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  • 1 Szent István University Department of Pathology and Forensic Veterinary Medicine, Faculty of Veterinary Science István utca 2 H-1078 Budapest Hungary
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This paper describes the occurrence of a rare skin tumour that has been removed surgically from the upper lip of a 13-year-old Tibetan spaniel. The tumour was 0.5 cm in diameter and macroscopically appeared as a single dermal mass, but histopathological analysis identified it as a biphasic collision mixed tumour. In the anatomically uniform tumour, 70% (4 mm in diameter) of the total parenchyma was formed by a high-grade sarcoma (with the presence of giant cells), and about 30% of it (1 mm in diameter) was a malignant melanoma (again with the presence of giant cells). The histologically distinct, but anatomically uniform tumour parts were separated by a macroscopically invisible, non-neoplastic epithelial process originating from the overlying hyperplastic epidermis. The two malignant components did not infiltrate the peritumoural vessels and each other’s substance. In the sarcoma part, the mitotic and apoptotic indexes were 32 and 8, respectively, whereas in the melanoma part the same parameters were 10 and 6, respectively. During the immunohistochemical investigations anti-α-SMA, anticytokeratin AE1-AE3, anti-Melan-A, anti-Ki-67 and anti-claudin-5 antibodies were applied. In conclusion, this is the first report of a primary cutaneous malignant biphasic collision mixed tumour formed by an anaplastic sarcoma with giant cells and a malignant melanoma.

  • Cantor, A. S., Moschos, S. and Jukic, D. M. (2010): A principal case of multiple lymphoid collision tumors involving both B-cell chronic lymphocytic leukemia and metastatic malignant melanoma. Dermatol. Online J. 7, 6–7.

    Jukic D. M. , 'A principal case of multiple lymphoid collision tumors involving both B-cell chronic lymphocytic leukemia and metastatic malignant melanoma ' (2010 ) 7 Dermatol. Online J. : 6 -7.

    • Search Google Scholar
  • Espinosa de los Monteros, A., Martín de las Mulas, J., Fernández, A., Orós, J. and Rodríguez, F. (2000): Immunohistopathologic characterization of a dermal melanocytoma-acanthoma in a German Shepherd Dog. Vet. Pathol. 3, 268–271.

    Rodríguez F. , 'Immunohistopathologic characterization of a dermal melanocytoma-acanthoma in a German Shepherd Dog ' (2000 ) 3 Vet. Pathol. : 268 -271.

    • Search Google Scholar
  • Falanga, V., Chartier, M., Butmarc, J. and Tibbetts, L. (2008): Collision of desmoplastic-neurotropic melanoma and squamous cell carcinoma on the lip. J. Cutan. Pathol. 5, 473–476.

    Tibbetts L. , 'Collision of desmoplastic-neurotropic melanoma and squamous cell carcinoma on the lip ' (2008 ) 5 J. Cutan. Pathol. : 473 -476.

    • Search Google Scholar
  • Goldschmidt, M. and Hendrick, M. (2000): Tumors of the skin and soft tissues. In: Meuten, D. (ed.) Tumors in Domestic Animals. 4th edition. Iowa State Press, Ames. pp. 81–84.

    Hendrick M. , '', in Tumors in Domestic Animals , (2000 ) -.

  • Goldschmidt, M. and Shofer, F. (1992): Skin Tumors of the Dog and Cat. Pergamon Press, Oxford. pp. 66–71.

    Shofer F. , '', in Skin Tumors of the Dog and Cat , (1992 ) -.

  • Gross, T. L., Ihrke, P. J., Walder, E. J. and Affolter, V. K. (2006): Skin Diseases of the Dog and Cat: Clinical and Histopathologic Diagnosis. 2nd edition, Blackwell Publishing, Oxford.

    Affolter V. K. , '', in Skin Diseases of the Dog and Cat: Clinical and Histopathologic Diagnosis , (2006 ) -.

  • Kerl, K., Wolf, I. H., Kamarachev, J., Cerroni, L. and Kerl, H. (2010): Collision tumors: CAMEL, METRO and other acronyms. J. Dtsch. Dermatol. Ges. 6, 471–472.

    Kerl H. , 'Collision tumors: CAMEL, METRO and other acronyms ' (2010 ) 6 J. Dtsch. Dermatol. Ges. : 471 -472.

    • Search Google Scholar
  • Légrády, A. and Jakab, Cs. (2010): Collision mixed tumour of the testicle in dog. Oncological case report and literature data [in Hungarian, with English abstract and figures]. Magyar Állatorvosok Lapja 132, 93–100.

    Jakab Cs. , 'Collision mixed tumour of the testicle in dog. Oncological case report and literature data [in Hungarian, with English abstract and figures] ' (2010 ) 132 Magyar Állatorvosok Lapja : 93 -100.

    • Search Google Scholar
  • Légrády, A., Jakab, Cs., Rusvai, M., Balka, Gy. and Kulka, J. (2010): Claudin-5 positive perianal collision mixed skin tumour in dog. Oncological case report [in Hungarian, with English abstract and figures]. Magyar Állatorvosok Lapja 132, 461–465.

    Kulka J. , 'Claudin-5 positive perianal collision mixed skin tumour in dog ' (2010 ) 132 Magyar Állatorvosok Lapja : 461 -465.

    • Search Google Scholar
  • MacEwen, E. G., Patnaik, A. K., Harvey, H. J., Hayes, A. A. and Matus, R. (1986): Canine oral melanoma: comparison of surgery versus surgery plus Corynebacterium parvum. Cancer Invest. 4, 397–402.

    Matus R. , 'Canine oral melanoma: comparison of surgery versus surgery plus Corynebacterium parvum ' (1986 ) 4 Cancer Invest. : 397 -402.

    • Search Google Scholar
  • Meyer, R. (1920): Beitrag zur Verstandigung über die Namengeburg in den Geschwülsten. Zbl. Allgem. Pathol. 30, 291–292.

    Meyer R. , 'Beitrag zur Verstandigung über die Namengeburg in den Geschwülsten ' (1920 ) 30 Zbl. Allgem. Pathol. : 291 -292.

    • Search Google Scholar
  • Park, S. I. and Cho, K. O. (2010): Dermal melanocytoma-acanthoma in an adult mixed breed dog. Jap. J. Vet. Res. 3–4, 165–169.

    Cho K. O. , 'Dermal melanocytoma-acanthoma in an adult mixed breed dog ' (2010 ) 3–4 Jap. J. Vet. Res. : 165 -169.

    • Search Google Scholar
  • Patnaik, A. K. and Mostofi, F. K. (1993): A clinicopathologic, histologic, and immunohistochemical study of mixed germ cell-stromal tumors of the testis in 16 dogs. Vet. Pathol. 30, 287–295.

    Mostofi F. K. , 'A clinicopathologic, histologic, and immunohistochemical study of mixed germ cell-stromal tumors of the testis in 16 dogs ' (1993 ) 30 Vet. Pathol. : 287 -295.

    • Search Google Scholar
  • Saito, S., Suzuki, K., Shibuya, H., Yamaguchi, T. and Sato, T. (2005): Melanocytic matricoma in a dog. Vet. Pathol. 4, 499–502.

    Sato T. , 'Melanocytic matricoma in a dog ' (2005 ) 4 Vet. Pathol. : 499 -502.

  • Salerni, G., Lovatto, L., Carrera, C., Palou, J., Alos, L., Puig-Butille, J. A., Badenas, C., Malvehy, J. and Puig, S. (2011): Correlation among dermoscopy, confocal reflectance microscopy, and histologic features of melanoma and basal cell carcinoma collision tumor. Dermatol. Surg. 2, 275–279.

    Puig S. , 'Correlation among dermoscopy, confocal reflectance microscopy, and histologic features of melanoma and basal cell carcinoma collision tumor ' (2011 ) 2 Dermatol. Surg. : 275 -279.

    • Search Google Scholar

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