View More View Less
  • 1 University of Thessaly Clinic of Obstetrics and Reproduction, Veterinary Faculty 224 Trikalon str. 43100 Karditsa Greece
  • 2 NAGREF Thessaloniki Greece
  • 3 Szent István University Faculty of Veterinary Science Budapest Hungary
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $836.00

Follicular development and oocyte quality were assessed by laparoscopic observation and in vitro fertilisation, respectively, in melatonin-treated (Group M) and control (Group C) anoestrous Chios ewes (n = 10 in each group). Fourteen days after melatonin insertion, all ewes had laparoscopic evaluation of the follicular population followed by oocyte pick-up (OPU); on day 22 intravaginal progestagen sponges were inserted for 14 days. Two days after sponge removal the follicular population was re-evaluated and a second follicular aspiration was performed. Collected oocytes from the second OPU underwent in vitro maturation, fertilisation and culture. The number of large follicles was higher in Group M than in the control ewes during the first OPU and tended to be so (P = 0.06) at the second. Morphologically, oocytes collected from controls were of better quality than those from Group M; however, more oocytes collected from melatonintreated animals fertilised and developed in vitro . These results indicate that melatonin is a potent regulator of follicular development and oocyte competence during the anoestrous period of the ewe.

  • Abecia, J. A., Forcada, F. and Zuniga, O. (2002): The effect of melatonin on the secretion of progesterone in sheep and on the development of ovine embryos in vitro . Vet. Res. Commun. 26 , 151–158.

    Zuniga O. , 'The effect of melatonin on the secretion of progesterone in sheep and on the development of ovine embryos in vitro ' (2002 ) 26 Vet. Res. Commun. : 151 -158.

    • Search Google Scholar
  • Dimitriadis, I., Papanikolaou, T., Vainas, E., Amiridis, G. S., Valasi, E., Samartzi, F. and Rekkas, C. (2005): Effects of melatonin on in vitro maturation of bovine oocytes. 9th ESDAR, September 2005, Murcia, Spain.

  • Forcada, F., Abecia, J. A., Cebrian-Perez, J. A., Muino-Blanco, T., Valares, J. A., Palacin, I. and Casao, A. (2006): The effect of melatonin implants during the seasonal anestrus on embryo production after superovulation in aged high-prolificacy Rasa Aragonesa ewes. Theriogenology 65 , 356–365.

    Casao A. , 'The effect of melatonin implants during the seasonal anestrus on embryo production after superovulation in aged high-prolificacy Rasa Aragonesa ewes ' (2006 ) 65 Theriogenology : 356 -365.

    • Search Google Scholar
  • Forcada, F., Abecia, J. A., Zuniga, O. and Lozano, J. M. (2002): Variation in the ability of melatonin implants inserted at two different times after the winter solstice to restore reproductive activity in reduced seasonality ewes. Aust. Journal Agric. Res. 53 , 167–173.

    Lozano J. M. , 'Variation in the ability of melatonin implants inserted at two different times after the winter solstice to restore reproductive activity in reduced seasonality ewes ' (2002 ) 53 Aust. Journal Agric. Res. : 167 -173.

    • Search Google Scholar
  • Haresign, W. (1992): Manipulation of reproduction in sheep. J. Reprod. Fertil. Suppl. 45 , 127–139.

    Haresign W. , 'Manipulation of reproduction in sheep ' (1992 ) 45 J. Reprod. Fertil. Suppl. : 127 -139.

    • Search Google Scholar
  • Ishizuka, B., Kuribayashi, Y., Murai, K., Ameniya, A. and Itoh, M. T. (2000): The effects of melatonin on in vitro fertilization and embryo development in mice. J. Pineal Res. 28 , 48–51.

    Itoh M. T. , 'The effects of melatonin on in vitro fertilization and embryo development in mice ' (2000 ) 28 J. Pineal Res. : 48 -51.

    • Search Google Scholar
  • Luther, J. S., Redmer, D. A., Reynolds, L. P., Choi, J. T., Pant, D., Navanukraw, C., Arnold, D. R., Scheaffer, A. N., Borowicz, P., Kirsch, J. D., Weigl, R. M., Kraft, K. C. and Grazul-Bilska, A. T. (2005): Ovarian follicular development and oocyte quality in anestrous ewes treated with melatonin, a controlled internal drug release (CIDR) device and follicle stimulating hormone. Theriogenology 63 , 2136–2146.

    Grazul-Bilska A. T. , 'Ovarian follicular development and oocyte quality in anestrous ewes treated with melatonin, a controlled internal drug release (CIDR) device and follicle stimulating hormone ' (2005 ) 63 Theriogenology : 2136 -2146.

    • Search Google Scholar
  • Malpaux, B., Viguie, C., Skinner, D. C., Thiery, J. C. and Chemineau, P. (1997): Control of the circannual rhythm of reproduction by melatonin in the ewe. Brain Res. Bull 44 , 431–438.

    Chemineau P. , 'Control of the circannual rhythm of reproduction by melatonin in the ewe ' (1997 ) 44 Brain Res. Bull : 431 -438.

    • Search Google Scholar
  • McEvoy, T. G., Robinson, J. J., Aitken, R. P. and Robertson, I. S. (1998): Melatonin treatment of embryo donor and recipient ewes during anestrus affects their endocrine status, but not ovulation rate, embryo survival or pregnancy. Theriogenology 49 , 943–955.

    Robertson I. S. , 'Melatonin treatment of embryo donor and recipient ewes during anestrus affects their endocrine status, but not ovulation rate, embryo survival or pregnancy ' (1998 ) 49 Theriogenology : 943 -955.

    • Search Google Scholar
  • Menegatos, J., Lainas, T., Deligiannis, C., Amiridis, G. S. and Xylouri, E. (2005): The breeding season and reproduction methods of Greek indigenous and imported sheep breeds. Proceedings of the 6th International Sheep Veterinary Congress. p. 242.

  • Nakamura, Y., Tamura, H., Takayama, H. and Kato, H. (2003): Increased endogenous level of melatonin in preovulatory human follicles does not directly influence progesterone production. Fertil. Steril. 80 , 1012–1016.

    Kato H. , 'Increased endogenous level of melatonin in preovulatory human follicles does not directly influence progesterone production ' (2003 ) 80 Fertil. Steril. : 1012 -1016.

    • Search Google Scholar
  • Noël, B., Mandiki, S. M. N., Perrad, B., Bister, J. L. and Paquay, R. (1999): Terminal follicular growth, ovulation rate and hormonal secretion after melatonin pretreatment prior to FGAPMSG synchronization in Suffolk ewes at the onset of the breeding season. Small Rumin. Res. 32 , 269–277.

    Paquay R. , 'Terminal follicular growth, ovulation rate and hormonal secretion after melatonin pretreatment prior to FGAPMSG synchronization in Suffolk ewes at the onset of the breeding season ' (1999 ) 32 Small Rumin. Res. : 269 -277.

    • Search Google Scholar
  • Papanikolaou, T., Amiridis, G. S., Dimitriadis, I., Vainas, E. and Rekkas, C. A. (2008): Effect of plasmin, plasminogen activators and a plasmin inhibitor on bovine in vitro embryo production. Reprod. Fertil. Dev. 20 , 320–327.

    Rekkas C. A. , 'Effect of plasmin, plasminogen activators and a plasmin inhibitor on bovine in vitro embryo production ' (2008 ) 20 Reprod. Fertil. Dev. : 320 -327.

    • Search Google Scholar
  • Parrish, J. J., Susko-Parrish, J., Winer, M. A. and First, N. L. (1988): Capacitation of bovine sperm by heparin. Biol. Reprod. 38 , 1171–1180.

    First N. L. , 'Capacitation of bovine sperm by heparin ' (1988 ) 38 Biol. Reprod. : 1171 -1180.

    • Search Google Scholar
  • Rondon, Z., Forcada, F., Zarazaga, L., Abecia, J. A. and Lozano, J. M. (1996): Oestrous activity, ovulation rate and plasma melatonin concentrations in Rasa Aragonesa ewes maintained at two different and constant body condition score levels and implanted or reimplanted with melatonin. Anim. Reprod. Sci. 41 , 225–236.

    Lozano J. M. , 'Oestrous activity, ovulation rate and plasma melatonin concentrations in Rasa Aragonesa ewes maintained at two different and constant body condition score levels and implanted or reimplanted with melatonin ' (1996 ) 41 Anim. Reprod. Sci. : 225 -236.

    • Search Google Scholar
  • Stenback, T. K., Redmer, D. A., Berginski, H. R., Erickson, A. S., Navanukraw, C., Toutges, M. J., Bilski, J. J., Kirsch, J. D., Kraft, K. C., Reynolds, L. P. and Grazul-Bilska, A. T. (2001): Effects of follicle stimulating hormone (FSH) on follicular development, oocyte retrieval, and in vitro fertilization (IVF) in ewes during breeding season and seasonal anestrus. Theriogenology 56 , 51–64.

    Grazul-Bilska A. T. , 'Effects of follicle stimulating hormone (FSH) on follicular development, oocyte retrieval, and in vitro fertilization (IVF) in ewes during breeding season and seasonal anestrus ' (2001 ) 56 Theriogenology : 51 -64.

    • Search Google Scholar
  • Thiery, J. C., Chemineau, P., Hernandez, X., Migaud, M. and Malpaux, B. (2002): Neuroendocrine interactions and seasonality. Dom. Anim. Endocr. 23 , 87–100.

    Malpaux B. , 'Neuroendocrine interactions and seasonality ' (2002 ) 23 Dom. Anim. Endocr. : 87 -100.

    • Search Google Scholar
  • Van Soom, A., Van Vlaenderen, I., Mahmoudzadeh, A. R., Deluyker, H. and de Kruif, A. (1992): Compaction rate of in vitro fertilized bovine embryos related to the interval from insemination to first cleavage. Theriogenology 38 , 905–919.

    Kruif A. , 'Compaction rate of in vitro fertilized bovine embryos related to the interval from insemination to first cleavage ' (1992 ) 38 Theriogenology : 905 -919.

    • Search Google Scholar
  • Yie, S. M., Niles, L. P. and Younglai, E. V. (1995): Melatonin receptors on human granulosa cell membranes. J. Clin. Endocrinol. Metab. 80 , 1747–1749.

    Younglai E. V. , 'Melatonin receptors on human granulosa cell membranes ' (1995 ) 80 J. Clin. Endocrinol. Metab. : 1747 -1749.

    • Search Google Scholar

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Jun 2020 0 1 1
Jul 2020 17 0 0
Aug 2020 10 0 0
Sep 2020 0 0 0
Oct 2020 4 0 0
Nov 2020 1 4 2
Dec 2020 0 0 0