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  • 1 Szent István University Department and Clinic of Internal Medicine István u. 2 H-1078 Budapest Hungary
  • 2 Szent István University Department of Biomathematics and Informatics, Faculty of Veterinary Science István u. 2 H-1078 Budapest Hungary
  • 3 National Institute of Oncology Gastroenterology Department Budapest Hungary
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Nutritional support in critically ill patients is a fundamental principle of patient care. Little is known about gallbladder motility during the interdigestive phase and in response to enteral feeding. The objective of this study was to investigate the effect of enteral feeding on gallbladder function in dogs. The cholagogue meal (Lipofundin infusion) was applied in four anatomical positions (jejunum, duodenojejunal junction, descending duodenum, stomach) in five healthy Beagle dogs. Gallbladder volume (GBV) was monitored by ultrasonography. Lipofundin infusion given through the feeding tube caused a maximal gallbladder contraction of 9.2% (range 3.7–13.9%) in the jejunum, 16.5% (9.1–22.1%) at the duodenojejunal junction and 26.3% (22.8–29.5%) in the descending duodenum. When the cholagogue meal was given through the mouth, it caused a mean 33.8% (28.6–46.5%) maximum gallbladder contraction in the same animals. In conclusion, we can establish that the ultrasound-guided gallbladder emptying method proved to be a useful technique for monitoring the cholagogue effect of Lipofundin meal applied in different anatomical positions of the intestine. The deeper the position of application, the smaller and shorter gallbladder contraction was evoked.

  • Adler, G. and Beglinger, C. (1990): Hormones as regulators of pancreatic secretion in man. Eur. J. Clin. Invest. 20, S27–S32.

    Beglinger C. , 'Hormones as regulators of pancreatic secretion in man ' (1990 ) 20 Eur. J. Clin. Invest. : S27 -S32.

    • Search Google Scholar
  • Bodoky, G., Harsanyi, L., Pap, A., Tihanyi, T. and Flautner, L. (1991): Effect of enteral nutrition on exocrine pancreatic function. Am. J. Surg. 161, 144–148.

    Flautner L. , 'Effect of enteral nutrition on exocrine pancreatic function ' (1991 ) 161 Am. J. Surg. : 144 -148.

    • Search Google Scholar
  • Conter, R. L., Roslyn, J. J. and Taylor, I. L. (1987a): Effects of peptide YY on gallbladder motility. Am. J. Physiol. 252, G736–G741.

    Taylor I. L. , 'Effects of peptide YY on gallbladder motility ' (1987 ) 252 Am. J. Physiol. : G736 -G741.

    • Search Google Scholar
  • Conter, R. L., Roslyn, J. J., DenBesten, L. and Taylor, I. L. (1987b): Pancreatic polypeptide enhances postcontractile gallbladder filling in the prairie dog. Gastroenterology 92, 771–776.

    Taylor I. L. , 'Pancreatic polypeptide enhances postcontractile gallbladder filling in the prairie dog ' (1987 ) 92 Gastroenterology : 771 -776.

    • Search Google Scholar
  • Deitch, E. A. (1990): The role of intestinal barrier failure and bacterial translocation in the development of systemic infection and multiple organ failure. Arch. Surg. 125, 403–404.

    Deitch E. A. , 'The role of intestinal barrier failure and bacterial translocation in the development of systemic infection and multiple organ failure ' (1990 ) 125 Arch. Surg. : 403 -404.

    • Search Google Scholar
  • Finn, S. T., Park, R. D., Twedt, D. C. and Curtis, C. R. (1991): Ultrasonographic assessment of sincalide-induced canine gallbladder emptying: an aid to the diagnosis of biliary obstruction. Vet. Radiol. 32, 269–276.

    Curtis C. R. , 'Ultrasonographic assessment of sincalide-induced canine gallbladder emptying: an aid to the diagnosis of biliary obstruction ' (1991 ) 32 Vet. Radiol. : 269 -276.

    • Search Google Scholar
  • Froehlich, F., Gonvers, J. J. and Fried, M. (1995): Role of nutrient fat and cholecystokinin in regulation of gallbladder emptying in man. Dig. Dis. Sci. 40, 529–533.

    Fried M. , 'Role of nutrient fat and cholecystokinin in regulation of gallbladder emptying in man ' (1995 ) 40 Dig. Dis. Sci. : 529 -533.

    • Search Google Scholar
  • Hopman, W. P., Jansen, J. B., Rosenbusch, G. and Lamers, C. B. (1987): Cephalic stimulation of gallbladder contraction in humans: role of cholecystokinin and the cholinergic system. Digestion 38, 197–203.

    Lamers C. B. , 'Cephalic stimulation of gallbladder contraction in humans: role of cholecystokinin and the cholinergic system ' (1987 ) 38 Digestion : 197 -203.

    • Search Google Scholar
  • Itoh, Z. and Takahashi, I. (1981): Periodic contractions of the canine gallbladder during the interdigestive state. Am. J. Physiol. 240, G183–G189.

    Takahashi I. , 'Periodic contractions of the canine gallbladder during the interdigestive state ' (1981 ) 240 Am. J. Physiol. : G183 -G189.

    • Search Google Scholar
  • Jonderko, K., Ferré, J. P. and Buéno, L. (1992): Real-time ultrasonography as a noninvasive tool for the examination of canine gallbladder emptying: a validation study. J. Pharmacol. Toxicol. Methods 27, 107–111.

    Buéno L. , 'Real-time ultrasonography as a noninvasive tool for the examination of canine gallbladder emptying: a validation study ' (1992 ) 27 J. Pharmacol. Toxicol. Methods : 107 -111.

    • Search Google Scholar
  • Layer, P., Peschel, S., Schlesinger, T. and Goebell, H. (1990): Human pancreatic secretion and intestinal motility: effects of ileal nutrient perfusion. Am. J. Physiol. 258, G196–G201.

    Goebell H. , 'Human pancreatic secretion and intestinal motility: effects of ileal nutrient perfusion ' (1990 ) 258 Am. J. Physiol. : G196 -G201.

    • Search Google Scholar
  • Ledeboer, M., Masclee, A. A., Biemond, I. and Lamers, C. B. (1997): Gallbladder motility and cholecystokinin secretion during continuous enteral nutrition. Am. J. Gastroenterol. 92, 2274–2279.

    Lamers C. B. , 'Gallbladder motility and cholecystokinin secretion during continuous enteral nutrition ' (1997 ) 92 Am. J. Gastroenterol. : 2274 -2279.

    • Search Google Scholar
  • Lobo, D. N., Memon, M. A., Allison, S. P. and Rowlands, B. J. (2000): Evolution of nutritional support in acute pancreatitis. Br. J. Surg. 87, 695–707.

    Rowlands B. J. , 'Evolution of nutritional support in acute pancreatitis ' (2000 ) 87 Br. J. Surg. : 695 -707.

    • Search Google Scholar
  • Magee, D. F., Naruse, S. and Pap, A. (1984): Vagal control of gallbladder contraction. J. Physiol. 355, 65–70.

    Pap A. , 'Vagal control of gallbladder contraction ' (1984 ) 355 J. Physiol. : 65 -70.

  • Matsumoto, T., Sarna, S. K., Condon, R. E., Dodds, W. J. and Mochinaga, N. (1988): Canine gallbladder cyclic motor activity. Am. J. Physiol. 255, G409–G416.

    Mochinaga N. , 'Canine gallbladder cyclic motor activity ' (1988 ) 255 Am. J. Physiol. : G409 -G416.

    • Search Google Scholar
  • Pápa, K., Psáder, R., Sterczer, A., Pap, A., Rinkinen, M. and Spillmann, T. (2009): Endoscopically guided nasojejunal tube placement in dogs for short-term postduodenal feeding. J. Vet. Emerg. Crit. Care. 19, 554–563.

    Spillmann T. , 'Endoscopically guided nasojejunal tube placement in dogs for short-term postduodenal feeding ' (2009 ) 19 J. Vet. Emerg. Crit. Care. : 554 -563.

    • Search Google Scholar
  • Pincheiro, J. C. and Bates, D. M. (2000): Mixed-Effects Models in S and S-PLUS. Springer, Pittsburgh, PA, USA. pp. 1–528.

    Bates D. M. , '', in Mixed-Effects Models in S and S-PLUS , (2000 ) -.

  • Qin, H. L., Su, Z. D., Hu, L. G., Ding, Z. X. and Lin, Q. T. (2002): Effect of early intrajejunal nutrition on pancreatic pathological features and gut barrier function in dogs with acute pancreatitis. Clin. Nutr. 21, 469–473.

    Lin Q. T. , 'Effect of early intrajejunal nutrition on pancreatic pathological features and gut barrier function in dogs with acute pancreatitis ' (2002 ) 21 Clin. Nutr. : 469 -473.

    • Search Google Scholar
  • R Development Core Team (2006): R: A Language and Environment for Statistical Computing. R Foundation for Statistical Computing, Vienna, Austria. ISBN 3-900051-07-0, URL http://www.R-project.org

  • Ramstedt, K. L., Center, S. A., Randolph, J. E., Yeager, A. E., Erb, H. N. and Warner, K. L. (2008): Changes in gallbladder volume in healthy dogs after food was withheld for 12 hours followed by ingestion of a meal or a meal containing erythromycin. Am. J. Vet. Res. 69, 647–651.

    Warner K. L. , 'Changes in gallbladder volume in healthy dogs after food was withheld for 12 hours followed by ingestion of a meal or a meal containing erythromycin ' (2008 ) 69 Am. J. Vet. Res. : 647 -651.

    • Search Google Scholar
  • Rothuizen, J., de Vries-Chalmers Hoynck van Papendrecht, R. and van den Brom, W. E. (1990): Post prandial and cholecystokinin-induced emptying of the gallbladder in dogs. Vet. Rec. 126, 505–507.

    Brom W. E. , 'Post prandial and cholecystokinin-induced emptying of the gallbladder in dogs ' (1990 ) 126 Vet. Rec. : 505 -507.

    • Search Google Scholar
  • Schjoldager, B. T. (1994): Role of CCK in gallbladder function. Ann. N. Y. Acad. Sci. 23, 207–218.

    Schjoldager B. T. , 'Role of CCK in gallbladder function ' (1994 ) 23 Ann. N. Y. Acad. Sci. : 207 -218.

    • Search Google Scholar
  • Scott, R. B. and Tan, D. T. (1993): Neural modulation of canine duodenal bile acid delivery in the interdigestive and postprandial periods. Am. J. Physiol. 264, G357–G366.

    Tan D. T. , 'Neural modulation of canine duodenal bile acid delivery in the interdigestive and postprandial periods ' (1993 ) 264 Am. J. Physiol. : G357 -G366.

    • Search Google Scholar
  • Sterczer, Á., Reiczigel, J., Psáder, R., Pápa, K., Vörös, K. and Pap, Á. (2012): Cholagogue-induced gallbladder emptying in the diagnosis of canine biliary obstruction. Acta Vet. Hung. 60, 199–209.

    Pap , 'Cholagogue-induced gallbladder emptying in the diagnosis of canine biliary obstruction ' (2012 ) 60 Acta Vet. Hung. : 199 -209.

    • Search Google Scholar
  • Sterczer, Á., Szénási, G., Vörös, K. and Pap, Á. (2000): Effects of lorglumide and atropine on MgSO4-induced gallbladder emptying in conscious dogs. Res. Vet. Sci. 69, 129–133.

    Pap , 'Effects of lorglumide and atropine on MgSO4-induced gallbladder emptying in conscious dogs ' (2000 ) 69 Res. Vet. Sci. : 129 -133.

    • Search Google Scholar
  • Sterczer, Á., Vörös, K. and Karsai, F. (1996): Effect of cholagogues on the volume of the gallbladder of dogs. Res. Vet. Sci. 60, 44–47.

    Karsai F. , 'Effect of cholagogues on the volume of the gallbladder of dogs ' (1996 ) 60 Res. Vet. Sci. : 44 -47.

    • Search Google Scholar
  • Takács, T., Hajnal, F., Németh, J., Lonovics, J. and Pap, A. (2000): Stimulated gastrointestinal hormone release and gallbladder contraction during continuous jejunal feeding in patients with pancreatic pseudocyst is inhibited by octreotide. Int. J. Pancreatol. 28, 215–220.

    Pap A. , 'Stimulated gastrointestinal hormone release and gallbladder contraction during continuous jejunal feeding in patients with pancreatic pseudocyst is inhibited by octreotide ' (2000 ) 28 Int. J. Pancreatol. : 215 -220.

    • Search Google Scholar
  • Vu, M. K., van der Veek, P. P., Frölich, M., Souverijn, J. H., Biemond, I., Lamers, C. B. and Masclee, A. A. (1999): Does jejunal feeding activate exocrine pancreatic secretion? Eur. J. Clin. Invest. 29, 1053–1059.

    Masclee A. A. , 'Does jejunal feeding activate exocrine pancreatic secretion? ' (1999 ) 29 Eur. J. Clin. Invest. : 1053 -1059.

    • Search Google Scholar
  • Vu, M. K., Van Oostayen, J. A., Biemond, I. and Masclee, A. A. (2001): Effect of somatostatin on postprandial gallbladder relaxation. Clin. Physiol. 21, 25–31.

    Masclee A. A. , 'Effect of somatostatin on postprandial gallbladder relaxation ' (2001 ) 21 Clin. Physiol. : 25 -31.

    • Search Google Scholar
  • Walker, J. P., Khalil, T., Wiener, I., Fagan, C. J., Townsend, C. M. Jr., Greeley, G. H. Jr. and Thompson, J. C. (1985): The role of neurotensin in human gallbladder motility. Ann. Surg. 201, 678–683.

    Thompson J. C. , 'The role of neurotensin in human gallbladder motility ' (1985 ) 201 Ann. Surg. : 678 -683.

    • Search Google Scholar

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