View More View Less
  • 1 Veterinary Clinic ‘Radvet’, Słupsk, Poland
  • | 2 University of Life Sciences in Lublin, 13 Akademicka Street, 20-950 Lublin, Poland
Restricted access

Purchase article

USD  $25.00

1 year subscription (Individual Only)

USD  $836.00

The purpose of this study was to assess the condition of cells in the conjunctiva and corneal epithelium prior to and during cyclosporine- or tacrolimusbased treatment of keratoconjunctivitis sicca (KCS). The study was performed on 40 dogs with KCS. The dogs were divided into two groups of 20 animals each. In Group I, 0.75% cyclosporine eye drops were administered three times a day, while in Group II 0.02% tacrolimus eye drops were administered twice daily. Additionally, each group was subdivided into three subgroups based on the results of the Schirmer I tear test (STT I). Evaluation of cellular metaplasia in the cornea and the palpebral and bulbar conjunctiva based on the Nelson–Adams scale was performed by impression cytology using Millipore round filters (Millipore VSWP 01300 DA) of 25 μm pore diameter applied to the studied area. Ophthalmological and cytological examinations were performed prior to the treatment as well as after one and two months of therapy. In both groups, a decrease in Nelson–Adams values was observed, corresponding to the increasing STT values [Rxy Spearman statistically significant correlation coefficient values between –0.75 (P < 0.001) and –0.45 (P < 0.01)]. The absence of goblet cells was observed in all dogs, regardless of the KCS stage. Goblet cells reappeared following both tacrolimus- and cyclosporine-based treatment in impression cytology specimens classified as 0 in the Nelson–Adams scale. The extent of corneal and conjunctival metaplasia in the course of tacrolimus- and cyclosporine-based treatment of KCS decreases with increasing STT values.

  • Adams, G. G. W., Dilly, P. N. and Kirkness, C. M. (1988): Monitoring ocular disease by impression cytology. Eye 2, 506516.

  • Aragona, P., Papa, V., Micali, A., Santocono, M. and Milazzo, G. (2002): Long term treatment with sodium hyaluronate-containing artificial tears reduces ocular surface damage in patients with dry eye. Br. J. Ophthalmol. 86, 181184.

    • Search Google Scholar
    • Export Citation
  • Balicki, I. (2005): Research on diagnostic and treatment of chronic superficial keratitis in dogs. Postdoctoral Dissertation. WAR Lublin 204, 1434.

    • Search Google Scholar
    • Export Citation
  • Balicki, I., Radziejewski, K. and Bielecki, W. (2011): Evaluation of corneal and conjunctival epithelium with the use of impression cytology in mixed-breed dogs diagnosed with keratoconjunctivitis sicca. Bull. Vet. Inst. Puławy 55, 493499.

    • Search Google Scholar
    • Export Citation
  • Balicki, I., Radziejewski, K. and Silmanowicz, P. (2008): Studies on keratoconjunctivitis sicca incidence in crossbreed dogs. Pol. J. Vet. Sci. 11, 353358.

    • Search Google Scholar
    • Export Citation
  • Barnett, K. (1997): Diagnosis and treatment of keratoconjunctivitis sicca in the dog. Vet. Rec. 120, 340345.

  • Bauer, G. A., Spiess, B. M. and Lutz, H. (1996): Exfoliative cytology of conjunctiva and cornea in domestic animals: a comparison of four collecting techniques. Vet. Comp. Ophthalmol. 6, 181186.

    • Search Google Scholar
    • Export Citation
  • Berdoulay, A., English, R. and Nadelstein, B. (2005): Effect of topical 0.02 % tacrolimus aqueous on tear production in dogs with keratoconjunctivitis sicca. Vet. Ophthalmol. 8, 225232.

    • Search Google Scholar
    • Export Citation
  • Braus, B. K., Lehenauer, B., Tichy, A., Nell, B. and Schwendenwein, I. (2016): Impression cytology as diagnostic tool in horses with and without ocular surface disease. Equine Vet J. 12, 17.

    • Search Google Scholar
    • Export Citation
  • Chambers, L., Fischer, C., McCalla, T., Parshall, C., Slatter, D. and Yakley, B. (2002): Topical tacrolimus in treatment of canine keratoconjunctivitis sicca: a multicenter preliminary clinical trial. Materials of Scientific Meeting of the American College of Veterinary Ophthalmologists, Denver.

  • Cowell, R. L., Tyler, R. D. and Meinkoth, J. H. (1990): Diagnostic Cytology and Hematology of the Dog and Cat. Mosby, Philadelphia.

  • Dellman, H. D. and Eurell, J. A. (1998): Textbook of Veterinary Histology. Williams and Wilkins, London.

  • Egbert, P. R., Lauber, S. and Maurice, D. M. (1977): A simple conjunctival biopsy. Am. J. Ophthalmol. 84, 798801.

  • Eördögh, R., Schwendenwein, I., Tichy, A. and Nell, B. (2015): Impression cytology: a novel sampling technique for conjunctival cytology of the feline eye. Vet. Ophthalmol. 18, 276284.

    • Search Google Scholar
    • Export Citation
  • Gelatt, K. N. (2007): Veterinary Ophthalmology, 4th edition. Blackwell Publishing, Ames, Iowa. pp. 633671.

  • Gilger, B. and Allen, J. (1998): Cyclosporine A in veterinary ophthalmology. Vet. Ophthalmol. 1, 181187.

  • Gilger, B., Andrews, J., Wilkie, D., Wyman, M. and Lairmore, M. (1995): Cellular immunity in dogs with keratoconjunctivitis sicca before and after treatment with topical 2% cyclosporine. Vet. Immunol. Immunopathol. 49, 199208.

    • Search Google Scholar
    • Export Citation
  • Kaswan, R. L., Martin, C. and Chapman, W. L. (1984): Keratoconjunctivitis sicca: histopathologic study of nictitating membrane and lacrimal glands from 28 canine cases. Am. J. Vet. Res. 45, 112118.

    • Search Google Scholar
    • Export Citation
  • Kaswan, R. L., Martin, C. and Dawe, D. (1985): Keratoconjunctivitis sicca: immunological evaluation of 62 canine cases. Am. J. Vet. Res. 46, 376383.

    • Search Google Scholar
    • Export Citation
  • Maggs, D. J., Miller, P. E. and Ofri, R. (2008): Slatter’s Fundamentals of Veterinary Ophthalmology, 4th edition. Saunders, St. Louis, pp. 166171.

    • Search Google Scholar
    • Export Citation
  • Marek, J. and Podhorska, M. (1995): Evaluation of changes in the cells of conjunctival epithelium in dry eye syndrome by impression cytology. Klinika Oczna 97, 176181.

    • Search Google Scholar
    • Export Citation
  • Matsumoto, I., Tsubota, K., Satake, Y., Kita, Y., Matsumura, R., Murata, H., Namekawa, T., Nishioka, K., Iwamoto, I., Saitoh, Y. and Sumida, T. (1996): Common T cell receptor clonotype in lacrimal glands and labial salivary glands from patients with Sjögren’s syndrome. J. Clin. Invest. 8, 19691977.

    • Search Google Scholar
    • Export Citation
  • Moore, C. P. and Collier, L. L. (1990): Ocular surface disease associated with loss of conjunctival goblet cells in dogs. J. Am. Anim. Hosp. Assoc. 26, 458465.

    • Search Google Scholar
    • Export Citation
  • Murube, J. and Rivas, L. (2003): Impression cytology on conjunctiva and cornea in dry eye patients establishes a correlation between squamous metaplasia and dry eye clinical severity. Eur. J. Ophthalmol. 13, 115127.

    • Search Google Scholar
    • Export Citation
  • Nelson, J. D. (1984): Conjunctival goblet cell densities in ocular surface disease. Arch. Ophthalmol. 102, 10491051.

  • Nelson, J. D. (1988): Impression cytology. Cornea 7, 7181.

  • Nelson, J. D., Havener, V. R. and Cameron, J. D. (1983): Cellulose acetate impressions of the ocular surface. Dry eye states. Arch. Ophthalmol. 101, 18691872.

    • Search Google Scholar
    • Export Citation
  • Nepp, J., Schauersberger, J., Schild, G., Jandrasits, K., Haslinger-Akramian, J., Derbolav, A. and Wedrich, A. (2001): The clinical use of viscoelastic artificial tears and sodium chloride in dry-eye syndrome. Biomaterials 22, 33053310.

    • Search Google Scholar
    • Export Citation
  • Oziębło-Kupczyk, M., Średzińska-Kita, D., Kita, K. and Mrugacz, M. (2006): Impression cytology in dry eye syndrome in selected rheumatological diseases [in Polish]. Klinika oczna 108, 1012.

    • Search Google Scholar
    • Export Citation
  • Radziejewski, K. and Balicki, I. (2016): Comparative clinical evaluation of tacrolimus and cyclosporine eye drops for the treatment of canine keratoconjunctivitis sicca. Acta Vet. Hung. 64, 313329.

    • Search Google Scholar
    • Export Citation
  • Reddy, M., Reddy, P. R. and Reddy, P. C. (1991): Conjunctival impression cytology in dry eye states. Indian J. Opthalmol. 39, 2224.

  • Sebbag, L., Reilly, C. M., Eid, R. and Maggs, D. J. (2016): Goblet cell density and distribution in cats with clinically and histologically normal conjunctiva. Vet. Ophthalmol. 19, Suppl. 1, 3843.

    • Search Google Scholar
    • Export Citation
  • Singh, M., Singh, G., Dwevedi, S., Singh, K., Kumar, D., Tiwari, A. and Aggarwal, M. (1997): Conjunctival impression cytology in xerophthalmia among rural children. Indian J. Opthalmol. 45, 2529.

    • Search Google Scholar
    • Export Citation
  • Thatcher, R. W., Darougar, S. and Jones, B. R. (1977): Conjunctival impression cytology. Arch. Ophthalmol. 95, 678681.

  • Tseng, S. C. G., Maumenee, A. E., Stark, W. J., Maumenee, I. H., Jensen, A. D., Green W. R. and Kenyon, K. R. (1995): Topical retinoid treatment for various dry eye disorders. Ophthalmology 92, 717733.

    • Search Google Scholar
    • Export Citation
  • Whitley, D., McLaughlin, S., Gilger, B. and Lindley, D. (1991): The treatments for keratoconjunctivitis sicca. Vet. Med. 11, 10761093.

    • Search Google Scholar
    • Export Citation

Author information is available in PDF.
Please, download the file from HERE.

The manuscript preparation instructions is available in PDF.
Please, download the file from HERE.

Senior editors

Editor-in-Chief: Mária BENKŐ

Managing Editor: András SZÉKELY

Editorial Board

  • Béla DÉNES (National Food Chain Safety Office, Budapest Hungary)
  • Edit ESZTERBAUER (Veterinary Medical Research Institute, Budapest, Hungary)
  • Hedvig FÉBEL (National Agricultural Innovation Centre, Herceghalom, Hungary)
  • László FODOR (University of Veterinary Medicine, Budapest, Hungary)
  • Balázs HARRACH (Veterinary Medical Research Institute, Budapest, Hungary)
  • Peter MASSÁNYI (Slovak University of Agriculture in Nitra, Nitra, Slovak Republic)
  • Béla NAGY (Veterinary Medical Research Institute, Budapest, Hungary)
  • Tibor NÉMETH (University of Veterinary Medicine, Budapest, Hungary)
  • Zsuzsanna NEOGRÁDY (University of Veterinary Medicine, Budapest, Hungary)
  • Alessandra PELAGALLI (University of Naples Federico II, Naples, Italy)
  • Kurt PFISTER (Ludwig-Maximilians-University of Munich, Munich, Germany)
  • László SOLTI (University of Veterinary Medicine, Budapest, Hungary)
  • József SZABÓ (University of Veterinary Medicine, Budapest, Hungary)
  • Péter VAJDOVICH (University of Veterinary Medicine, Budapest, Hungary)
  • János VARGA (University of Veterinary Medicine, Budapest, Hungary)
  • Štefan VILČEK (University of Veterinary Medicine in Kosice, Kosice, Slovak Republic)
  • Károly VÖRÖS (University of Veterinary Medicine, Budapest, Hungary)
  • Herbert WEISSENBÖCK (University of Veterinary Medicine, Vienna, Austria)
  • Attila ZSARNOVSZKY (Szent István University, Gödöllő, Hungary)

ACTA VETERINARIA HUNGARICA
Institute for Veterinary Medical Research
Centre for Agricultural Research
Hungarian Academy of Sciences
P.O. Box 18, H-1581 Budapest, Hungary
Phone: (36 1) 467 4081 (ed.-in-chief) or (36 1) 213 9793 (editor) Fax: (36 1) 467 4076 (ed.-in-chief) or (36 1) 213 9793

Indexing and Abstracting Services:

  • Biological Abstracts
  • BIOSIS Previews
  • CAB Abstracts
  • Chemical Abstracts
  • Current Contents: Agriculture, Biology and Environmental Sciences
  • Elsevier Science Navigator
  • Focus On: Veterinary Science and Medicine
  • Global Health
  • Index Medicus
  • Index Veterinarius
  • Medline
  • Science Citation Index
  • Science Citation Index Expanded (SciSearch)
  • SCOPUS
  • The ISI Alerting Services
  • Zoological Abstracts

 

2020  
Total Cites 987
WoS
Journal
Impact Factor
0,955
Rank by Veterinary Sciences 101/146 (Q3)
Impact Factor  
Impact Factor 0,920
without
Journal Self Cites
5 Year 1,164
Impact Factor
Journal  0,57
Citation Indicator  
Rank by Journal  Veterinary Sciences 93/166 (Q3)
Citation Indicator   
Citable 49
Items
Total 49
Articles
Total 0
Reviews
Scimago 33
H-index
Scimago 0,395
Journal Rank
Scimago Veterinary (miscellaneous) Q2
Quartile Score  
Scopus 355/217=1,6
Scite Score  
Scopus General Veterinary 73/183 (Q2)
Scite Score Rank  
Scopus 0,565
SNIP  
Days from  145
sumbission  
to acceptance  
Days from  150
acceptance  
to publication  
Acceptance 19%
Rate

 

2019  
Total Cites
WoS
798
Impact Factor 0,991
Impact Factor
without
Journal Self Cites
0,897
5 Year
Impact Factor
1,092
Immediacy
Index
0,119
Citable
Items
59
Total
Articles
59
Total
Reviews
0
Cited
Half-Life
9,1
Citing
Half-Life
9,2
Eigenfactor
Score
0,00080
Article Influence
Score
0,253
% Articles
in
Citable Items
100,00
Normalized
Eigenfactor
0,09791
Average
IF
Percentile
42,606
Scimago
H-index
32
Scimago
Journal Rank
0,372
Scopus
Scite Score
335/213=1,6
Scopus
Scite Score Rank
General Veterinary 62/178 (Q2)
Scopus
SNIP
0,634
Acceptance
Rate
18%

 

Acta Veterinaria Hungarica
Publication Model Hybrid
Submission Fee none
Article Processing Charge 1100 EUR/article
Printed Color Illustrations 40 EUR (or 10 000 HUF) + VAT / piece
Regional discounts on country of the funding agency World Bank Lower-middle-income economies: 50%
World Bank Low-income economies: 100%
Further Discounts Editorial Board / Advisory Board members: 50%
Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100%
Subscription Information Online subsscription: 696 EUR / 872 USD
Print + online subscription: 804 EUR / 1004 USD
Online subscribers are entitled access to all back issues published by Akadémiai Kiadó for each title for the duration of the subscription, as well as Online First content for the subscribed content.
Purchase per Title Individual articles are sold on the displayed price.

Acta Veterinaria Hungarica
Language English
Size A4
Year of
Foundation
1951
Publication
Programme
2020 Volume 68
Volumes
per Year
1
Issues
per Year
4
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-6290 (Print)
ISSN 1588-2705 (Online)

Monthly Content Usage

Abstract Views Full Text Views PDF Downloads
Feb 2021 11 0 0
Mar 2021 10 0 0
Apr 2021 8 0 0
May 2021 12 0 0
Jun 2021 12 0 0
Jul 2021 15 0 0
Aug 2021 0 0 0