Epidemiological and pathological features of primary cardiac tumours in dogs from Poland in 1970–2014

Izabela Janus; Marcin Nowak; Agnieszka Noszczyk-Nowak; Rafał Ciaputa; Małgorzata Kandefer-Gola; Urszula Pasławska; Rafał Sapierzyński; Wojciech Łopuszyński; Iwona Otrocka-Domagała

doi:10.1556/004.2016.010

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Acta Veterinaria Hungarica

Volume/Issue:: Volume 64: Issue 1

Epidemiological and pathological features of primary cardiac tumours in dogs from Poland in 1970–2014

Authors:

Izabela Janus

Izabela Janus Department of Pathology, Wroclaw University of Environmental and Life Sciences, C. K. Norwida 31, 50375 Wroclaw, Poland

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Marcin Nowak

Marcin Nowak Department of Pathology, Wroclaw University of Environmental and Life Sciences, C. K. Norwida 31, 50375 Wroclaw, Poland

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Agnieszka Noszczyk-Nowak

Agnieszka Noszczyk-Nowak Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, C. K. Norwida 31, 50375 Wroclaw, Poland

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Rafał Ciaputa

Rafał Ciaputa Department of Pathology, Wroclaw University of Environmental and Life Sciences, C. K. Norwida 31, 50375 Wroclaw, Poland

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Małgorzata Kandefer-Gola

Małgorzata Kandefer-Gola Department of Pathology, Wroclaw University of Environmental and Life Sciences, C. K. Norwida 31, 50375 Wroclaw, Poland

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Urszula Pasławska

Urszula Pasławska Department of Internal Medicine and Clinic of Diseases of Horses, Dogs and Cats, Wroclaw University of Environmental and Life Sciences, C. K. Norwida 31, 50375 Wroclaw, Poland

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Rafał Sapierzyński

Rafał Sapierzyński Department of Pathology and Veterinary Diagnostics, Faculty of Veterinary Medicine Warsaw University of Life Sciences (SGGW), Warsaw, Poland

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Wojciech Łopuszyński

Wojciech Łopuszyński Department of Pathological Anatomy, Faculty of Veterinary Medicine, University of Life Sciences, Lublin, Poland

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, and

Iwona Otrocka-Domagała

Iwona Otrocka-Domagała Department of Pathological Anatomy, Warmia and Mazury University in Olsztyn, Olsztyn, Poland

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Pages:: 90–102

Online Publication Date:: Mar 2016

Publication Date:: 01 Mar 2016

Article Category:: Journal Article

DOI:: https://doi.org/10.1556/004.2016.010

Keywords:: Cardiac tumour; haemangiosarcoma; immunohistochemistry; dog

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Primary heart tumours affect less than 1% of dogs. Due to their rare incidence, every research showing the frequency of cardiac tumours is valuable. Routine diagnostics is often complemented with immunohistochemical analysis. This study was conducted on 110 patient records from all veterinary faculties in Poland from dogs diagnosed with heart tumours between 1970 and 2014. The dogs’ age, breed and sex with tumour localisation and histopathological diagnosis were analysed. Because of its most common incidence, samples of haemangiosarcoma underwent further examination with assessment of the expression of cell markers that have not been evaluated earlier (i.e. minichromosome maintenance proteins and beta-catenin). We noted 111 tumours including 88.3% malignant and 10.8% benign ones. Haemangiosarcoma and aortic body tumour were the most frequent cardiac neoplasms in the dogs examined (45.9% and 27.9% of all tumours, respectively). Immunohistochemical analysis of haemangiosarcoma showed a positive expression of all markers examined. CD31, vimentin, and beta-catenin showed a positive reaction in all 11 samples examined. At least one proliferative marker (Ki-67, MCM-3 or MCM-7) showed a positive reaction in each sample. MCM-3 showed a higher expression than the two other proliferative markers (P = 0.006), but only Ki-67 showed a positive correlation with the mitotic index (P > 0.05, r = 0.89). Although beta-catenin, MCM-3 and MCM-7 showed a positive reaction in the haemangiosarcomas examined, their usefulness as diagnostic and prognostic factors should be a topic of further research.

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Acta Veterinaria Hungarica

Print ISSN:: 0236-6290

Online ISSN:: 1588-2705

Editorial Board

Mária BENKŐ (Acta Veterinaria Hungarica, Budapest, Hungary)
Gábor BODÓ (University of Veterinary Medicine, Budapest, Hungary)
Béla DÉNES (University of Veterinary Medicine, Budapest Hungary)
Edit ESZTERBAUER (Veterinary Medical Research Institute, Budapest, Hungary)
Hedvig FÉBEL (University of Veterinary Medicine, Budapest, Hungary)
László FODOR (University of Veterinary Medicine, Budapest, Hungary)
János GÁL (University of Veterinary Medicine, Budapest, Hungary)
Balázs HARRACH (Veterinary Medical Research Institute, Budapest, Hungary)
Peter MASSÁNYI (Slovak University of Agriculture in Nitra, Nitra, Slovak Republic)
Béla NAGY (Veterinary Medical Research Institute, Budapest, Hungary)
Tibor NÉMETH (University of Veterinary Medicine, Budapest, Hungary)
Zsuzsanna NEOGRÁDY (University of Veterinary Medicine, Budapest, Hungary)
Dušan PALIĆ (Ludwig Maximilian University, Munich, Germany)
Alessandra PELAGALLI (University of Naples Federico II, Naples, Italy)
Kurt PFISTER (Ludwig-Maximilians-University of Munich, Munich, Germany)
László SOLTI (University of Veterinary Medicine, Budapest, Hungary)
József SZABÓ (University of Veterinary Medicine, Budapest, Hungary)
Péter VAJDOVICH (University of Veterinary Medicine, Budapest, Hungary)
János VARGA (University of Veterinary Medicine, Budapest, Hungary)
Štefan VILČEK (University of Veterinary Medicine in Kosice, Kosice, Slovak Republic)
Károly VÖRÖS (University of Veterinary Medicine, Budapest, Hungary)
Herbert WEISSENBÖCK (University of Veterinary Medicine, Vienna, Austria)
Attila ZSARNOVSZKY (Szent István University, Gödöllő, Hungary)

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Acta Veterinaria Hungarica
Language	English
Size	A4
Year of Foundation	1951
Volumes per Year	1
Issues per Year	4
Founder	Magyar Tudományos Akadémia
Founder's Address	H-1051 Budapest, Hungary, Széchenyi István tér 9.
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ISSN	0236-6290 (Print)
ISSN	1588-2705 (Online)