Acta Veterinaria Hungarica
Volume/Issue:
Volume 68: Issue 4
Treatment of cranial cruciate ligament injuries in dogs using a combination of tibial tuberosity advancement procedure and autologous mesenchymal stem cells/multipotent mesenchymal stromal cells – A pilot study
Authors:
Saša Koprivec Klinika Loka d.o.o, Škofja Loka, Slovenia

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Marko Novak Klinika Loka d.o.o, Škofja Loka, Slovenia

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Stanislav Bernik Klinika Loka d.o.o, Škofja Loka, Slovenia

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Metka Voga Institute for Preclinical Sciences, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, 1000 Ljubljana, Slovenia

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Luka Mohorič Animacel Biotechnology Ltd., Ljubljana, Slovenia

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Gregor Majdič Institute for Preclinical Sciences, Veterinary Faculty, University of Ljubljana, Gerbičeva 60, 1000 Ljubljana, Slovenia

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https://orcid.org/0000-0001-9620-2683
Pages:
405–412
Online Publication Date:
02 Mar 2021
Publication Date:
19 Apr 2021
Article Category:
Research Article
DOI:
https://doi.org/10.1556/004.2020.00063
Keywords (English):
dog; stifle joint; cranial cruciate ligament; tibial tuberosity advancement; autologous multipotent mesenchymal stromal cells; stem cells; fibroin; cancellous bone tissue scaffold
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Abstract

In the present pilot study, we evaluated different supplemental therapies using autologous multipotent mesenchymal stromal cells (MMSCs) for the treatment of cranial cruciate ligament defects in dogs. We used tibial tuberosity advancement (TTA) and augmented it by supportive therapy with MMSCs in three patient groups. In the first patient group, the dogs were injected with MMSCs directly into the treated stifle one month after surgery. In the second group, MMSCs were delivered in a silk fibroin scaffold which was placed in the osteotomy gap during surgery. In the third group, MMSCs were first mixed with bone tissue and blood from the patient and delivered into the osteotomy gap during surgery. In the control group, patients underwent the TTA procedure but did not receive MMSC treatment. In the group of patients who received cells in the silk fibroin scaffold during surgery, the osteotomy gap did not heal, presumably due to the low absorption of silk fibroin. Patients who received MMSCs mixed with bone tissue and blood during surgery into the osteotomy gap recovered clinically faster and had better healing of the osteotomy gap than dogs from the other two treated groups and from the control group, as assessed by clinical examination and quantification of radiographs. In conclusion, dogs that received stem cells directly into the osteotomy gap (Group 3) recovered faster compared to dogs from Groups 1 (MMSCs injected into the joint one month after surgery), 2 (cells implanted into the osteotomy gap in a silk fibroin scaffold), and the control group that did not receive additional MMSCs treatment.

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Cover Acta Veterinaria Hungarica
Acta Veterinaria Hungarica
Print ISSN:
0236-6290
Online ISSN:
1588-2705

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Senior editors

Editor-in-Chief: Mária BENKŐ

Managing Editor: András SZÉKELY

Editorial Board

  • Béla DÉNES (National Food Chain Safety Office, Budapest Hungary)
  • Edit ESZTERBAUER (Veterinary Medical Research Institute, Budapest, Hungary)
  • Hedvig FÉBEL (National Agricultural Innovation Centre, Herceghalom, Hungary)
  • László FODOR (University of Veterinary Medicine, Budapest, Hungary)
  • Balázs HARRACH (Veterinary Medical Research Institute, Budapest, Hungary)
  • Peter MASSÁNYI (Slovak University of Agriculture in Nitra, Nitra, Slovak Republic)
  • Béla NAGY (Veterinary Medical Research Institute, Budapest, Hungary)
  • Tibor NÉMETH (University of Veterinary Medicine, Budapest, Hungary)
  • Zsuzsanna NEOGRÁDY (University of Veterinary Medicine, Budapest, Hungary)
  • Alessandra PELAGALLI (University of Naples Federico II, Naples, Italy)
  • Kurt PFISTER (Ludwig-Maximilians-University of Munich, Munich, Germany)
  • László SOLTI (University of Veterinary Medicine, Budapest, Hungary)
  • József SZABÓ (University of Veterinary Medicine, Budapest, Hungary)
  • Péter VAJDOVICH (University of Veterinary Medicine, Budapest, Hungary)
  • János VARGA (University of Veterinary Medicine, Budapest, Hungary)
  • Štefan VILČEK (University of Veterinary Medicine in Kosice, Kosice, Slovak Republic)
  • Károly VÖRÖS (University of Veterinary Medicine, Budapest, Hungary)
  • Herbert WEISSENBÖCK (University of Veterinary Medicine, Vienna, Austria)
  • Attila ZSARNOVSZKY (Szent István University, Gödöllő, Hungary)

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2022  
Web of Science  
Total Cites
WoS		 972
Journal Impact Factor 0.900
Rank by Impact Factor

Veterinary Sciences 95/143
Impact Factor
without
Journal Self Cites		 0.900
5 Year
Impact Factor		 1.1
Journal Citation Indicator 0.47
Rank by Journal Citation Indicator

Veterinary Sciences 103/170
Scimago  
Scimago
H-index		 38
Scimago
Journal Rank		 0.277
Scimago Quartile Score

Veterinary (miscellaneous) Q2
Scopus  
Scopus
Cite Score		 1.9
Scopus
CIte Score Rank		 General Veterinary 76/186 (59th PCTL)
Scopus
SNIP		 0.475

2021  
Web of Science  
Total Cites
WoS		 1040
Journal Impact Factor 0,959
Rank by Impact Factor Veterinary Sciences 103/144
Impact Factor
without
Journal Self Cites		 0,876
5 Year
Impact Factor		 1,222
Journal Citation Indicator 0,48
Rank by Journal Citation Indicator Veterinary Sciences 106/168
Scimago  
Scimago
H-index		 36
Scimago
Journal Rank		 0,313
Scimago Quartile Score Veterinary (miscellaneous) (Q2)
Scopus  
Scopus
Cite Score		 1,7
Scopus
CIte Score Rank		 General Veterinary 79/183 (Q2)
Scopus
SNIP		 0,610

2020  
Total Cites 987
WoS
Journal
Impact Factor		 0,955
Rank by Veterinary Sciences 101/146 (Q3)
Impact Factor  
Impact Factor 0,920
without
Journal Self Cites
5 Year 1,164
Impact Factor
Journal  0,57
Citation Indicator  
Rank by Journal  Veterinary Sciences 93/166 (Q3)
Citation Indicator   
Citable 49
Items
Total 49
Articles
Total 0
Reviews
Scimago 33
H-index
Scimago 0,395
Journal Rank
Scimago Veterinary (miscellaneous) Q2
Quartile Score  
Scopus 355/217=1,6
Scite Score  
Scopus General Veterinary 73/183 (Q2)
Scite Score Rank  
Scopus 0,565
SNIP  
Days from  145
submission  
to acceptance  
Days from  150
acceptance  
to publication  
Acceptance 19%
Rate

 

2019  
Total Cites
WoS		 798
Impact Factor 0,991
Impact Factor
without
Journal Self Cites		 0,897
5 Year
Impact Factor		 1,092
Immediacy
Index		 0,119
Citable
Items		 59
Total
Articles		 59
Total
Reviews		 0
Cited
Half-Life		 9,1
Citing
Half-Life		 9,2
Eigenfactor
Score		 0,00080
Article Influence
Score		 0,253
% Articles
in
Citable Items		 100,00
Normalized
Eigenfactor		 0,09791
Average
IF
Percentile		 42,606
Scimago
H-index		 32
Scimago
Journal Rank		 0,372
Scopus
Scite Score		 335/213=1,6
Scopus
Scite Score Rank		 General Veterinary 62/178 (Q2)
Scopus
SNIP		 0,634
Acceptance
Rate		 18%

 

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Acta Veterinaria Hungarica
Language English
Size A4
Year of
Foundation		 1951
Volumes
per Year		 1
Issues
per Year		 4
Founder Magyar Tudományos Akadémia
Founder's
Address		 H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address		 H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher		 Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-6290 (Print)
ISSN 1588-2705 (Online)

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