Acta Veterinaria Hungarica
Volume/Issue:
Volume 60: Issue 3
Sequence analysis for the complete proviral genome of avian leukosis virus subgroup J associated with haemangiomas, leiomyosarcomas and myelomas in layer flocks
Authors: Yue Qu, Honglei Sun, Meiyu Sun 2 , Delong Li 1 , Liting Qin 2 , Yulong Gao 2 , Xiaomei Wang 2 , and Sidang Liu 1
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  • 1 Shandong Agricultural University College of Animal Science and Veterinary Medicine Taian 271018 P. R. China
  • 2 Chinese Academy of Agricultural Sciences Division of Avian Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute Harbin, Heilongjiang P. R. China
  • 3 Liaoning Medical University College of Animal Husbandry and Veterinary Science Jinzhou City, Liaoning P. R. China
  • 4 China Agricultural University Key Laboratory of Zoonosis of the Ministry of Agriculture, College of Veterinary Medicine Beijing P. R. China
DOI:
https://doi.org/10.1556/avet.2012.029
Page Count:
343–354
Publication Date:
01 Sep 2012
Online Publication Date:
17 Aug 2012
Article Category:
Research Article
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Avian leukosis virus subgroup J (ALV-J) can cause a variety of neoplasms, including mainly myeloid leukosis (myelocytomatosis) and nephromas. Other tumours, such as histiocytic sarcoma (HS), haemangiosarcoma and mesothelioma, may also develop. In a previous article we described a case in which myeloid leukosis, haemangiomas and leiomyosarcomas appeared simultaneously in a commercial layer flock with infection by ALV-J. The present research was completed to understand the molecular characteristics of the ALV-J strain that induced clinical myeloid leukosis, haemangiomas and leiomyosarcomas. Two strains of ALV-J (SDAU1001 and SDAU1002) were isolated and identified, and their full-length sequences were analysed. The complete genome nucleotide sequences of these two isolates were different in length, 7652 nt and 7636 nt, respectively. They shared 98.9% identity with each other, and 93.4% to 97.8% nucleotide identity to the reference ALV-J isolates. A 19-nucleotide repeat sequence was identified in the primer binding site (PBS) leader region of isolate SDAU1001. A base substitution mutation (base 15 C-T) in this insertion was identified. However, the identical insertion at the same site was not found in SDAU1002. The gag and pol genes of the two viruses were more conserved than the env gene. One key deletion in the E element was a common feature of SDAU1001 and SDAU1002. SDAU1001 and SDAU1002, possibly recombinants of ALV-J and another avian retrovirus, may share the same ancestor. Co-infection by SDAU1001 and SDAU1002 isolates is a possible explanation why myeloid leukosis, haemangiomas, and leiomyosarcomas appeared simultaneously in the same commercial layer flock.

  • Arshad, S. S., Bland, A. P., Hacker, S. M. and Payne, L. N. (1997a): A low incidence of histiocytic sarcomatosis associated with infection of chickens with HPRS-103 strain of subgroup J avian leucosis virus. Avian Dis. 41, 947–956.

    Payne L. N. , 'A low incidence of histiocytic sarcomatosis associated with infection of chickens with HPRS-103 strain of subgroup J avian leucosis virus ' (1997 ) 41 Avian Dis. : 947 -956.

    • Search Google Scholar

  • Arshad, S. S., Howes, K., Barron, G. S., Smith, L. M., Russell, P. H. and Payne, L. N. (1997b): Tissue tropism of the HPRS-103 strain of J subgroup avian leukosis virus and a derivative acutely transforming virus. Vet. Pathol. 34, 127–137.

    Payne L. N. , 'Tissue tropism of the HPRS-103 strain of J subgroup avian leukosis virus and a derivative acutely transforming virus ' (1997 ) 34 Vet. Pathol. : 127 -137.

    • Search Google Scholar

  • Arshad, S. S., Smith, L. M., Howes, K., Russell, P. H., Venugopal, K. and Payne, L. N. (1999): Tropism of subgroup J avian leukosis virus as detected by in situ hybridization. Avian Pathol. 28, 163–169.

    Payne L. N. , 'Tropism of subgroup J avian leukosis virus as detected by in situ hybridization ' (1999 ) 28 Avian Pathol. : 163 -169.

    • Search Google Scholar

  • Bai, J., Payne, L. N. and Skinner, M. A. (1995): HPRS-103 (exogenous avian leukosis virus, subgroup J) has an env gene related to those of endogenous elements EAV-0 and E51 and an E element found previously only in sarcoma viruses. J. Virol. 69, 779–784.

    Skinner M. A. , 'HPRS-103 (exogenous avian leukosis virus, subgroup J) has an env gene related to those of endogenous elements EAV-0 and E51 and an E element found previously only in sarcoma viruses ' (1995 ) 69 J. Virol. : 779 -784.

    • Search Google Scholar

  • Barnard, R. J. O., Elleder, D. and Young, J. A. T. (2006): Avian sarcoma and leukosis virus-receptor interactions: from classical genetics to novel insights into virus-cell membrane fusion. Virology 344, 25–29.

    Young J. A. T. , 'Avian sarcoma and leukosis virus-receptor interactions: from classical genetics to novel insights into virus-cell membrane fusion ' (2006 ) 344 Virology : 25 -29.

    • Search Google Scholar

  • Benson, S. J., Ruis, B. L., Fadly, A. M. and Conklin, K. F. (1998): The unique envelope gene of the subgroup J avian leukosis virus derives from ev/J proviruses, a novel family of avian endogenous viruses. J. Virol. 72, 10157–10164.

    Conklin K. F. , 'The unique envelope gene of the subgroup J avian leukosis virus derives from ev/J proviruses, a novel family of avian endogenous viruses ' (1998 ) 72 J. Virol. : 10157 -10164.

    • Search Google Scholar

  • Brown, D. W., Blast, B. P. and Robinson, H. L. (1988): Long terminal repeat (LTR) sequences, env, and a region near the 50 LTR influence the pathogenic potential of recombinants between Rous-associated virus types 0 and 1. J. Virol. 62, 3431–3437.

    Robinson H. L. , 'Long terminal repeat (LTR) sequences, env, and a region near the 50 LTR influence the pathogenic potential of recombinants between Rous-associated virus types 0 and 1 ' (1988 ) 62 J. Virol. : 3431 -3437.

    • Search Google Scholar

  • Cheng, Z. Q., Zhang, L., Liu, S. D., Zhang, L. J. and Cui, Z. Z. (2005): Emerging of avian leucosis virus subgroup J in a flock of Chinese local breed. Wei Sheng Wu Xue Bao 45, 584–587.

    Cui Z. Z. , 'Emerging of avian leucosis virus subgroup J in a flock of Chinese local breed ' (2005 ) 45 Wei Sheng Wu Xue Bao : 584 -587.

    • Search Google Scholar

  • Cheng, Z. Q., Liu, J. Z., Cui, Z. Z. and Zhang, L. (2010): Tumors associated with avian leukosis virus subgroup J in layer hens during 2007 to 2009 in China. J. Vet. Med. Sci. 72, 1027–1033.

    Zhang L. , 'Tumors associated with avian leukosis virus subgroup J in layer hens during 2007 to 2009 in China ' (2010 ) 72 J. Vet. Med. Sci. : 1027 -1033.

    • Search Google Scholar

  • Chesters, P. M., Howes, K., McKay, J. C., Payne, L. N. and Venugopal, K. (2001): Acutely transforming avian leukosis virus subgroup J strain 966: defective genome encodes a 72-kilodalton Gag-Myc fusion protein. J. Virol. 75, 4219–4225.

    Venugopal K. , 'Acutely transforming avian leukosis virus subgroup J strain 966: defective genome encodes a 72-kilodalton Gag-Myc fusion protein ' (2001 ) 75 J. Virol. : 4219 -4225.

    • Search Google Scholar

  • Chesters, P. M., Howes, K., Petherbridge, L., Evans, S., Payne, L. N. and Venugopal, K. (2002): The viral envelope is a major determinant for the induction of lymphoid and myeloid tumours by avian leukosis virus subgroups A and J, respectively. J. Gen. Virol. 83, 2553–2561.

    Venugopal K. , 'The viral envelope is a major determinant for the induction of lymphoid and myeloid tumours by avian leukosis virus subgroups A and J, respectively ' (2002 ) 83 J. Gen. Virol. : 2553 -2561.

    • Search Google Scholar

  • Chesters, P. M., Lorraine, P. S. and Nair, V. K. (2006): E (XSR) element contributes to the oncogenicity of avian leukosis virus (subgroup J). J. Gen. Virol. 87, 2685–2692.

    Nair V. K. , 'E (XSR) element contributes to the oncogenicity of avian leukosis virus (subgroup J) ' (2006 ) 87 J. Gen. Virol. : 2685 -2692.

    • Search Google Scholar

  • Darlix, J. L. and Spahr, P. F. (1983): High spontaneous mutation rate of Rous sarcoma virus demonstrated by direct sequencing of the RNA genome. Nucleic Acids Res. 11, 5953–5967.

    Spahr P. F. , 'High spontaneous mutation rate of Rous sarcoma virus demonstrated by direct sequencing of the RNA genome ' (1983 ) 11 Nucleic Acids Res. : 5953 -5967.

    • Search Google Scholar

  • Ding, J. B., Jiang, S. J., Zhu, H. F. and Cui, Z. Z. (2007): Establishment and employment of PCR technique for distinguishing Marek’s disease virus vaccine strain CVI988 from other MDV strains. Chin. J. Vet. Sci. 27, 39–42.

    Cui Z. Z. , 'Establishment and employment of PCR technique for distinguishing Marek’s disease virus vaccine strain CVI988 from other MDV strains ' (2007 ) 27 Chin. J. Vet. Sci. : 39 -42.

    • Search Google Scholar

  • Domingo, E. and Holland, J. J. (1988): High error rates, population equilibrium, and evolution of RNA replication systems. In: Domingo, E., Ahlquist, P. and Holland, J. J. (eds) RNA Genetics 3, 3–36. CRC Press, Boca Raton, FL.

    Holland J. J. , '', in RNA Genetics , (1988 ) -.

  • Dorsey, J. F., Cunnick, J. M., Mane, S. M. and Wu, J. (2002): Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl (+) K562 leukemic cells by Gab2. Blood 99, 1388–1397.

    Wu J. , 'Regulation of the Erk2-Elk1 signaling pathway and megakaryocytic differentiation of Bcr-Abl (+) K562 leukemic cells by Gab2 ' (2002 ) 99 Blood : 1388 -1397.

    • Search Google Scholar

  • Fung, Y. K., Lewis, W. G., Crittenden, L. B. and Kung, H. J. (1983): Activation of the cellular oncogene c-erbB by LTR insertion: molecular basis for induction of erythroblastosis by avian leukosis virus. Cell 33, 357–368.

    Kung H. J. , 'Activation of the cellular oncogene c-erbB by LTR insertion: molecular basis for induction of erythroblastosis by avian leukosis virus ' (1983 ) 33 Cell : 357 -368.

    • Search Google Scholar

  • Gilles, F., Raes, M. B., Stehelin, D., Vandenbunder, B. and Fafeur, V. (1996): The c-ets-1 protooncogene is a new early-response gene differentially regulated by cytokines and growth factors in human fibroblasts. Exp. Cell Res. 222, 370–378.

    Fafeur V. , 'The c-ets-1 protooncogene is a new early-response gene differentially regulated by cytokines and growth factors in human fibroblasts ' (1996 ) 222 Exp. Cell Res. : 370 -378.

    • Search Google Scholar

  • Goldberg, Y., Treier, M., Ghysdael, J. and Bohmann, D. (1994): Repression of AP-1-stimulated transcription by c-Ets-1. J. Biol. Chem. 269, 16566–16573.

    Bohmann D. , 'Repression of AP-1-stimulated transcription by c-Ets-1 ' (1994 ) 269 J. Biol. Chem. : 16566 -16573.

    • Search Google Scholar

  • Grant, J. W., Gallagher, P. J. and Hendinger, C. (1998): Hemangioblastoma. An immunohistochemical study of ten cases. Acta Neuropathol. 76, 82–86.

    Hendinger C. , 'Hemangioblastoma. An immunohistochemical study of ten cases ' (1998 ) 76 Acta Neuropathol. : 82 -86.

    • Search Google Scholar

  • Hackett, P. B., Dalton, M. W., Johnson, D. P. and Petersen, R. B. (1991): Phylogenetic and physical analysis of the 5’leader RNA sequences of avian retroviruses. Nucleic Acids Res. 24, 6929–6934.

    Petersen R. B. , 'Phylogenetic and physical analysis of the 5’leader RNA sequences of avian retroviruses ' (1991 ) 24 Nucleic Acids Res. : 6929 -6934.

    • Search Google Scholar

  • Hayward, W. S., Neel, B. G. and Astrin, S. M. (1981): Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis. Nature 290, 475–480.

    Astrin S. M. , 'Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis ' (1981 ) 290 Nature : 475 -480.

    • Search Google Scholar

  • Ji, R. L., Liu, Y. L., Qin, A. J., Ding, J. B., Jin, W. J., Zhao, W. M., Cui, Z. Z., Duan, S. H., Gao, H. P. and Han, F. W. (2001): Co-infection detection of the chicken infectious anemia virus and reticuloendotheliosis virus in the immunodepression flock. Chin. J. Vet. Drug 35, 1–3.

    Han F. W. , 'Co-infection detection of the chicken infectious anemia virus and reticuloendotheliosis virus in the immunodepression flock ' (2001 ) 35 Chin. J. Vet. Drug : 1 -3.

    • Search Google Scholar

  • Lupiani, B., Hunt, H. D., Silva, R. F. and Fadly, A. M. (2000): Identification and characterization of recombinant subgroup J avian leukosis viruses (ALV) expressing subgroup A ALV envelope. Virology 276, 37–43.

    Fadly A. M. , 'Identification and characterization of recombinant subgroup J avian leukosis viruses (ALV) expressing subgroup A ALV envelope ' (2000 ) 276 Virology : 37 -43.

    • Search Google Scholar

  • Lupiani, B., Williams, S. M., Silva, R. F., Hunt, H. D. and Fadly, A. M. (2003): Pathogenicity of two recombinant avian leukosis viruses. Avian Dis. 47, 425–432.

    Fadly A. M. , 'Pathogenicity of two recombinant avian leukosis viruses ' (2003 ) 47 Avian Dis. : 425 -432.

    • Search Google Scholar

  • Mays, J. K., Pandiri, A. R. and Fadly, A. M. (2006): Susceptibility of various parental lines of commercial White Leghorn layers to infection with a naturally occurring recombinant avian leukosis virus containing subgroup B envelope and subgroup J long terminal repeat. Avian Dis. 50, 342–347.

    Fadly A. M. , 'Susceptibility of various parental lines of commercial White Leghorn layers to infection with a naturally occurring recombinant avian leukosis virus containing subgroup B envelope and subgroup J long terminal repeat ' (2006 ) 50 Avian Dis. : 342 -347.

    • Search Google Scholar

  • Melder, D. C., Pandkrata, V. S. and Federspiel, M. J. (2003): Evolutionary pressure of a receptor competitor selects different subgroup a avian leukosis virus escape variants with altered receptors interactions. J. Virol. 77, 10504–10514.

    Federspiel M. J. , 'Evolutionary pressure of a receptor competitor selects different subgroup a avian leukosis virus escape variants with altered receptors interactions ' (2003 ) 77 J. Virol. : 10504 -10514.

    • Search Google Scholar

  • Payne, L. N. (1998): HPRS-103: a retrovirus strikes back. The emergence of subgroup J avian leucosis virus. Avian Pathol. 27, S36–45.

    Payne L. N. , 'HPRS-103: a retrovirus strikes back. The emergence of subgroup J avian leucosis virus ' (1998 ) 27 Avian Pathol. : S36 -45.

    • Search Google Scholar

  • Payne, L. N., Brown, S. R., Bumstead, N., Howes, K., Frazier, J. A. and Thouless, M. E. (1991): A novel subgroup of exogenous avian leukosis virus in chickens. J. Gen. Virol. 72, 801–807.

    Thouless M. E. , 'A novel subgroup of exogenous avian leukosis virus in chickens ' (1991 ) 72 J. Gen. Virol. : 801 -807.

    • Search Google Scholar

  • Qin, A., Lee, L. F., Fadly, A., Hunt, H. and Cui, Z. (2001): Development and characterization of monoclonal antibodies to subgroup J avian leukosis virus. Avian Dis. 45, 938–945.

    Cui Z. , 'Development and characterization of monoclonal antibodies to subgroup J avian leukosis virus ' (2001 ) 45 Avian Dis. : 938 -945.

    • Search Google Scholar

  • Silva, R. F., Fadly, A. M. and Hunt, H. D. (2000): Hypervariability in the envelope genes of subgroup J avian leukosis viruses obtained from different farms in the U.S. Virology 272, 106–111.

    Hunt H. D. , 'Hypervariability in the envelope genes of subgroup J avian leukosis viruses obtained from different farms in the U ' (2000 ) 272 Virology : 106 -111.

    • Search Google Scholar

  • Smith, L. M., Brown, S. R., Howes, K., McLeod, S., Arshad, S. S., Barron, G. S., Venugopal, K., McKay, J. C. and Payne, L. N. (1998): Development and application of PCR tests for the detection of subgroup J avian leukosis virus. Virus Res. 54, 87–98.

    Payne L. N. , 'Development and application of PCR tests for the detection of subgroup J avian leukosis virus ' (1998 ) 54 Virus Res. : 87 -98.

    • Search Google Scholar

  • Smith, L. M., Toye, A. A., Howes, K., Bumstead, N., Payne, L. N. and Venugopal, K. (1999): Novel endogenous retroviral sequences in the chicken genome closely related to HPRS-103 (subgroup J) avian leukosis virus. J. Gen. Virol. 80, 261–268.

    Venugopal K. , 'Novel endogenous retroviral sequences in the chicken genome closely related to HPRS-103 (subgroup J) avian leukosis virus ' (1999 ) 80 J. Gen. Virol. : 261 -268.

    • Search Google Scholar

  • Sun, H. L., Qin, M., Xiao, Y. H., Yang, F., Ni, W. and Liu, S. D. (2010): Haemangiomas, leiomyosarcoma and myeloma caused by subgroup J avian leukosis virus in a commercial layer flock. Acta Vet. Hung. 58, 441–451.

    Liu S. D. , 'Haemangiomas, leiomyosarcoma and myeloma caused by subgroup J avian leukosis virus in a commercial layer flock ' (2010 ) 58 Acta Vet. Hung. : 441 -451.

    • Search Google Scholar

  • Wu, X. P., Qian, K., Qin, A. J., Shen, H. Y., Wang, P. P., Jin, W. J. and Eltahir, Y. M. (2010): Recombinant avian leukosis viruses of subgroup J isolated from field-infected commercial layer chickens with hemangioma and myeloid leukosis possess an insertion in the E element. Vet. Res. Commun. 34, 619–632.

    Eltahir Y. M. , 'Recombinant avian leukosis viruses of subgroup J isolated from field-infected commercial layer chickens with hemangioma and myeloid leukosis possess an insertion in the E element ' (2010 ) 34 Vet. Res. Commun. : 619 -632.

    • Search Google Scholar

  • Xin, C. A., Cao, W. S., Luo, K. J., Zhang, G. H., Ren, T., Xu, C. G. and Liao, M. (2006): Preliminary diagnosis report of the hemangioma suspected of avian leukosis virus infection in commercial layer chicken. Poul. Hus. Dis. Control 11, 2.

    Liao M. , 'Preliminary diagnosis report of the hemangioma suspected of avian leukosis virus infection in commercial layer chicken ' (2006 ) 11 Poul. Hus. Dis. Control : 2 -.

    • Search Google Scholar

  • Xu, B. R., Dong, W. X., He, Z. Q., Yu, Ch. M., Li, N., Feng, X. Y., Lee, L. F. and Li, M. X. (2003): Expression of mutant tumor suppressor gene p53 in egg-type chicken infected with avian leukosis virus subgroup. J. J. Agric. Biotechn. 11, 276–279.

    Li M. X. , 'Expression of mutant tumor suppressor gene p53 in egg-type chicken infected with avian leukosis virus subgroup ' (2003 ) 11 J. J. Agric. Biotechn. : 276 -279.

    • Search Google Scholar

  • Xu, B. R., Dong, W. X., Yu, Ch. M., He, Z. Q., Lv, Y. L., Sun, Y. Z., Feng, X. Y., Li, N., Lee, L. F. and Li, M. X. (2004): Occurrence of avian leukosis virus subgroup J in commercial layer flocks in China. Avian Pathol. 33, 13–17.

    Li M. X. , 'Occurrence of avian leukosis virus subgroup J in commercial layer flocks in China ' (2004 ) 33 Avian Pathol. : 13 -17.

    • Search Google Scholar

  • Zavala, G., Cheng, S. and Jackwood, M. W. (2007): Molecular epidemiology of avian leukosis virus subgroup J and evolutionary history of its 3’ untranslated region. Avian Dis. 51, 942–953.

    Jackwood M. W. , 'Molecular epidemiology of avian leukosis virus subgroup J and evolutionary history of its 3’ untranslated region ' (2007 ) 51 Avian Dis. : 942 -953.

    • Search Google Scholar
Cover Acta Veterinaria Hungarica
Acta Veterinaria Hungarica
Print ISSN:
0236-6290
Online ISSN:
1588-2705
Keywords:
Avian leukosis subgroup J (ALV-J); myeloma; haemangioma; leiomyosarcoma; sequence analysis

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