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  • 1 National Autonomous University of Mexico (UNAM) Department of Physiology and Pharmacology, School of Veterinary Medicine Av. Universidad 3000 Mexico City 04510 Mexico
  • 2 Autonomous University of the State of Mexico Center for Research and Advanced Studies in Animal Health Toluca Mexico
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The aim of this trial was to assess the clinical efficacy of neural therapy (NT) when treating canine atopic dermatitis. Eighteen dogs (no control group), with at least a 12-month history of having nonseasonal atopic dermatitis, were included. No medication with either glucocorticoids or cyclosporin was allowed during the trial. One set of NT was given by injecting an intravenous dose of 0.1 mg/kg of a 0.7% procaine solution, followed by 10 to 25 intradermal injections of the same solution in a volume of 0.1–0.3 mL per site. Dogs were given 6–13 sets of NT during the therapy. The dermatological condition of each patient was evaluated before and after the treatment using two scales: the pruritus visual analogue scale (PVAS) and the canine atopic dermatitis extent and severity index (CADESI). The reduction of pruritus was statistically significant using a Wilcoxon matched-pairs signed-ranks test (P < 0.001). No adverse side effects were observed. NT seems to be an effective alternative to control signs related to canine atopic dermatitis.

  • Barbagli, P. and Bollettin, R. (1998): Therapy of articular and periarticular pain with local anaesthetics (neural therapy of Huneke): Long and short term results [in Italian]. Minerva Anestesiol. 64 , 35–43.

    Bollettin R. , 'Therapy of articular and periarticular pain with local anaesthetics (neural therapy of Huneke): Long and short term results [in Italian] ' (1998 ) 64 Minerva Anestesiol. : 35 -43.

    • Search Google Scholar
  • Barop, H. (1996): Lehrbuch und Atlas der Neuraltherapie nach Huneke. Hipokkrates Verlag, Stuttgart.

    Barop H. , '', in Lehrbuch und Atlas der Neuraltherapie nach Huneke , (1996 ) -.

  • Becke, H. (1988): Possibilities of neural therapy in internal medicine [in German]. Z. Gesamte Inn. Med. 43 , 643–645.

    Becke H. , 'Possibilities of neural therapy in internal medicine [in German] ' (1988 ) 43 Z. Gesamte Inn. Med. : 643 -645.

    • Search Google Scholar
  • Bevier, D. E. (1990): Long-term management of atopic disease in the dog. Vet. Clin. North Am. Small Anim. Pract. 20 , 1487–1507.

    Bevier D. E. , 'Long-term management of atopic disease in the dog ' (1990 ) 20 Vet. Clin. North Am. Small Anim. Pract. : 1487 -1507.

    • Search Google Scholar
  • Blackwood, L., German, A. J., Stell, A. J. and O’Neill, T. (2004): Multicentric lymphoma in a dog after cyclosporine therapy. J. Small Anim. Pract. 45 , 259–262.

    O’Neill T. , 'Multicentric lymphoma in a dog after cyclosporine therapy ' (2004 ) 45 J. Small Anim. Pract. : 259 -262.

    • Search Google Scholar
  • Cassuto, J., Sinclair, R. and Bonderovic, M. (2006): Anti-inflammatory properties of local anesthetics and their present and potential clinical implications. Acta Anaesthesiol. Scand. 50 , 265–282.

    Bonderovic M. , 'Anti-inflammatory properties of local anesthetics and their present and potential clinical implications ' (2006 ) 50 Acta Anaesthesiol. Scand. : 265 -282.

    • Search Google Scholar
  • DeBoer, D. J. and Hillier, A. (2001): The ACVD task force on canine atopic dermatitis (XV): fundamental concepts in clinical diagnosis. Vet. Immunol. Immunopathol. 81 , 271–276.

    Hillier A. , 'The ACVD task force on canine atopic dermatitis (XV): fundamental concepts in clinical diagnosis ' (2001 ) 81 Vet. Immunol. Immunopathol. : 271 -276.

    • Search Google Scholar
  • Ding, Z. N., Yoshita, Y., Hirota, K., Yamamoto, K., Kobayashi, T. and Murakami, S. (1992): Brainstem auditory evoked potentials during procaine toxicity in dogs. Can. J. Anaesth. 39 , 600–603.

    Murakami S. , 'Brainstem auditory evoked potentials during procaine toxicity in dogs ' (1992 ) 39 Can. J. Anaesth. : 600 -603.

    • Search Google Scholar
  • Eisenmenger, E., Kasper, I. and Eisenmenger, M. (1989): Observations of the pain syndrome in the loin and hip region of horses and experimental treatment with neural therapy [in German]. Pferdeheilkunde 5 , 193–199.

    Eisenmenger M. , 'Observations of the pain syndrome in the loin and hip region of horses and experimental treatment with neural therapy [in German] ' (1989 ) 5 Pferdeheilkunde : 193 -199.

    • Search Google Scholar
  • Fischer, L. (2001): Neuraltherapie nach Huneke: Grundlagen, Technik, praktische Anwendungen. 2. Aufl., Hipokkrates Verlag, Stuttgart.

    Fischer L. , '', in Neuraltherapie nach Huneke: Grundlagen, Technik, praktische Anwendungen , (2001 ) -.

    • Search Google Scholar
  • Frank, B. L. (1999): Neural therapy. Phys. Med. Rehabil. Clin. N. Am. 10 , 573–582.

    Frank B. L. , 'Neural therapy ' (1999 ) 10 Phys. Med. Rehabil. Clin. N. Am. : 573 -582.

  • Gibson, R. G. and Gibson, S. L. (1999): Neural therapy in the treatment of Multiple Sclerosis. J. Altern. Complement. Med. 5 , 543–552.

    Gibson S. L. , 'Neural therapy in the treatment of Multiple Sclerosis ' (1999 ) 5 J. Altern. Complement. Med. : 543 -552.

    • Search Google Scholar
  • Gnirs, K. and Prélaud, P. (2005): Cutaneous manifestations of neurological diseases: review of neuropathophysiology and diseases causing pruritus. Vet. Dermatol. 16 , 137–146.

    Prélaud P. , 'Cutaneous manifestations of neurological diseases: review of neuropathophysiology and diseases causing pruritus ' (2005 ) 16 Vet. Dermatol. : 137 -146.

    • Search Google Scholar
  • Hill, P. B., Lo, A., Eden, C. A., Huntley, S., Morey, V., Ramsey, S., Richardson, C., Smith, D. J., Sutton, C., Taylor, M. D., Thorpe, E., Tidmarsh, R. and Williams, V. (2006): Survey of prevalence, diagnosis and treatment of dermatological conditions in small animals in general practice. Vet. Rec. 158 , 533–539.

    Williams V. , 'Survey of prevalence, diagnosis and treatment of dermatological conditions in small animals in general practice ' (2006 ) 158 Vet. Rec. : 533 -539.

    • Search Google Scholar
  • Kasaba, T., Onizuka, S. and Takasaki, M. (2003): Procaine and mepivacaine have less toxicity in vitro than other clinically used local anesthetics. Anesth. Analg. 97 , 85–90.

    Takasaki M. , 'Procaine and mepivacaine have less toxicity in vitro than other clinically used local anesthetics ' (2003 ) 97 Anesth. Analg. : 85 -90.

    • Search Google Scholar
  • Kothbauer, O. (1990): Acupuncture and neural therapy of infertility in cows; diagnosis and therapy. Tierärztl. Umschau 45 , 225–237.

    Kothbauer O. , 'Acupuncture and neural therapy of infertility in cows; diagnosis and therapy ' (1990 ) 45 Tierärztl. Umschau : 225 -237.

    • Search Google Scholar
  • Lecanu, L., Wenguo, Y., Xu, J., Greeson, J. and Papadopoulos, V. (2005): Local anesthetic procaine protects rat pheochromocytoma PC12 cells against beta-amyloid-induced neurotoxicity. Pharmacology 74 , 65–78.

    Papadopoulos V. , 'Local anesthetic procaine protects rat pheochromocytoma PC12 cells against beta-amyloid-induced neurotoxicity ' (2005 ) 74 Pharmacology : 65 -78.

    • Search Google Scholar
  • Mama, K. R. and Steffey, E. P. (2001): Local anesthetics. In: Adams, H. R. (ed.) Veterinary Pharmacology and Therapeutics. 8th edition. Iowa State University Press, Ames, IA, USA. pp. 343–359.

    Steffey E. P. , '', in Veterinary Pharmacology and Therapeutics , (2001 ) -.

  • Marsella, R. (2006): Atopy: new targets and new therapies. Vet. Clin. North Am. Small Anim. Pract. 36 , 161–174.

    Marsella R. , 'Atopy: new targets and new therapies ' (2006 ) 36 Vet. Clin. North Am. Small Anim. Pract. : 161 -174.

    • Search Google Scholar
  • Miljkovic, V., Pavlovic, V. and Petrujkic, T. (1993): Neural-therapy of infertility in cows caused by uterine adnexitis. Acta Vet. (Beograd) 43 , 113–119.

    Petrujkic T. , 'Neural-therapy of infertility in cows caused by uterine adnexitis ' (1993 ) 43 Acta Vet. (Beograd) : 113 -119.

    • Search Google Scholar
  • Nagle, T. M., Torres, S. M., Horne, K. L., Grover, R. and Stevens, M. T. (2001): A randomized, double-blind, placebo-controlled trial to investigate the efficacy and safety of a Chinese herbal product (P07P) for the treatment of canine atopic dermatitis. Vet. Dermatol. 12 , 265–274.

    Stevens M. T. , 'A randomized, double-blind, placebo-controlled trial to investigate the efficacy and safety of a Chinese herbal product (P07P) for the treatment of canine atopic dermatitis ' (2001 ) 12 Vet. Dermatol. : 265 -274.

    • Search Google Scholar
  • Olivry, T. (2006): CADESI format 2006. http://www.cvm.ncsu.edu/docs/thierry_olivry.html . Accessed Jan. 13, 2006

  • Olivry, T. and Sousa, C. A. (2001): The ACVD task force on canine atopic dermatitis (XX): glucocorticoid pharmacotherapy. Vet. Immunol. Immunopathol. 81 , 317–322.

    Sousa C. A. , 'The ACVD task force on canine atopic dermatitis (XX): glucocorticoid pharmacotherapy ' (2001 ) 81 Vet. Immunol. Immunopathol. : 317 -322.

    • Search Google Scholar
  • Siqueira, R. A., Costa, J. C., Cordeiro, R. S., Serra, M. F., Silva, P. M. and Martins, M. A. (2005): Local anaesthetic medication for the treatment of asthma. Mem. Inst. Oswaldo Cruz 100 , 161–165.

    Martins M. A. , 'Local anaesthetic medication for the treatment of asthma ' (2005 ) 100 Mem. Inst. Oswaldo Cruz : 161 -165.

    • Search Google Scholar
  • Spernol, R. and Riss, P. (1982): Urodynamic evaluation of the effect of neural therapy in motor and sensory urgency [in German]. Geburtshilfe Frauenheilkd. 42 , 527–529.

    Riss P. , 'Urodynamic evaluation of the effect of neural therapy in motor and sensory urgency [in German] ' (1982 ) 42 Geburtshilfe Frauenheilkd. : 527 -529.

    • Search Google Scholar
  • Steffan, J., Alexander, D., Brovedani, F. and Fisch, R. D. (2003): Comparison of cyclosporine A with methylprednisolone for treatment of canine atopic dermatitis: a parallel blinded randomized controlled trial. Vet. Dermatol. 14 , 11–22.

    Fisch R. D. , 'Comparison of cyclosporine A with methylprednisolone for treatment of canine atopic dermatitis: a parallel blinded randomized controlled trial ' (2003 ) 14 Vet. Dermatol. : 11 -22.

    • Search Google Scholar
  • Steffan, J., Favrot, C. and Mueller, R. (2006): A systematic review and meta-analysis of the efficacy and safety of cyclosporin for the treatment of atopic dermatitis in dogs. Vet. Dermatol. 17 , 3–16.

    Mueller R. , 'A systematic review and meta-analysis of the efficacy and safety of cyclosporin for the treatment of atopic dermatitis in dogs ' (2006 ) 17 Vet. Dermatol. : 3 -16.

    • Search Google Scholar
  • Steffan, J., Parks, C. and Seewald, W. (2005): North American Veterinary Dermatology Cyclosporine Study Group: Clinical trial evaluating the efficacy and safety of cyclosporine in dogs with atopic dermatitis. J. Am. Vet. Med. Assoc. 226 , 1855–1863.

    Seewald W. , 'North American Veterinary Dermatology Cyclosporine Study Group: Clinical trial evaluating the efficacy and safety of cyclosporine in dogs with atopic dermatitis ' (2005 ) 226 J. Am. Vet. Med. Assoc. : 1855 -1863.

    • Search Google Scholar
  • Sumano, H., Goiz, G. and Clifford, V. (2002): Use of electrical stimulation for wound healing in dogs. Isr. J. Vet. Med. 57 , 31–37.

    Clifford V. , 'Use of electrical stimulation for wound healing in dogs ' (2002 ) 57 Isr. J. Vet. Med. : 31 -37.

    • Search Google Scholar
  • Tarpataki, N. (2006): Recent developments in canine atopic dermatitis: A review. Acta Vet. Hung. 54 , 473–484.

    Tarpataki N. , 'Recent developments in canine atopic dermatitis: A review ' (2006 ) 54 Acta Vet. Hung. : 473 -484.

    • Search Google Scholar
  • Tarpataki, N., Pápa, K., Reiczigel, J., Vajdovich, P. and Vörös, K. (2006): Prevalence and features of canine atopic dermatitis in Hungary. Acta Vet. Hung. 54 , 353–366.

    Vörös K. , 'Prevalence and features of canine atopic dermatitis in Hungary ' (2006 ) 54 Acta Vet. Hung. : 353 -366.

    • Search Google Scholar
  • Willemse, T. (1990): Atopic dermatitis in dogs: new diagnostic criteria [in German]. Tierärztl. Prax. 18 , 525–528.

    Willemse T. , 'Atopic dermatitis in dogs: new diagnostic criteria [in German] ' (1990 ) 18 Tierärztl. Prax. : 525 -528.

    • Search Google Scholar
  • Wood, M. and Wood, A. (eds) (1990): Local anesthetic agents. In: Drugs and Anesthesia: Pharmacology for Anesthesiologists. 2nd edition. Williams and Wilkins, Baltimore, USA. pp. 319–345.

  • Zohmann, A. (1989): Theory and practice of the therapeutic use of local anaesthetics (neuraltherapy) in the dog with particular reference to the cervicothoracic block of the stellate ganglion [in German]. Prakt. Tierarzt 70 , 10–15.

    Zohmann A. , 'Theory and practice of the therapeutic use of local anaesthetics (neuraltherapy) in the dog with particular reference to the cervicothoracic block of the stellate ganglion [in German] ' (1989 ) 70 Prakt. Tierarzt : 10 -15.

    • Search Google Scholar
  • Zohmann, A. (1990): General principles of neural therapy, a review [in German]. Berl. Münch. Tierärztl. Wochenschr. 103 , 244–247.

    Zohmann A. , 'General principles of neural therapy, a review [in German] ' (1990 ) 103 Berl. Münch. Tierärztl. Wochenschr. : 244 -247.

    • Search Google Scholar
  • Zohmann, A. (1994): Influence of acupuncture and neural therapy on immunological disorders [in German]. Prakt. Tierarzt 75 , 93–98.

    Zohmann A. , 'Influence of acupuncture and neural therapy on immunological disorders [in German] ' (1994 ) 75 Prakt. Tierarzt : 93 -98.

    • Search Google Scholar
  • Zohmann, A. (1997): Basis and use of neural therapy in diagnosis and treatment [in German]. Schweiz. Arch. Tierheilkd. 139 , 117–125.

    Zohmann A. , 'Basis and use of neural therapy in diagnosis and treatment [in German] ' (1997 ) 139 Schweiz. Arch. Tierheilkd. : 117 -125.

    • Search Google Scholar
  • Zohmann, A. J. (1999): Application of neural therapy to cattle [in German]. Ganzheitliche Tiermedizin 13 , 100–102.

    Zohmann A. J. , 'Application of neural therapy to cattle [in German] ' (1999 ) 13 Ganzheitliche Tiermedizin : 100 -102.

    • Search Google Scholar
  • Olivry, T., DeBoer, D. J., Griffin, C. E., Halliwell, R. E., Hill, P. B., Hillier, A., Marsella, R. and Sousa, C. A. (2001): The ACVD task force on canine atopic dermatitis: forewords and lexicon. Vet. Immunol. Immunopathol. 81 , 143–146.

    Sousa C. A. , 'The ACVD task force on canine atopic dermatitis: forewords and lexicon ' (2001 ) 81 Vet. Immunol. Immunopathol. : 143 -146.

    • Search Google Scholar
  • Olivry, T., Rivierre, C., Jackson, H. A., Murphy, K. M., Davidson, G. and Sousa, C. A. (2002): Cyclosporine decreases skin lesions and pruritus in dogs with atopic dermatitis: a blinded randomized prednisolone-controlled trial. Vet. Dermatol. 13 , 77–87.

    Sousa C. A. , 'Cyclosporine decreases skin lesions and pruritus in dogs with atopic dermatitis: a blinded randomized prednisolone-controlled trial ' (2002 ) 13 Vet. Dermatol. : 77 -87.

    • Search Google Scholar
  • Radowicz, S. N. and Power, H. T. (2005): Long-term use of cyclosporine in the treatment of canine atopic dermatitis. Vet. Dermatol. 16 , 81–86.

    Power H. T. , 'Long-term use of cyclosporine in the treatment of canine atopic dermatitis ' (2005 ) 16 Vet. Dermatol. : 81 -86.

    • Search Google Scholar
  • Scott, D. W., Miller, W. H. and Griffin, C. E. (eds) (2001): Small Animal Dermatology. 6th edition. W. B. Saunders, Philadelphia, USA.

    '', in Small Animal Dermatology , (2001 ) -.

  • Scott, S. (2001): Developments in veterinary acupuncture. Acupunct. Med. 19 , 27–31.

    Scott S. , 'Developments in veterinary acupuncture ' (2001 ) 19 Acupunct. Med. : 27 -31.

  • Sheskin, D. J. (2004): Handbook of Parametric and Nonparametric Statistical Procedures. Chapman and Hall/CRC, Florida, USA.

    Sheskin D. J. , '', in Handbook of Parametric and Nonparametric Statistical Procedures , (2004 ) -.

    • Search Google Scholar

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