The most common causes of heart failure in dogs are valvular disease, predominantly endocardiosis, and myocardial disease, predominantly dilated cardiomyopathy. They are related to changes in the expression of several genes in the heart muscle and in peripheral blood nuclear cells which could be considered as prognostic or diagnostic markers of heart disease in dogs. Since many human genetic markers of heart failure have turned out to be useless in dogs, the screening for genomic markers of canine heart failure could give more insight into the molecular pathology of these diseases and aid the development of new treatment strategies.
-
Aupperle, H., März, I., Thielebein, J., Dinges, G. and Schoon, H. A. (2010): Histomorphological findings and expression of matrix metalloproteinases and their tissue specific inhibitors (TIMPs) in normal tricuspid valves and in chronic tricuspid valvular disease in dogs. Vet. J. 183, 176–183.
Schoon H. A. , 'Histomorphological findings and expression of matrix metalloproteinases and their tissue specific inhibitors (TIMPs) in normal tricuspid valves and in chronic tricuspid valvular disease in dogs ' (2010 ) 183 Vet. J. : 176 -183.
-
Aupperle, H., März, I., Thielebein, J. and Schoon, H. A. (2008): Expression of transforming growth factor-beta1, -beta2 and -beta3 in normal and diseased canine mitral valves. J. Comp. Pathol. 139, 97–107.
Schoon H. A. , 'Expression of transforming growth factor-beta1, -beta2 and -beta3 in normal and diseased canine mitral valves ' (2008 ) 139 J. Comp. Pathol. : 97 -107.
-
Aupperle, H., Thielebein, J., Kiefer, B., März, I., Dinges, G. and Schoon, H. A. (2009a): An immunohistochemical study of the role of matrix metalloproteinases and their tissue inhibitors in chronic mitral valvular disease (valvular endocardiosis) in dogs. Vet. J. 180, 88–94.
Schoon H. A. , 'An immunohistochemical study of the role of matrix metalloproteinases and their tissue inhibitors in chronic mitral valvular disease (valvular endocardiosis) in dogs ' (2009 ) 180 Vet. J. : 88 -94.
-
Aupperle, H., Thielebein, J., Kiefer, B., März, I., Dinges, G., Schoon, H. A. and Schubert, A. (2009b): Expression of genes encoding matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in normal and diseased canine mitral valves. J. Comp. Pathol. 140, 271–277.
Schubert A. , 'Expression of genes encoding matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) in normal and diseased canine mitral valves ' (2009 ) 140 J. Comp. Pathol. : 271 -277.
-
Baumgartner, C. and Glaus, T. M. (2004): Acquired cardiac diseases in the dog: a retrospective analysis. Schweiz. Arch. Tierheilkd. 146, 423–430.
Glaus T. M. , 'Acquired cardiac diseases in the dog: a retrospective analysis ' (2004 ) 146 Schweiz. Arch. Tierheilkd. : 423 -430.
-
Dahl, C. P., Husberg, C., Gullestad, L., Waehre, A., Damås, J. K., Vinge, L. E., Finsen, A. V., Ueland, T., Florholmen, G., Aakhus, S., Halvorsen, B., Aukrust, P., Oie, E., Yndestad, A. and Christensen, G. (2009): Increased production of CXCL16 in experimental and clinical heart failure: a possible role in extracellular matrix remodeling. Circ. Heart Fail. 2, 624–632.
Christensen G. , 'Increased production of CXCL16 in experimental and clinical heart failure: a possible role in extracellular matrix remodeling ' (2009 ) 2 Circ. Heart Fail. : 624 -632.
-
Disatian, S., Ehrhart, E. J., Zimmerman, S. and Orton, E. C. (2008): Interstitial cells from dogs with naturally occurring myxomatous mitral valve disease undergo phenotype transformation. J. Heart Valve Dis. 17, 402–412.
Orton E. C. , 'Interstitial cells from dogs with naturally occurring myxomatous mitral valve disease undergo phenotype transformation ' (2008 ) 17 J. Heart Valve Dis. : 402 -412.
-
Donnelly, K. B. (2008): Cardiac valvular pathology: comparative pathology and animal models of acquired cardiac valvular diseases. Toxicol. Pathol. 36, 204–217.
Donnelly K. B. , 'Cardiac valvular pathology: comparative pathology and animal models of acquired cardiac valvular diseases ' (2008 ) 36 Toxicol. Pathol. : 204 -217.
-
Fonfara, S., Tew, S., Clegg, P. and Dukes-McEwan, J. (2010): Cytokine and matrix metalloproteinase expression in blood samples of dogs with congestive heart failure. In: Proceedings of the American College of Veterinary Internal Medicine — Cardiology Forum, p. 1.
-
Häggström, J., Duelund Pedersen, H. and Kvart, C. (2004): New insights into degenerative mitral valve disease in dogs. Vet. Clin. North Am. Small Anim. Pract. 34, 1209–1226.
Kvart C. , 'New insights into degenerative mitral valve disease in dogs ' (2004 ) 34 Vet. Clin. North Am. Small Anim. Pract. : 1209 -1226.
-
Kanno, N., Asano, K., Teshima, K., Kutara, K., Seki, M., Edamura, K., Kano, R., Hasegawa, A. and Tanaka, S. (2008): Gene expression of adrenomedullin in canine normal tissues and diseased hearts. J. Vet. Med. Sci. 71, 789–792.
Tanaka S. , 'Gene expression of adrenomedullin in canine normal tissues and diseased hearts ' (2008 ) 71 J. Vet. Med. Sci. : 789 -792.
-
Lee, J. S., Pak, S. I. and Hyun, C. (2009): Calcium reuptake related genes as a cardiac biomarker in dogs with chronic mitral valvular insufficiency. J. Vet. Intern. Med. 23, 832–839.
Hyun C. , 'Calcium reuptake related genes as a cardiac biomarker in dogs with chronic mitral valvular insufficiency ' (2009 ) 23 J. Vet. Intern. Med. : 832 -839.
-
Ljungvall, I., Rajamäki, M. M., Crosara, S., Olsen, L. H., Kvart, C., Borgarelli, M., Höglund, K. and Häggström, J. (2011): Evaluation of plasma activity of matrix metalloproteinase-2 and -9 in dogs with myxomatous mitral valve disease. Am. J. Vet. Res. 72, 1022–1028.
Häggström J. , 'Evaluation of plasma activity of matrix metalloproteinase-2 and -9 in dogs with myxomatous mitral valve disease ' (2011 ) 72 Am. J. Vet. Res. : 1022 -1028.
-
Markwald, R. M., Norris, R. A., Moreno-Rodriguez, R. and Levine, R. A. (2010): Developmental basis of adult cardiovascular diseases: Valvular heart diseases. Ann. N.Y. Acad. Sci. 1188, 177–183.
Levine R. A. , 'Developmental basis of adult cardiovascular diseases: Valvular heart diseases ' (2010 ) 1188 Ann. N.Y. Acad. Sci. : 177 -183.
-
Meurs, K. M., Hendrix, K. P. and Norgard, M. M. (2008): Molecular evaluation of five cardiac genes in Doberman Pinschers with dilated cardiomyopathy. Am. J. Vet. Res. 69, 1050–1053.
Norgard M. M. , 'Molecular evaluation of five cardiac genes in Doberman Pinschers with dilated cardiomyopathy ' (2008 ) 69 Am. J. Vet. Res. : 1050 -1053.
-
Meurs, K. M., Lahmers, S., Keene, B. W., Mauceli, E., Acland, G. and Lindblad-Toh, K. (2010): A splice site mutation in a gene encoding for a mitochondrial protein is associated with the development of dilated cardiomyopathy in the Doberman Pinscher. In: Proceedings of the American College of Veterinary Internal Medicine — Cardiology Forum, p. 25.
-
Meurs, K. M., Magnon, A. L., Spier, A. W., Miller, M. W., Lehmkuhl, L. B. and Towbin, J. A. (2001): Evaluation of the cardiac actin gene in Doberman Pinschers with dilated cardiomyopathy. Am. J. Vet. Res. 62, 33–36.
Towbin J. A. , 'Evaluation of the cardiac actin gene in Doberman Pinschers with dilated cardiomyopathy ' (2001 ) 62 Am. J. Vet. Res. : 33 -36.
-
Mishra, S., Sabbah, H. N., Rastogi, S., Imai, M. and Gupta, R. C. (2005): Reduced sarcoplasmic reticulum Ca2+ uptake and increased Na+-Ca2+ exchanger expression in left ventricle myocardium of dogs with progression of heart failure. Heart Vessels 20, 23–32.
Gupta R. C. , 'Reduced sarcoplasmic reticulum Ca2+ uptake and increased Na+-Ca2+ exchanger expression in left ventricle myocardium of dogs with progression of heart failure ' (2005 ) 20 Heart Vessels : 23 -32.
-
Moon, H. S., Choi, E. and Hyun, C. (2008): The cardiac sodium-calcium exchanger gene (NCX-1) is a potential canine cardiac biomarker of chronic mitral valvular insufficiency. J. Vet. Intern. Med. 22, 1360–1365.
Hyun C. , 'The cardiac sodium-calcium exchanger gene (NCX-1) is a potential canine cardiac biomarker of chronic mitral valvular insufficiency ' (2008 ) 22 J. Vet. Intern. Med. : 1360 -1365.
-
Nam, S. J., Han, S. H., Kim, H. W. and Hyun, C. (2010): The cardiac biomarker sodium-calcium exchanger (NCX-1) can differentiate between heart failure and renal failure: a comparative study of NCX-1 expression in dogs with chronic mitral valvular insufficiency and azotemia. J. Vet. Intern. Med. 24, 1383–1387.
Hyun C. , 'The cardiac biomarker sodium-calcium exchanger (NCX-1) can differentiate between heart failure and renal failure: a comparative study of NCX-1 expression in dogs with chronic mitral valvular insufficiency and azotemia ' (2010 ) 24 J. Vet. Intern. Med. : 1383 -1387.
-
Obayashi, K., Miyagawa-Tomita, S., Matsumoto, H., Koyama, H., Nakanishi, T. and Hirose, H. (2011): Effects of transforming growth factor-β3 and matrix metalloproteinase-3 on the pathogenesis of chronic mitral valvular disease in dogs. Am. J. Vet. Res. 72, 194–202.
Hirose H. , 'Effects of transforming growth factor-β3 and matrix metalloproteinase-3 on the pathogenesis of chronic mitral valvular disease in dogs ' (2011 ) 72 Am. J. Vet. Res. : 194 -202.
-
Olsen, L. H., Fredholm, M. and Pedersen, H. D. (1999): Epidemiology and inheritance of mitral valve prolapse in Dachshunds. J. Vet. Intern. Med. 13, 448–456.
Pedersen H. D. , 'Epidemiology and inheritance of mitral valve prolapse in Dachshunds ' (1999 ) 13 J. Vet. Intern. Med. : 448 -456.
-
Oyama, M. A. and Chittur, S. (2005): Genomic expression patterns of cardiac tissues from dogs with dilated cardiomyopathy. Am. J. Vet. Res. 66, 1140–1155.
Chittur S. , 'Genomic expression patterns of cardiac tissues from dogs with dilated cardiomyopathy ' (2005 ) 66 Am. J. Vet. Res. : 1140 -1155.
-
Oyama, M. A. and Chittur, S. V. (2006): Genomic expression patterns of mitral valve tissues from dogs with degenerative mitral valve disease. Am. J. Vet. Res. 67, 1307–1318.
Chittur S. V. , 'Genomic expression patterns of mitral valve tissues from dogs with degenerative mitral valve disease ' (2006 ) 67 Am. J. Vet. Res. : 1307 -1318.
-
Oyama, M. A., Chittur, S. V. and Reynolds, C. A. (2009): Decreased triadin and increased calstabin 2 expression in Great Danes with dilated cardiomyopathy. J. Vet. Intern. Med. 23, 1014–1019.
Reynolds C. A. , 'Decreased triadin and increased calstabin 2 expression in Great Danes with dilated cardiomyopathy ' (2009 ) 23 J. Vet. Intern. Med. : 1014 -1019.
-
Oyama, M. A. and Levy, R. J. (2010): Insights into serotonin signaling mechanisms associated with canine degenerative mitral valve disease. J. Vet. Intern. Med. 24, 27–36.
Levy R. J. , 'Insights into serotonin signaling mechanisms associated with canine degenerative mitral valve disease ' (2010 ) 24 J. Vet. Intern. Med. : 27 -36.
-
Oyama, M., Trafny, D., Meurs, K. and Chittur, S. (2010): Comparative blood-based transcriptional activity in healthy Doberman Pinschers and occult cardiomyopathy or congestive heart failure. In: Proceedings of the 20th Annual ECVIM-CA Congress (ESVC, European Society of Veterinary Cardiology), p. 34.
-
Philipp, U., Broschk, C., Vollmar, A. and Distl, O. (2007a): Evaluation of tafazzin as candidate for dilated cardiomyopathy in Irish wolfhounds. J. Hered. 98, 506–509.
Distl O. , 'Evaluation of tafazzin as candidate for dilated cardiomyopathy in Irish wolfhounds ' (2007 ) 98 J. Hered. : 506 -509.
-
Philipp, U., Vollmar, A. and Distl, O. (2007b): Evaluation of six candidate genes for dilated cardiomyopathy in Irish wolfhounds. Anim. Genet. 39, 88–89.
Distl O. , 'Evaluation of six candidate genes for dilated cardiomyopathy in Irish wolfhounds ' (2007 ) 39 Anim. Genet. : 88 -89.
-
Richardson, P., McKenna, W., Bristow, M., Maisch, B., Mautner, B., O’Connell, J., Olsen, E., Thiene, G., Goodwin, J., Gyarfas, I., Martin, I. and Nordet, P. (1996): Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the definition and classification of cardiomyopathies. Circulation. 93, 841–842.
Nordet P. , 'Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the definition and classification of cardiomyopathies ' (1996 ) 93 Circulation. : 841 -842.
-
Rush, J. E. (2004): Canine chronic valvular heart disease: pathology and pathogenesis. In: Proceedings of the American College of Veterinary Internal Medicine — Cardiology Forum, p. 58.
-
Shahrara, S., Tidholm, A., Drvota, V., Häggstöm, J. and Sylvén, C. (1999): Upregulation of thyroid hormone receptor beta 1 and beta 2 messenger RNA in the myocardium of dogs with dilated cardiomyopathy or chronic valvular disease. Am. J. Vet. Res. 60, 848–852.
Sylvén C. , 'Upregulation of thyroid hormone receptor beta 1 and beta 2 messenger RNA in the myocardium of dogs with dilated cardiomyopathy or chronic valvular disease ' (1999 ) 60 Am. J. Vet. Res. : 848 -852.
-
Stabej, P., Imholz, S., Versteeg, S. A., Zijlstra, C., Stokhof, A. A., Domanjko-Petric, A., Leegwater, P. A. and van Oost, B. A. (2004): Characterization of the canine desmin (DES) gene and evaluation as a candidate gene for dilated cardiomyopathy in the Dobermann. Gene. 340, 241–249.
Oost B. A. , 'Characterization of the canine desmin (DES) gene and evaluation as a candidate gene for dilated cardiomyopathy in the Dobermann ' (2004 ) 340 Gene. : 241 -249.
-
Stabej, P., Leegwater, P. A., Imholz, S., Versteeg, S. A., Zijlstra, C., Stokhof, A. A., Domanjko-Petriè, A. and van Oost, B. A. (2005a): The canine sarcoglycan delta gene: BAC clone contig assembly, chromosome assignment and interrogation as a candidate gene for dilated cardiomyopathy in Dobermann dogs. Cytogenet. Genome Res. 111, 140–146.
Oost B. A. , 'The canine sarcoglycan delta gene: BAC clone contig assembly, chromosome assignment and interrogation as a candidate gene for dilated cardiomyopathy in Dobermann dogs ' (2005 ) 111 Cytogenet. Genome Res. : 140 -146.
-
Stabej, P., Leegwater, P. A., Stokhof, A. A., Domanjko-Petric, A. and van Oost, B. A. (2005b): Evaluation of the phospholamban gene in purebred large-breed dogs with dilated cardiomyopathy. Am. J. Vet. Res. 66, 432–436.
Oost B. A. , 'Evaluation of the phospholamban gene in purebred large-breed dogs with dilated cardiomyopathy ' (2005 ) 66 Am. J. Vet. Res. : 432 -436.
-
Summerfield, N., Peters, M. E., Hercock, C. A., Mobasheri, A. and Young, I. S. (2010): Immunohistochemical evidence for expression of fast-twitch type sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA1) in German shepherd dogs with dilated cardiomyopathy myocardium. J. Vet. Cardiol. 12, 17–23.
Young I. S. , 'Immunohistochemical evidence for expression of fast-twitch type sarco(endo)plasmic reticulum Ca2+ ATPase (SERCA1) in German shepherd dogs with dilated cardiomyopathy myocardium ' (2010 ) 12 J. Vet. Cardiol. : 17 -23.
-
Tidholm, A. and Jönsson, L. (2005): Histologic characterization of canine dilated cardiomyopathy. Vet. Pathol. 42, 1–8.
Jönsson L. , 'Histologic characterization of canine dilated cardiomyopathy ' (2005 ) 42 Vet. Pathol. : 1 -8.
-
Wang, T. J., Larson, M. G., Levy, D., Benjamin, E. J., Leip, E. P., Omland, T., Wolf, P. A. and Vasan, R. S. (2004): Plasma natriuretic peptide levels and the risk of cardiovascular events and death. N. Engl. J. Med. 350, 655–663.
Vasan R. S. , 'Plasma natriuretic peptide levels and the risk of cardiovascular events and death ' (2004 ) 350 N. Engl. J. Med. : 655 -663.
-
Wiersma, A. C., Stabej, P., Leegwater, P. A., Van Oost, B. A., Ollier, W. E. and Dukes-McEwan, J. (2007): Evaluation of 15 candidate genes for dilated cardiomyopathy in the Newfoundland dog. J. Hered. 99, 73–80.
Dukes-McEwan J. , 'Evaluation of 15 candidate genes for dilated cardiomyopathy in the Newfoundland dog ' (2007 ) 99 J. Hered. : 73 -80.
-
Zheng, J., Chen, Y., Pat, B., Dell’italia, L. A., Tillson, M., Dillon, A. R., Powell, P. C., Shi, K., Shah, N., Denney, T., Husain, A. and Dell’Italia, L. J. (2009): Microarray identifies extensive downregulation of noncollagen extracellular matrix and profibrotic growth factor genes in chronic isolated mitral regurgitation in the dog. Circulation 119, 2086–2095.
Dell’Italia L. J. , 'Microarray identifies extensive downregulation of noncollagen extracellular matrix and profibrotic growth factor genes in chronic isolated mitral regurgitation in the dog ' (2009 ) 119 Circulation : 2086 -2095.
-
Zois, N. E., Gry Moesgaard, S., Kjelgaard-Hansen, M., Rasmussen, C. E., Falk, T., Häggström, J., Pedersen, H. D. and Olsen, L. H. (2010): Tumor necrosis factor Α (TNF-α) serum cytokine concentrations in dogs with different degree of myxomatous mitral valve disease. In: Proceedings of the 20th Annual ECVIM-CA Congress (ESVC, European Society of Veterinary Cardiology), p. 46.
Monthly Content Usage
| Abstract Views | Full Text Views | PDF Downloads | |
|---|---|---|---|
| Oct 2020 | 5 | 1 | 1 |
| Nov 2020 | 7 | 2 | 4 |
| Dec 2020 | 6 | 1 | 2 |
| Jan 2021 | 59 | 0 | 0 |
| Feb 2021 | 27 | 0 | 0 |
| Mar 2021 | 3 | 2 | 2 |
| Apr 2021 | 0 | 0 | 0 |
Copyright Akadémiai Kiadó
AKJournals is the trademark of Akadémiai Kiadó's journal publishing business branch.
Copyright Akadémiai Kiadó AKJournals is the trademark of Akadémiai Kiadó's journal publishing business branch.
Powered by PubFactory