View More View Less
  • 1 Hungarian Academy of Sciences, Hungária krt. 21, H-1143 Budapest, Hungary
  • 2 Szent István University, Budapest, Hungary
  • 3 National Food Chain Safety Office, Budapest, Hungary
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $836.00

The susceptibility of 29 Bacillus anthracis strains, collected in Hungary between 1933 and 2014, was tested to 10 antibiotics with commercially available minimum inhibitory concentration (MIC) test strips. All strains were susceptible to amoxicillin, ciprofloxacin, clindamycin, doxycycline, gentamicin, penicillin, rifampicin, and vancomycin. Intermediate susceptibility to erythromycin and cefotaxime was detected in 17.2% (5/29) and 58.6% (17/29) of the strains, respectively. Correlations were not observed between the isolation date, location, host species, genotype, and antibiotic susceptibility profile of strains.

  • Birdsell, D. N., Pearson, T., Price, E. P., Hornstra, H. M., Nera, R. D., Stone, N., Gruendike, J., Kaufman, E. L., Pettus, A. H., Hurbon, A. N., Buchhagen, J. L., Harms, N. J., Chanturia, G., Gyuranecz, M., Wagner, D. M. and Keim, P. S. (2012): Melt analysis of mismatch amplification mutation assays (Melt-MAMA): a functional study of a cost-effective SNP genotyping assay in bacterial models. PLoS One 7, e32866.

    • Search Google Scholar
    • Export Citation
  • Caplan, D. M., Ivana, S. and Caplan, M. E. (2009): Susceptibility to antibiotics of Bacillus anthracis strains isolated in Romania. Roum. Arch. Microbiol. Immunol. 68, 106110.

    • Search Google Scholar
    • Export Citation
  • Cavallo, J. D., Ramisse, F., Girardet, M., Vaissaire, J., Mock, M. and Hernandez, E. (2002): Antibiotic susceptibilities of 96 isolates of Bacillus anthracis isolated in France between 1994 and 2000. Antimicrob. Agents Chemother. 46, 23072309.

    • Search Google Scholar
    • Export Citation
  • Clinical and Laboratory Standards Institute (2011): Performance Standards for Antimicrobial Susceptibility Testing: Thirtieth Informational Supplement M45-A2. CLSI, Wayne, PA, USA.

    • Search Google Scholar
    • Export Citation
  • Coker, P. R., Smith, K. L. and Hugh-Jones, M. E. (2002): Antimicrobial susceptibilities of diverse Bacillus anthracis isolates. Antimicrob. Agents Chemother. 46, 38433845.

    • Search Google Scholar
    • Export Citation
  • Doganay, M. and Aydin, N. (1991): Antimicrobial susceptibility of Bacillus anthracis. Scand. J. Infect. Dis. 23, 333335.

  • Easterday, W. R., Van Ert, M. N., Simonson, T. S., Wagner, D. M., Kenefic, L. J., Allender, C. J. and Keim, P. (2005): Use of single nucleotide polymorphisms in the plcR gene for specific identification of Bacillus anthracis. J. Clin. Microbiol. 43, 19951997.

    • Search Google Scholar
    • Export Citation
  • Fasanella, A., Galante, D., Garofolo, G. and Jones, M. H. (2010): Anthrax undervalued zoonosis. Vet. Microbiol. 140, 318331.

  • Habrun, B., Racic, I., Kompes, G., Spicic, S., Benic, M., Mihaljevic, Z. and Cvetnic, Z. (2011): The antimicrobial susceptibility and virulence factors of Bacillus anthracis strains isolated in Croatia. Veterinarni Medicina 56, 2227.

    • Search Google Scholar
    • Export Citation
  • Hanczaruk, M., Reischl, U., Holzmann, T., Frangoulidis, D., Wagner, D. M., Keim, P. S., Antwerpen, M. H., Meyer, H. and Grass, G. (2014): Injectional anthrax in heroin users, Europe, 2000–2012. Emerg. Infect. Dis. 20, 322323.

    • Search Google Scholar
    • Export Citation
  • Lightfoot, N. F., Scott, R. J. D. and Turnbull, P. C. B. (1990): Antimicrobial susceptibility of Bacillus anthracis. Salisbury Med. Bull. 68, 9598.

    • Search Google Scholar
    • Export Citation
  • Luna, V. A., King, D. S., Gulledge, J., Cannons, A. C., Amuso, P. T. and Cattani, J. (2007): Susceptibility of Bacillus anthracis, Bacillus cereus, Bacillus mycoides, Bacillus pseudomycoides and Bacillus thuringiensis to 24 antimicrobials using Sensititre automated microbroth dilution and Etest agar gradient diffusion methods. J. Antimicrob. Chemother. 60, 555567.

    • Search Google Scholar
    • Export Citation
  • Mohammed, M. J., Marston, C. K., Popovic, T., Weyant, R. S. and Tenover, F. C. (2002): Antimicrobial susceptibility testing of Bacillus anthracis: comparison of results obtained by using the National Committee for Clinical Laboratory Standards broth microdilution reference and Etest agar gradient diffusion methods. J. Clin. Microbiol. 40, 19021907.

    • Search Google Scholar
    • Export Citation
  • Odendaal, M. W., Pieterson, P. M., de Vos, V. and Botha, A. D. (1991): The antibiotic sensitivity patterns of Bacillus anthracis isolated from the Kruger National Park. Onderstepoort J. Vet. Res. 58, 1719.

    • Search Google Scholar
    • Export Citation
  • Ortatatli, M., Karagoz, A., Percin, D., Kenar, L., Kilic, S. and Durmaz, R. (2012): Antimicrobial susceptibility and molecular subtyping of 55 Turkish Bacillus anthracis strains using 25- loci multiple-locus VNTR analysis. Comp. Immunol. Microbiol. Infect. Dis. 35, 355361.

    • Search Google Scholar
    • Export Citation
  • Quinn, P. J., Markey, B. K., Leonard, F. C., Hartigan, P., Fanning, S. and FitzPatrick, E. S. (2011): Veterinary Microbiology and Microbial Disease. 2nd edition. Blackwell, Oxford.

    • Search Google Scholar
    • Export Citation
  • Turnbull, P. C., Sirianni, N. M., LeBron, C. I., Samaan, M. N., Sutton, F. N., Reyes, A. E. and Peruski, L. F. Jr. (2004): MICs of selected antibiotics for Bacillus anthracis, Bacillus cereus, Bacillus thuringiensis, and Bacillus mycoides from a range of clinical and environmental sources as determined by the Etest. J. Clin. Microbiol. 42, 36263634.

    • Search Google Scholar
    • Export Citation
  • Van Ert, M. N., Easterday, W. R., Huynh, L. Y., Okinaka, R. T., Hugh-Jones, M. E., Ravel, J., Zanecki, S. R., Pearson, T., Simonson, T. S., U’Ren, J. M., Kachur, S. M., Leadem-Dougherty, R. R., Rhoton, S. D., Zinser, G., Farlow, J., Coker, P. R., Smith, K. L., Wang, B., Kenefic, L. J., Fraser-Liggett, C. M., Wagner, D. M. and Keim, P. (2007): Global genetic population structure of Bacillus anthracis. PloS One 2, e461.

    • Search Google Scholar
    • Export Citation
  • World Health Organization and International Office of Epizootics (2008): Anthrax in humans and animals. WHO, Geneva, Switzerland.

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Sep 2020 9 0 0
Oct 2020 7 0 0
Nov 2020 14 0 0
Dec 2020 11 0 0
Jan 2021 11 0 0
Feb 2021 11 0 0
Mar 2021 3 0 0