Acta Veterinaria Hungarica
Volume/Issue:
Volume 60: Issue 2
Ligand-induced changes in Oestrogen and thyroid hormone receptor expression in the developing rat cerebellum: A comparative quantitative PCR and Western blot study
Authors:
Trudy Scalise Szent István University Department of Physiology and Biochemistry, Faculty of Veterinary Sciences István u. 2 H-1078 Budapest Hungary

Search for other papers by Trudy Scalise in
Current site
Google Scholar
PubMed Close
,
Andrea Győrffy Szent István University Department of Physiology and Biochemistry, Faculty of Veterinary Sciences István u. 2 H-1078 Budapest Hungary

Search for other papers by Andrea Győrffy in
Current site
Google Scholar
PubMed Close
,
István Tóth Szent István University Department of Physiology and Biochemistry, Faculty of Veterinary Sciences István u. 2 H-1078 Budapest Hungary

Search for other papers by István Tóth in
Current site
Google Scholar
PubMed Close
,
Dávid Kiss Szent István University Department of Physiology and Biochemistry, Faculty of Veterinary Sciences István u. 2 H-1078 Budapest Hungary

Search for other papers by Dávid Kiss in
Current site
Google Scholar
PubMed Close
,
Virág Somogyi Szent István University Department of Physiology and Biochemistry, Faculty of Veterinary Sciences István u. 2 H-1078 Budapest Hungary

Search for other papers by Virág Somogyi in
Current site
Google Scholar
PubMed Close
,
Gréta Goszleth Szent István University Department of Physiology and Biochemistry, Faculty of Veterinary Sciences István u. 2 H-1078 Budapest Hungary

Search for other papers by Gréta Goszleth in
Current site
Google Scholar
PubMed Close
,
Tibor Bartha Szent István University Department of Physiology and Biochemistry, Faculty of Veterinary Sciences István u. 2 H-1078 Budapest Hungary

Search for other papers by Tibor Bartha in
Current site
Google Scholar
PubMed Close
,
László Frenyó Szent István University Department of Physiology and Biochemistry, Faculty of Veterinary Sciences István u. 2 H-1078 Budapest Hungary

Search for other papers by László Frenyó in
Current site
Google Scholar
PubMed Close
, and
Attila Zsarnovszky Szent István University Department of Physiology and Biochemistry, Faculty of Veterinary Sciences István u. 2 H-1078 Budapest Hungary

Search for other papers by Attila Zsarnovszky in
Current site
Google Scholar
PubMed Close
Pages:
263–284
Online Publication Date:
18 May 2012
Publication Date:
01 Jun 2012
Article Category:
Journal Article
DOI:
https://doi.org/10.1556/avet.2012.023
Keywords:
Oestrogen; thyroid; receptors; interaction; developing; cerebellum
Restricted access

Oestrogen (E2) and thyroid hormones (THs) are key regulators of cerebellar development. Recent reports implicate a complex mechanism through which E2 and THs influence the expression levels of each other’s receptors (ERs and TRs) to precisely mediate developmental signals and modulate signal strength. We examined the modulating effects of E2 and THs on the expression levels of their receptor mRNAs and proteins in cultured cerebellar cells obtained from 7-day-old rat pups. Cerebellar granule cell cultures were treated with either E2, THs or a combination of these hormones, and resulting receptor expression levels were determined by quantitative PCR and Western blot techniques. The results were compared to non-treated controls and to samples obtained from 14-day-old in situ cerebella. Additionally, we determined the glial effects on the regulation of ER-TR expression levels. The results show that (i) ER and TR expression depends on the combined presence of E2 and THs; (ii) glial cells mediate the hormonal regulation of neuronal ER-TR expression and (iii) loss of tissue integrity results in characteristic changes in ER-TR expression levels. These observations suggest that both E2 and THs, in adequate amounts, are required for the precise orchestration of cerebellar development and that alterations in the ratio of E2/THs may influence signalling mechanisms involved in neurodevelopment. Comparison of data from in vitro and in situ samples revealed a shift in receptor expression levels after loss of tissue integrity, suggesting that such adjusting/regenerative mechanisms may function after cerebellar tissue injury as well.

  • Collapse
  • Expand
Cover Acta Veterinaria Hungarica
Acta Veterinaria Hungarica
Print ISSN:
0236-6290
Online ISSN:
1588-2705

Senior editors

Editor-in-Chief: Ferenc BASKA

Editorial assistant: Szilvia PÁLINKÁS

 

Editorial Board

  • Mária BENKŐ (Acta Veterinaria Hungarica, Budapest, Hungary)
  • Gábor BODÓ (University of Veterinary Medicine, Budapest, Hungary)
  • Béla DÉNES (University of Veterinary Medicine, Budapest Hungary)
  • Edit ESZTERBAUER (Veterinary Medical Research Institute, Budapest, Hungary)
  • Hedvig FÉBEL (University of Veterinary Medicine, Budapest, Hungary)
  • László FODOR (University of Veterinary Medicine, Budapest, Hungary)
  • János GÁL (University of Veterinary Medicine, Budapest, Hungary)
  • Balázs HARRACH (Veterinary Medical Research Institute, Budapest, Hungary)
  • Peter MASSÁNYI (Slovak University of Agriculture in Nitra, Nitra, Slovak Republic)
  • Béla NAGY (Veterinary Medical Research Institute, Budapest, Hungary)
  • Tibor NÉMETH (University of Veterinary Medicine, Budapest, Hungary)
  • Zsuzsanna NEOGRÁDY (University of Veterinary Medicine, Budapest, Hungary)
  • Dušan PALIĆ (Ludwig Maximilian University, Munich, Germany)
  • Alessandra PELAGALLI (University of Naples Federico II, Naples, Italy)
  • Kurt PFISTER (Ludwig-Maximilians-University of Munich, Munich, Germany)
  • László SOLTI (University of Veterinary Medicine, Budapest, Hungary)
  • József SZABÓ (University of Veterinary Medicine, Budapest, Hungary)
  • Péter VAJDOVICH (University of Veterinary Medicine, Budapest, Hungary)
  • János VARGA (University of Veterinary Medicine, Budapest, Hungary)
  • Štefan VILČEK (University of Veterinary Medicine in Kosice, Kosice, Slovak Republic)
  • Károly VÖRÖS (University of Veterinary Medicine, Budapest, Hungary)
  • Herbert WEISSENBÖCK (University of Veterinary Medicine, Vienna, Austria)
  • Attila ZSARNOVSZKY (Szent István University, Gödöllő, Hungary)

ACTA VETERINARIA HUNGARICA
Institute for Veterinary Medical Research
Centre for Agricultural Research
Hungarian Academy of Sciences
P.O. Box 18, H-1581 Budapest, Hungary
Phone: (36 1) 287 7073 (ed.-in-chief) or (36 1) 467 4081 (editor)

E-mail: acta.veterinaria@univet.hu (ed.-in-chief)

Indexing and Abstracting Services:

  • Biological Abstracts
  • BIOSIS Previews
  • CAB Abstracts
  • Chemical Abstracts
  • Current Contents: Agriculture, Biology and Environmental Sciences
  • Elsevier Science Navigator
  • Focus On: Veterinary Science and Medicine
  • Global Health
  • Index Medicus
  • Index Veterinarius
  • Medline
  • Science Citation Index
  • Science Citation Index Expanded (SciSearch)
  • SCOPUS
  • The ISI Alerting Services
  • Zoological Abstracts

 

2023  
Web of Science  
Journal Impact Factor 0.7
Rank by Impact Factor Q3 (Veterinary Sciences)
Journal Citation Indicator 0.4
Scopus  
CiteScore 1.8
CiteScore rank Q2 (General Veterinary)
SNIP 0.39
Scimago  
SJR index 0.258
SJR Q rank Q3

Acta Veterinaria Hungarica
Publication Model Hybrid
Submission Fee none
Article Processing Charge 1100 EUR/article
Printed Color Illustrations 40 EUR (or 10 000 HUF) + VAT / piece
Regional discounts on country of the funding agency World Bank Lower-middle-income economies: 50%
World Bank Low-income economies: 100%
Further Discounts Editorial Board / Advisory Board members: 50%
Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100%
Subscription fee 2025 Online subsscription: 832 EUR / 916 USD
Print + online subscription: 960 EUR / 1054 USD
Subscription Information Online subscribers are entitled access to all back issues published by Akadémiai Kiadó for each title for the duration of the subscription, as well as Online First content for the subscribed content.
Purchase per Title Individual articles are sold on the displayed price.

Acta Veterinaria Hungarica
Language English
Size A4
Year of
Foundation		 1951
Volumes
per Year		 1
Issues
per Year		 4
Founder Magyar Tudományos Akadémia
Founder's
Address		 H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-6290 (Print)
ISSN 1588-2705 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Apr 2024 36 0 0
May 2024 20 0 0
Jun 2024 25 0 0
Jul 2024 33 0 0
Aug 2024 36 0 0
Sep 2024 21 0 0
Oct 2024 4 0 0