Acta Veterinaria Hungarica
Volume/Issue:
Volume 59: Issue 3
Assessment of the cardiotoxicity of tulathromycin in rabbits
Authors: Ayse Er 1 , Feray Altan 2 , Gul Cetin 3 , Burak Dik 1 , Muammer Elmas 1 , and Enver Yazar 1
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  • 1 University of Selcuk Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine 42075 Campus, Konya Turkey
  • 2 University of Dicle Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine Diyarbakir Turkey
  • 3 University of Mehmet Akif Ersoy Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine Burdur Turkey
DOI:
https://doi.org/10.1556/avet.2011.015
Page Count:
327–335
Publication Date:
01 Sep 2011
Online Publication Date:
04 Jul 2011
Article Category:
Research Article
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The aim of this study was to determine the cardiotoxic potency of tulathromycin. Tulathromycin (10 mg/kg, SC) was administered to ten adult male rabbits, and blood samples were obtained before and after drug administration (0 and 6 hours). Serum cardiac damage markers (troponin I, creatine kinase-MB, myoglobin, lactate dehydrogenase, aspartate aminotransferase), routine serum biochemical values (alkaline phosphatase, alanine aminotransferase, gamma-glutamyltransferase, creatinine, blood urea nitrogen, cholesterol, triglyceride, high-density lipoprotein, amylase, total protein, albumin, glucose, calcium, ionised calcium, sodium, potassium), white blood cell (WBC) and red blood cell (RBC) counts, arterial blood gas parameters (pH, partial carbon dioxide pressure, partial oxygen pressure, actual bicarbonate, standard bicarbonate, total carbon dioxide, base excess in vivo, base excess in vitro, oxygen saturation, packed cell volume, haemoglobin) and serum oxidative status (malondialdehyde, nitric oxide, superoxide dismutase, retinol, β-carotene) were measured. Increased levels of troponin I, creatine kinase-MB and creatinine, and decreased WBC counts, ionised calcium and potassium levels were observed after drug administration. Tulathromycin treatment may cause cardiotoxicity, but its effects may be less dramatic than those of other macrolide antibiotics frequently used in veterinary medicine.

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Cover Acta Veterinaria Hungarica
Acta Veterinaria Hungarica
Print ISSN:
0236-6290
Online ISSN:
1588-2705
Keywords:
Tulathromycin; cardiotoxicity

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