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  • 1 Szent István University Department and Clinic of Internal Medicine István u. 2 H-1078 Budapest Hungary
  • 2 Szent István University Department of Biomathematics and Informatics, Faculty of Veterinary Science István u. 2 H-1078 Budapest Hungary
  • 3 National Institute of Oncology Gastroenterology Department Budapest Hungary
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The efficacy of ultrasound-guided cholagogue-induced gallbladder emptying for differentiating obstructive from non-obstructive hepatobiliary diseases was studied in icteric dogs. In 7 healthy Beagle dogs, Lipofundin 20% infusion (2 ml/kg orally) evoked a vigorous gallbladder contraction of 44.2% (range: 35.3–57.6%) and proved to be a useful, well-tolerable meal for routine use. In 24 icteric dogs, gallbladder contraction was evoked by different cholagogues: the maximum reduction in gallbladder volume (%) for the three non-obstructive icteric dogs was 43.9% (range, 39.0–46.5%). The average gallbladder contraction of the 21 dogs with biliary obstruction was less than 5%. In conclusion, the stimulation of gallbladder contraction with orally applied magnesium sulphate (MgSO4) or Lipofundin can be well demonstrated by ultrasound in dogs. The examination of cholagogue-induced gallbladder emptying is a valuable technique in icteric patients to indicate surgical intervention.

  • Boer, S. Y., Masclee, A. M., Jebbink, M. C. W., Schipper, J., Jansen, J. B. and Lamers, C. B. (1992): Effect of intravenous fat on cholecystokinin secretion and gallbladder motility in man. J. Parent. Enter. Nutr. 16, 16–19.

    Lamers C. B. , 'Effect of intravenous fat on cholecystokinin secretion and gallbladder motility in man ' (1992 ) 16 J. Parent. Enter. Nutr. : 16 -19.

    • Search Google Scholar
  • Cay, A., Imamoglu, M., Sarihan, H. and Ahmetoglu, A. (2006): Ultrasonographic evaluation of fatty meal stimulated gallbladder contraction in the diagnosis of biliary dyskinesia in children. Acta Paediatr. 95, 838–842.

    Ahmetoglu A. , 'Ultrasonographic evaluation of fatty meal stimulated gallbladder contraction in the diagnosis of biliary dyskinesia in children ' (2006 ) 95 Acta Paediatr. : 838 -842.

    • Search Google Scholar
  • Egbert, R. N., Braunstein, P., Lyons, K. P. and Miller, D. R. (1983): Total bile duct obstruction. Arch. Surg. 118, 709–712.

    Miller D. R. , 'Total bile duct obstruction ' (1983 ) 118 Arch. Surg. : 709 -712.

  • Everson, G. T., Braverman, D. Z., Johnson, M. L. and Kern, F. (1980): A critical evaluation of real-time ultrasonography for the study of gallbladder volume and contraction. Gastroenterology 79, 40–46.

    Kern F. , 'A critical evaluation of real-time ultrasonography for the study of gallbladder volume and contraction ' (1980 ) 79 Gastroenterology : 40 -46.

    • Search Google Scholar
  • Finn, S. T., Park, R. D., Tyler, J. W., Twedt, D. C. and Curtis, C. R. (1991): Ultrasonographic assessment of sincalide-induced canine gallbladder emptying: an aid to the diagnosis of biliary obstruction. Vet. Rad. 32, 269–276.

    Curtis C. R. , 'Ultrasonographic assessment of sincalide-induced canine gallbladder emptying: an aid to the diagnosis of biliary obstruction ' (1991 ) 32 Vet. Rad. : 269 -276.

    • Search Google Scholar
  • Head, L. L. and Daniel, G. B. (2005): Correlation between hepatobiliary scintigraphy and surgery or postmortem examination findings in dogs and cats with extrahepatic biliary obstruction, partial obstruction, or patency of the biliary system: 18 cases (1995–2004). J. Am. Vet. Med. Assoc. 10, 1618–1624.

    Daniel G. B. , 'Correlation between hepatobiliary scintigraphy and surgery or postmortem examination findings in dogs and cats with extrahepatic biliary obstruction, partial obstruction, or patency of the biliary system: 18 cases (1995–2004) ' (2005 ) 10 J. Am. Vet. Med. Assoc. : 1618 -1624.

    • Search Google Scholar
  • Hopman, W. P. M., Rosenbusch, G., Jansen, J. B. M. and Lamers, C. B. H. (1985): Gallbladder contraction: effects of fatty meals and cholecystokinin. Radiology 157, 37–39.

    Lamers C. B. H. , 'Gallbladder contraction: effects of fatty meals and cholecystokinin ' (1985 ) 157 Radiology : 37 -39.

    • Search Google Scholar
  • Jonderko, K. and Bueno, L. (1997): Effect of peripherally and centrally administered calcitonin on gallbladder emptying in dogs. Gastroenterology 32, 380–388.

    Bueno L. , 'Effect of peripherally and centrally administered calcitonin on gallbladder emptying in dogs ' (1997 ) 32 Gastroenterology : 380 -388.

    • Search Google Scholar
  • Jonderko, K., Ferre, J. P. and Bueno, L. (1992): Real-time ultrasonography as a noninvasive tool for the examination of canine gallbladder emptying: a validation study. J. Pharmacol. Toxicol. Methods 27, 107–111.

    Bueno L. , 'Real-time ultrasonography as a noninvasive tool for the examination of canine gallbladder emptying: a validation study ' (1992 ) 27 J. Pharmacol. Toxicol. Methods : 107 -111.

    • Search Google Scholar
  • Jonderko, K., Ferre, J. P. and Bueno, L. (1994): Noninvasive evaluation of kinetics of gallbladder emptying and filling in the dog. A real-time ultrasonographic study. Dig. Dis. Sci. 39, 2624–2633.

    Bueno L. , 'Noninvasive evaluation of kinetics of gallbladder emptying and filling in the dog. A real-time ultrasonographic study ' (1994 ) 39 Dig. Dis. Sci. : 2624 -2633.

    • Search Google Scholar
  • Kishk, S. M. A., Darweesh, R. M. A., Dodds, W. J., Lawson, T. L., Stewart, E. T. and Kern, M. K. (1987): Sonographic evaluation of resting gallbladder volume and postprandial emptying in patients with gallstone. J. Am. Roentgenology 148, 875–879.

    Kern M. K. , 'Sonographic evaluation of resting gallbladder volume and postprandial emptying in patients with gallstone ' (1987 ) 148 J. Am. Roentgenology : 875 -879.

    • Search Google Scholar
  • Marin, G. A. (1987): Differential diagnosis of jaundice. Hepatocellular versus obstructive disease. Postgrad. Med. 81, 178–182.

    Marin G. A. , 'Differential diagnosis of jaundice ' (1987 ) 81 Hepatocellular versus obstructive disease. Postgrad. Med. : 178 -182.

    • Search Google Scholar
  • Mayhew, P. D., Holt, D. E., McLear, R. C. and Washabau, R. J. (2002): Pathogenesis and outcome of extrahepatic biliary obstruction in cat. J. Small Anim. Pract. 43, 247–253.

    Washabau R. J. , 'Pathogenesis and outcome of extrahepatic biliary obstruction in cat ' (2002 ) 43 J. Small Anim. Pract. : 247 -253.

    • Search Google Scholar
  • Muhletaler, C. A., Gerlock, A. J., Fleischer, A. C. and James, A. E. (1980): Diagnosis of obstructive jaundice with nondilated bile ducts. Am. J. Roentgenology 134, 1149–1152.

    James A. E. , 'Diagnosis of obstructive jaundice with nondilated bile ducts ' (1980 ) 134 Am. J. Roentgenology : 1149 -1152.

    • Search Google Scholar
  • Nyland, T. G. and Gillett, N. A. (1982): Sonographic evaluation of experimental bile duct ligation in the dog. Vet. Radiol. 23, 252–260.

    Gillett N. A. , 'Sonographic evaluation of experimental bile duct ligation in the dog ' (1982 ) 23 Vet. Radiol. : 252 -260.

    • Search Google Scholar
  • Nyland, T. G., Mattoon, J. S. and Wisner, E. R. (1995): Ultrasonography of the liver. In: Nyland, T. G. and Mattoon, J. S. (eds) Veterinary Diagnostic Ultrasound. First edition. W. B. Saunders Company, Philadelphia. pp. 52–84.

    Wisner E. R. , '', in Veterinary Diagnostic Ultrasound , (1995 ) -.

  • Penninck, D. and D’Anjou, M. (2008): Disorders of the Biliary System. In: Penninck, D. (ed.) Atlas of Small Animal Ultrasonography. First edition. Blackwell Publishing, Iowa. pp. 242–248.

    D’Anjou M. , '', in Atlas of Small Animal Ultrasonography , (2008 ) -.

  • Portincasa, P., Altomare, D. F., Moschetta, A., Baldassarre, G., Di Ciaula, A., Venneman, N. G., Rinaldi, M., Vendemiale, G., Memeo, V., van Berge-Henegouwen, G. P. and Palasciano, G. (2000): The effect of acute oral erythromycin on gallbladder motility and on upper gastrointestinal symptoms in gastrectomized patients with and without gallstones: a randomized, placebo-controlled ultrasonographic study. Am. J. Gastroenterol. 95, 3444–3451.

    Palasciano G. , 'The effect of acute oral erythromycin on gallbladder motility and on upper gastrointestinal symptoms in gastrectomized patients with and without gallstones: a randomized, placebo-controlled ultrasonographic study ' (2000 ) 95 Am. J. Gastroenterol. : 3444 -3451.

    • Search Google Scholar
  • Ramstedt, K. L., Center, S. A., Randolph, J. E., Yeager, A. E., Erb, H. N. and Warner, K. L. (2008): Changes in gallbladder volume in healthy dogs after food was withheld for 12 hours followed by ingestion of a meal or a meal containing erythromycin. Am. J. Vet. Med. 69, 647–651.

    Warner K. L. , 'Changes in gallbladder volume in healthy dogs after food was withheld for 12 hours followed by ingestion of a meal or a meal containing erythromycin ' (2008 ) 69 Am. J. Vet. Med. : 647 -651.

    • Search Google Scholar
  • Raptopoulos, V., Fabian, T. M., Silva, W., D’Orsi, C. J., Karellas, A. and Compton, C. C. (1985): The effect of time and cholecystectomy on experimental biliary tree dilatation. Invest. Rad. 20, 276–286.

    Compton C. C. , 'The effect of time and cholecystectomy on experimental biliary tree dilatation ' (1985 ) 20 Invest. Rad. : 276 -286.

    • Search Google Scholar
  • Rosenquist, C. J. and Barcia, T. C. (1983): Studies of gallbladder contraction using intramuscular sincalide. Radiology 146, 21–23.

    Barcia T. C. , 'Studies of gallbladder contraction using intramuscular sincalide ' (1983 ) 146 Radiology : 21 -23.

    • Search Google Scholar
  • Rothuizen, J., de Vries-Chalmers Hoynck van Papendrecht, R. and van den Brom, W. E. (1990): Post prandial and cholecystokinin-induced emptying of the gall bladder in dogs. Vet. Rec. 126, 505–507.

    Brom W. E. , 'Post prandial and cholecystokinin-induced emptying of the gall bladder in dogs ' (1990 ) 126 Vet. Rec. : 505 -507.

    • Search Google Scholar
  • R Development Core Team (2006): R: A language and environment for statistical computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, URL http://www.R-project.org

  • Spillmann, T., Schnell-Kretschmer, H., Dick, M., Grondahl, K. A., Lenhard, T. C. and Rust, S. K. (2005): Endoscopic retrograde cholangio-pancreatography in dogs with chronic gastrointestinal problems. Vet. Radiol. Ultrasound 46, 293–299.

    Rust S. K. , 'Endoscopic retrograde cholangio-pancreatography in dogs with chronic gastrointestinal problems ' (2005 ) 46 Vet. Radiol. Ultrasound : 293 -299.

    • Search Google Scholar
  • Sterczer, Á., Szénási, G., Vörös, K. and Pap, Á. (2000): Effects of lorglumide and atropine on MgSO4-induced gallbladder emptying in conscious dogs. Res. Vet. Sci. 69, 129–133.

    Pap , 'Effects of lorglumide and atropine on MgSO4-induced gallbladder emptying in conscious dogs ' (2000 ) 69 Res. Vet. Sci. : 129 -133.

    • Search Google Scholar
  • Sterczer, Á., Vörös, K. and Karsai, F. (1996): Effect of cholagogues on the volume of the gallbladder of dogs. Res. Vet. Sci. 60, 44–47.

    Karsai F. , 'Effect of cholagogues on the volume of the gallbladder of dogs ' (1996 ) 60 Res. Vet. Sci. : 44 -47.

    • Search Google Scholar
  • Traynor, O. J., Dozois, R. R. and DiMagno, E. P. (1984): Canine interdigestive and postprandial gallbladder motility and emptying. Am. J. Physiol. 246, G426–G432.

    DiMagno E. P. , 'Canine interdigestive and postprandial gallbladder motility and emptying ' (1984 ) 246 Am. J. Physiol. : G426 -G432.

    • Search Google Scholar
  • Willard, M. D. and Fossum, T. W. (2005): Diseases of the gallbladder and extrahepatic biliary system. In: Ettinger, S. J. and Feldman, E. C. (eds) Textbook of Veterinary Internal Medicine. Fifth edition. Elsevier Saunders, St. Louis. pp. 1478–1481.

    Fossum T. W. , '', in Textbook of Veterinary Internal Medicine , (2005 ) -.

  • Willson, S. A., Gosink, B. B. and Vansonnenberg, E. (1986): Unchanged size of a dilated common bile duct after a fatty meal: results and significance. Radiology 160, 29–31.

    Vansonnenberg E. , 'Unchanged size of a dilated common bile duct after a fatty meal: results and significance ' (1986 ) 160 Radiology : 29 -31.

    • Search Google Scholar

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