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  • 1 University of Nigeria Department of Veterinary Obstetrics and Reproductive Diseases Nsukka Enugu State Nigeria
  • | 2 University of Nigeria Department of Veterinary Physiology and Pharmacology Nsukka Enugu State Nigeria
  • | 3 University of Nigeria Department of Veterinary Pathology and Microbiology Nsukka Enugu State Nigeria
  • | 4 Ahmadu Bello University Department of Veterinary Surgery and Medicine Zaria Kaduna State Nigeria
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This study investigated the effects of administration of monosodium L-glutamate (MSG) on serum gonadotrophin-releasing hormone (GnRH), luteinising hormone (LH), testosterone and total cholesterol (TC), cauda epididymal sperm reserves (CESR) and testicular histomorphology of adult male albino rats. Eighty-four rats, randomly assigned to 7 groups of 12 rats each, were used for the study. Varying low doses (0.25, 0.50 or 1.00 g/kg body weight) of MSG were administered orally or subcutaneously at 48-h intervals for six weeks. Serum GnRH, LH, testosterone and TC, and CESR were evaluated on days 14, 28 and 42 of MSG administration. Testicular histomorphology was evaluated on day 42. The results showed that the mean serum GnRH, LH and testosterone levels, and the CESR of all the treated groups were significantly (P < 0.05) lower than those of the untreated control on days 14, 28 and 42 of MSG administration. The mean serum TC levels of all the treated groups were also significantly (P < 0.05) lower than those of the control group on days 14 and 28. No lesions were observed on sections of the testes. It was concluded that MSG administration for 14, 28 and 42 days led to significantly lower serum levels of GnRH, LH, testosterone and TC, and significantly lower CESR.

  • Ahluwalia, P. and Malik, V. B. T. (1989): Effects of monosodium glutamate (MSG) on lipids, blood glucose and cholesterol in adult male mice. Toxicol. Lett. 45, 195–198.

    Malik V. B. T. , 'Effects of monosodium glutamate (MSG) on lipids, blood glucose and cholesterol in adult male mice ' (1989 ) 45 Toxicol. Lett. : 195 -198.

    • Search Google Scholar
  • Allain, C. C., Poon, L. S., Chan, C. S., Richmond, W. and Fu, P. C. (1974): Enzymatic determination of total cholesterol. Clin. Chem. 20, 470–475.

    Fu P. C. , 'Enzymatic determination of total cholesterol ' (1974 ) 20 Clin. Chem. : 470 -475.

  • Allen, D. H., Delohery, J. and Baker, G. (1987): Monosodium L-glutamate-induced asthma. J. Allergy Clin. Immunol. 80, 530–537.

    Baker G. , 'Monosodium L-glutamate-induced asthma ' (1987 ) 80 J. Allergy Clin. Immunol. : 530 -537.

    • Search Google Scholar
  • Amman, R. P. and Almquist, J. O. (1961): Reproductive capacity of dairy bulls. 1. Technique for direct measurement of gonadal and extragonadal sperm reserves. J. Dairy Sci. 44, 1537–1539.

    Almquist J. O. , 'Reproductive capacity of dairy bulls. 1. Technique for direct measurement of gonadal and extragonadal sperm reserves ' (1961 ) 44 J. Dairy Sci. : 1537 -1539.

    • Search Google Scholar
  • Bhattacharya, T., Bhakta, A. and Ghosh, S. K. (2011): Long term effect of monosodium glutamate to liver of albino mice after neonatal exposure. Nepal Med. Coll. J. 13, 11–16.

    Ghosh S. K. , 'Long term effect of monosodium glutamate to liver of albino mice after neonatal exposure ' (2011 ) 13 Nepal Med. Coll. J. : 11 -16.

    • Search Google Scholar
  • Bazzano, G., D’Elia, J. A. and Olson, R. E. (1970): Monosodium glutamate: Feeding of large amounts to man and gerbils. Science 169, 1208–1209.

    Olson R. E. , 'Monosodium glutamate: Feeding of large amounts to man and gerbils ' (1970 ) 169 Science : 1208 -1209.

    • Search Google Scholar
  • Bodnár, I., Göőz, P., Okamura, H., Tóth, B. E., Vecsernyés, M., Halász, B. and Nagy, G. M. (2001): Effect of neonatal treatment with monosodium glutamate on dopaminergic and L-DOPA-ergic neurons of the medial basal hypothalamus and on prolactin and MSH secretion of rats. Brain Res. Bull. 55, 767–774.

    Nagy G. M. , 'Effect of neonatal treatment with monosodium glutamate on dopaminergic and L-DOPA-ergic neurons of the medial basal hypothalamus and on prolactin and MSH secretion of rats ' (2001 ) 55 Brain Res. Bull. : 767 -774.

    • Search Google Scholar
  • Dieguez, C., Vozguez, M. J., Roweto, A., Lopez, M. and Nogueiras, R. (2011): Hypothalamic control of lipid metabolism: focus on leptin, ghrelin and melanocortins. Neuroendocrinology 93, 1–11.

    Nogueiras R. , 'Hypothalamic control of lipid metabolism: focus on leptin, ghrelin and melanocortins ' (2011 ) 93 Neuroendocrinology : 1 -11.

    • Search Google Scholar
  • Ebling, F. J., Arthurs, O. J., Turney, B. W. and Cronins, A. S. (1998): Seasonal endocrine rhythms in the male Siberian hamster persist after monosodium glutamate-induced lesions of the arcuate nucleus in the neonatal period. J. Endocrinol. 10, 701–712.

    Cronins A. S. , 'Seasonal endocrine rhythms in the male Siberian hamster persist after monosodium glutamate-induced lesions of the arcuate nucleus in the neonatal period ' (1998 ) 10 J. Endocrinol. : 701 -712.

    • Search Google Scholar
  • Ekins, R. P. (1998): Ligand assays: from electrophoresis to miniaturized microarrays. Clin. Chem. 44, 2015–2030.

    Ekins R. P. , 'Ligand assays: from electrophoresis to miniaturized microarrays ' (1998 ) 44 Clin. Chem. : 2015 -2030.

    • Search Google Scholar
  • FASEB (1995): Analysis of Adverse Reactions to Monosodium Glutamate (MSG) — Report. Life Sciences Research Office, Federation of American Societies for Experimental Biology (FASEB), Washington, D.C.

    '', in Analysis of Adverse Reactions to Monosodium Glutamate (MSG) — Report , (1995 ) -.

  • Fernandes, G. S., Arena, A. C., Campos, K. E., Volpato, G. T., Anselmo-Franci, J. A., Damasceno, D. C. and Kempinos, W. G. (2012): Glutamate induced obesity leads to decreased sperm reserves and acceleration of transit time in the epididymis of adult male rats. Reprod. Biol. Endocrinol. 10, 105–111.

    Kempinos W. G. , 'Glutamate induced obesity leads to decreased sperm reserves and acceleration of transit time in the epididymis of adult male rats ' (2012 ) 10 Reprod. Biol. Endocrinol. : 105 -111.

    • Search Google Scholar
  • FSANZ (Food Standards Australia New Zealand) (2003): Monosodium glutamate: A safety assessment. Technical Report Series No. 20, FSANZ, Canberra.

    '', in Monosodium glutamate: A safety assessment , (2003 ) -.

  • Gallagher, R. (2003): Animal research is for human welfare. Scientist 17, 1–3.

    Gallagher R. , 'Animal research is for human welfare ' (2003 ) 17 Scientist : 1 -3.

  • Gong, S. L., Xia, F. Q., Wei, J., Li, X. Y., Sun, T. H., Lu, Z. and Liu, S. Z. (1995): Harmful effects of MSG on function of hypothalamus-pituitary-target gland system. Biomed. Environ. Sci. 8, 310–317.

    Liu S. Z. , 'Harmful effects of MSG on function of hypothalamus-pituitary-target gland system ' (1995 ) 8 Biomed. Environ. Sci. : 310 -317.

    • Search Google Scholar
  • Hu, J., Zhang, Z., Shen, W. J. and Azhar, S. (2010): Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones. Nutr. Metab. 7, 47–72.

    Azhar S. , 'Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones ' (2010 ) 7 Nutr. Metab. : 47 -72.

    • Search Google Scholar
  • Igwebuike, U. M., Ochiogu, I. S., Ihedinihu, B. C., Ikokide, J. E. and Idika, I. K. (2011): The effects of oral administration of monosodium glutamate (MSG) on the testicular morphology and cauda epididymal sperm reserves of young and adult male rats. Vet. Arhiv 81, 525–534.

    Idika I. K. , 'The effects of oral administration of monosodium glutamate (MSG) on the testicular morphology and cauda epididymal sperm reserves of young and adult male rats ' (2011 ) 81 Vet. Arhiv : 525 -534.

    • Search Google Scholar
  • Inyang, B., Ojewunmi, O. and Ebuehi, O. (2012): Toxicological effects of monosodium glutamate on the liver enzyme markers and lipid profile of adult Wistar rats. Asian J. Biol. Pharmaceut. Res. 3, 266–273.

    Ebuehi O. , 'Toxicological effects of monosodium glutamate on the liver enzyme markers and lipid profile of adult Wistar rats ' (2012 ) 3 Asian J. Biol. Pharmaceut. Res. : 266 -273.

    • Search Google Scholar
  • Ismail, N. H. (2012): Assessment of DNA damage in testes from young Wistar male rats treated with monosodium glutamate. Life Sci. J. 9, 930–939.

    Ismail N. H. , 'Assessment of DNA damage in testes from young Wistar male rats treated with monosodium glutamate ' (2012 ) 9 Life Sci. J. : 930 -939.

    • Search Google Scholar
  • JECFA (The Joint FAO/WHO Expert Committee on Food Additives) (1988): L-glutamic acid and its ammonium, calcium, monosodium and potassium salts. In: Toxicological Evaluation of Certain Food Additives and Contaminants. Cambridge University Press, New York. pp. 97–161.

    '', in Toxicological Evaluation of Certain Food Additives and Contaminants , (1988 ) -.

  • McLachlan, R. I., Wreford, N. G., O’Donnell, L., De Kretser, D. M. and Robertson, D. M. (1996): The endocrine regulation of spermatogenesis: independent roles for testosterone and FSH. J. Endocrinol. 148, 1–9.

    Robertson D. M. , 'The endocrine regulation of spermatogenesis: independent roles for testosterone and FSH ' (1996 ) 148 J. Endocrinol. : 1 -9.

    • Search Google Scholar
  • Meraiyebu, A., Akintayo, C. O., Uzoechi, A. C. and Okere, S. (2012): The effects of orally administered monosodium glutamate (MSG) on blood thrombocyte, blood coagulation and bleeding in rats. J. Pharm. Biol. Sci. 4, 4–8.

    Okere S. , 'The effects of orally administered monosodium glutamate (MSG) on blood thrombocyte, blood coagulation and bleeding in rats ' (2012 ) 4 J. Pharm. Biol. Sci. : 4 -8.

    • Search Google Scholar
  • Mohamed, I. K. (2012): The effects of oral dosage of monosodium glutamate applied for short and long terms on the histology and ultrastructure of testes of adult rats. J. Anim. Vet. Adv. 11, 124–133.

    Mohamed I. K. , 'The effects of oral dosage of monosodium glutamate applied for short and long terms on the histology and ultrastructure of testes of adult rats ' (2012 ) 11 J. Anim. Vet. Adv. : 124 -133.

    • Search Google Scholar
  • Nayanatara, A., Vinodini, N. A., Damodar, C., Ahemed, B., Ramaswamy, C. R., Shabarinath, M. and Bhat, M. R. (2008): Role of ascorbic acid in monosodium glutamate mediated effect on testicular weight, sperm morphology and sperm count in rat testis. J. Chinese Clin. Med. 3, 1–5.

    Bhat M. R. , 'Role of ascorbic acid in monosodium glutamate mediated effect on testicular weight, sperm morphology and sperm count in rat testis ' (2008 ) 3 J. Chinese Clin. Med. : 1 -5.

    • Search Google Scholar
  • Nemeroff, C. B., Lamartiniere, C. A., Mason, G. A., Squibb, R. E., Hong, J. S. and Bondy, S. C. (1981): Marked reduction of gonadal hormone level in rats treated neonatally with monosodium L-glutamate: further evidence for disruption of hypothalamic-pituitary-gonadal axis regulation. Neuroendocrinology 33, 2265–2267.

    Bondy S. C. , 'Marked reduction of gonadal hormone level in rats treated neonatally with monosodium L-glutamate: further evidence for disruption of hypothalamic-pituitary-gonadal axis regulation ' (1981 ) 33 Neuroendocrinology : 2265 -2267.

    • Search Google Scholar
  • Norris, D. O. (1997): Vertebrate Endocrinology. Academic Press, San Diego, CA, USA.

    Norris D. O. , '', in Vertebrate Endocrinology , (1997 ) -.

  • Nosseir, N. S., Ali, N. H. M. and Ebaid, N. (2012): A histological and morphometric study of monosodium glutamate toxic effect on testicular structure and potentiality of recovery in adult albino rats. Res. J. Biol. 2, 66–78.

    Ebaid N. , 'A histological and morphometric study of monosodium glutamate toxic effect on testicular structure and potentiality of recovery in adult albino rats ' (2012 ) 2 Res. J. Biol. : 66 -78.

    • Search Google Scholar
  • Olney, J. W. and Sharpe, L. G. (1969): Brain lesions in an infant rhesus monkey treated with monosodium glutamate. Science 166, 386–388.

    Sharpe L. G. , 'Brain lesions in an infant rhesus monkey treated with monosodium glutamate ' (1969 ) 166 Science : 386 -388.

    • Search Google Scholar
  • Pakarainen, T., Zhang, F., Makela, S., Poutane, M. and Huhtaniemi, I. (2005): Testosterone replacement therapy induces spermatogenesis and partially restores fertility in luteinizing hormone receptor knockout mice. Endocrinology 146, 596–606.

    Huhtaniemi I. , 'Testosterone replacement therapy induces spermatogenesis and partially restores fertility in luteinizing hormone receptor knockout mice ' (2005 ) 146 Endocrinology : 596 -606.

    • Search Google Scholar
  • Palkovits, M., Arimura, A., Brownstein, M., Schally, A. V. and Saavedra, J. M. (1974): Luteinizing hormone-releasing hormone (LH-RH) content of the hypothalamic nuclei in rat. Endocrinology 96, 554–558.

    Saavedra J. M. , 'Luteinizing hormone-releasing hormone (LH-RH) content of the hypothalamic nuclei in rat ' (1974 ) 96 Endocrinology : 554 -558.

    • Search Google Scholar
  • Pizzi, W. J., Barnhart, J. E. and Fanslow, D. J. (1977): Monosodium glutamate administration to the newborn reduces reproductive ability in female and male mice. Science 196, 452–454.

    Fanslow D. J. , 'Monosodium glutamate administration to the newborn reduces reproductive ability in female and male mice ' (1977 ) 196 Science : 452 -454.

    • Search Google Scholar
  • Raiten, D. J., Talbot, J. M. and Fisher, K. D. (eds) (1995): Executive summary from the report: analysis of adverse reactions to monosodium glutamate (MSG). J. Nutr. 125, 2892S–2906S.

    '', in Executive summary from the report: analysis of adverse reactions to monosodium glutamate (MSG) , (1995 ) -.

  • Reynolds, W. A., Lemkey-Johnston, N., Filer, L. J. Jr. and Pitkin, R. M. (1971): Monosodium glutamate: absence of hypothalamic lesions after ingestion by newborn primates. Science 172, 1342–1344.

    Pitkin R. M. , 'Monosodium glutamate: absence of hypothalamic lesions after ingestion by newborn primates ' (1971 ) 172 Science : 1342 -1344.

    • Search Google Scholar
  • Rhodes, J., Titherley, A. C., Norman, J. A., Wood, R. and Lord, D. W. (1991): A survey of the monosodium glutamate content of foods and an estimation of the dietary intake of monosodium glutamate. Food Addit. Contam. 8, 265–274.

    Lord D. W. , 'A survey of the monosodium glutamate content of foods and an estimation of the dietary intake of monosodium glutamate ' (1991 ) 8 Food Addit. Contam. : 265 -274.

    • Search Google Scholar
  • Sahelian, R. (2014): Glutamate benefit and side effects, risk and danger. www.raysahelian.com/glutamate.html . Accessed 25 March 2013

    Sahelian R. , '', in Glutamate benefit and side effects, risk and danger , (2014 ) -.

  • Stocco, D. M. (1998): Testosterone biosynthesis. In: Neill, J. D. and Knobil, E. (eds) Encyclopedia of Reproduction. Volume 4. Academic Press, New York. pp. 784–789.

    Stocco D. M. , '', in Encyclopedia of Reproduction , (1998 ) -.

  • Tafelski, T. J. and Lamperti, A. A. (1977): The effects of a single injection of monosodium glutamate on the reproductive neuroendocrine axis of the female hamster. Biol. Reprod. 17, 404–411.

    Lamperti A. A. , 'The effects of a single injection of monosodium glutamate on the reproductive neuroendocrine axis of the female hamster ' (1977 ) 17 Biol. Reprod. : 404 -411.

    • Search Google Scholar
  • Tordoff, M. G., Aleman, T. R. and Murphy, M. C. (2012): No effects of monosodium glutamate consumption on the body weight or composition of adult rats and mice. Physiol. Behav. 107, 338–345.

    Murphy M. C. , 'No effects of monosodium glutamate consumption on the body weight or composition of adult rats and mice ' (2012 ) 107 Physiol. Behav. : 338 -345.

    • Search Google Scholar
  • Walker, W. H. (2011): Testosterone signaling and the regulation of spermatogenesis. Spermatogenesis 1, 116–120.

    Walker W. H. , 'Testosterone signaling and the regulation of spermatogenesis ' (2011 ) 1 Spermatogenesis : 116 -120.

    • Search Google Scholar
  • Wang, R., Yeh, S., Tzeng, C. and Chang, C. (2009): Androgen receptor roles in spermatogenesis and fertility: Lessons from testicular cell-specific androgen receptor knockout mice. Endocr. Rev. 30, 119–132.

    Chang C. , 'Androgen receptor roles in spermatogenesis and fertility: Lessons from testicular cell-specific androgen receptor knockout mice ' (2009 ) 30 Endocr. Rev. : 119 -132.

    • Search Google Scholar
  • Yang, W. H., Drouin, M. A., Herbert, M., Mao, Y. and Karsh, J. (1997): The monosodium glutamate symptom complex: assessment in a double-blind, placebo-controlled, randomized study. J. Allergy Clin. Immunol. 99, 757–762.

    Karsh J. , 'The monosodium glutamate symptom complex: assessment in a double-blind, placebo-controlled, randomized study ' (1997 ) 99 J. Allergy Clin. Immunol. : 757 -762.

    • Search Google Scholar

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Editor-in-Chief: Mária BENKŐ

Managing Editor: András SZÉKELY

Editorial Board

  • Béla DÉNES (National Food Chain Safety Office, Budapest Hungary)
  • Edit ESZTERBAUER (Veterinary Medical Research Institute, Budapest, Hungary)
  • Hedvig FÉBEL (National Agricultural Innovation Centre, Herceghalom, Hungary)
  • László FODOR (University of Veterinary Medicine, Budapest, Hungary)
  • Balázs HARRACH (Veterinary Medical Research Institute, Budapest, Hungary)
  • Peter MASSÁNYI (Slovak University of Agriculture in Nitra, Nitra, Slovak Republic)
  • Béla NAGY (Veterinary Medical Research Institute, Budapest, Hungary)
  • Tibor NÉMETH (University of Veterinary Medicine, Budapest, Hungary)
  • Zsuzsanna NEOGRÁDY (University of Veterinary Medicine, Budapest, Hungary)
  • Alessandra PELAGALLI (University of Naples Federico II, Naples, Italy)
  • Kurt PFISTER (Ludwig-Maximilians-University of Munich, Munich, Germany)
  • László SOLTI (University of Veterinary Medicine, Budapest, Hungary)
  • József SZABÓ (University of Veterinary Medicine, Budapest, Hungary)
  • Péter VAJDOVICH (University of Veterinary Medicine, Budapest, Hungary)
  • János VARGA (University of Veterinary Medicine, Budapest, Hungary)
  • Štefan VILČEK (University of Veterinary Medicine in Kosice, Kosice, Slovak Republic)
  • Károly VÖRÖS (University of Veterinary Medicine, Budapest, Hungary)
  • Herbert WEISSENBÖCK (University of Veterinary Medicine, Vienna, Austria)
  • Attila ZSARNOVSZKY (Szent István University, Gödöllő, Hungary)

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2019  
Total Cites
WoS
798
Impact Factor 0,991
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without
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Acta Veterinaria Hungarica
Language English
Size A4
Year of
Foundation
1951
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2020 Volume 68
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per Year
1
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4
Founder Magyar Tudományos Akadémia
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ISSN 0236-6290 (Print)
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