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  • 1 University of Selcuk Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine 42075 Campus, Konya Turkey
  • | 2 University of Dicle Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine Diyarbakir Turkey
  • | 3 University of Mehmet Akif Ersoy Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine Burdur Turkey
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The aim of this study was to determine the cardiotoxic potency of tulathromycin. Tulathromycin (10 mg/kg, SC) was administered to ten adult male rabbits, and blood samples were obtained before and after drug administration (0 and 6 hours). Serum cardiac damage markers (troponin I, creatine kinase-MB, myoglobin, lactate dehydrogenase, aspartate aminotransferase), routine serum biochemical values (alkaline phosphatase, alanine aminotransferase, gamma-glutamyltransferase, creatinine, blood urea nitrogen, cholesterol, triglyceride, high-density lipoprotein, amylase, total protein, albumin, glucose, calcium, ionised calcium, sodium, potassium), white blood cell (WBC) and red blood cell (RBC) counts, arterial blood gas parameters (pH, partial carbon dioxide pressure, partial oxygen pressure, actual bicarbonate, standard bicarbonate, total carbon dioxide, base excess in vivo, base excess in vitro, oxygen saturation, packed cell volume, haemoglobin) and serum oxidative status (malondialdehyde, nitric oxide, superoxide dismutase, retinol, β-carotene) were measured. Increased levels of troponin I, creatine kinase-MB and creatinine, and decreased WBC counts, ionised calcium and potassium levels were observed after drug administration. Tulathromycin treatment may cause cardiotoxicity, but its effects may be less dramatic than those of other macrolide antibiotics frequently used in veterinary medicine.

  • Abu-Gharbieh, E., Vasina, V., Poluzzi, E. and DePonti, F. (2004): Antibacterial macrolides: a drugs class with a complex pharmacological profile. Pharmacol. Res. 50, 211–222.

    DePonti F. , 'Antibacterial macrolides: a drugs class with a complex pharmacological profile ' (2004 ) 50 Pharmacol. Res. : 211 -222.

    • Search Google Scholar
  • Adamcova, M., Kokstein, Z. and Vavrova, J. (1997): Clinical utility of cardiac troponin I and cardiac troponin T measurements. Acta Medica 40, 83–87.

    Vavrova J. , 'Clinical utility of cardiac troponin I and cardiac troponin T measurements ' (1997 ) 40 Acta Medica : 83 -87.

    • Search Google Scholar
  • Altunok, V., Yazar, E., Elmas, M., Tras, B., Bas, A. L. and Col, R. (2002): Investigation of haematological and biochemical side effects of tilmicosin in healthy New Zealand rabbits. J. Vet. Med. B 49, 68–70.

    Col R. , 'Investigation of haematological and biochemical side effects of tilmicosin in healthy New Zealand rabbits ' (2002 ) 49 J. Vet. Med. B : 68 -70.

    • Search Google Scholar
  • Anadon, A. and Reeve-Johnson, L. (1999): Macrolide antibiotics, drug interactions and microsomal enzymes: implications for veterinary medicine. Res. Vet. Sci. 66, 197–203.

    Reeve-Johnson L. , 'Macrolide antibiotics, drug interactions and microsomal enzymes: implications for veterinary medicine ' (1999 ) 66 Res. Vet. Sci. : 197 -203.

    • Search Google Scholar
  • Bas, S., Bas, A., Estepa, J. C., Mayer-Valor, R., Rodriguez, M. and Aguilera-Tejero, E. (2004): Parathyroid gland functions in the uremic rabbit. Domest. Anim. Endocrinol. 26, 99–110.

    Aguilera-Tejero E. , 'Parathyroid gland functions in the uremic rabbit ' (2004 ) 26 Domest. Anim. Endocrinol. : 99 -110.

    • Search Google Scholar
  • Bauer, N. B., Brinke, N., Heiss, C., Skorupa, A. B., Peters, F., Kraus, R., Schnettler, R. and Moritz, A. (2009): Biodegradable beta-tri-calciumphosphate/hydroxyethyl methacrylate enhanced three component bone adhesive demonstrates biocompatibility without evidence of systemic toxicity in a rabbit model. J. Biomed. Mater. Res. B Appl. Biomater. 90, 767–777.

    Moritz A. , 'Biodegradable beta-tri-calciumphosphate/hydroxyethyl methacrylate enhanced three component bone adhesive demonstrates biocompatibility without evidence of systemic toxicity in a rabbit model ' (2009 ) 90 J. Biomed. Mater. Res. B Appl. Biomater. : 767 -777.

    • Search Google Scholar
  • Celik, I., Kara, M., Yegin, E. and Koylu, H. (1998): Concentrations of creatine kinase and myocardial creatine kinase in rabbits constituted experimental hyperthyroidism. Tr. J. Biology 22, 1–5.

    Koylu H. , 'Concentrations of creatine kinase and myocardial creatine kinase in rabbits constituted experimental hyperthyroidism ' (1998 ) 22 Tr. J. Biology : 1 -5.

    • Search Google Scholar
  • Draper, H. H., McGirr, L. G. and Hadley, M. (1986): The metabolism of malondialdehyde. Lipids 21, 305–307.

    Hadley M. , 'The metabolism of malondialdehyde ' (1986 ) 21 Lipids : 305 -307.

  • Ekici, O. D. and Isik, N. (2011): Investigation of the cardiotoxicity of imidocarb in lambs. Revue Med. Vet. 162, 40–44.

    Isik N. , 'Investigation of the cardiotoxicity of imidocarb in lambs ' (2011 ) 162 Revue Med. Vet. : 40 -44.

    • Search Google Scholar
  • Elmas, M., Yazar, E., Uney, K. and Er Karabacak, A. (2006): Influence of Escherichia coli endotoxin-induced endotoxaemia on the pharmacokinetics of enrofloxacin after intravenous administration in rabbits. J. Vet. Med. A 53, 410–414.

    Er Karabacak A. , 'Influence of Escherichia coli endotoxin-induced endotoxaemia on the pharmacokinetics of enrofloxacin after intravenous administration in rabbits ' (2006 ) 53 J. Vet. Med. A : 410 -414.

    • Search Google Scholar
  • Fromm, R. E. (2007): Cardiac troponins in the intensive care unit: common causes of increased levels and interpretation. Crit. Care Med. 35, 584–588.

    Fromm R. E. , 'Cardiac troponins in the intensive care unit: common causes of increased levels and interpretation ' (2007 ) 35 Crit. Care Med. : 584 -588.

    • Search Google Scholar
  • Hernandez-Divers, S. J. (2004): Rabbits. In: Carpenter, J. W. (ed.) Exotic Animal Formulary. Third edition. Elsevier Saunders, Londra, UK. pp. 411–414.

    Hernandez-Divers S. J. , '', in Exotic Animal Formulary , (2004 ) -.

  • Huerkamp, M. J. (2003): The Rabbit. In: Ballard, B. and Cheek, R. (eds) Exotic Animal Medicine for the Veterinary Technician. Iowa State Press, USA. pp. 191–226.

    Huerkamp M. J. , '', in Exotic Animal Medicine for the Veterinary Technician , (2003 ) -.

  • Jordan, W. H., Byrd, R. A., Cochrane, R. L., Hanasono, G. K., Hoyt, J. A., Main, B. W., Meyerhoff, R. D. and Sarazan, R. D. (1993): A review of the toxicology of the antibiotic MICOTIL 300. Vet. Hum. Toxicol. 35, 151–158.

    Sarazan R. D. , 'A review of the toxicology of the antibiotic MICOTIL 300 ' (1993 ) 35 Vet. Hum. Toxicol. : 151 -158.

    • Search Google Scholar
  • Justo, D., Mardi, T. and Zeltser, D. (2004): Roxithromycin-induced torsades de pointes. Eur. J. Intern. Med. 15, 326–327.

    Zeltser D. , 'Roxithromycin-induced torsades de pointes ' (2004 ) 15 Eur. J. Intern. Med. : 326 -327.

    • Search Google Scholar
  • Kart, A., Yapar, K., Karapehlivan, M. and Citil, M. (2007): The possible protective effect of L-carnitine on tilmicosin-induced cardiotoxicity in mice. J. Vet. Med. A 54, 144–146.

    Citil M. , 'The possible protective effect of L-carnitine on tilmicosin-induced cardiotoxicity in mice ' (2007 ) 54 J. Vet. Med. A : 144 -146.

    • Search Google Scholar
  • Kitagawa, H., Yamazaki, T., Akiyama, T., Nosaka, S. and Mori, H. (2008): Isoflurane attenuates myoglobin release during ischemic and/or reperfusion periods. Acta Anaesthesiol. Scand. 52, 650–657.

    Mori H. , 'Isoflurane attenuates myoglobin release during ischemic and/or reperfusion periods ' (2008 ) 52 Acta Anaesthesiol. Scand. : 650 -657.

    • Search Google Scholar
  • Kundu, S., Williams, S. R., Nordt, S. P. and Clark, R. F. (1997): Clarithromycin-induced ventricular tachycardia. Ann. Emerg. Med. 30, 542–544.

    Clark R. F. , 'Clarithromycin-induced ventricular tachycardia ' (1997 ) 30 Ann. Emerg. Med. : 542 -544.

    • Search Google Scholar
  • Mathapati, S., Arumugam, S. B. and Verma, R. S. (2009): High cholesterol diet increases MMP9 and CD40 immunopositivity in early atherosclerotic plaque in rabbits. Acta Histochem. 112, 618–623.

    Verma R. S. , 'High cholesterol diet increases MMP9 and CD40 immunopositivity in early atherosclerotic plaque in rabbits ' (2009 ) 112 Acta Histochem. : 618 -623.

    • Search Google Scholar
  • McGuigan, M. A. (1994): Human exposures to tilmicosin (MICOTIL). Vet. Human Toxicol. 36, 306–308.

    McGuigan M. A. , 'Human exposures to tilmicosin (MICOTIL) ' (1994 ) 36 Vet. Human Toxicol. : 306 -308.

    • Search Google Scholar
  • Miranda, K. M., Espey, M. G. and Wink, D. A. (2001): A rapid, simple spectrophotometric method for detection of nitrate and nitrite. Nitric Oxide 5, 62–71.

    Wink D. A. , 'A rapid, simple spectrophotometric method for detection of nitrate and nitrite ' (2001 ) 5 Nitric Oxide : 62 -71.

    • Search Google Scholar
  • O’Brien, P. J. (2008): Cardiac troponin is the most effective translational safety biomarker for myocardial injury in cardiotoxicity. Toxicology 245, 206–218.

    O’Brien P. J. , 'Cardiac troponin is the most effective translational safety biomarker for myocardial injury in cardiotoxicity ' (2008 ) 245 Toxicology : 206 -218.

    • Search Google Scholar
  • Ooi, D. S., Isotalo, P. A. and Veinot, J. P. (2000): Correlation of antemortem serum creatine kinase, creatine kinase-MB, troponin I, and troponin T with cardiac pathology. Clin. Chem. 46, 338–344.

    Veinot J. P. , 'Correlation of antemortem serum creatine kinase, creatine kinase-MB, troponin I, and troponin T with cardiac pathology ' (2000 ) 46 Clin. Chem. : 338 -344.

    • Search Google Scholar
  • Panteghini, M. (2000): Present issues in the determination of troponins and other markers of cardiac damage. Clin. Biochem. 33, 161–166.

    Panteghini M. , 'Present issues in the determination of troponins and other markers of cardiac damage ' (2000 ) 33 Clin. Biochem. : 161 -166.

    • Search Google Scholar
  • Richardson, V. (2003): Rabbits Health, Husbandry and Diseases. Malden, Blackwell Science, UK. pp. 19–28.

    Richardson V. , '', in Rabbits Health, Husbandry and Diseases , (2003 ) -.

  • Robinson, D. J. and Christenson, R. H. (1999): Creatine kinase and its CK-MB isoenzyme: the conventional marker for the diagnosis of acute myocardial infarction. J. Emerg. Med. 17, 95–104.

    Christenson R. H. , 'Creatine kinase and its CK-MB isoenzyme: the conventional marker for the diagnosis of acute myocardial infarction ' (1999 ) 17 J. Emerg. Med. : 95 -104.

    • Search Google Scholar
  • Sun, Y., Oberley, L. W. and Li, Y. (1988): A simple method for clinical assay of superoxide dismutase. Clin. Chem. 34, 497–500.

    Li Y. , 'A simple method for clinical assay of superoxide dismutase ' (1988 ) 34 Clin. Chem. : 497 -500.

    • Search Google Scholar
  • Suzuki, J. and Katoh, N. (1990): A simple and cheap method for measuring serum vitamin-A in cattle using only a spectrophotometer. Nippon Juigaku Zasshi. 52, 1281–1283.

    Katoh N. , 'A simple and cheap method for measuring serum vitamin-A in cattle using only a spectrophotometer ' (1990 ) 52 Nippon Juigaku Zasshi. : 1281 -1283.

    • Search Google Scholar
  • Von Essen, S., Spencer, J., Hass, B., List, P. and Seifert, A. (2003): Unintentional human exposure to tilmicosin (Micotil® 300). J. Toxicol. 41, 229–233.

    Seifert A. , 'Unintentional human exposure to tilmicosin (Micotil® 300) ' (2003 ) 41 J. Toxicol. : 229 -233.

    • Search Google Scholar
  • Yanni, A. E., Perrea, D. N. and Yatzidis, H. A. (2005): Effect of antiatherogenic L-aspartate and Lglutamate on serum lipoproteins cholesterol and apolipoproteins A-1 and B in rabbits fed with high cholesterol diet. Nutr. Metab. Cardiovasc. Dis. 15, 161–165.

    Yatzidis H. A. , 'Effect of antiatherogenic L-aspartate and Lglutamate on serum lipoproteins cholesterol and apolipoproteins A-1 and B in rabbits fed with high cholesterol diet ' (2005 ) 15 Nutr. Metab. Cardiovasc. Dis. : 161 -165.

    • Search Google Scholar
  • Yao, L., Kuai, J., Liu, X., Yu, D., Yang, Y., Tao, L., Zeng, X. and Chai, W. (2009): Pretreatment with fentanyl and propofol attenuates myocardial injury in rabbits with acute hemorrhagic shock. J. Surg. Res. 155, 25–31.

    Chai W. , 'Pretreatment with fentanyl and propofol attenuates myocardial injury in rabbits with acute hemorrhagic shock ' (2009 ) 155 J. Surg. Res. : 25 -31.

    • Search Google Scholar
  • Yazar, E. (2009): Chemotherapeutics. In: Yazar, E (ed.) Veterinary Drugs. Nobel Press, Istanbul, Turkey. pp. 19–107.

    Yazar E. , '', in Veterinary Drugs , (2009 ) -.

  • Yazar, E., Altunok, V., Elmas, M., Tras, B., Bas, A. L. and Ozdemir, V. (2001): Effect of tilmicosin on cardiac muscle and serum creatine kinases activities and serum total protein level in healthy male Balb/C mice. Revue Med. Vet. 152, 881–883.

    Ozdemir V. , 'Effect of tilmicosin on cardiac muscle and serum creatine kinases activities and serum total protein level in healthy male Balb/C mice ' (2001 ) 152 Revue Med. Vet. : 881 -883.

    • Search Google Scholar
  • Yazar, E., Altunok, V., Elmas, M., Tras, B., Bas, A. L. and Ozdemir, V. (2002a): Effect of tilmicosin on cardiac superoxide dismutase and glutathione peroxidase activities. J. Vet. Med. B 49, 209–210.

    Ozdemir V. , 'Effect of tilmicosin on cardiac superoxide dismutase and glutathione peroxidase activities ' (2002 ) 49 J. Vet. Med. B : 209 -210.

    • Search Google Scholar
  • Yazar, E., Birdane, Y. O., Elmas, M., Tras, B. and Bas, A. L. (2002b): Effect of tilmicosin on serum creatine kinase, creatine kinase-MB and troponin I levels in New Zealand White rabbits. Arch. Geflügelk. 66, 237–239.

    Bas A. L. , 'Effect of tilmicosin on serum creatine kinase, creatine kinase-MB and troponin I levels in New Zealand White rabbits ' (2002 ) 66 Arch. Geflügelk. : 237 -239.

    • Search Google Scholar
  • Yazar, E., Oztekin, E., Sivrikaya, A., Col, R., Elmas, M. and Bas, A. L. (2004): Effects of different doses of tilmicosin on malondialdehyde and glutathione concentrations in mice. Acta Vet. Brno 73, 69–72.

    Bas A. L. , 'Effects of different doses of tilmicosin on malondialdehyde and glutathione concentrations in mice ' (2004 ) 73 Acta Vet. Brno : 69 -72.

    • Search Google Scholar
  • Ypsilantis, P., Politou, M., Mikroulis, D., Pitiakoudis, M., Lambropoulou, M., Tsigalou, C., Didilis, V., Bougioukas, G., Papadopoulos, N., Manolas, C. and Simopoulos, C. (2007): Organ toxicity and mortality in propofol-sedated rabbits under prolonged mechanical ventilation. Anesth. Analg. 105, 155–166.

    Simopoulos C. , 'Organ toxicity and mortality in propofol-sedated rabbits under prolonged mechanical ventilation ' (2007 ) 105 Anesth. Analg. : 155 -166.

    • Search Google Scholar

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Senior editors

Editor-in-Chief: Mária BENKŐ

Managing Editor: András SZÉKELY

Editorial Board

  • Béla DÉNES (National Food Chain Safety Office, Budapest Hungary)
  • Edit ESZTERBAUER (Veterinary Medical Research Institute, Budapest, Hungary)
  • Hedvig FÉBEL (National Agricultural Innovation Centre, Herceghalom, Hungary)
  • László FODOR (University of Veterinary Medicine, Budapest, Hungary)
  • Balázs HARRACH (Veterinary Medical Research Institute, Budapest, Hungary)
  • Peter MASSÁNYI (Slovak University of Agriculture in Nitra, Nitra, Slovak Republic)
  • Béla NAGY (Veterinary Medical Research Institute, Budapest, Hungary)
  • Tibor NÉMETH (University of Veterinary Medicine, Budapest, Hungary)
  • Zsuzsanna NEOGRÁDY (University of Veterinary Medicine, Budapest, Hungary)
  • Alessandra PELAGALLI (University of Naples Federico II, Naples, Italy)
  • Kurt PFISTER (Ludwig-Maximilians-University of Munich, Munich, Germany)
  • László SOLTI (University of Veterinary Medicine, Budapest, Hungary)
  • József SZABÓ (University of Veterinary Medicine, Budapest, Hungary)
  • Péter VAJDOVICH (University of Veterinary Medicine, Budapest, Hungary)
  • János VARGA (University of Veterinary Medicine, Budapest, Hungary)
  • Štefan VILČEK (University of Veterinary Medicine in Kosice, Kosice, Slovak Republic)
  • Károly VÖRÖS (University of Veterinary Medicine, Budapest, Hungary)
  • Herbert WEISSENBÖCK (University of Veterinary Medicine, Vienna, Austria)
  • Attila ZSARNOVSZKY (Szent István University, Gödöllő, Hungary)

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Phone: (36 1) 467 4081 (ed.-in-chief) or (36 1) 213 9793 (editor) Fax: (36 1) 467 4076 (ed.-in-chief) or (36 1) 213 9793

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2020  
Total Cites 987
WoS
Journal
Impact Factor
0,955
Rank by Veterinary Sciences 101/146 (Q3)
Impact Factor  
Impact Factor 0,920
without
Journal Self Cites
5 Year 1,164
Impact Factor
Journal  0,57
Citation Indicator  
Rank by Journal  Veterinary Sciences 93/166 (Q3)
Citation Indicator   
Citable 49
Items
Total 49
Articles
Total 0
Reviews
Scimago 33
H-index
Scimago 0,395
Journal Rank
Scimago Veterinary (miscellaneous) Q2
Quartile Score  
Scopus 355/217=1,6
Scite Score  
Scopus General Veterinary 73/183 (Q2)
Scite Score Rank  
Scopus 0,565
SNIP  
Days from  145
sumbission  
to acceptance  
Days from  150
acceptance  
to publication  
Acceptance 19%
Rate

 

2019  
Total Cites
WoS
798
Impact Factor 0,991
Impact Factor
without
Journal Self Cites
0,897
5 Year
Impact Factor
1,092
Immediacy
Index
0,119
Citable
Items
59
Total
Articles
59
Total
Reviews
0
Cited
Half-Life
9,1
Citing
Half-Life
9,2
Eigenfactor
Score
0,00080
Article Influence
Score
0,253
% Articles
in
Citable Items
100,00
Normalized
Eigenfactor
0,09791
Average
IF
Percentile
42,606
Scimago
H-index
32
Scimago
Journal Rank
0,372
Scopus
Scite Score
335/213=1,6
Scopus
Scite Score Rank
General Veterinary 62/178 (Q2)
Scopus
SNIP
0,634
Acceptance
Rate
18%

 

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Acta Veterinaria Hungarica
Language English
Size A4
Year of
Foundation
1951
Publication
Programme
2020 Volume 68
Volumes
per Year
1
Issues
per Year
4
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-6290 (Print)
ISSN 1588-2705 (Online)

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