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  • 1 University of Zaragoza Department of Animal Pathology, Veterinary Faculty C/Miguel Servet 177 50013 Zaragoza Spain
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This report describes the clinical and histopathological characteristics of a squamous cell carcinoma infiltrating the cervix and the vaginal wall, producing reproductive symptoms and subnormal fertility in an adult ewe. Necropsy showed a large (15-cm-long) neoplastic mass infiltrating the vaginal wall and the cervix. Histopathological examination revealed atypical squamous epithelial cords invading the basal membrane and dermis, round anaplastic cells, focal areas of necrosis, keratinisation of isolated cells, and pronounced infiltration by mononuclear cells around the cords. No squamous cell carcinoma of such localisation has been reported from sheep before. In humans, this tumour is the most common gynaecological malignancy in the world.

  • Cattani, P., Zannoni, G. F., Ricci, C., D’Onghia, S., Trivellizzi, I. N., Di Franco, A., Vellone, V. G., Durante, M., Fadda, G., Scambia, G., Capelli, G. and De Vincenzo, R. (2009): Clinical performance of human papillomavirus E6 and E7 mRNA testing for high-grade lesions of the cervix. J. Clin. Microbiol. 47, 3895–3901.

    Vincenzo R. , 'Clinical performance of human papillomavirus E6 and E7 mRNA testing for high-grade lesions of the cervix ' (2009 ) 47 J. Clin. Microbiol. : 3895 -3901.

    • Search Google Scholar
  • Hawkins, C. D., Swan, R. A. and Chapman, H. M. (1981): The epidemiology of squamous cell carcinoma of the perineal region of sheep. Aust. Vet. J. 57, 455–457.

    Chapman H. M. , 'The epidemiology of squamous cell carcinoma of the perineal region of sheep ' (1981 ) 57 Aust. Vet. J. : 455 -457.

    • Search Google Scholar
  • Jansen, K. U. (2004): Vaccines against cervical cancer. Expert Opin. Biol. Ther. 4, 1803–1809.

    Jansen K. U. , 'Vaccines against cervical cancer ' (2004 ) 4 Expert Opin. Biol. Ther. : 1803 -1809.

    • Search Google Scholar
  • Lagadic, M., Wyers, M., Mialot, J. P. and Parodi, A. L. (1982): Observation d’une enzootie de cancers de la vulve chez la brebis. Zbl. Vet. Med. A 29, 123–135.

    Parodi A. L. , 'Observation d’une enzootie de cancers de la vulve chez la brebis ' (1982 ) 29 Zbl. Vet. Med. A : 123 -135.

    • Search Google Scholar
  • Mayun, A. A., Nggada, H. A., Audu, B. M., Pindiga, U. H., Khalil, M. I. and Musa, A. B. (2008): Histopathological analysis of non-squamous cell malignancies of the uterine cervix in Maiduguri, Nigeria. Afr. J. Med. Sci. 37, 369–373.

    Musa A. B. , 'Histopathological analysis of non-squamous cell malignancies of the uterine cervix in Maiduguri, Nigeria ' (2008 ) 37 Afr. J. Med. Sci. : 369 -373.

    • Search Google Scholar
  • Méndez, A., Pérez, J., Ruíz-Villamor, E., García, R., Martín, M. P. and Mozos, E. (1997): Clinicopathological study of an outbreak of squamous cell carcinoma in sheep. Vet. Rec. 141, 597–600.

    Mozos E. , 'Clinicopathological study of an outbreak of squamous cell carcinoma in sheep ' (1997 ) 141 Vet. Rec. : 597 -600.

    • Search Google Scholar
  • Tilbrook, P. A., Sterrett, G. and Kulski, J. K. (1992): Detection of papillomaviral-like DNA sequences in premalignant and malignant perineal lesions of sheep. Vet. Microbiol. 31, 327–341.

    Kulski J. K. , 'Detection of papillomaviral-like DNA sequences in premalignant and malignant perineal lesions of sheep ' (1992 ) 31 Vet. Microbiol. : 327 -341.

    • Search Google Scholar
  • Trenfield, K., Spradbrow, P. B. and Vanselow, B. A. (1990): Detection of papillomavirus DNA in precancerous lesions of the ears of sheep. Vet. Microbiol. 25, 103–116.

    Vanselow B. A. , 'Detection of papillomavirus DNA in precancerous lesions of the ears of sheep ' (1990 ) 25 Vet. Microbiol. : 103 -116.

    • Search Google Scholar
  • Tustin, R. C., Thornton, D. J. and McNaughton, H. (1982): High incidence of squamous cell carcinoma of the vulva in Merino ewes on a South African farm. J. South Afr. Vet. Assoc. 53, 141–143.

    McNaughton H. , 'High incidence of squamous cell carcinoma of the vulva in Merino ewes on a South African farm ' (1982 ) 53 J. South Afr. Vet. Assoc. : 141 -143.

    • Search Google Scholar
  • Vandegraaff, R. (1976): Squamous-cell carcinoma of the vulva in Merino sheep. Aust. Vet. J. 52, 21–23.

    Vandegraaff R. , 'Squamous-cell carcinoma of the vulva in Merino sheep ' (1976 ) 52 Aust. Vet. J. : 21 -23.

    • Search Google Scholar
  • Vanselow, B. A. and Spradbrow, P. B. (1982): Papillomaviruses, papillomas and squamous cell carcinomas in sheep. Vet. Rec. 12, 561–562.

    Spradbrow P. B. , 'Papillomaviruses, papillomas and squamous cell carcinomas in sheep ' (1982 ) 12 Vet. Rec. : 561 -562.

    • Search Google Scholar
  • Vanselow, B. A. and Spradbrow, P. B. (1983): Squamous cell carcinoma of the vulva, hyperkeratosis and papillomaviruses in a ewe. Aust. Vet. J. 60, 194–195.

    Spradbrow P. B. , 'Squamous cell carcinoma of the vulva, hyperkeratosis and papillomaviruses in a ewe ' (1983 ) 60 Aust. Vet. J. : 194 -195.

    • Search Google Scholar