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  • 1 College of Veterinary Medicine, Shahrekord University Department of Basic Sciences Shahrekord Iran
  • 2 College of Veterinary Medicine, Shahrekord University Department of Clinical Sciences Shahrekord Iran
  • 3 Islamic Azad University, Shahrekord Branch Department of Basic Sciences, Faculty of Veterinary Medicine Shahrekord Iran
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To clarify the effect of orally administered citric acid on the electrocardiographic parameters of pulmonary hypertensive broilers, chicks were reared at high altitude and treated with citric acid for 45 days. Increase of cardiac indices such as right ventricle/total ventricles (RV/TV), RV/body weight and TV/body weight ratio was not observed in the treated groups as compared to the control groups. Decrease of S amplitude in the treated groups (leads II, III, aVF) was only significant (P < 0.05) at 45 days of age (leads II, aVF; 1.5 g/l of citric acid). There were significant reductions of T amplitude at 28 (lead aVR) and 36 days (lead aVL) and significant reductions of R wave at 28 (lead aVL, all doses of citric acid) and 45 days of age (lead aVR, 1 and 1.5 g/l citric acid) in the treated groups. The QRS interval was significantly higher at 28 (leads III and aVF), 36 (leads II, III and aVF, 1 g/l citric acid) and 45 days of age (leads II and aVF) in the treated groups. The QT interval was significantly (P < 0.05) increased at 28 and 45 days of age (lead aVL) and the RR interval also showed an increase at 28 (leads aVR and aVL) and 45 (lead aVL) days of age as compared to the controls. Our data indicate that citric acid modulates the induction of pulmonary hypertension at high altitude and this effect is detectable in the electrocardiographic parameters.

  • Arab, H. A., Jamshidi, R., Rassouli, A., Shams, G. and Hassanzadeh, M. H. (2006): Generation of hydroxyl radicals during ascites experimentally induced in broilers. Br. Poult Sci. 47 , 216–222.

    Hassanzadeh M. H. , 'Generation of hydroxyl radicals during ascites experimentally induced in broilers ' (2006 ) 47 Br. Poult Sci. : 216 -222.

    • Search Google Scholar
  • Atapattu, N. S. B. M. and Nelligaswatta, C. J. (2005): Effects of citric acid on the performance and the utilization of phosphorus and crude protein in broiler chickens fed on rice by-products based diets. Int. J. Poult. Sci. 4 , 990–993.

    Nelligaswatta C. J. , 'Effects of citric acid on the performance and the utilization of phosphorus and crude protein in broiler chickens fed on rice by-products based diets ' (2005 ) 4 Int. J. Poult. Sci. : 990 -993.

    • Search Google Scholar
  • Baghbanzadeh, A. and Decuypere, E. (2008): Ascites syndrome in broilers: physiological and nutritional perspectives. Avian Pathol. 37 , 117–126.

    Decuypere E. , 'Ascites syndrome in broilers: physiological and nutritional perspectives ' (2008 ) 37 Avian Pathol. : 117 -126.

    • Search Google Scholar
  • Boling-Frankenbach, S. D., Snow, J. L., Parsons, C. M. and Baker, D. H. (2001): The effect of citric acid on the calcium and phosphorus requirements of chicks fed corn-soybean meal diets. Poult. Sci. 80 , 783–788.

    Baker D. H. , 'The effect of citric acid on the calcium and phosphorus requirements of chicks fed corn-soybean meal diets ' (2001 ) 80 Poult. Sci. : 783 -788.

    • Search Google Scholar
  • Brenes, A., Viveros, A., Arija, I., Centeno, C., Pizarro, M. and Carmen, B. (2003): The effect of citric acid and microbial phytase on mineral utilization in broiler chicks. Anim. Feed Sci. Tec. 110 , 210–219.

    Carmen B. , 'The effect of citric acid and microbial phytase on mineral utilization in broiler chicks ' (2003 ) 110 Anim. Feed Sci. Tec. : 210 -219.

    • Search Google Scholar
  • Cinar, A., Belge, F., Donmez, N., Tas, A., Selcuk, M. and Tatar, M. (2006): Effects of stress produced by adrenocorticotropin (ACTH) on ECG and some blood parameters in vitamin C treated and non-treated chickens. Veterinarski Arhiv 76 , 227–235.

    Tatar M. , 'Effects of stress produced by adrenocorticotropin (ACTH) on ECG and some blood parameters in vitamin C treated and non-treated chickens ' (2006 ) 76 Veterinarski Arhiv : 227 -235.

    • Search Google Scholar
  • Hassanpour, H., Teshfam, M., Modirsanei, M. and Emadi, L. (2005): Comparative studies of the electrocardiographic parameters, mean electrical axis (MEA) and cardiac index (RV/TV) in normal and experimentally ascites (using cold) groups of broilers. Proceedings of the ISAH Congress Warsaw, Poland, vol. 2 , 18–20.

    Emadi L. , 'Comparative studies of the electrocardiographic parameters, mean electrical axis (MEA) and cardiac index (RV/TV) in normal and experimentally ascites (using cold) groups of broilers ' (2005 ) 2 Proceedings of the ISAH Congress Warsaw, Poland : 18 -20.

    • Search Google Scholar
  • Hassanzadeh, M., Buyse, J. and Decuypere, E. (2008): Further evidence for the involvement of anatomical parameters of the cardiopulmonary system in the development of ascites syndrome in broiler chickens. Acta Vet. Hung. 56 , 71–80.

    Decuypere E. , 'Further evidence for the involvement of anatomical parameters of the cardiopulmonary system in the development of ascites syndrome in broiler chickens ' (2008 ) 56 Acta Vet. Hung. : 71 -80.

    • Search Google Scholar
  • Hassanzadeh, M., Fard, M. H., Buyse, J., Bruggeman, V. and Decuypere, E. (2004): Effect of chronic hypoxia during embryonic development on physiological functioning and on hatching and post-hatching parameters related to ascites syndrome in broiler chickens. Avian Pathol. 33 , 558–564.

    Decuypere E. , 'Effect of chronic hypoxia during embryonic development on physiological functioning and on hatching and post-hatching parameters related to ascites syndrome in broiler chickens ' (2004 ) 33 Avian Pathol. : 558 -564.

    • Search Google Scholar
  • Hassanzadeh, M., Gilanpour, H., Charkhkar, S., Buyse, J. and Decuypere, E. (2005): Anatomical parameters of cardiopulmonary system in three different lines of chickens: further evidence for involvement in ascites syndrome. Avian Pathol. 34 , 188–193.

    Decuypere E. , 'Anatomical parameters of cardiopulmonary system in three different lines of chickens: further evidence for involvement in ascites syndrome ' (2005 ) 34 Avian Pathol. : 188 -193.

    • Search Google Scholar
  • Hernandez, A. (1987): Hypoxic ascites in broilers: a review of several studies done in Colombia. Avian Dis. 31 , 658–661.

    Hernandez A. , 'Hypoxic ascites in broilers: a review of several studies done in Colombia ' (1987 ) 31 Avian Dis. : 658 -661.

    • Search Google Scholar
  • Julian, R. J. (2000): Physiological, management and environmental triggers of the ascites syndrome: a review. Avian Pathol. 29 , 519–527.

    Julian R. J. , 'Physiological, management and environmental triggers of the ascites syndrome: a review ' (2000 ) 29 Avian Pathol. : 519 -527.

    • Search Google Scholar
  • Martinez, L. A., Jeffrey, J. S. and Odom, T. W. (1997): Electrocardiographic diagnosis of cardiomyopathies in Aves. Poult. Avian Biol. Rev. 8 , 9–20.

    Odom T. W. , 'Electrocardiographic diagnosis of cardiomyopathies in Aves ' (1997 ) 8 Poult. Avian Biol. Rev. : 9 -20.

    • Search Google Scholar
  • Martinez-Amezcua, C., Parsons, C. M. and Baker, D. H. (2006): Effect of microbial phytase and citric acid on phosphorus bioavailability, apparent metabolizable energy, and amino acid digestibility in distillers dried grains with solubles in chicks. Poult. Sci. 85 , 470–475.

    Baker D. H. , 'Effect of microbial phytase and citric acid on phosphorus bioavailability, apparent metabolizable energy, and amino acid digestibility in distillers dried grains with solubles in chicks ' (2006 ) 85 Poult. Sci. : 470 -475.

    • Search Google Scholar
  • National Research Council (1994): Nutrient Requirements of Poultry. National Academy Press, Washington, D. C.

    '', in Nutrient Requirements of Poultry , (1994 ) -.

  • Owen, R. L., Wideman, R. F., Leach, R. M., Cowen, B. S., Dunn, P. A. and Ford, B. C. (1995): Physiologic and electrocardiographic changes occurring in broilers reared at high altitude. Avian Dis. 39 , 108–115.

    Ford B. C. , 'Physiologic and electrocardiographic changes occurring in broilers reared at high altitude ' (1995 ) 39 Avian Dis. : 108 -115.

    • Search Google Scholar
  • Rafacz-Livingston, K. A., Martinez-Amezcua, C., Parsons, C. M., Baker, D. H. and Snow, J. (2005): Citric acid improves phytate phosphorus utilization in crossbred and commercial broiler chicks. Poult. Sci. 84 , 1370–1375.

    Snow J. , 'Citric acid improves phytate phosphorus utilization in crossbred and commercial broiler chicks ' (2005 ) 84 Poult. Sci. : 1370 -1375.

    • Search Google Scholar
  • Rice, J. P., Pleasant, R. S. and Radcliffe, J. S. (2002): The Effect of Citric Acid, Phytase, and Their Interaction on Gastric pH, and Ca, P, and Dry Matter Digestibilities. Swine Research Report, Purdue University, West Lafayette, IN.

    Radcliffe J. S. , '', in The Effect of Citric Acid, Phytase, and Their Interaction on Gastric pH, and Ca, P, and Dry Matter Digestibilities , (2002 ) -.

    • Search Google Scholar
  • Samaja, M., Crespi, T., Guazzi, M. and Vandegriff, K. D. (2003): Oxygen transport in blood at high altitude: role of the hemoglobin-oxygen affinity and impact of the phenomena related to hemoglobin allosterism and red cell function. Eur. J. Appl. Physiol. 90 , 351–359.

    Vandegriff K. D. , 'Oxygen transport in blood at high altitude: role of the hemoglobin-oxygen affinity and impact of the phenomena related to hemoglobin allosterism and red cell function ' (2003 ) 90 Eur. J. Appl. Physiol. : 351 -359.

    • Search Google Scholar
  • Schamroth, L. (1985): An Introduction to Electrocardiography. Sixth edition. Johannesburg, South Africa.

  • Teshfam, M., Nikbakht Brujeni, G. H. and Hassanpour, H. (2006): Evaluation of endothelial and inducible nitric oxide synthases mRNA expression in the lung of broiler chickens with developmental pulmonary hypertension due to cold stress. Br. Poult. Sci. 47 , 223–229.

    Hassanpour H. , 'Evaluation of endothelial and inducible nitric oxide synthases mRNA expression in the lung of broiler chickens with developmental pulmonary hypertension due to cold stress ' (2006 ) 47 Br. Poult. Sci. : 223 -229.

    • Search Google Scholar
  • Van den Berg, A. J., Halkes, S. B., Van Ufford, H. C., Hoekstra, M. J. and Beukelman, C. J. (2003): A novel formulation of metal ions and citric acid reduces reactive oxygen species in vitro . J. Wound Care 12 , 413–418.

    Beukelman C. J. , 'A novel formulation of metal ions and citric acid reduces reactive oxygen species in vitro ' (2003 ) 12 J. Wound Care : 413 -418.

    • Search Google Scholar
  • Wideman, R. F. (2001): Pathophysiology of heart/lung disorders: pulmonary hypertension syndrome in broiler chickens. World’s Poult. Sci. J. 57 , 289–307.

    Wideman R. F. , 'Pathophysiology of heart/lung disorders: pulmonary hypertension syndrome in broiler chickens ' (2001 ) 57 World’s Poult. Sci. J. : 289 -307.

    • Search Google Scholar
  • Xiang, R. P., Sun, W. D., Wang, J. Y. and Wang, X. L. (2002): Effect of vitamin C on pulmonary hypertension and muscularisation of pulmonary arterioles in broilers. Br. Poult. Sci. 43 , 705–712.

    Wang X. L. , 'Effect of vitamin C on pulmonary hypertension and muscularisation of pulmonary arterioles in broilers ' (2002 ) 43 Br. Poult. Sci. : 705 -712.

    • Search Google Scholar

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