Authors:
Ivanka Cizelj University of Ljubljana, Groblje 3, SI-1230 Domžale, Slovenia

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Daliborka Dušanić University of Ljubljana, Groblje 3, SI-1230 Domžale, Slovenia

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Dušan Benčina University of Ljubljana, Groblje 3, SI-1230 Domžale, Slovenia

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Mojca Narat University of Ljubljana, Groblje 3, SI-1230 Domžale, Slovenia

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The complex interplay between Mycoplasma synoviae and chicken chondrocytes (CCH), which come into direct contact during infectious synovitis, has been examined at the level of gene expression. Our previous studies demonstrated a significant influence of M. synoviae on the level of CCH gene expression. Here, we show for the first time that in vitro co-cultivation of M. synoviae and CCH also induces upregulation of gene expression in this mycoplasma. We observed significantly increased expression of genes important for M. synoviae pathogenicity, including cysteine protease cysP, neuraminidase nanH, haemagglutinin vlhA, and the putative nuclease MS53_0284. Moreover, the pattern of gene expression was dependent on the infection environment. In CCH, significant changes in the expression of genes encoding catabolic enzymes of the cartilage extracellular matrix (cathepsins B, K and L, aggrecanase ADAM10, and matrix metalloproteinase MMP2) were demonstrated. Infection of CCH with M. synoviae also elevated the expression of the gene encoding peptidyl arginine deiminase, type III (PADI3), which is responsible for the post-translational citrullination of proteins.

  • Bartok, B. and Firestein, G. S. (2010): Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol. Rev. 233, 233255.

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  • Bercic, R. L., Cizelj, I., Dušanic, D., Narat, M., Zorman-Rojs, O., Dovc, P. and Bencina, D. (2011): Neuraminidase of Mycoplasma synoviae desialylates heavy chain of the chicken immunoglobulin G and glycoproteins of chicken tracheal mucus. Avian Pathol. 40, 299308.

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  • Cecchini, K. R., Gorton, T. S. and Geary, S. J. (2007): Transcriptional responses of Mycoplasma gallisepticum strain R in association with eukaryotic cells. J. Bacteriol. 189, 58035807.

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    • Export Citation
  • Cizelj, I., Bercic, R. L., Dušanic, D., Narat, M., Kos, J., Dovc, P. and Bencina, D. (2011): Mycoplasma gallisepticum and Mycoplasma synoviae express a cysteine protease CysP, which can cleave chicken IgG into Fab and Fc. Microbiology 157, 362372.

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  • Dušanic, D., Bencina, D., Oven, I., Cizelj, I., Bencina, M. and Narat, M. (2012): Mycoplasma synoviae induces upregulation of apoptotic genes, secretion of nitric oxide and appearance of an apoptotic phenotype in infected chicken chondrocytes. Vet. Res. 43, 7.

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  • Dušanic, D., Bercic, R. L., Cizelj, I., Salmic, S., Narat, M. and Bencina, D. (2009): Mycoplasma synoviae invades non-phagocytic chicken cells in vitro. Vet. Microbiol. 138, 114119.

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  • Goldring, M. B. and Marcu, K. B. (2009): Cartilage homeostasis in health and rheumatic diseases. Arthritis Res. Ther. 11, 224.

  • Hallamaa, K. M., Tang, S. L., Ficorilli, N. and Browning, G. F. (2008): Differential expression of lipoprotein genes in Mycoplasma pneumoniae after contact with human lung epithelial cells, and under oxidative and acidic stress. BMC Microbiol. 8, 124.

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  • Kerr, K. M. and Olson, N. O. (1970): Pathology of chickens inoculated experimentally or contactinfected with Mycoplasma synoviae. Avian Dis. 14, 290320.

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  • Lockaby, S. B., Hoerr, F. J., Lauerman, L. H. and Kleven, S. H. (1998): Pathogenicity of Mycoplasma synoviae in broiler chickens. Vet. Pathol. 35, 178190.

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    • Export Citation
  • Morrow, C. J., Whithear, K. G. and Kleven, S. H. (1990): Restriction endonuclease analysis of Mycoplasma synoviae strains. Avian Dis. 34, 611616.

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  • Narat, M., Bencina, D., Kleven, S. H. and Habe, F. (1998): The hemagglutination-positive phenotype of Mycoplasma synoviae induces experimental infectious synovitis in chickens more frequently than does the hemagglutination-negative phenotype. Infect. Immun. 66, 60046009.

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    • Export Citation
  • Noormohammadi, A. H., Markham, P. F., Whithear, K. G., Walker, I. D., Gurevich, V. A., Ley, D. H. and Browning, G. F. (1997): Mycoplasma synoviae has two distinct phase-variable major membrane antigens, one of which is a putative hemagglutinin. Infect. Immun. 65, 25422547.

    • Search Google Scholar
    • Export Citation
  • Novak, J. F., Hayes, J. D. and McMaster, J. H. (1995): Mycoplasma-mediated bone resorption in bone organ cultures. Microbios 81, 241260.

    • Search Google Scholar
    • Export Citation
  • Pfaffl, M. W. (2001): A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29, e45.

  • Razin, S., Yogev, D. and Naot, Y. (1998): Molecular biology and pathogenicity of mycoplasmas. Microbiol. Mol. Biol. Rev. 62, 10941156.

    • Search Google Scholar
    • Export Citation
  • Rodwell, A. W. and Whitcomb, R. F. (1983): Methods for direct and indirect measurement of mycoplasma growth. In: Tully, J. G. and Razin, S. (eds) Methods in Mycoplasmology. Academic Press, New York–London. pp. 185196.

    • Search Google Scholar
    • Export Citation
  • Uysal, H., Nandakumar, K. S., Kessel, C., Haag, S., Carlsen, S., Burkhardt, H. and Holmdahl, R. (2010): Antibodies to citrullinated proteins: molecular interactions and arthritogenicity. Immunol. Rev. 233, 933.

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  • Vasconcelos, A. T., Ferreira, H. B., Bizarro, C. V., Bonatto, S. L., Carvalho, M. O., Pinto, P. M., Almeida, D. F., Almeida, L. G., Almeida, R., Alves-Filho, L., Assuncao, E. N., Azevedo, V. A., Bogo, M. R., Brigido, M. M., Brocchi, M., Burity, H. A., Camargo, A. A., Camargo, S. S., Carepo, M. S., Carraro, D. M., de Mattos Cascardo, J. C., Castro, L. A., Cavalcanti, G., Chemale, G., Collevatti, R. G., Cunha, C. W., Dallagiovanna, B., Dambros, B. P., Dellagostin, O. A., Falcao, C., Fantinatti-Garboggini, F., Felipe, M. S., Fiorentin, L., Franco, G. R., Freitas, N. S., Frias, D., Grangeiro, T. B., Grisard, E. C., Guimaraes, C. T., Hungria, M., Jardim, S. N., Krieger, M. A., Laurino, J. P., Lima, L. F., Lopes, M. I., Loreto, E. L., Madeira, H. M., Manfio, G. P., Maranhao, A. Q., Martinkovics, C. T., Medeiros, S. R., Moreira, M. A., Neiva, M., Ramalho-Neto, C. E., Nicolas, M. F., Oliveira, S. C., Paixao, R. F., Pedrosa, F. O., Pena, S. D., Pereira, M., Pereira-Ferrari, L., Piffer, I., Pinto, L. S., Potrich, D. P., Salim, A. C., Santos, F. R., Schmitt, R., Schneider, M. P., Schrank, A., Schrank, I. S., Schuck, A. F., Seuanez, H. N., Silva, D. W., Silva, R., Silva, S. C., Soares, C. M., Souza, K. R., Souza, R. C., Staats, C. C., Steffens, M. B., Teixeira, S. M., Urmenyi, T. P., Vainstein, M. H., Zuccherato, L. W., Simpson, A. J. and Zaha, A. (2005): Swine and poultry pathogens: the complete genome sequences of two strains of Mycoplasma hyopneumoniae and a strain of Mycoplasma synoviae. J. Bacteriol. 187, 55685577.

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  • Vossenaar, E. R., Radstake, T. R., van der Heijden, A., van Mansum, M. A., Dieteren, C., de Rooij, D. J., Barrera, P., Zendman, A. J. and van Venrooij, W. J. (2004): Expression and activity of citrullinating peptidylarginine deiminase enzymes in monocytes and macrophages. Ann. Rheum. Dis. 63, 373381.

    • Search Google Scholar
    • Export Citation
  • Yamada, R. (2005): Peptidylarginine deiminase type 4, anticitrullinated peptide antibodies, and rheumatoid arthritis. Autoimmun. Rev. 4, 201206.

    • Search Google Scholar
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Senior editors

Editor-in-Chief: Ferenc BASKA

 

Editorial Board

  • Béla DÉNES (National Food Chain Safety Office, Budapest Hungary)
  • Edit ESZTERBAUER (Veterinary Medical Research Institute, Budapest, Hungary)
  • Hedvig FÉBEL (National Agricultural Innovation Centre, Herceghalom, Hungary)
  • László FODOR (University of Veterinary Medicine, Budapest, Hungary)
  • Balázs HARRACH (Veterinary Medical Research Institute, Budapest, Hungary)
  • Peter MASSÁNYI (Slovak University of Agriculture in Nitra, Nitra, Slovak Republic)
  • Béla NAGY (Veterinary Medical Research Institute, Budapest, Hungary)
  • Tibor NÉMETH (University of Veterinary Medicine, Budapest, Hungary)
  • Zsuzsanna NEOGRÁDY (University of Veterinary Medicine, Budapest, Hungary)
  • Alessandra PELAGALLI (University of Naples Federico II, Naples, Italy)
  • Kurt PFISTER (Ludwig-Maximilians-University of Munich, Munich, Germany)
  • László SOLTI (University of Veterinary Medicine, Budapest, Hungary)
  • József SZABÓ (University of Veterinary Medicine, Budapest, Hungary)
  • Péter VAJDOVICH (University of Veterinary Medicine, Budapest, Hungary)
  • János VARGA (University of Veterinary Medicine, Budapest, Hungary)
  • Štefan VILČEK (University of Veterinary Medicine in Kosice, Kosice, Slovak Republic)
  • Károly VÖRÖS (University of Veterinary Medicine, Budapest, Hungary)
  • Herbert WEISSENBÖCK (University of Veterinary Medicine, Vienna, Austria)
  • Attila ZSARNOVSZKY (Szent István University, Gödöllő, Hungary)

ACTA VETERINARIA HUNGARICA
Institute for Veterinary Medical Research
Centre for Agricultural Research
Hungarian Academy of Sciences
P.O. Box 18, H-1581 Budapest, Hungary
Phone: (36 1) 287 7073 (ed.-in-chief) or (36 1) 467 4081 (editor)

E-mail: acta.veterinaria@univet.hu (ed.-in-chief)

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2022  
Web of Science  
Total Cites
WoS
972
Journal Impact Factor 0.900
Rank by Impact Factor

Veterinary Sciences 95/143

Impact Factor
without
Journal Self Cites
0.900
5 Year
Impact Factor
1.1
Journal Citation Indicator 0.47
Rank by Journal Citation Indicator

Veterinary Sciences 103/170

Scimago  
Scimago
H-index
38
Scimago
Journal Rank
0.277
Scimago Quartile Score

Veterinary (miscellaneous) Q2

Scopus  
Scopus
Cite Score
1.9
Scopus
CIte Score Rank
General Veterinary 76/186 (59th PCTL)
Scopus
SNIP
0.475

2021  
Web of Science  
Total Cites
WoS
1040
Journal Impact Factor 0,959
Rank by Impact Factor Veterinary Sciences 103/144
Impact Factor
without
Journal Self Cites
0,876
5 Year
Impact Factor
1,222
Journal Citation Indicator 0,48
Rank by Journal Citation Indicator Veterinary Sciences 106/168
Scimago  
Scimago
H-index
36
Scimago
Journal Rank
0,313
Scimago Quartile Score Veterinary (miscellaneous) (Q2)
Scopus  
Scopus
Cite Score
1,7
Scopus
CIte Score Rank
General Veterinary 79/183 (Q2)
Scopus
SNIP
0,610

2020  
Total Cites 987
WoS
Journal
Impact Factor
0,955
Rank by Veterinary Sciences 101/146 (Q3)
Impact Factor  
Impact Factor 0,920
without
Journal Self Cites
5 Year 1,164
Impact Factor
Journal  0,57
Citation Indicator  
Rank by Journal  Veterinary Sciences 93/166 (Q3)
Citation Indicator   
Citable 49
Items
Total 49
Articles
Total 0
Reviews
Scimago 33
H-index
Scimago 0,395
Journal Rank
Scimago Veterinary (miscellaneous) Q2
Quartile Score  
Scopus 355/217=1,6
Scite Score  
Scopus General Veterinary 73/183 (Q2)
Scite Score Rank  
Scopus 0,565
SNIP  
Days from  145
submission  
to acceptance  
Days from  150
acceptance  
to publication  
Acceptance 19%
Rate

 

2019  
Total Cites
WoS
798
Impact Factor 0,991
Impact Factor
without
Journal Self Cites
0,897
5 Year
Impact Factor
1,092
Immediacy
Index
0,119
Citable
Items
59
Total
Articles
59
Total
Reviews
0
Cited
Half-Life
9,1
Citing
Half-Life
9,2
Eigenfactor
Score
0,00080
Article Influence
Score
0,253
% Articles
in
Citable Items
100,00
Normalized
Eigenfactor
0,09791
Average
IF
Percentile
42,606
Scimago
H-index
32
Scimago
Journal Rank
0,372
Scopus
Scite Score
335/213=1,6
Scopus
Scite Score Rank
General Veterinary 62/178 (Q2)
Scopus
SNIP
0,634
Acceptance
Rate
18%

 

Acta Veterinaria Hungarica
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Acta Veterinaria Hungarica
Language English
Size A4
Year of
Foundation
1951
Volumes
per Year
1
Issues
per Year
4
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-6290 (Print)
ISSN 1588-2705 (Online)

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