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  • 1 Cornell University Department of Clinical Sciences Ithaca NY 14853 USA
  • | 2 Cornell University Department of Population Medicine and Diagnostic Sciences, College of Veterinary Medicine Ithaca NY 14853 USA
  • | 3 Rhinebeck Equine 26 Losee Lane Rhinebeck NY USA
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Changes in ELISA serology are frequently used to determine antibiotic treatment success for Lyme disease in horses. This concept was based upon a previous report showing a marked decline in ELISA values in experimentally infected and antibiotic-treated ponies. Changes in Lyme serology following antibiotic treatment in naturally infected horses have not been reported. The objective of this study was to compare Borrelia ELISA antibody concentrations in naturally exposed horses both before and following antibiotic treatment for Lyme disease. A retrospective study was performed comparing oxytetracycline- or doxycyclinetreated (n = 68) and untreated (n = 183) horses from a single equine practice and their change in Borrelia ELISA values over a similar time period. Antibiotictreated horses had a decline in ELISA values in comparison to control horses (P ≤ 0.05) and untreated horses were twice as likely to have their ELISA values increase (OR = 0.5; 95% C.I. = 0.3–0.9) compared to treated horses. The magnitude of the decline in ELISA units following treatments was small compared to that previously reported in experimentally infected and treated ponies. Field-exposed horses with high Borrelia burgdorferi ELISA values who are treated with either oxytetracycline or doxycycline can be expected to have only a small decline in ELISA values following treatment. Persistently high ELISA titres following appropriate treatments for Lyme disease may not, without appropriate clinical signs, be a reason for more prolonged treatment.

  • Barthold, S. W., Levy, S. A., Fikrig, E., Bockenstedt, L. K. and Smith, A. L. (1995): Serologic responses of dogs naturally exposed to or vaccinated against Borrelia burgdorferi infection. J. Am. Vet. Med. Assoc. 207, 1435–1440.

    Smith A. L. , 'Serologic responses of dogs naturally exposed to or vaccinated against Borrelia burgdorferi infection ' (1995 ) 207 J. Am. Vet. Med. Assoc. : 1435 -1440.

    • Search Google Scholar
  • Bryant, J. E., Brown, M. P., Gronwall, R. R. and Merritt, K. A. (2000): Study of intragastric administration of doxycycline: pharmacokinetics including body fluid, endometrial and minimum inhibitor concentrations. Equine Vet. J. 32, 233–238.

    Merritt K. A. , 'Study of intragastric administration of doxycycline: pharmacokinetics including body fluid, endometrial and minimum inhibitor concentrations ' (2000 ) 32 Equine Vet. J. : 233 -238.

    • Search Google Scholar
  • Burgdorfer, W., Barbour, A. G., Hayes, S. F., Benach, J. L., Grunwaldt, E. and Davis, J. P. (1982): Lyme disease — a tick-borne spirochetosis? Science 216, 1317–1319.

    Davis J. P. , 'Lyme disease — a tick-borne spirochetosis? ' (1982 ) 216 Science : 1317 -1319.

    • Search Google Scholar
  • Butler, C. M., Houwers, D. J., Jongejan, F. and van der Kolk, J. H. (2005): Borrelia burgdorferi infections with special reference to horses. A review. Vet. Q. 27, 146–156.

    Kolk J. H. , 'Borrelia burgdorferi infections with special reference to horses ' (2005 ) 27 A review. Vet. Q. : 146 -156.

    • Search Google Scholar
  • Chandrashekar, R., Daniluk, D. and Moffitt, S. (2008): Serologic diagnosis of equine borreliosis: evaluation of an in-clinic enzyme-linked immunosorbent assay (SNAP® 4Dx®). Intern. J. Appl. Res. Vet. Med. 6, 145–150.

    Moffitt S. , 'Serologic diagnosis of equine borreliosis: evaluation of an in-clinic enzyme-linked immunosorbent assay (SNAP® 4Dx®) ' (2008 ) 6 Intern. J. Appl. Res. Vet. Med. : 145 -150.

    • Search Google Scholar
  • Chang, Y. F., Ku, Y. W., Chang, C. F., Chang, C. D., McDonough, S. P., Divers, T., Pough, M. and Torres, A. (2005): Antibiotic treatment of experimentally Borrelia burgdorferiinfected ponies. Vet. Microbiol. 107, 285–294.

    Torres A. , 'Antibiotic treatment of experimentally Borrelia burgdorferiinfected ponies ' (2005 ) 107 Vet. Microbiol. : 285 -294.

    • Search Google Scholar
  • Chang, Y. F., Novosol, V., McDonough, S. P., Chang, C. F., Jacobson, R. H., Divers, T., Quimby, F. W., Shin, S. and Lein, D. H. (2000): Experimental infection of ponies with Borrelia burgdorferi by exposure to Ixodid ticks. Vet. Pathol. 37, 68–76.

    Lein D. H. , 'Experimental infection of ponies with Borrelia burgdorferi by exposure to Ixodid ticks ' (2000 ) 37 Vet. Pathol. : 68 -76.

    • Search Google Scholar
  • DeVilbiss, B. A., Mohammed, H. O. and Divers, T. J. (2009): Perception of equine practitioners regarding the occurrence of selected equine neurologic diseases in the northeast over a 10-year period. J. Equine Vet. Sci. 29, 237–246.

    Divers T. J. , 'Perception of equine practitioners regarding the occurrence of selected equine neurologic diseases in the northeast over a 10-year period ' (2009 ) 29 J. Equine Vet. Sci. : 237 -246.

    • Search Google Scholar
  • Divers, T. J., Mair, T. S. and Chang, Y. F. (2009): Lyme disease in horses. In: Mair, T. S. and Hutchinson, R. E. (eds) Infectious Diseases of the Horse. Equine Veterinary Journal, Ltd., Cambridgeshire, UK. pp. 289–290.

    Chang Y. F. , '', in Infectious Diseases of the Horse , (2009 ) -.

  • Feder, H. M. Jr., Gerber, M. A., Luger, S. W. and Ryan, R. W. (1992): Persistence of serum antibodies to Borrelia burgdorferi in patients treated for Lyme disease. Clin. Infect. Dis. 15, 788–793.

    Ryan R. W. , 'Persistence of serum antibodies to Borrelia burgdorferi in patients treated for Lyme disease ' (1992 ) 15 Clin. Infect. Dis. : 788 -793.

    • Search Google Scholar
  • Fleming, R. V., Marques, A. R., Klempner, M. S., Schmid, C. H., Dally, L. G., Martin, D. S. and Philipp, M. T. (2004): Pre-treatment and post-treatment assessment of the C(6) test in patients with persistent symptoms and a history of Lyme borreliosis. Eur. J. Clin. Microbiol. Infect. Dis. 23, 615–618.

    Philipp M. T. , 'Pre-treatment and post-treatment assessment of the C(6) test in patients with persistent symptoms and a history of Lyme borreliosis ' (2004 ) 23 Eur. J. Clin. Microbiol. Infect. Dis. : 615 -618.

    • Search Google Scholar
  • Girschick, H. J., Morbach, H. and Tappe, D. (2009): Treatment of Lyme borreliosis. Arthritis Res. Ther. 11, 258.

    Tappe D. , 'Treatment of Lyme borreliosis ' (2009 ) 11 Arthritis Res. Ther. : 258 -.

  • Glatz, M., Golestani, M., Kerl, H. and Müllegger, R. R. (2006): Clinical relevance of different IgG and IgM serum antibody responses to Borrelia burgdorferi after antibiotic therapy for erythema migrans. Arch. Dermatol. 142, 862–868.

    Müllegger R. R. , 'Clinical relevance of different IgG and IgM serum antibody responses to Borrelia burgdorferi after antibiotic therapy for erythema migrans ' (2006 ) 142 Arch. Dermatol. : 862 -868.

    • Search Google Scholar
  • Hammers-Berggren, S., Lebech, A. M., Karlsson, M., Svenungsson, B., Hansen, K. and Stiernstedt, G. (1994): Serological follow-up after treatment of patients with erythema migrans and neuroborreliosis. J. Clin. Microbiol. 32, 1519–1525.

    Stiernstedt G. , 'Serological follow-up after treatment of patients with erythema migrans and neuroborreliosis ' (1994 ) 32 J. Clin. Microbiol. : 1519 -1525.

    • Search Google Scholar
  • Imai, D. M., Barr, B. C., Daft, B., Bertone, J. J., Feng, S., Hodzic, E., Johnston, J. M., Olsen, K. J. and Barthold, S. W. (2011): Lyme neuroborreliosis in 2 horses. Vet. Pathol. 48, 1151–1157.

    Barthold S. W. , 'Lyme neuroborreliosis in 2 horses ' (2011 ) 48 Vet. Pathol. : 1151 -1157.

  • Johnson, A. L., Divers, T. J. and Chang, Y. F. (2008): Validation of an in-clinic enzyme-linked immunosorbent assay kit for diagnosis of Borrelia burgdorferi infection in horses. J. Vet. Diagn. Invest. 20, 321–324.

    Chang Y. F. , 'Validation of an in-clinic enzyme-linked immunosorbent assay kit for diagnosis of Borrelia burgdorferi infection in horses ' (2008 ) 20 J. Vet. Diagn. Invest. : 321 -324.

    • Search Google Scholar
  • Kalish, R. A., McHugh, G., Granquist, J., Shea, B., Ruthazer, R. and Steere, A. C. (2001): Persistence of immunoglobulin M or immunoglobulin G antibody responses to Borrelia burgdorferi 10–20 years after active Lyme disease. Clin. Infect. Dis. 33, 780–785.

    Steere A. C. , 'Persistence of immunoglobulin M or immunoglobulin G antibody responses to Borrelia burgdorferi 10–20 years after active Lyme disease ' (2001 ) 33 Clin. Infect. Dis. : 780 -785.

    • Search Google Scholar
  • Kannian, P., McHugh, G., Johnson, B. J., Bacon, R. M., Glickstein, L. J. and Steere, A. C. (2007): Antibody responses to Borrelia burgdorferi in patients with antibiotic-refractory, antibiotic-responsive, or non-antibiotic-treated Lyme arthritis. Arthritis Rheum. 56, 4216–4225.

    Steere A. C. , 'Antibody responses to Borrelia burgdorferi in patients with antibiotic-refractory, antibiotic-responsive, or non-antibiotic-treated Lyme arthritis ' (2007 ) 56 Arthritis Rheum. : 4216 -4225.

    • Search Google Scholar
  • Krause, P. J., Foley, D. T., Burke, G. S., Christianson, D., Closter, L. and Spielman, A. (2006): Reinfection and relapse in early Lyme disease. Am. J. Trop. Med. Hyg. 75, 1090–1094.

    Spielman A. , 'Reinfection and relapse in early Lyme disease ' (2006 ) 75 Am. J. Trop. Med. Hyg. : 1090 -1094.

    • Search Google Scholar
  • Levy, S. A., O’Connor, T. P., Hanscom, J. L., Shields, P., Lorentzen, L. and Dimarco, A. A. (2008): Quantitative measurement of C6 antibody following antibiotic treatment of Borrelia burgdorferi antibody-positive nonclinical dogs. Clin. Vaccine Immunol. 15, 115–119.

    Dimarco A. A. , 'Quantitative measurement of C6 antibody following antibiotic treatment of Borrelia burgdorferi antibody-positive nonclinical dogs ' (2008 ) 15 Clin. Vaccine Immunol. : 115 -119.

    • Search Google Scholar
  • Lomholt, H., Lebech, A. M., Hansen, K., Brandrup, F. and Halkier-Sorensen, L. (2000): Long-term serological follow-up of patients treated for chronic cutaneous borreliosis or culturepositive erythema migrans. Acta Derm. Venereol. 80, 362–366.

    Halkier-Sorensen L. , 'Long-term serological follow-up of patients treated for chronic cutaneous borreliosis or culturepositive erythema migrans ' (2000 ) 80 Acta Derm. Venereol. : 362 -366.

    • Search Google Scholar
  • Magnarelli, L. A. and Fikrig, E. (2005): Detection of antibodies to Borrelia burgdorferi in naturally infected horses in the USA by enzyme-linked immunosorbent assay using whole-cell and recombinant antigens. Res. Vet. Sci. 79, 99–103.

    Fikrig E. , 'Detection of antibodies to Borrelia burgdorferi in naturally infected horses in the USA by enzyme-linked immunosorbent assay using whole-cell and recombinant antigens ' (2005 ) 79 Res. Vet. Sci. : 99 -103.

    • Search Google Scholar
  • Magnarelli, L. A., Ijdo, J. W., Van Andel, A. E., Wu, C., Padula, S. J. and Fikrig, E. (2000): Serologic confirmation of Ehrlichia equi and Borrelia burgdorferi infection in horses from the northeastern United States. J. Am. Vet. Med. Assoc. 217, 1045–1050.

    Fikrig E. , 'Serologic confirmation of Ehrlichia equi and Borrelia burgdorferi infection in horses from the northeastern United States ' (2000 ) 217 J. Am. Vet. Med. Assoc. : 1045 -1050.

    • Search Google Scholar
  • Müllegger, R. and Glatz, M. (2008): Skin manifestations of Lyme borreliosis: diagnosis and management. Am. J. Clin. Dermatol. 9, 355–368.

    Glatz M. , 'Skin manifestations of Lyme borreliosis: diagnosis and management ' (2008 ) 9 Am. J. Clin. Dermatol. : 355 -368.

    • Search Google Scholar
  • Nadelman, R. B. and Wormser, G. P. (2007): Reinfection in patients with Lyme disease. Clin. Infect. Dis. 45, 1032–1038.

    Wormser G. P. , 'Reinfection in patients with Lyme disease ' (2007 ) 45 Clin. Infect. Dis. : 1032 -1038.

    • Search Google Scholar
  • Philipp, M. T., Wormser, G. P., Marques, A. R., Bittker, S., Martin, D. S., Nowakowski, J. and Dally, L. G. (2005): A decline in C6 antibody titer occurs in successfully treated patients with culture-confirmed early localized or early disseminated Lyme borreliosis. Clin. Diagn. Lab. Immunol. 12, 1069–1074.

    Dally L. G. , 'A decline in C6 antibody titer occurs in successfully treated patients with culture-confirmed early localized or early disseminated Lyme borreliosis ' (2005 ) 12 Clin. Diagn. Lab. Immunol. : 1069 -1074.

    • Search Google Scholar
  • Prasad, A. and Sankar, D. (1999): Overdiagnosis and overtreatment of Lyme neuroborreliosis are preventable. Postgrad. Med. 75, 650–656.

    Sankar D. , 'Overdiagnosis and overtreatment of Lyme neuroborreliosis are preventable ' (1999 ) 75 Postgrad. Med. : 650 -656.

    • Search Google Scholar
  • Sears, K. P., Divers, T. J., Neff, R. T., Miller, W. H. J. and McDonough, S. P. (2012): A case of Borrelia-associated cutaneous pseudolymphoma in a horse. Vet. Dermatol. 23, 153–156.

    McDonough S. P. , 'A case of Borrelia-associated cutaneous pseudolymphoma in a horse ' (2012 ) 23 Vet. Dermatol. : 153 -156.

    • Search Google Scholar
  • Shin, S. J., Chang, Y. F., Jacobson, R. H., Shaw, E., Lauderdale, T. L., Appel, M. J. and Lein, D. H. (1993): Cross-reactivity between B. burgdorferi and other spirochetes affects specificity of serotests for detection of antibodies to Lyme disease agent in dogs. Vet. Microbiol. 36, 161–174.

    Lein D. H. , 'Cross-reactivity between B. burgdorferi and other spirochetes affects specificity of serotests for detection of antibodies to Lyme disease agent in dogs ' (1993 ) 36 Vet. Microbiol. : 161 -174.

    • Search Google Scholar
  • Stricker, R. B. (2007): Counterpoint: long-term antibiotic therapy improves persistent symptoms associated with Lyme disease. Clin. Infect. Dis. 45, 149–157.

    Stricker R. B. , 'Counterpoint: long-term antibiotic therapy improves persistent symptoms associated with Lyme disease ' (2007 ) 45 Clin. Infect. Dis. : 149 -157.

    • Search Google Scholar
  • Wagner, B., Freer, H., Rollins, A., Erb, H. N., Lu, Z. and Gröhn, Y. (2011): Development of a multiplex assay for the detection of antibodies to Borrelia burgdorferi in horses and its validation using Bayesian and conventional statistical methods. Vet. Immunol. Immunopathol. 144, 374–378.

    Gröhn Y. , 'Development of a multiplex assay for the detection of antibodies to Borrelia burgdorferi in horses and its validation using Bayesian and conventional statistical methods ' (2011 ) 144 Vet. Immunol. Immunopathol. : 374 -378.

    • Search Google Scholar

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Editor-in-Chief: Mária BENKŐ

Managing Editor: András SZÉKELY

Editorial Board

  • Béla DÉNES (National Food Chain Safety Office, Budapest Hungary)
  • Edit ESZTERBAUER (Veterinary Medical Research Institute, Budapest, Hungary)
  • Hedvig FÉBEL (National Agricultural Innovation Centre, Herceghalom, Hungary)
  • László FODOR (University of Veterinary Medicine, Budapest, Hungary)
  • Balázs HARRACH (Veterinary Medical Research Institute, Budapest, Hungary)
  • Peter MASSÁNYI (Slovak University of Agriculture in Nitra, Nitra, Slovak Republic)
  • Béla NAGY (Veterinary Medical Research Institute, Budapest, Hungary)
  • Tibor NÉMETH (University of Veterinary Medicine, Budapest, Hungary)
  • Zsuzsanna NEOGRÁDY (University of Veterinary Medicine, Budapest, Hungary)
  • Alessandra PELAGALLI (University of Naples Federico II, Naples, Italy)
  • Kurt PFISTER (Ludwig-Maximilians-University of Munich, Munich, Germany)
  • László SOLTI (University of Veterinary Medicine, Budapest, Hungary)
  • József SZABÓ (University of Veterinary Medicine, Budapest, Hungary)
  • Péter VAJDOVICH (University of Veterinary Medicine, Budapest, Hungary)
  • János VARGA (University of Veterinary Medicine, Budapest, Hungary)
  • Štefan VILČEK (University of Veterinary Medicine in Kosice, Kosice, Slovak Republic)
  • Károly VÖRÖS (University of Veterinary Medicine, Budapest, Hungary)
  • Herbert WEISSENBÖCK (University of Veterinary Medicine, Vienna, Austria)
  • Attila ZSARNOVSZKY (Szent István University, Gödöllő, Hungary)

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2020  
Total Cites 987
WoS
Journal
Impact Factor
0,955
Rank by Veterinary Sciences 101/146 (Q3)
Impact Factor  
Impact Factor 0,920
without
Journal Self Cites
5 Year 1,164
Impact Factor
Journal  0,57
Citation Indicator  
Rank by Journal  Veterinary Sciences 93/166 (Q3)
Citation Indicator   
Citable 49
Items
Total 49
Articles
Total 0
Reviews
Scimago 33
H-index
Scimago 0,395
Journal Rank
Scimago Veterinary (miscellaneous) Q2
Quartile Score  
Scopus 355/217=1,6
Scite Score  
Scopus General Veterinary 73/183 (Q2)
Scite Score Rank  
Scopus 0,565
SNIP  
Days from  145
sumbission  
to acceptance  
Days from  150
acceptance  
to publication  
Acceptance 19%
Rate

 

2019  
Total Cites
WoS
798
Impact Factor 0,991
Impact Factor
without
Journal Self Cites
0,897
5 Year
Impact Factor
1,092
Immediacy
Index
0,119
Citable
Items
59
Total
Articles
59
Total
Reviews
0
Cited
Half-Life
9,1
Citing
Half-Life
9,2
Eigenfactor
Score
0,00080
Article Influence
Score
0,253
% Articles
in
Citable Items
100,00
Normalized
Eigenfactor
0,09791
Average
IF
Percentile
42,606
Scimago
H-index
32
Scimago
Journal Rank
0,372
Scopus
Scite Score
335/213=1,6
Scopus
Scite Score Rank
General Veterinary 62/178 (Q2)
Scopus
SNIP
0,634
Acceptance
Rate
18%

 

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Acta Veterinaria Hungarica
Language English
Size A4
Year of
Foundation
1951
Publication
Programme
2020 Volume 68
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per Year
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Founder Magyar Tudományos Akadémia
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