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Andrzej Rychlik
rychlik@uwm.edu.pl
https://orcid.org/0000-0001-7279-3407
Andrzej Rychlik
Department of Clinical Diagnostics, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10-957, Olsztyn , Poland
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Slawomir Gonkowski
Slawomir Gonkowski
Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn , Poland
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Krystyna Makowska
Krystyna Makowska
Department of Clinical Diagnostics, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10-957, Olsztyn , Poland
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Ewa Kaczmar
Ewa Kaczmar
Department of Clinical Diagnostics, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 14, 10-957, Olsztyn , Poland
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Jaroslaw Calka
Jaroslaw Calka
Department of Clinical Physiology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Olsztyn , Poland
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Abstract
Due to its difficult diagnosis and complicated treatment, inflammatory bowel disease (IBD) in dogs is a challenge for the veterinarian. Several aspects connected with pathological changes during IBD still remain unknown. Since one of these aspects is the participation of intestinal innervation in the evolution of the disease, the aim of this study was to demonstrate changes in the number and distribution of intramucosal colonic nerve fibres immunoreactive to substance P (SP) arising as the disease progresses. SP is one of the most important neuronal factors in intestinal innervation which, among other tasks, takes part in the conduction of pain stimuli. Using routine immunofluorescence technique, the density of nerve fibres containing SP was evaluated within mucosal biopsy specimens collected from the descending colon of healthy dogs and animals suffering from IBD of varying severity. The results of the study indicate that during severe IBD the number of nerve fibres containing SP located in the colonic mucosal layer increases in comparison to control animals. The number of SP-positive intramucosal nerves amounted to 10.99 ± 2.11 nerves per observation field in healthy dogs, 14.62 ± 2.86 in dogs with mild IBD, 14.80 ± 0.91 in dogs with moderate IBD and 19.03 ± 6.11 in animals with severe IBD. The observed changes were directly proportional to the intensity of the disease process. These observations may suggest a role of this neuronal substance in pathological processes occurring during IBD. Although the exact mechanism of the observed changes has not been completely explained, the results obtained in this investigation may contribute to improving the diagnosis and treatment of this disease, as well as the staging of canine IBD in veterinary practice.
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ACTA VETERINARIA HUNGARICA
Institute for Veterinary Medical Research
Centre for Agricultural Research
Hungarian Academy of Sciences
P.O. Box 18, H-1581 Budapest, Hungary
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| 2022 | |
|---|---|
| Web of Science | |
| Total Cites WoS |
972 |
| Journal Impact Factor | 0.900 |
| Rank by Impact Factor |
Veterinary Sciences 95/143 |
| Impact Factor without Journal Self Cites |
0.900 |
| 5 Year Impact Factor |
1.1 |
| Journal Citation Indicator | 0.47 |
| Rank by Journal Citation Indicator |
Veterinary Sciences 103/170 |
| Scimago | |
| Scimago H-index |
38 |
| Scimago Journal Rank |
0.277 |
| Scimago Quartile Score |
Veterinary (miscellaneous) Q2 |
| Scopus | |
| Scopus Cite Score |
1.9 |
| Scopus CIte Score Rank |
General Veterinary 76/186 (59th PCTL) |
| Scopus SNIP |
0.475 |
| 2021 | |
|---|---|
| Web of Science | |
| Total Cites WoS |
1040 |
| Journal Impact Factor | 0,959 |
| Rank by Impact Factor | Veterinary Sciences 103/144 |
| Impact Factor without Journal Self Cites |
0,876 |
| 5 Year Impact Factor |
1,222 |
| Journal Citation Indicator | 0,48 |
| Rank by Journal Citation Indicator | Veterinary Sciences 106/168 |
| Scimago | |
| Scimago H-index |
36 |
| Scimago Journal Rank |
0,313 |
| Scimago Quartile Score | Veterinary (miscellaneous) (Q2) |
| Scopus | |
| Scopus Cite Score |
1,7 |
| Scopus CIte Score Rank |
General Veterinary 79/183 (Q2) |
| Scopus SNIP |
0,610 |
| 2020 | |
| Total Cites | 987 |
| WoS | |
| Journal Impact Factor |
0,955 |
| Rank by | Veterinary Sciences 101/146 (Q3) |
| Impact Factor | |
| Impact Factor | 0,920 |
| without | |
| Journal Self Cites | |
| 5 Year | 1,164 |
| Impact Factor | |
| Journal | 0,57 |
| Citation Indicator | |
| Rank by Journal | Veterinary Sciences 93/166 (Q3) |
| Citation Indicator | |
| Citable | 49 |
| Items | |
| Total | 49 |
| Articles | |
| Total | 0 |
| Reviews | |
| Scimago | 33 |
| H-index | |
| Scimago | 0,395 |
| Journal Rank | |
| Scimago | Veterinary (miscellaneous) Q2 |
| Quartile Score | |
| Scopus | 355/217=1,6 |
| Scite Score | |
| Scopus | General Veterinary 73/183 (Q2) |
| Scite Score Rank | |
| Scopus | 0,565 |
| SNIP | |
| Days from | 145 |
| submission | |
| to acceptance | |
| Days from | 150 |
| acceptance | |
| to publication | |
| Acceptance | 19% |
| Rate |
| 2019 | |
|---|---|
| Total Cites WoS |
798 |
| Impact Factor | 0,991 |
| Impact Factor without Journal Self Cites |
0,897 |
| 5 Year Impact Factor |
1,092 |
| Immediacy Index |
0,119 |
| Citable Items |
59 |
| Total Articles |
59 |
| Total Reviews |
0 |
| Cited Half-Life |
9,1 |
| Citing Half-Life |
9,2 |
| Eigenfactor Score |
0,00080 |
| Article Influence Score |
0,253 |
| % Articles in Citable Items |
100,00 |
| Normalized Eigenfactor |
0,09791 |
| Average IF Percentile |
42,606 |
| Scimago H-index |
32 |
| Scimago Journal Rank |
0,372 |
| Scopus Scite Score |
335/213=1,6 |
| Scopus Scite Score Rank |
General Veterinary 62/178 (Q2) |
| Scopus SNIP |
0,634 |
| Acceptance Rate |
18% |
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| Acta Veterinaria Hungarica | |
|---|---|
| Language | English |
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1951 |
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1 |
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4 |
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