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  • 1 Szent István University Department of Parasitology and Zoology, Faculty of Veterinary Science István u. 2 H-1078 Budapest Hungary
  • 2 Pfizer Animal Health Budapest Hungary
  • 3 Dr. Bubó-Vet Szigetszentmiklós Hungary
  • 4 Szent István University Department of Biomathematics and Informatics, Faculty of Veterinary Science Budapest Hungary
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Subcutaneous dirofilariosis caused by Dirofilaria repens is common in dogs and it is an emerging helminthozoonosis in Europe, Asia, Africa and also in Hungary. Macrocyclic lactones are used for preventing the infection; however, their activity against the microfilariae and mature stages of this species is questionable. Selamectin is widely used for the prophylaxis of heartworm ( D. immitis ) infection. The objective of the present study was to test the microfilaricidal efficacy of the topical formulation of selamectin in dogs naturally infected with D. repens . A total of 78 Beagle dogs were examined for the presence of circulating microfilariae by Knott’s test. Twenty-three of the microfilaraemic dogs were divided into four groups and included in the trial. The dogs received monthly or biweekly selamectin treatment and were subjected to monthly blood testing for a period of 252 or 336 days. At the end of the study, 65% of the dogs were not microfilaraemic and the rest had low number of microfilariae in their blood. These results indicate that chronic spot-on selamectin treatment may be a useful tool also in the control of canine subcutaneous dirofilariosis.

  • Baneth, G., Volansky, Z., Anug, Y., Favia, G., Bain, O., Goldstein, R. E. and Harrus, S. (2002): Dirofilaria repens infection in a dog: diagnosis and treatment with melarsomine and doramectin. Vet. Parasitol. 105 , 173–178.

    Harrus S. , 'Dirofilaria repens infection in a dog: diagnosis and treatment with melarsomine and doramectin ' (2002 ) 105 Vet. Parasitol. : 173 -178.

    • Search Google Scholar
  • Cancrini, G., Tassi, P. and Coluzzi, M. (1989): Ivermectin against larval stages of Dirofilaria repens in dogs. Parassitologia 31 , 177–182.

    Coluzzi M. , 'Ivermectin against larval stages of Dirofilaria repens in dogs ' (1989 ) 31 Parassitologia : 177 -182.

    • Search Google Scholar
  • Casiraghi, M., Bazzocchi, C., Mortarino, M., Ottina, E. and Genchi, C. (2006): A simple molecular method for discriminating common filarial nematodes of dogs ( Canis familiaris ). Vet. Parasitol. 141 , 368–372.

    Genchi C. , 'A simple molecular method for discriminating common filarial nematodes of dogs (Canis familiaris) ' (2006 ) 141 Vet. Parasitol. : 368 -372.

    • Search Google Scholar
  • Clemence, R. G., Sarasola, P., Genchi, C., Smith, D. G., Shanks, D. J., Jernigan, A. D. and Rowan, T. G. (2000): Efficacy of selamectin in the prevention of adult heartworm ( Dirofilaria immitis ) infection in dogs in northern Italy. Vet. Parasitol. 91 , 251–258.

    Rowan T. G. , 'Efficacy of selamectin in the prevention of adult heartworm (Dirofilaria immitis) infection in dogs in northern Italy ' (2000 ) 91 Vet. Parasitol. : 251 -258.

    • Search Google Scholar
  • Fisher, M. A. and Shanks, D. J. (2008): A review of the off-label use of selamectin (Stronghold/Revolution) in dogs and cats. Acta Vet. Scand. 50 , 46 http://www.actavetscand.com/content/50/1/46

    Shanks D. J. , 'A review of the off-label use of selamectin (Stronghold/Revolution) in dogs and cats ' (2008 ) 50 Acta Vet. Scand. : 46 -.

    • Search Google Scholar
  • Fok, É., Jacsó, O., Szebeni, Zs., Győrffy, A., Sükösd, L., Lukács, Z. and Schaper, R. (2010): Elimination of Dirofilaria (syn. Nochtiella ) repens microfilariae in dogs with monthly treatments of moxidectin 2.5%/imidacloprid 10% (Advocate®, Bayer) spot-on. Parasitology Research, 18 February DOI:10.1007/s00436-010-1783-4

  • Fok, É., Kiss, G., Majoros, G., Jacsó, O., Farkas, R. and Gyurkovszky, M. (2007): Preliminary results of an epidemiological survey on dirofilariosis of dogs and cats in Hungary. In: Genchi, C., Rinaldi, L. and Cringoli, G. (eds) Mappe Parassitologiche 8. Rolando Editore, Naples. pp. 195–196.

    Gyurkovszky M. , '', in Mappe Parassitologiche 8 , (2007 ) -.

  • Fok, É., Szabó, Z. and Farkas, R. (1998): The first autochthonous case of a dog infected with Dirofilaria repens in Hungary (in Hungarian). Kisállatorvoslás 4 , 218–219.

    Farkas R. , 'The first autochthonous case of a dog infected with Dirofilaria repens in Hungary (in Hungarian) ' (1998 ) 4 Kisállatorvoslás : 218 -219.

    • Search Google Scholar
  • Genchi, C., Poglayen, G., Kramer, L., Casiraghi, M., Venco, L. and Brianti, E. (2002): Efficacy of selamectin in the prophylaxis of Dirofilaria repens infestations in dogs (in Italian). Veterinaria 16 , 69–71.

    Brianti E. , 'Efficacy of selamectin in the prophylaxis of Dirofilaria repens infestations in dogs (in Italian) ' (2002 ) 16 Veterinaria : 69 -7.

    • Search Google Scholar
  • Genchi, C., Rinaldi, L. and Cringoli, G. (2007): Dirofilaria immitis and D. repens in dog and cat and human infections. Mappe Parassitologiche 8. Rolando Editore, Naples, Italy. pp. 81–116.

    Cringoli G. , '', in Mappe Parassitologiche 8 , (2007 ) -.

  • Jacsó, O., Mándoki, M., Majoros, G., Pétsch, M., Mortarino, M., Genchi, C. and Fok, É. (2009): First autochthonous Dirofilaria immitis (Leidy, 1856) infection in a dog in Hungary. Helminthologia 46 , 159–161.

    Fok , 'First autochthonous Dirofilaria immitis (Leidy, 1856) infection in a dog in Hungary ' (2009 ) 46 Helminthologia : 159 -161.

    • Search Google Scholar
  • Kamalu, B. T. (1991): Canine filariasis caused by Dirofilaria repens in Southeastern Nigeria. Vet. Parasitol. 40 , 335–338.

    Kamalu B. T. , 'Canine filariasis caused by Dirofilaria repens in Southeastern Nigeria ' (1991 ) 40 Vet. Parasitol. : 335 -338.

    • Search Google Scholar
  • Lifschitz, A., Virkel, G., Sallovitz, J., Sutra, J. F., Galtier, P., Alvinerie, M. and Lanusse, C. (2000): Comparative distribution of ivermectin and doramectin to parasite location tissues in cattle. Vet. Parasitol. 87 , 327–338.

    Lanusse C. , 'Comparative distribution of ivermectin and doramectin to parasite location tissues in cattle ' (2000 ) 87 Vet. Parasitol. : 327 -338.

    • Search Google Scholar
  • Manfredi, M. T., Di Cerbo, A. and Genchi, M. (2007): Biology of filarial worms parasitizing dogs and cats. In: Genchi, C., Rinaldi, L. and Cringoli, G. (eds) Mappe Parassitologiche 8. Rolando Editore, Naples, Italy. pp. 41–45.

    Genchi M. , '', in Mappe Parassitologiche 8 , (2007 ) -.

  • Marconcini, A., Magi, M. and Hecht Contin, B. (1993): The value of ivermectin in the prophylaxis of Dirofilaria repens infestation in naturally infected dogs (in Italian). Parassitologia 35 , 67–71.

    Hecht Contin B. , 'The value of ivermectin in the prophylaxis of Dirofilaria repens infestation in naturally infected dogs (in Italian) ' (1993 ) 35 Parassitologia : 67 -71.

    • Search Google Scholar
  • McCall, J. W., Dzimianski, M. T., Steffens, W. L., Supakorndej, N., Supakorndej, P., Mansour, A. E., Ard, M. B., McCall, S. D., Hack, R. and Domingo, D. (2007): Safety and efficacy of selamectin in dogs with Dirofilaria immitis infection. In: Genchi, C., Rinaldi, L. and Cringoli, G. (eds) Mappe Parassitologiche 8. Rolando Editore, Naples, Italy. pp. 164–174.

    Domingo D. , '', in Mappe Parassitologiche 8 , (2007 ) -.

  • McTier, T. L., Shanks, D. J., Watson, P., McCall, J. W., Genchi, C., Six, R. H., Thomas, C. A., Dickin, S. K., Pengo, G., Rowan, T. G. and Jernigan, A. D. (2000): Prevention of experimentally induced heartworm ( Dirofilaria immitis ) infections in dogs and cats with a single topical application of selamectin. Vet. Parasitol. 91 , 259–268.

    Jernigan A. D. , 'Prevention of experimentally induced heartworm (Dirofilaria immitis) infections in dogs and cats with a single topical application of selamectin ' (2000 ) 91 Vet. Parasitol. : 259 -268.

    • Search Google Scholar
  • Pampiglione, S. and Rivasi, F. (2000): Human dirofilariosis due to Dirofilaria repens : update of world literature from 1995 to 2000. Parassitologia 42 , 231–254.

    Rivasi F. , 'Human dirofilariosis due to Dirofilaria repens: update of world literature from 1995 to 2000 ' (2000 ) 42 Parassitologia : 231 -254.

    • Search Google Scholar
  • Pampiglione, S., Elek, G., Pálfi, P., Vetési, F. and Varga, I. (1999): Human Dirofilaria repens infection in Hungary: A case in the spermatic cord and a review of the literature. Acta Vet. Hung. 47 , 77–83.

    Varga I. , 'Human Dirofilaria repens infection in Hungary: A case in the spermatic cord and a review of the literature ' (1999 ) 47 Acta Vet. Hung. : 77 -83.

    • Search Google Scholar
  • Pingen, C. H., Lorentz, S., Magnis, J., Menn, B., Schaper, R. and Naucke, T. J. (2009): Successful treatment of Dirofilaria repens infections in dogs with melarsomine (Immiticide® Merial) against adults and a combination of moxidectin 2.5%/imidacloprid 10% (Advocate®, Bayer) against microfilariae. Second European Dirofilaria Days (SEDD), 16–18 September, Salamanca, Abstract, 021.

  • Rossi, L., Ferroglio, E. and Agostini, A. (2002): Use of moxidectin tablets in the control of canine subcutaneous dirofilariosis. Vet. Rec. 150 , 383.

    Agostini A. , 'Use of moxidectin tablets in the control of canine subcutaneous dirofilariosis ' (2002 ) 150 Vet. Rec. : 383 -.

    • Search Google Scholar
  • Rossi, L., Ferroglio, E. and Agostini, A. (2004): Use of an injectable, sustained-release formulation of moxidectin to prevent canine subcutaneous dirofilariosis. Vet. Rec. 154 , 26–27.

    Agostini A. , 'Use of an injectable, sustained-release formulation of moxidectin to prevent canine subcutaneous dirofilariosis ' (2004 ) 154 Vet. Rec. : 26 -27.

    • Search Google Scholar
  • Széll, Z., Sréter, T., Csikós, K., Kátai, Z., Dobos-Kovács, M., Vetési, F. and Varga, I. (1999): Autochthonous infection with Dirofilaria repens in dogs in Hungary (in Hungarian, with English abstract). Magyar Állatorvosok Lapja 121 , 100–104.

    Varga I. , 'Autochthonous infection with Dirofilaria repens in dogs in Hungary (in Hungarian, with English abstract) ' (1999 ) 121 Magyar Állatorvosok Lapja : 100 -104.

    • Search Google Scholar
  • Szénási, Zs., Hári Kovács, A., Pampiglione, S., Fioravanti, M. L., Kucsera, I., Tánczos, B. and Tiszlavitz, L. (2008): Human dirofilariosis in Hungary: an emerging zoonosis in Central Europe. Wiener Klin. Wschr. 120 , 96–102.

    Tiszlavitz L. , 'Human dirofilariosis in Hungary: an emerging zoonosis in Central Europe ' (2008 ) 120 Wiener Klin. Wschr. : 96 -102.

    • Search Google Scholar
  • Tarello, W. (2002): Dermatitis associated with Dirofilaria ( Nochtiella ) repens microfilariae in dogs from Central Italy. Acta Vet. Hung. 50 , 63–78.

    Tarello W. , 'Dermatitis associated with Dirofilaria (Nochtiella) repens microfilariae in dogs from Central Italy ' (2002 ) 50 Acta Vet. Hung. : 63 -78.

    • Search Google Scholar
  • Webber, W. A. F. and Hawking, F. (1955): Experimental maintenance of Dirofilaria repens and D. immitis in dogs. Exp. Parasitol. 4 , 143–164.

    Hawking F. , 'Experimental maintenance of Dirofilaria repens and D. immitis in dogs ' (1955 ) 4 Exp. Parasitol. : 143 -164.

    • Search Google Scholar

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