Immunohistochemical detection of arteriolar hyperplasia in canine liver biopsy samples using the claudin-5 antibody

Csaba Jakab; Miklós Rusvai; Péter Gálfi; Ágnes Szabára; Zoltán Szabó; Janina Kulka

doi:10.1556/avet.58.2010.4.3

Jump to Content

Acta Veterinaria Hungarica

Volume/Issue:: Volume 58: Issue 4

Immunohistochemical detection of arteriolar hyperplasia in canine liver biopsy samples using the claudin-5 antibody

Authors:

Csaba Jakab

Csaba Jakab Department of Pathology and Forensic Veterinary Medicine István u. 2 H-1078 Budapest Hungary

Search for other papers by Csaba Jakab in
Current site
Google Scholar
PubMed

Miklós Rusvai

Miklós Rusvai Department of Pathology and Forensic Veterinary Medicine István u. 2 H-1078 Budapest Hungary

Search for other papers by Miklós Rusvai in
Current site
Google Scholar
PubMed

Péter Gálfi

Péter Gálfi Department of Pharmacology and Toxicology István u. 2 H-1078 Budapest Hungary

Search for other papers by Péter Gálfi in
Current site
Google Scholar
PubMed

Ágnes Szabára

Ágnes Szabára Department of Pathology and Forensic Veterinary Medicine István u. 2 H-1078 Budapest Hungary

Search for other papers by Ágnes Szabára in
Current site
Google Scholar
PubMed

Zoltán Szabó

Zoltán Szabó C. J. Hall Veterinary Surgeons — Exotic Centre London UK

Search for other papers by Zoltán Szabó in
Current site
Google Scholar
PubMed

, and

Janina Kulka

Janina Kulka Semmelweis University 2nd Department of Pathology Budapest Hungary

Search for other papers by Janina Kulka in
Current site
Google Scholar
PubMed

View More View Less

Pages:: 423–430

Online Publication Date:: 18 Nov 2010

Publication Date:: 01 Dec 2010

Article Category:: Journal Article

DOI:: https://doi.org/10.1556/avet.58.2010.4.3

Keywords:: Arteriolar hyperplasia; dog; liver; biopsy; claudin-5; immunohistochemistry

Restricted access

Purchase article

USD $25.00

1 year subscription (Individual Only)

USD $836.00

USD $25.00

Click here to view the full Terms and Conditions

USD $836.00

Click here to view the full Terms and Conditions

Claudins are key tight junctional proteins between adjacent epithelial, mesothelial or endothelial cells, which are responsible for the permeability of the paracellular space. This paper describes that the endothelial cells of normal hepatic arterioles, portal venules and portal lymphatics as well as the endothelium of sinusoids from dogs show strong membranous claudin-5 cross-reactivity. In 25 liver biopsy samples taken from dogs with portal vein hypoperfusion, an increased number of arterioles was detected in the portal areas (PAs) by the use of humanised anti-claudin-5 antibody. The increased number of hyperplastic hepatic arterioles per PA was 5–6, 8–12 and 15–20 in the case of small, medium-sized and large PAs, respectively. It is suggested that the claudin-5 marker can improve the detection of hepatic arteriolar proliferation in the PAs of liver samples.

Save
Cite
Email this content

Share Link

Copy this link, or click below to email it to a friend
Email this content
or copy the link directly:

https://akjournals.com/abstract/journals/004/58/4/article-p423.xml
The link was not copied. Your current browser may not support copying via this button.

Link copied successfully

Collapse
Expand

Acta Veterinaria Hungarica

Print ISSN:: 0236-6290

Online ISSN:: 1588-2705

Submit Your Manuscript

Author informations are available in PDF.
Please, download the file from HERE

The manuscript preparation instructions are available in PDF.
Please, download the file from HERE

Editorial Board

Mária BENKŐ (Acta Veterinaria Hungarica, Budapest, Hungary)
Gábor BODÓ (University of Veterinary Medicine, Budapest, Hungary)
Béla DÉNES (University of Veterinary Medicine, Budapest Hungary)
Edit ESZTERBAUER (Veterinary Medical Research Institute, Budapest, Hungary)
Hedvig FÉBEL (University of Veterinary Medicine, Budapest, Hungary)
László FODOR (University of Veterinary Medicine, Budapest, Hungary)
János GÁL (University of Veterinary Medicine, Budapest, Hungary)
Balázs HARRACH (Veterinary Medical Research Institute, Budapest, Hungary)
Peter MASSÁNYI (Slovak University of Agriculture in Nitra, Nitra, Slovak Republic)
Béla NAGY (Veterinary Medical Research Institute, Budapest, Hungary)
Tibor NÉMETH (University of Veterinary Medicine, Budapest, Hungary)
Zsuzsanna NEOGRÁDY (University of Veterinary Medicine, Budapest, Hungary)
Dušan PALIĆ (Ludwig Maximilian University, Munich, Germany)
Alessandra PELAGALLI (University of Naples Federico II, Naples, Italy)
Kurt PFISTER (Ludwig-Maximilians-University of Munich, Munich, Germany)
László SOLTI (University of Veterinary Medicine, Budapest, Hungary)
József SZABÓ (University of Veterinary Medicine, Budapest, Hungary)
Péter VAJDOVICH (University of Veterinary Medicine, Budapest, Hungary)
János VARGA (University of Veterinary Medicine, Budapest, Hungary)
Štefan VILČEK (University of Veterinary Medicine in Kosice, Kosice, Slovak Republic)
Károly VÖRÖS (University of Veterinary Medicine, Budapest, Hungary)
Herbert WEISSENBÖCK (University of Veterinary Medicine, Vienna, Austria)
Attila ZSARNOVSZKY (Szent István University, Gödöllő, Hungary)

ACTA VETERINARIA HUNGARICA
Institute for Veterinary Medical Research
Centre for Agricultural Research
Hungarian Academy of Sciences
P.O. Box 18, H-1581 Budapest, Hungary
Phone: (36 1) 287 7073 (ed.-in-chief) or (36 1) 467 4081 (editor)

E-mail: acta.veterinaria@univet.hu (ed.-in-chief)

Indexing and Abstracting Services:

Biological Abstracts
BIOSIS Previews
CAB Abstracts
Chemical Abstracts
Current Contents: Agriculture, Biology and Environmental Sciences
Elsevier Science Navigator
Focus On: Veterinary Science and Medicine
Global Health
Index Medicus
Index Veterinarius
Medline
Science Citation Index
Science Citation Index Expanded (SciSearch)
SCOPUS
The ISI Alerting Services
Zoological Abstracts

2023
Web of Science
Journal Impact Factor	0.7
Rank by Impact Factor	Q3 (Veterinary Sciences)
Journal Citation Indicator	0.4
Scopus
CiteScore	1.8
CiteScore rank	Q2 (General Veterinary)
SNIP	0.39
Scimago
SJR index	0.258
SJR Q rank	Q3

Acta Veterinaria Hungarica
Publication Model	Hybrid
Submission Fee	none
Article Processing Charge	1100 EUR/article
Printed Color Illustrations	40 EUR (or 10 000 HUF) + VAT / piece
Regional discounts on country of the funding agency	World Bank Lower-middle-income economies: 50% World Bank Low-income economies: 100%
Further Discounts	Editorial Board / Advisory Board members: 50% Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100%
Subscription fee 2025	Online subsscription: 832 EUR / 916 USD Print + online subscription: 960 EUR / 1054 USD
Subscription Information	Online subscribers are entitled access to all back issues published by Akadémiai Kiadó for each title for the duration of the subscription, as well as Online First content for the subscribed content.
Purchase per Title	Individual articles are sold on the displayed price.

Acta Veterinaria Hungarica
Language	English
Size	A4
Year of Foundation	1951
Volumes per Year	1
Issues per Year	4
Founder	Magyar Tudományos Akadémia
Founder's Address	H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher	Akadémiai Kiadó
Publisher's Address	H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible Publisher	Chief Executive Officer, Akadémiai Kiadó
ISSN	0236-6290 (Print)
ISSN	1588-2705 (Online)