): Molybdenum, nickel, cobalt vanadium, and strontium in total diets. J. Am. Diet. Assoc. 87 , 1644–1650.

    Jones J. W. , 'Molybdenum, nickel, cobalt vanadium, and strontium in total diets ' (1987 ) 87 J. Am. Diet. Assoc. : 1644 -1650.

    • Search Google Scholar
  • Rajagopalan, K. V. (1988): Molybdenum: An essential trace element in human nutrition. Ann. Rev. Nutr. 8 , 401–427.

    Rajagopalan K. V. , 'Molybdenum: An essential trace element in human nutrition ' (1988 ) 8 Ann. Rev. Nutr. : 401 -427.

    • Search Google Scholar
  • Reul, B. A., Becker, D. J., Ongembe, L. N., Bailey, C. J., Henquin, J. C. and Brichard, S. M. (1997): Improvement of glucose homeostasis and hepatic insulin resistance in ob/ob mice given oral molybdate. J. Endocrinol. 155 , 55–64.

    Brichard S. M. , 'Improvement of glucose homeostasis and hepatic insulin resistance in ob/ob mice given oral molybdate ' (1997 ) 155 J. Endocrinol. : 55 -64.

    • Search Google Scholar
  • Sas, B. (1989): Secondary copper deficiency in cattle caused by molybdenum contamination of fodder: A case history. Vet. Hum. Toxicol. 1 , 29–33.

    Sas B. , 'Secondary copper deficiency in cattle caused by molybdenum contamination of fodder: A case history ' (1989 ) 1 Vet. Hum. Toxicol. : 29 -33.

    • Search Google Scholar
  • SCF (Scientific Committee on Food) (2000): Opinion of the Scientific Committee on Food on the tolerable upper intake level of molybdenum. SCF/SC/NUT/UPPERLEV/22. European Commission, Brussels. pp. 1–15.

    '', in Opinion of the Scientific Committee on Food on the tolerable upper intake level of molybdenum , (2000 ) -.

  • Suttle, N. F. (1991): The interactions between copper, molybdenum, and sulphur in ruminant nutrition. Annu. Rev. Nutr. 11 , 121–140.

    Suttle N. F. , 'The interactions between copper, molybdenum, and sulphur in ruminant nutrition ' (1991 ) 11 Annu. Rev. Nutr. : 121 -140.

    • Search Google Scholar
  • Suttle, N. F. and Small, J. (1993): Evidence for delayed availability of copper in supplementation trials with lambs on molybdenum-rich pastures. In: Anke, M. et al. (eds) Trace Elements in Man and Animals — TEMA 8, Verlag Media Touristik, Gersdorf, Germany. pp. 651–654.

    Small J. , '', in Trace Elements in Man and Animals — TEMA 8 , (1993 ) -.

  • Szilágyi, M. (1990): Effect of lithium and nickel supply on biochemical parameters in farm animals (in Hungarian). Ph.D. Thesis, Budapest.

  • Szilágyi, M., Anke, M., Sankari, S., Mézes, M., Wittmann, M., Marton, I. and Radnai, Gy. (1997): Trace elements in oxidative stress syndrome. In: Pollet, S. (ed.) Proc. International Symposium on Trace Elements in Human: New Perspectives. pp. 511–521.

  • Szilágyi, M., Fekete, S., Wittmann, M., Mézes, M., Sankari, S., Abaza, M., El-Sebai, A., Harczy, I. and Rózsa, L. (1996): Biochemical and physiological constituents in farm animals exposed to cadmium, lead molybdenum, mercury and selenium. In: Pais, I. (ed.) Proc. 7th Trace Element Symposium, Budapest. pp. 121–126.

  • Ward, J. D., Gengelbach, G. P. and Spears, J. W. (1997): The effects of copper deficiency with or without high dietary iron or molybdenum on immune function of cattle. J. Anim. Sci. 75 , 1400–1408.

    Spears J. W. , 'The effects of copper deficiency with or without high dietary iron or molybdenum on immune function of cattle ' (1997 ) 75 J. Anim. Sci. : 1400 -1408.

    • Search Google Scholar
  • Wittenberg, K. M. and Devlin, T. J. (1988): Effects of dietary molybdenum on productivity and metabolic parameters of lactating ewes and their offspring. Can. J. Anim. Sci. 68 , 769–778.

    Devlin T. J. , 'Effects of dietary molybdenum on productivity and metabolic parameters of lactating ewes and their offspring ' (1988 ) 68 Can. J. Anim. Sci. : 769 -778.

    • Search Google Scholar
  • Wolford, S. T., Schroer, R. A., Gohs, F. X., Gallo, P. P., Brodeck, M., Falk, H. B. and Ruhren, R. (1986): Reference range data base for serum chemistry and hematology values in laboratory animals. J. Toxicol. Environm. Health 18 , 161–188.

    Ruhren R. , 'Reference range data base for serum chemistry and hematology values in laboratory animals ' (1986 ) 18 J. Toxicol. Environm. Health : 161 -188.

    • Search Google Scholar

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Jan 2021 5 0 0
Feb 2021 13 0 0
Mar 2021 13 0 0
Apr 2021 7 0 0
May 2021 21 0 0
Jun 2021 11 0 0
Jul 2021 0 0 0