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  • 1 Korea Zoonosis Research Institute, Jeonbuk National University, 820-120 Hana-ro, Iksan, Jeonbuk 54531, Republic of Korea
  • | 2 Department of Bioactive Material Sciences and Institute for Molecular Biology and Genetics, Jeonbuk National University, Jeonju, Jeonbuk 54531, Republic of Korea
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Abstract

Interferon-induced transmembrane protein 3 (IFITM3) plays a pivotal role in antiviral capacity in several species. However, to date, investigations of the IFITM3 protein in cattle have been rare. According to recent studies, interspecific differences in the IFITM3 protein result in several unique features of the IFITM3 protein relative to primates and birds. Thus, in the present study, we investigated the bovine IFITM3 protein based on nucleotide and amino acid sequences to find its distinct features. We found that the bovine IFITM3 gene showed a significantly different length and homology relative to other species, including primates, rodents and birds. Phylogenetic analyses indicated that the bovine IFITM3 gene and IFITM3 protein showed closer evolutionary distance with primates than with rodents. However, cattle showed an independent clade among primates, rodents and birds. Multiple sequence alignment of the IFITM3 protein indicated that the bovine IFITM3 protein contains 36 bovine-specific amino acids. Notably, the bovine IFITM3 protein was predicted to prefer inside-to-outside topology of intramembrane domain 1 (IMD1) and inside-to-outside topology of transmembrane domain 2 by TMpred and three membrane embedding domains according to the SOSUI system.

  • Acutis, P. L., Colussi, S., Santagada, G., Laurenza, C., Maniaci, M. G., Riina, M. V., Peletto, S., Goldmann, W., Bossers, A., Caramelli, M., Cristoferi, I., Maione, S., Sacchi, P. and Rasero, R. (2008): Genetic variability of the PRNP gene in goat breeds from Northern and Southern Italy. J. Appl. Microbiol. 104, 17821789.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Allen, E. K., Randolph, A. G., Bhangale, T., Dogra, P., Ohlson, M., Oshansky, C. M., Zamora, A. E., Shannon, J. P., Finkelstein, D., Dressen, A., DeVincenzo, J., Caniza, M., Youngblood, B., Rosenberger, C. M. and Thomas, P. G. (2017): SNP-mediated disruption of CTCF binding at the IFITM3 promoter is associated with risk of severe influenza in humans. Nat. Med. 23, 975983.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Bailey, C. C., Huang, I. C., Kam, C. and Farzan, M. (2012): Ifitm3 limits the severity of acute influenza in mice. PLoS Pathog. 8, e1002909.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Bedford, J. G., O’Keeffe, M., Reading, P. C. and Wakim, L. M. (2019): Rapid interferon independent expression of IFITM3 following T cell activation protects cells from influenza virus infection. PLoS One 14, e0210132.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Blyth, G. A., Chan, W. F., Webster, R. G. and Magor, K. E. (2016): Duck interferon-inducible transmembrane protein 3 mediates restriction of influenza viruses. J. Virol. 90, 103116.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Everitt, A. R., Clare, S., Pertel, T., John, S. P., Wash, R. S., Smith, S. E., Chin, C. R., Feeley, E. M., Sims, J. S., Adams, D. J., Wise, H. M., Kane, L., Goulding, D., Digard, P., Anttila, V., Baillie, J. K., Walsh, T. S., Hume, D. A., Palotie, A., Xue, Y., Colonna, V., Tyler-Smith, C., Dunning, J., Gordon, S. B., Gen, I. I., Smyth, R. L., Openshaw, P. J., Dougan, G., Brass, A. L. and Kellam, P. (2012): IFITM3 restricts the morbidity and mortality associated with influenza. Nature 484, 519523.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Feeley, E. M., Sims, J. S., John, S. P., Chin, C. R., Pertel, T., Chen, L. M., Gaiha, G. D., Ryan, B. J., Donis, R. O., Elledge, S. J. and Brass, A. L. (2011): IFITM3 inhibits influenza A virus infection by preventing cytosolic entry. PLoS Pathog. 7, e1002337.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Hirokawa, T., Boon-Chieng, S. and Mitaku, S. (1998): SOSUI: classification and secondary structure prediction system for membrane proteins. Bioinformatics 14, 378379.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Ikeda, M., Arai, M., Okuno, T. and Shimizu, T. (2003): TMPDB: a database of experimentally-characterized transmembrane topologies. Nucleic Acids Res. 31, 406409.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Jia, R., Xu, F., Qian, J., Yao, Y., Miao, C., Zheng, Y. M., Liu, S. L., Guo, F., Geng, Y., Qiao, W. and Liang, C. (2014): Identification of an endocytic signal essential for the antiviral action of IFITM3. Cell Microbiol. 16, 10801093.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • John, S. P., Chin, C. R., Perreira, J. M., Feeley, E. M., Aker, A. M., Savidis, G., Smith, S. E., Elia, A. E., Everitt, A. R., Vora, M., Pertel, T., Elledge, S. J., Kellam, P. and Brass, A. L. (2013): The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication. J. Virol. 87, 78377852.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Kern, R. J., Lindholm-Perry, A. K., Freetly, H. C., Snelling, W. M., Kern, J. W., Keele, J. W., Miles, J. R., Foote, A. P., Oliver, W. T., Kuehn, L. A. and Ludden, P. A. (2016): Transcriptome differences in the rumen of beef steers with variation in feed intake and gain. Gene 586, 1226.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Kim, Y. C. and Jeong, B. H. (2017): No correlation of the disease severity of influenza A virus infection with the rs12252 polymorphism of the interferon-induced transmembrane protein 3 gene. Intervirology 60, 6974.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Kim, Y. C. and Jeong, B. H. (2020): Ethnic variation in risk genotypes based on single nucleotide polymorphisms (SNPs) of the interferon-inducible transmembrane 3 (IFITM3) gene, a susceptibility factor for pandemic 2009 H1N1 influenza A virus. Immunogenetics 72, 447453.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Kim, Y. C., Jeong, M. J. and Jeong, B. H. (2019): Genetic characteristics and polymorphisms in the chicken interferon-induced transmembrane protein (IFITM3) gene. Vet. Res. Commun. 43, 203214.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Kim, Y. C., Jeong, M. J. and Jeong, B. H. (2020): Strong association of regulatory single nucleotide polymorphisms (SNPs) of the IFITM3 gene with influenza H1N1 2009 pandemic virus infection. Cell. Mol. Immunol. 17, 662664.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Kim, Y. C., Jeong, M. J. and Jeong, B. H. (2021a): Genetic association between the rs12252 SNP of the interferon-induced transmembrane protein gene and influenza A virus infection in the Korean population. Mol. Cell. Toxicol. 17, 5157.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Kim, Y. C., Won, S. Y. and Jeong, B. H. (2021b): The first association study of single-nucleotide polymorphisms (SNPs) of the IFITM1 gene with influenza H1N1 2009 pandemic virus infection. Mol. Cell. Toxicol. 17, 179186.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Klein, C., Bauersachs, S., Ulbrich, S. E., Einspanier, R., Meyer, H. H. D., Schmidt, S. E. M., Reichenbach, H. D., Vermehren, M., Sinowatz, F., Blum, H. and Wolf, E. (2006): Monozygotic twin model reveals novel embryo-induced transcriptome changes of bovine endometrium in the preattachment period. Biol. Reprod. 74, 253264.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Kumar, S., Stecher, G., Li, M., Knyaz, C. and Tamura, K. (2018): MEGA X: Molecular evolutionary genetics analysis across computing platforms. Mol. Biol. Evol. 35, 15471549.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Li, C., Zheng, H., Wang, Y., Dong, W., Liu, Y., Zhang, L. and Zhang, Y. (2019): Antiviral role of IFITM proteins in classical swine fever virus infection. Viruses 11, 126.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Munoz-Moreno, R., Cuesta-Geijo, M. A., Martinez-Romero, C., Barrado-Gil, L., Galindo, I., Garcia-Sastre, A. and Alonso, C. (2016): Antiviral role of IFITM proteins in African swine fever virus infection. PLoS One 11, e0154366.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Perreira, J. M., Chin, C. R., Feeley, E. M. and Brass, A. L. (2013): IFITMs restrict the replication of multiple pathogenic viruses. J. Mol. Biol. 425, 49374955.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Prabhu, S. S., Chakraborty, T. T., Kumar, N. and Banerjee, I. (2018): Association between IFITM3 rs12252 polymorphism and influenza susceptibility and severity: a meta-analysis. Gene 674, 7079.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Pru, J. K., Austin, K. J., Haas, A. L. and Hansen, T. R. (2001): Pregnancy and interferon-tau upregulate gene expression of members of the 1-8 family in the bovine uterus. Biol. Reprod. 65, 14711480.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Seo, G. S., Lee, J. K., Yu, J. I., Yun, K. J., Chae, S. C. and Choi, S. C. (2010): Identification of the polymorphisms in IFITM3 gene and their association in a Korean population with ulcerative colitis. Exp. Mol. Med. 42, 99104.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Sievers, F. and Higgins, D. G. (2014): Clustal omega. Curr. Protoc. Bioinformatics 48, 3.13.13.13.6.

  • Smith, C., Berg, D., Beaumont, S., Standley, N. T., Wells, D. N. and Pfeffer, P. L. (2007): Simultaneous gene quantitation of multiple genes in individual bovine nuclear transfer blastocysts. Reproduction 133, 231242.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Smith, J., Smith, N., Yu, L., Paton, I. R., Gutowska, M. W., Forrest, H. L., Danner, A. F., Seiler, J. P., Digard, P., Webster, R. G. and Burt, D. W. (2015): A comparative analysis of host responses to avian influenza infection in ducks and chickens highlights a role for the interferon-induced transmembrane proteins in viral resistance. BMC Genom. 16, 574.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Yanez, D. C., Ross, S. and Crompton, T. (2020): The IFITM protein family in adaptive immunity. Immunology 159, 365372.

  • Zani, A. and Yount, J. S. (2018): Antiviral protection by IFITM3 in vivo. Curr. Clin. Microbiol. Rep. 5, 229237.

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Senior editors

Editor-in-Chief: Mária BENKŐ

Managing Editor: András SZÉKELY

Editorial Board

  • Béla DÉNES (National Food Chain Safety Office, Budapest Hungary)
  • Edit ESZTERBAUER (Veterinary Medical Research Institute, Budapest, Hungary)
  • Hedvig FÉBEL (National Agricultural Innovation Centre, Herceghalom, Hungary)
  • László FODOR (University of Veterinary Medicine, Budapest, Hungary)
  • Balázs HARRACH (Veterinary Medical Research Institute, Budapest, Hungary)
  • Peter MASSÁNYI (Slovak University of Agriculture in Nitra, Nitra, Slovak Republic)
  • Béla NAGY (Veterinary Medical Research Institute, Budapest, Hungary)
  • Tibor NÉMETH (University of Veterinary Medicine, Budapest, Hungary)
  • Zsuzsanna NEOGRÁDY (University of Veterinary Medicine, Budapest, Hungary)
  • Alessandra PELAGALLI (University of Naples Federico II, Naples, Italy)
  • Kurt PFISTER (Ludwig-Maximilians-University of Munich, Munich, Germany)
  • László SOLTI (University of Veterinary Medicine, Budapest, Hungary)
  • József SZABÓ (University of Veterinary Medicine, Budapest, Hungary)
  • Péter VAJDOVICH (University of Veterinary Medicine, Budapest, Hungary)
  • János VARGA (University of Veterinary Medicine, Budapest, Hungary)
  • Štefan VILČEK (University of Veterinary Medicine in Kosice, Kosice, Slovak Republic)
  • Károly VÖRÖS (University of Veterinary Medicine, Budapest, Hungary)
  • Herbert WEISSENBÖCK (University of Veterinary Medicine, Vienna, Austria)
  • Attila ZSARNOVSZKY (Szent István University, Gödöllő, Hungary)

ACTA VETERINARIA HUNGARICA
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Phone: (36 1) 467 4081 (ed.-in-chief) or (36 1) 213 9793 (editor) Fax: (36 1) 467 4076 (ed.-in-chief) or (36 1) 213 9793

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2020  
Total Cites 987
WoS
Journal
Impact Factor
0,955
Rank by Veterinary Sciences 101/146 (Q3)
Impact Factor  
Impact Factor 0,920
without
Journal Self Cites
5 Year 1,164
Impact Factor
Journal  0,57
Citation Indicator  
Rank by Journal  Veterinary Sciences 93/166 (Q3)
Citation Indicator   
Citable 49
Items
Total 49
Articles
Total 0
Reviews
Scimago 33
H-index
Scimago 0,395
Journal Rank
Scimago Veterinary (miscellaneous) Q2
Quartile Score  
Scopus 355/217=1,6
Scite Score  
Scopus General Veterinary 73/183 (Q2)
Scite Score Rank  
Scopus 0,565
SNIP  
Days from  145
sumbission  
to acceptance  
Days from  150
acceptance  
to publication  
Acceptance 19%
Rate

 

2019  
Total Cites
WoS
798
Impact Factor 0,991
Impact Factor
without
Journal Self Cites
0,897
5 Year
Impact Factor
1,092
Immediacy
Index
0,119
Citable
Items
59
Total
Articles
59
Total
Reviews
0
Cited
Half-Life
9,1
Citing
Half-Life
9,2
Eigenfactor
Score
0,00080
Article Influence
Score
0,253
% Articles
in
Citable Items
100,00
Normalized
Eigenfactor
0,09791
Average
IF
Percentile
42,606
Scimago
H-index
32
Scimago
Journal Rank
0,372
Scopus
Scite Score
335/213=1,6
Scopus
Scite Score Rank
General Veterinary 62/178 (Q2)
Scopus
SNIP
0,634
Acceptance
Rate
18%

 

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Acta Veterinaria Hungarica
Language English
Size A4
Year of
Foundation
1951
Publication
Programme
2020 Volume 68
Volumes
per Year
1
Issues
per Year
4
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-6290 (Print)
ISSN 1588-2705 (Online)

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