View More View Less
  • 1 Intervet Schering-Plough Animal Health Wim de Körverstraat 35 NL-5831 AN Boxmeer The Netherlands
  • 2 Intervet SA Beaucouzé France
  • 3 CEBIPHAR Fondettes France
  • 4 Intervet Italy S.r.l. Peschiera Borromeo (MI) Italy
  • 5 Faculty of Veternary Medicine Parma Italy
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $836.00

The efficacy of an inactivated bovine respiratory syncytial virus (BRSV) — bovine parainfluenza type 3 (PI3) — Mannheimia haemolytica ( Mh ) combination vaccine was examined in two field studies. Calves were vaccinated (i) with the inactivated vaccine, (ii) a modified live/killed viral combination vaccine, or (iii) left unvaccinated. The efficacy of the vaccines was judged by the (i) number of treated animals, (ii) number of individual antibiotic treatments per calf and (iii) mortality rates. After vaccination with the inactivated vaccine, the number of calves requiring antibiotic treatment was significantly lower than in the unvaccinated group (odds ratios: 0.26 first study and 0.53 second study), but differences between vaccination with live/killed combination vaccines and controls were not significant (odds ratios: 0.56 and 0.90, respectively). In both studies, a number of unvaccinated controls died due to respiratory disease (4.6% first and 6.7% second study). By contrast, none of the animals vaccinated with the inactivated vaccine died in the first study and only 3.3% in the second study. The mortality rates for the groups vaccinated with the live vaccine (1.3% and 7.8%) were similar to the unvaccinated controls. In summary, these data demonstrate the efficacy of the inactivated vaccine under field conditions.

  • Alkan, F., Ozkul, A., Bilge-Dagalp, S., Yesilbag, K., Oguzoglu, T. C., Akca, Y. and Burgu, I. (2000): Virological and serological studies on the role of PI-3 virus, BRSV, BVDV and BHV-1 on respiratory infections of cattle. I. The detection of etiological agents by direct immunofluorescence technique. Dtsch. Tierärztl. Wochenschr. 107 , 193–195.

    Burgu I. , 'Virological and serological studies on the role of PI-3 virus, BRSV, BVDV and BHV-1 on respiratory infections of cattle. I. The detection of etiological agents by direct immunofluorescence technique ' (2000 ) 107 Dtsch. Tierärztl. Wochenschr. : 193 -195.

    • Search Google Scholar
  • Babiuk, L. A., Lawman, M. J. and Ohmann, H. B. (1988): Viral-bacterial synergistic interaction in respiratory disease. Adv. Virus Res. 35 , 219–249.

    Ohmann H. B. , 'Viral-bacterial synergistic interaction in respiratory disease ' (1988 ) 35 Adv. Virus Res. : 219 -249.

    • Search Google Scholar
  • Baker, J. C., Ellis, J. A. and Clark, E. G. (1997): Bovine respiratory syncytial virus. Vet. Clin. North Am. Food Anim. Pract. 13 , 425–454.

    Clark E. G. , 'Bovine respiratory syncytial virus ' (1997 ) 13 Vet. Clin. North Am. Food Anim. Pract. : 425 -454.

    • Search Google Scholar
  • Bryson, D. G., McFerran, J. B., Ball, H. J. and Neill, S. D. (1978): Observations on outbreaks of respiratory disease in housed animals — (1) Epidemiological, clinical and microbiological findings. Vet. Rec. 103 , 485–489.

    Neill S. D. , 'Observations on outbreaks of respiratory disease in housed animals — (1) Epidemiological, clinical and microbiological findings ' (1978 ) 103 Vet. Rec. : 485 -489.

    • Search Google Scholar
  • Ellis, J. A., Hassard, L. E. and Morley, P. S. (1995): Bovine respiratory syncytial virus-specific immune responses in calves after inoculation with commercially available vaccines. J. Am. Vet. Med. Assoc. 206 , 354–361.

    Morley P. S. , 'Bovine respiratory syncytial virus-specific immune responses in calves after inoculation with commercially available vaccines ' (1995 ) 206 J. Am. Vet. Med. Assoc. : 354 -361.

    • Search Google Scholar
  • Fulton, R. W., Confer, A. W., Burge, L. J., Perino, L. J., d’Offay, J. M., Payton, M. E. and Mock, R. E. (1995): Antibody responses by cattle after vaccination with commercial viral vaccines containing bovine herpesvirus-1, bovine viral diarrhea virus, parainfluenza-3 virus, and bovine respiratory syncytial virus immunogens and subsequent revaccination at day 140. Vaccine 13 , 725–733.

    Mock R. E. , 'Antibody responses by cattle after vaccination with commercial viral vaccines containing bovine herpesvirus-1, bovine viral diarrhea virus, parainfluenza-3 virus, and bovine respiratory syncytial virus immunogens and subsequent revaccination at day 140 ' (1995 ) 13 Vaccine : 725 -733.

    • Search Google Scholar
  • Gilmour, N. J., Donachie, W., Sutherland, A. D., Gilmour, J. S., Jones, G. E. and Quirie, M. (1991): Vaccine containing iron-regulated proteins of Pasteurella haemolytica A2 enhances protection against experimental pasteurellosis in lambs. Vaccine 9 , 137–140.

    Quirie M. , 'Vaccine containing iron-regulated proteins of Pasteurella haemolytica A2 enhances protection against experimental pasteurellosis in lambs ' (1991 ) 9 Vaccine : 137 -140.

    • Search Google Scholar
  • Howard, C. J., Stott, E. J., Thomas, L. H., Gourlay, R. N. and Taylor, G. (1987): Protection against respiratory disease in calves induced by vaccines containing respiratory syncytial virus, parainfluenza type 3 virus, Mycoplasma bovis and M. dispar . Vet. Rec. 121 , 372–376.

    Taylor G. , 'Protection against respiratory disease in calves induced by vaccines containing respiratory syncytial virus, parainfluenza type 3 virus, Mycoplasma bovis and M. dispar ' (1987 ) 121 Vet. Rec. : 372 -376.

    • Search Google Scholar
  • Kerkhofs, P., Tignon, M., Petry, H., Mawhinney, I. and Sustronck, B. (2004): Immune responses to bovine respiratory syncytial virus (BRSV) following use of an inactivated BRSV-PI3- Mannheimia haemolytica vaccine and a modified live BRSV-BVDV vaccine. Vet. J. 167 , 208–210.

    Sustronck B. , 'Immune responses to bovine respiratory syncytial virus (BRSV) following use of an inactivated BRSV-PI3-Mannheimia haemolytica vaccine and a modified live BRSV-BVDV vaccine ' (2004 ) 167 Vet. J. : 208 -210.

    • Search Google Scholar
  • Loneragan, G. H., Gould, D. H., Mason, G. L., Garry, F. B., Yost, G. S., Miles, D. G., Hoffman, B. W. and Mills, L. J. (2001): Involvement of microbial respiratory pathogens in acute interstitial pneumonia in feedlot cattle. Am. J. Vet. Res. 62 , 1519–1524.

    Mills L. J. , 'Involvement of microbial respiratory pathogens in acute interstitial pneumonia in feedlot cattle ' (2001 ) 62 Am. J. Vet. Res. : 1519 -1524.

    • Search Google Scholar
  • Mawhinney, I. C. and Burrows, M. R. (2005): Protection against bovine respiratory syncytial virus challenge following a single dose of vaccine in young calves with maternal antibody. Vet. Rec. 156 , 139–143.

    Burrows M. R. , 'Protection against bovine respiratory syncytial virus challenge following a single dose of vaccine in young calves with maternal antibody ' (2005 ) 156 Vet. Rec. : 139 -143.

    • Search Google Scholar
  • Odendaal, M. W., Morris, S., du Preez, E. and Aitchison, H. (1997): The humoral immune response in cattle after immunization with a multivalent IBR/PI3/ Pasteurella haemolytica A1 leukotoxin vaccine. Onderstepoort J. Vet. Res. 64 , 205–212.

    Aitchison H. , 'The humoral immune response in cattle after immunization with a multivalent IBR/PI3/Pasteurella haemolytica A1 leukotoxin vaccine ' (1997 ) 64 Onderstepoort J. Vet. Res. : 205 -212.

    • Search Google Scholar
  • Patel, J. R. (2004): Evaluation of a quadrivalent inactivated vaccine for the protection of cattle against diseases due to common viral infections. J. S. Afr. Vet. Assoc. 75 , 137–146.

    Patel J. R. , 'Evaluation of a quadrivalent inactivated vaccine for the protection of cattle against diseases due to common viral infections ' (2004 ) 75 J. S. Afr. Vet. Assoc. : 137 -146.

    • Search Google Scholar
  • Peters, A. R., Thevasagayam, S. J., Wiseman, A. and Salt, J. S. (2004): Duration of immunity of a quadrivalent vaccine against respiratory diseases caused by BHV-1, PI3V, BVDV, and BRSV in experimentally infected calves. Prev. Vet. Med. 66 , 63–77.

    Salt J. S. , 'Duration of immunity of a quadrivalent vaccine against respiratory diseases caused by BHV-1, PI3V, BVDV, and BRSV in experimentally infected calves ' (2004 ) 66 Prev. Vet. Med. : 63 -77.

    • Search Google Scholar
  • Stott, E. J., Thomas, L. H., Howard, C. J. and Gourlay, R. N. (1987): Field trial of a quadrivalent vaccine against calf respiratory disease. Vet. Rec. 121 , 342–347.

    Gourlay R. N. , 'Field trial of a quadrivalent vaccine against calf respiratory disease ' (1987 ) 121 Vet. Rec. : 342 -347.

    • Search Google Scholar
  • Welsh, R. D., Dye, L. B., Payton, M. E. and Confer, A. W. (2004): Isolation and antimicrobial susceptibilities of bacterial pathogens from bovine pneumonia: 1994–2002. J. Vet. Diagn. Invest. 16 , 426–431.

    Confer A. W. , 'Isolation and antimicrobial susceptibilities of bacterial pathogens from bovine pneumonia: 1994–2002 ' (2004 ) 16 J. Vet. Diagn. Invest. : 426 -431.

    • Search Google Scholar
  • West, K. and Ellis, J. (1997): Functional analysis of antibody responses of feedlot cattle to bovine respiratory syncytial virus following vaccination with mixed vaccines. Can. J. Vet. Res. 61 , 28–33.

    Ellis J. , 'Functional analysis of antibody responses of feedlot cattle to bovine respiratory syncytial virus following vaccination with mixed vaccines ' (1997 ) 61 Can. J. Vet. Res. : 28 -33.

    • Search Google Scholar

The author instruction is available in PDF.
Please, download the file from HERE.

 

MANUSCRIPT SUBMISSION

  • Impact Factor (2019): 0.991
  • Scimago Journal Rank (2019): 0.372
  • SJR Hirsch-Index (2019): 32
  • SJR Quartile Score (2019): Q2 Veterinary (miscellaneous)
  • Impact Factor (2018): 1.059
  • Scimago Journal Rank (2018): 0.517
  • SJR Hirsch-Index (2018): 30
  • SJR Quartile Score (2018): Q2 Veterinary (miscellaneous)

Language: English

Founded in 1951
Publication: One volume of four issues annually
Publication Programme: 2020. Vol. 68.
Indexing and Abstracting Services:

  • Biological Abstracts

     

  • BIOSIS Previews
  • CAB Abstracts
  • Chemical Abstracts
  • Current Contents: Agriculture, Biology and Environmental Sciences
  • Elsevier Science Navigator
  • Focus On: Veterinary Science and Medicine
  • Global Health
  • Index Medicus
  • Index Veterinarius
  • Medline
  • Science Citation Index
  • Science Citation Index Expanded (SciSearch)
  • SCOPUS
  • The ISI Alerting Services
  • Zoological Abstracts

 

Subscribers can access the electronic version of every printed article.

Senior editors

Editor(s)-in-Chief: Benkő, Mária

Managing Editor(s): Székely, András

Editorial Board

      Dénes, Béla
      Eszterbauer, Edit
      Fébel, Hedvig
      Fodor, László
      Harrach, Balázs
      Andras Komaromy (USA)
      Peter Massanyi (Slovak Republic)
      Nagy, Béla
      Németh, Tibor
      Neogrády, Zsuzsanna
      Kurt Pfister (Germany)
      Solti, László
      Szabó, József
      Vajdovich, Péter
      Varga, János
      Štefan, Vilĉek (Slovak Republic)
      Vörös, Károly
      Herbert Weissenböck (Austria)
      Zsarnovszky, Attila

ACTA VETERINARIA HUNGARICA
Institute for Veterinary Medical Research
Centre for Agricultural Research
Hungarian Academy of Sciences
P.O. Box 18, H-1581 Budapest, Hungary
Phone: (36 1) 467 4081 (ed.-in-chief) or (36 1) 213 9793 (editor) Fax: (36 1) 467 4076 (ed.-in-chief) or (36 1) 213 9793