View More View Less
  • 1 Chonbuk National University, 820-120, Hana-ro, Iksan, Jeonbuk 570-390, Republic of Korea
  • | 2 Chonbuk National University, Jeonju, Republic of Korea
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $836.00

Prion protein is encoded by the prion protein gene (PRNP). Polymorphisms of several members of the prion gene family have shown association with prion diseases in several species. Recent studies on a novel member of the prion gene family in rams have shown that prion-related protein gene (PRNT) has a linkage with codon 26 of prion-like protein (PRND). In a previous study, codon 26 polymorphism of PRND has shown connection with PRNP haplotype which is strongly associated with scrapie vulnerability. In addition, the genotype of a single nucleotide polymorphism (SNP) at codon 26 of PRND is related to fertilisation capacity. These findings necessitate studies on the SNP of PRNT gene which is connected with PRND. In goat, several polymorphism studies have been performed for PRNP, PRND, and shadow of prion protein gene (SPRN). However, polymorphism on PRNT has not been reported. Hence, the objective of this study was to determine the genotype and allelic distribution of SNPs of PRNT in 238 Korean native goats and compare PRNT DNA sequences between Korean native goats and several ruminant species. A total of five SNPs, including PRNT c.-114G > T, PRNT c.-58A > G in the upstream of PRNT gene, PRNT c.71C > T (p.Ala24Val) and PRNT c.102G > A in the open reading frame (ORF) and c.321C > T in the downstream of PRNT gene, were found in this study. All five SNPs of caprine PRNT gene in Korean native goat are in complete linkage disequilibrium (LD) with a D’ value of 1.0. Interestingly, comparative sequence analysis of the PRNT gene revealed five mismatches between DNA sequences of Korean native goats and those of goats deposited in the GenBank. Korean native black goats also showed 5 mismatches in PRNT ORF with cattle. To the best of our knowledge, this is the first genetic research of the PRNT gene in goat.

  • Behrens, A., Genoud, N., Naumann, H., Rulicke, T., Janett, F., Heppner, F. L., Ledermann, B. and Aguzzi, A. (2002): Absence of the prion protein homologue Doppel causes male sterility. EMBO J. 21, 36523658.

    • Search Google Scholar
    • Export Citation
  • Bouzalas, I. G., Dovas, C. I., Banos, G., Papanastasopoulou, M., Kritas, S., Oevermann, A., Papakostaki, D., Evangelia, C., Papadopoulos, O., Seuberlich, T. and Koptopoulos, G. (2010): Caprine PRNP polymorphisms at codons 171, 211, 222 and 240 in a Greek herd and their association with classical scrapie. J. Gen. Virol. 91, 16291634.

    • Search Google Scholar
    • Export Citation
  • Choi, S. H., Kim, I. C., Kim, D. S., Kim, D. W., Chae, S. H., Choi, H. H., Choi, I., Yeo, J. S., Song, M. N. and Park, H. S. (2006): Comparative genomic organization of the human and bovine PRNP locus. Genomics 87, 598607.

    • Search Google Scholar
    • Export Citation
  • Ferreira, L. M., Garcia-Herreros, M., Domingos, A., Marques, C. C., Mesquita, P., Barbas, J. P., Baptista, M. C., Pimenta, J., Horta, A. E., Prates, J. A. and Pereira, R. M. (2016): Prion protein 2 (dublet) gene (PRND): role in ovine semen capacitation, cryopreservation and fertility. Reprod. Fertil. Dev. April 2016. doi: 10. 1071/RD15214. [Epub ahead of print].

    • Search Google Scholar
    • Export Citation
  • Goldmann, W., Martin, T., Foster, J., Hughes, S., Smith, G., Hughes, K., Dawson, M. and Hunter, N. (1996): Novel polymorphisms in the caprine PrP gene: a codon 142 mutation associated with scrapie incubation period. J. Gen. Virol. 77, 28852891.

    • Search Google Scholar
    • Export Citation
  • Greenlee, J. J., Kunkle, R. A., Richt, J. A., Nicholson, E. M. and Hamir, A. N. (2014): Lack of prion accumulation in lymphoid tissues of PRNP ARQ/ARR sheep intracranially inoculated with the agent of scrapie. PloS One 9, e108029.

    • Search Google Scholar
    • Export Citation
  • Greenlee, J. J., Smith, J. D. and Hamir, A. N. (2016): Oral inoculation of neonatal Suffolk sheep with the agent of classical scrapie results in PrP(Sc) accumulation in sheep with the PRNP ARQ/ARQ but not the ARQ/ARR genotype. Res. Vet. Sci. 105, 188191.

    • Search Google Scholar
    • Export Citation
  • Hunter, N., Goldmann, W., Foster, J. D., Cairns, D. and Smith, G. (1997 a): Natural scrapie and PrP genotype: case-control studies in British sheep. Vet. Rec. 141, 137140.

    • Search Google Scholar
    • Export Citation
  • Hunter, N., Moore, L., Hosie, B. D., Dingwall, W. S. and Greig, A. (1997 b): Association between natural scrapie and PrP genotype in a flock of Suffolk sheep in Scotland. Vet. Rec. 140, 5963.

    • Search Google Scholar
    • Export Citation
  • Jeong, B. H., Jin, H. T., Carp, R. I. and Kim, Y. S. (2013): Bovine spongiform encephalopathy (BSE)-associated polymorphisms of the prion protein (PRNP) gene in Korean native cattle. Anim. Genet. 44, 356357.

    • Search Google Scholar
    • Export Citation
  • Jeong, B. H., Kim, N. H., Choi, E. K., Lee, C., Song, Y. H., Kim, J. I., Carp, R. I. and Kim, Y. S. (2005 a): Polymorphism at 3' UTR +28 of the prion-like protein gene is associated with sporadic Creutzfeldt-Jakob disease. Eur. J. Hum. Genet. 13, 10941097.

    • Search Google Scholar
    • Export Citation
  • Jeong, B. H., Lee, K. H., Kim, N. H., Jin, J. K., Kim, J. I., Carp, R. I. and Kim, Y. S. (2005 b): Association of sporadic Creutzfeldt-Jakob disease with homozygous genotypes at PRNP codons 129 and 219 in the Korean population. Neurogenetics 6, 229232.

    • Search Google Scholar
    • Export Citation
  • Jeong, B. H., Lee, Y. J., Kim, N. H., Carp, R. I. and Kim, Y. S. (2006): Genotype distribution of the prion protein gene (PRNP) promoter polymorphisms in Korean cattle. Genome 49, 15391544.

    • Search Google Scholar
    • Export Citation
  • Jeong, B. H., Nam, J. H., Lee, Y. J., Lee, K. H., Jang, M. K., Carp, R. I., Lee, H. D., Ju, Y. R., Ahn Jo, S., Park, K. Y. and Kim, Y. S. (2004): Polymorphisms of the prion protein gene (PRNP) in a Korean population. J. Hum. Genet. 49, 319324.

    • Search Google Scholar
    • Export Citation
  • Jeong, B. H., Sohn, H. J., Lee, J. O., Kim, N. H., Kim, J. I., Lee, S. Y., Cho, I. S., Joo, Y. S., Carp, R. I. and Kim, Y. S. (2005 c): Polymorphisms of the prion protein gene (PRNP) in Hanwoo (Bos taurus coreanae) and Holstein cattle. Genes Genet. Syst. 80, 303308.

    • Search Google Scholar
    • Export Citation
  • Kocer, A., Gallozzi, M., Renault, L., Tilly, G., Pinheiro, I., Le Provost, F., Pailhoux, E. and Vilotte, J. L. (2007): Goat PRND expression pattern suggests its involvement in early sex differentiation. Dev. Dyn. 236, 836842.

    • Search Google Scholar
    • Export Citation
  • Lagares, A., Roux, I. and Valverde, C. (2016): Phylogenetic distribution and evolutionary pattern of an a-proteobacterial small RNA gene that controls polyhydroxybutyrate accumulation in Sinorhizobium meliloti. Mol. Phylogenet. Evol. 99, 182193.

    • Search Google Scholar
    • Export Citation
  • Laplanche, J. L., Chatelain, J., Westaway, D., Thomas, S., Dussaucy, M., Brugere-Picoux, J. and Launay, J. M. (1993): PrP polymorphisms associated with natural scrapie discovered by denaturing gradient gel electrophoresis. Genomics 15, 3037.

    • Search Google Scholar
    • Export Citation
  • Makrinou, E., Collinge, J. and Antoniou, M. (2002): Genomic characterization of the human prion protein (PrP) gene locus. Mamm. Genome. 13, 696703.

    • Search Google Scholar
    • Export Citation
  • Mesquita, P., Batista, M., Marques, M. R., Santos, I. C., Pimenta, J., Silva Pereira, M., Carolino, I., Santos Silva, F., Oliveira Sousa, M. C., Gama, L. T., Fontes, C. M., Horta, A. E., Prates, J. A. and Pereira, R. M. (2010): Prion-like Doppel gene polymorphisms and scrapie susceptibility in Portuguese sheep breeds. Anim. Genet. 41, 311314.

    • Search Google Scholar
    • Export Citation
  • Mesquita, P., Garcia, V., Marques, M. R., Santos Silva, F., Oliveira Sousa, M. C., Carolino, I., Pimenta, J., Fontes, C. M., Horta, A. E., Prates, J. A. and Pereira, R. M. (2016): The prionrelated protein (testis-specific) gene (PRNT) is highly polymorphic in Portuguese sheep. Anim. Genet. 47, 128132.

    • Search Google Scholar
    • Export Citation
  • Ortiz-Pelaez, A., Georgiadou, S., Simmons, M. M., Windl, O., Dawson, M., Arnold, M. E., Neocleous, P. and Papasavva-Stylianou, P. (2015): Allelic variants at codon 146 in the PRNP gene show significant differences in the risk for natural scrapie in Cypriot goats. Epidemiol. Infect. 143, 13041310.

    • Search Google Scholar
    • Export Citation
  • Paisley, D., Banks, S., Selfridge, J., McLennan, N. F., Ritchie, A. M., McEwan, C., Irvine, D. S., Saunders, P. T., Manson, J. C. and Melton, D. W. (2004): Male infertility and DNA damage in Doppel knockout and prion protein/Doppel double-knockout mice. Am. J. Pathol. 164, 22792288.

    • Search Google Scholar
    • Export Citation
  • Pereira, R. M., Mesquita, P., Batista, M., Baptista, M. C., Barbas, J. P., Pimenta, J., Santos, I. C., Marques, M. R., Vasques, M. I., Silva Pereira, M., Santos Silva, F., Oliveira Sousa, M. C., Fontes, C. M., Horta, A. E., Prates, J. A. and Marques, C. C. (2009): Doppel gene polymorphisms in Portuguese sheep breeds: insights on ram fertility. Anim. Reprod. Sci. 114, 157166.

    • Search Google Scholar
    • Export Citation
  • Pimenta, J., Domingos, A., Santos, P., Marques, C. C., Cantante, C., Santos, A., Barbas, J. P., Baptista, M. C., Horta, A. E., Viegas, A., Mesquita, P., Goncalves, J., Fontes, C. A., Prates, J. A. and Pereira, R. M. . (2012): Is PRNT a pseudogene? Identification of ram Prt in testis and ejaculated spermatozoa. PloS One 7, e42957.

    • Search Google Scholar
    • Export Citation
  • Premzl, M. and Gamulin, V. (2007): Comparative genomic analysis of prion genes. BMC Genomics 8, 1.

  • Prusiner, S. B. (1998): Prions. Proc. Natl. Acad. Sci. U S A 95, 1336313383.

  • Srithayakumar, V., Mitchell, G. B. and White, B. N. (2016): Identification of amino acid variation in the prion protein associated with classical scrapie in Canadian dairy goats. BMC Vet. Res. 12, 59.

    • Search Google Scholar
    • Export Citation
  • Wadsworth, J. D., Joiner, S., Linehan, J. M., Balkema-Buschmann, A., Spiropoulos, J., Simmons, M. M., Griffiths, P. C., Groschup, M. H., Hope, J., Brandner, S., Asante, E. A. and Collinge, J. (2013): Atypical scrapie prions from sheep and lack of disease in transgenic mice overexpressing human prion protein. Emerg. Infect. Dis. 19, 17311739.

    • Search Google Scholar
    • Export Citation
  • Wilesmith, J. W., Wells, G. A., Cranwell, M. P. and Ryan, J. B. (1988): Bovine spongiform encephalopathy: epidemiological studies. Vet. Rec. 123, 638644.

    • Search Google Scholar
    • Export Citation
  • Wilson, R., Plinston, C., Hunter, N., Casalone, C., Corona, C., Tagliavini, F., Suardi, S., Ruggerone, M., Moda, F., Graziano, S., Sbriccoli, M., Cardone, F., Pocchiari, M., Ingrosso, L., Baron, T., Richt, J., Andreoletti, O., Simmons, M., Lockey, R., Manson, J. C. and Barron, R. M. (2012): Chronic wasting disease and atypical forms of bovine spongiform encephalopathy and scrapie are not transmissible to mice expressing wild-type levels of human prion protein. J. Gen. Virol. 93, 16241629.

    • Search Google Scholar
    • Export Citation
  • Zabel, M. D. and Reid, C. (2015): A brief history of prions. Pathog. Dis. 73, ftv087.

Author information is available in PDF.
Please, download the file from HERE.

The manuscript preparation instructions is available in PDF.
Please, download the file from HERE.

Senior editors

Editor-in-Chief: Mária BENKŐ

Managing Editor: András SZÉKELY

Editorial Board

  • Béla DÉNES (National Food Chain Safety Office, Budapest Hungary)
  • Edit ESZTERBAUER (Veterinary Medical Research Institute, Budapest, Hungary)
  • Hedvig FÉBEL (National Agricultural Innovation Centre, Herceghalom, Hungary)
  • László FODOR (University of Veterinary Medicine, Budapest, Hungary)
  • Balázs HARRACH (Veterinary Medical Research Institute, Budapest, Hungary)
  • Peter MASSÁNYI (Slovak University of Agriculture in Nitra, Nitra, Slovak Republic)
  • Béla NAGY (Veterinary Medical Research Institute, Budapest, Hungary)
  • Tibor NÉMETH (University of Veterinary Medicine, Budapest, Hungary)
  • Zsuzsanna NEOGRÁDY (University of Veterinary Medicine, Budapest, Hungary)
  • Alessandra PELAGALLI (University of Naples Federico II, Naples, Italy)
  • Kurt PFISTER (Ludwig-Maximilians-University of Munich, Munich, Germany)
  • László SOLTI (University of Veterinary Medicine, Budapest, Hungary)
  • József SZABÓ (University of Veterinary Medicine, Budapest, Hungary)
  • Péter VAJDOVICH (University of Veterinary Medicine, Budapest, Hungary)
  • János VARGA (University of Veterinary Medicine, Budapest, Hungary)
  • Štefan VILČEK (University of Veterinary Medicine in Kosice, Kosice, Slovak Republic)
  • Károly VÖRÖS (University of Veterinary Medicine, Budapest, Hungary)
  • Herbert WEISSENBÖCK (University of Veterinary Medicine, Vienna, Austria)
  • Attila ZSARNOVSZKY (Szent István University, Gödöllő, Hungary)

ACTA VETERINARIA HUNGARICA
Institute for Veterinary Medical Research
Centre for Agricultural Research
Hungarian Academy of Sciences
P.O. Box 18, H-1581 Budapest, Hungary
Phone: (36 1) 467 4081 (ed.-in-chief) or (36 1) 213 9793 (editor) Fax: (36 1) 467 4076 (ed.-in-chief) or (36 1) 213 9793

Indexing and Abstracting Services:

  • Biological Abstracts
  • BIOSIS Previews
  • CAB Abstracts
  • Chemical Abstracts
  • Current Contents: Agriculture, Biology and Environmental Sciences
  • Elsevier Science Navigator
  • Focus On: Veterinary Science and Medicine
  • Global Health
  • Index Medicus
  • Index Veterinarius
  • Medline
  • Science Citation Index
  • Science Citation Index Expanded (SciSearch)
  • SCOPUS
  • The ISI Alerting Services
  • Zoological Abstracts

 

2020  
Total Cites 987
WoS
Journal
Impact Factor
0,955
Rank by Veterinary Sciences 101/146 (Q3)
Impact Factor  
Impact Factor 0,920
without
Journal Self Cites
5 Year 1,164
Impact Factor
Journal  0,57
Citation Indicator  
Rank by Journal  Veterinary Sciences 93/166 (Q3)
Citation Indicator   
Citable 49
Items
Total 49
Articles
Total 0
Reviews
Scimago 33
H-index
Scimago 0,395
Journal Rank
Scimago Veterinary (miscellaneous) Q2
Quartile Score  
Scopus 355/217=1,6
Scite Score  
Scopus General Veterinary 73/183 (Q2)
Scite Score Rank  
Scopus 0,565
SNIP  
Days from  145
sumbission  
to acceptance  
Days from  150
acceptance  
to publication  
Acceptance 19%
Rate

 

2019  
Total Cites
WoS
798
Impact Factor 0,991
Impact Factor
without
Journal Self Cites
0,897
5 Year
Impact Factor
1,092
Immediacy
Index
0,119
Citable
Items
59
Total
Articles
59
Total
Reviews
0
Cited
Half-Life
9,1
Citing
Half-Life
9,2
Eigenfactor
Score
0,00080
Article Influence
Score
0,253
% Articles
in
Citable Items
100,00
Normalized
Eigenfactor
0,09791
Average
IF
Percentile
42,606
Scimago
H-index
32
Scimago
Journal Rank
0,372
Scopus
Scite Score
335/213=1,6
Scopus
Scite Score Rank
General Veterinary 62/178 (Q2)
Scopus
SNIP
0,634
Acceptance
Rate
18%

 

Acta Veterinaria Hungarica
Publication Model Hybrid
Submission Fee none
Article Processing Charge 1100 EUR/article
Printed Color Illustrations 40 EUR (or 10 000 HUF) + VAT / piece
Regional discounts on country of the funding agency World Bank Lower-middle-income economies: 50%
World Bank Low-income economies: 100%
Further Discounts Editorial Board / Advisory Board members: 50%
Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100%
Subscription fee 2021 Online subsscription: 696 EUR / 872 USD
Print + online subscription: 804 EUR / 1004 USD
Subscription fee 2022 Online subsscription: 710 EUR / 892 USD
Print + online subscription: 824 EUR / 1028 USD
Subscription Information Online subscribers are entitled access to all back issues published by Akadémiai Kiadó for each title for the duration of the subscription, as well as Online First content for the subscribed content.
Purchase per Title Individual articles are sold on the displayed price.

Acta Veterinaria Hungarica
Language English
Size A4
Year of
Foundation
1951
Publication
Programme
2020 Volume 68
Volumes
per Year
1
Issues
per Year
4
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-6290 (Print)
ISSN 1588-2705 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
May 2021 10 1 2
Jun 2021 21 0 0
Jul 2021 19 0 0
Aug 2021 32 0 0
Sep 2021 36 0 0
Oct 2021 9 0 0
Nov 2021 0 0 0