Authors:
Tábata Maués Department of Pathology and Veterinary Clinic, Faculty of Veterinary, Universidade Federal Fluminense, Av. Alm. Ary Parreiras, 507, Icaraí, 24220-000, Niterói, RJ, Brazil

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Táya Figueiredo de Oliveira Department of Pathology and Veterinary Clinic, Faculty of Veterinary, Universidade Federal Fluminense, Av. Alm. Ary Parreiras, 507, Icaraí, 24220-000, Niterói, RJ, Brazil

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Kênia Balbi El-Jaick Department of Genetics and Molecular Biology, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro, Brazil

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Agnes Marie Sá Figueiredo Department of Medical Microbiology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

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Maria De Lourdes Gonçalves Ferreira Department of Pathology and Veterinary Clinic, Faculty of Veterinary, Universidade Federal Fluminense, Av. Alm. Ary Parreiras, 507, Icaraí, 24220-000, Niterói, RJ, Brazil

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Ana Maria Reis Ferreira Department of Pathology and Veterinary Clinic, Faculty of Veterinary, Universidade Federal Fluminense, Av. Alm. Ary Parreiras, 507, Icaraí, 24220-000, Niterói, RJ, Brazil

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Abstract

TP53 and PGAM1 genes play a key role in glycolysis which is an essential metabolic pathway of cancer cells for obtaining energy. The purpose of this work was to evaluate PGAM1 and TP53 mRNA expressions in canine mammary carcinomas (CMC) and to correlate them with animal data and tumour histological features. None of the nine samples analysed revealed PGAM1 DNA sequence variations. PGAM1 and TP53 RNA expressions from 21 CMC were analysed using a one-step reverse transcription-PCR kit and its platform system. Most CMC samples had low levels of PGAM1 mRNA (71.5%) and normal expression of TP53 mRNA (95.2%). Our results suggest a different feature of the Warburg effect on canine mammary cancer cells compared to human cells.

  • Clemmensen, A., Hansen, A. E., Holst, P., Schøier, C., Bisgaard, S., Johannesen, H. H., Ardenkjær-Larsen, J. H., Kristensen, A. T and Kjaer, A. (2020): [68Ga]Ga-NODAGA-E[(cRGDyK)]2 PET and hyperpolarized [1-13C]pyruvate MRSI (hyperPET) in canine cancer patients: simultaneous imaging of angiogenesis and the Warburg effect. Eur. J. Nucl. Med. Mol. Imag. 48, 395405.

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    • Search Google Scholar
    • Export Citation
  • Costa, A., Oliveira, J. T., Gärtner, F., Kohn, B., Gruber, A. D. and Klopfleisch, R. (2011): Potential markers for detection of circulating canine mammary tumor cells in the peripheral blood. Vet. J. 190, 165168.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Dalgin, G. S. and DeLisi, C. (2005): Simple discriminant functions identify small sets of genes that distinguish cancer phenotype from normal. Genome Informatics 6, 245253.

    • Search Google Scholar
    • Export Citation
  • Durany, N., Joseph, J., Jimenez, O. M., Climent, F., Fernández, P. L., Rivera, F. and Carreras, J. (2000): Phosphoglycerate mutase, 2,3-bisphosphoglycerate phosphatase, creatine kinase and enolase activity and isoenzymes in breast carcinoma. Br. J. Cancer 82, 2027.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Feng, Y., Zhang, X., Zhang, S., Xu, S., Chen, X., Zhou, C., Wang, X., Xie, X. and Luet, W. (2020): Paclitaxel resistance in ovarian cancers relies on a PGAM1 mediated glycolytic metabolism. Res. Square. https://doi.org/10.21203/rs.3.rs-103118/v1.

    • Search Google Scholar
    • Export Citation
  • Gutte, H., Hansen, A. E., Larsen, M. M. E., Rahbek, S., Johannesen, H. H., Ardenkjaer-Larsen, J., Kristensen, A. T., Højgaard, L. and Kjaer, A. (2015): In vivo phenotyping of tumor metabolism in a canine cancer patient with simultaneous 18F-FDG-PET and hyperpolarized 13C-pyruvate magnetic resonance spectroscopic imaging (hyperPET): mismatch demonstrates that FDG may not always reflect the Warburg effect. Diagnostics 5, 287289.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Hanahan, D. and Weinberg, R. A. (2011): Hallmarks of cancer: the next generation. Cell 144, 646674.

  • Hitosugi, T., Zhou, L., Elf, S., Fan, J., Kang, H. B., Seo, J. H., Shan, C., Dai, Q., Zhang, L., Xie, J., Gu, T. L., Jin, P., Aleckovic, M., Leroy, G., Kang, Y., Sudderth, J. A., Deberardinis, R. J., Luan, C. H., Chen, G. Z., Muller, S., Shin, D. M., Owonikoko, T. K., Lonial, S., Arellano, M. L., Khoury, H. J., Khuri, F. R., Lee, B. H., Ye, K., Boggon, T. J., Kang, S., He, C. and Chen, J. (2012): Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell 22, 585600.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Hussain, S., Saxena, S., Shrivastava, S., Arora, R., Singh, R. J., Jena, S. C., Kumar, N., Sharma, A. K., Sahoo, M., Tiwari, A. K., Mishra, B. P. and Singh, R. K. (2018): Multiplexed autoantibody signature for serological detection of canine mammary tumours. Sci. Rep. 8, 114.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Jin, L. and Zhou, Y. (2019): Crucial role of the pentose phosphate pathway in malignant tumors (Review). Oncol. Lett. 17, 42134221.

  • Klopfleisch, R., Klose, P. and Gruber, A. D. (2010): The combined expression pattern of bmp2, ltbp4, and derl1 discriminates malignant from benign canine mammary tumors. Vet. Pathol. 47, 446454.

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    • Search Google Scholar
    • Export Citation
  • Kondoh, H., Lleonart, M. E., Gil, J., Wang, J., Degan, P., Peters, G., Martinez, D., Carnero, A. and Beach, D. (2005): Glycolytic enzymes can modulate cellular life span. Cancer Res. 65, 177185.

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  • Liu, X., Tan, X., Liu, P., Wu, Y., Qian, S. and Zhang, X. (2018): Phosphoglycerate mutase 1 (PGAM1) promotes pancreatic ductal adenocarcinoma (PDAC) metastasis by acting as a novel downstream target of the PI3K/Akt/mTOR pathway. Oncol. Res. 26, 11231131.

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  • Mikawa, T., Okamoto, K., LLeonart, M. E., Yoshida, Y., Takaori-Kondo, A., Yokode, M., Inagaki, N. and Kondoh H. (2014a): Posttranscriptional regulation of glycolytic enzyme phosphoglycerate mutase. Sci. Proc. 1, 14.

    • Search Google Scholar
    • Export Citation
  • Mikawa, T., Maruyama, T., Okamoto, K., Nakagama, H., LLeonart, M. E., Tsusaka, T., Hori, K., Murakami, I., Izumi, T., Takaori-Kondo, A., Yokode, M., Peters, G., Beach, D. and Kondoh, H. (2014b): Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2. J. Cell Biol. 204, 729745.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Owen, L. N. (1980): Mammary glands. In: Owen, L. N. (ed.) TNM Classification of Tumours in Domestic Animals. First edition. World Health Organization, Geneva. pp. 1620.

    • Search Google Scholar
    • Export Citation
  • Qu, J., Sun, W., Zhong, J., Lv, H., Zhu, M., Xu, J., Jin, N., Xie, Z., Tan, M., Lin, S., Geng, M., Ding, J. and Huang, M. (2017): Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells. J. Cell Biol. 216, 409424.

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    • Search Google Scholar
    • Export Citation
  • Ren, F., Wu, H., Lei, Y., Zhang, H., Liu, R., Zhao, Y., Chen, X., Zeng, D., Tong, A., Chen, L., Wei, Y. and Huang, C. (2010): Quantitative proteomics identification of phosphoglycerate mutase 1 as a novel therapeutic target in hepatocellular carcinoma. Mol. Cancer 9, 81.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Ruiz-Lozano, P., Hixon, M. L. and Wagner, M. W. (1999): P53 is a transcriptional activator of the muscle-specific phosphoglycerate mutase gene and contributes in vivo to the control of its cardiac expression. Cell Growth Differ. 10, 295306.

    • Search Google Scholar
    • Export Citation
  • Semenza, G. L. (2012): Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol. Sci. 33, 207214.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Shen, L., Sun, X., Fu, Z., Yang, G., Li, J. and Yao, L. (2012): The fundamental role of the p53 pathway in tumor metabolism and its implication in tumor therapy. Clin. Cancer Res. 18, 15611567.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Shi, L., Jones, W. D., Jensen, R. V., Harris, S. C., Perkins, R. G., Goodsaid, F. M., Guo, L., Croner, L. J., Boysen, C., Fang, H., Qian, F., Amur, S., Bao, W., Barbacioru, C. C., Bertholet, V., Cao, X. M., Chu, T. M., Collins, P. J., Fan, X. H., Frueh, F. W., Fuscoe, J. C., Guo, X., Han, J., Herman, D., Hong, H., Kawasaki, E. S., Li, Q. Z., Luo, Y., Ma, Y., Mei, N., Peterson, R. L., Puri, R. K., Shippy, R., Su, Z., Sun, Y. A., Sun, H., Thorn, B., Turpaz, Y., Wang, C., Wang, S. J., Warrington, J. A., Willey, J. C., Wu, J., Xie, Q., Zhang, L., Zhang, L., Zhong, S., Wolfinger, R. D. and Tong, W. (2008): The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies. BMC Bioinf. 12, S10.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Warburg, O. (1956): On the origin of cancer cells. Science 123, 309314.

  • Zamani-Ahmadmahmudi, M., Nassiri, S. M. and Rahbarghazi, R. (2014): Serological proteome analysis of dogs with breast cancer unveils common serum biomarkers with human counterparts. Electrophoresis 35, 901910.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Zhang, C., Liu, J., Liang, Y., Wu, R., Zhao, Y., Hong, X., Lin, M., Yu, H., Liu, L., Levine, A. J., Hu, W. and Feng, Z. (2013): Tumor-associated mutant p53 drives the Warburg effect. Nat. Commun. 4, 2935.

    • Crossref
    • Search Google Scholar
    • Export Citation
  • Zhang, D., Wu, H., Zhang, X., Ding, X., Huang, M., Geng, M., Li, H. and Xie, Z. (2017): Phosphoglycerate mutase 1 predicts the poor prognosis of oral squamous cell carcinoma and is associated with cell migration. J. Cancer 8, 19431951.

    • Crossref
    • Search Google Scholar
    • Export Citation
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Senior editors

Editor-in-Chief: Ferenc BASKA

Editorial assistant: Szilvia PÁLINKÁS

 

Editorial Board

  • Mária BENKŐ (Acta Veterinaria Hungarica, Budapest, Hungary)
  • Gábor BODÓ (University of Veterinary Medicine, Budapest, Hungary)
  • Béla DÉNES (University of Veterinary Medicine, Budapest Hungary)
  • Edit ESZTERBAUER (Veterinary Medical Research Institute, Budapest, Hungary)
  • Hedvig FÉBEL (University of Veterinary Medicine, Budapest, Hungary)
  • László FODOR (University of Veterinary Medicine, Budapest, Hungary)
  • János GÁL (University of Veterinary Medicine, Budapest, Hungary)
  • Balázs HARRACH (Veterinary Medical Research Institute, Budapest, Hungary)
  • Peter MASSÁNYI (Slovak University of Agriculture in Nitra, Nitra, Slovak Republic)
  • Béla NAGY (Veterinary Medical Research Institute, Budapest, Hungary)
  • Tibor NÉMETH (University of Veterinary Medicine, Budapest, Hungary)
  • Zsuzsanna NEOGRÁDY (University of Veterinary Medicine, Budapest, Hungary)
  • Dušan PALIĆ (Ludwig Maximilian University, Munich, Germany)
  • Alessandra PELAGALLI (University of Naples Federico II, Naples, Italy)
  • Kurt PFISTER (Ludwig-Maximilians-University of Munich, Munich, Germany)
  • László SOLTI (University of Veterinary Medicine, Budapest, Hungary)
  • József SZABÓ (University of Veterinary Medicine, Budapest, Hungary)
  • Péter VAJDOVICH (University of Veterinary Medicine, Budapest, Hungary)
  • János VARGA (University of Veterinary Medicine, Budapest, Hungary)
  • Štefan VILČEK (University of Veterinary Medicine in Kosice, Kosice, Slovak Republic)
  • Károly VÖRÖS (University of Veterinary Medicine, Budapest, Hungary)
  • Herbert WEISSENBÖCK (University of Veterinary Medicine, Vienna, Austria)
  • Attila ZSARNOVSZKY (Szent István University, Gödöllő, Hungary)

ACTA VETERINARIA HUNGARICA
Institute for Veterinary Medical Research
Centre for Agricultural Research
Hungarian Academy of Sciences
P.O. Box 18, H-1581 Budapest, Hungary
Phone: (36 1) 287 7073 (ed.-in-chief) or (36 1) 467 4081 (editor)

E-mail: acta.veterinaria@univet.hu (ed.-in-chief)

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2023  
Web of Science  
Journal Impact Factor 0.7
Rank by Impact Factor Q3 (Veterinary Sciences)
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Scopus  
CiteScore 1.8
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Acta Veterinaria Hungarica
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Acta Veterinaria Hungarica
Language English
Size A4
Year of
Foundation
1951
Volumes
per Year
1
Issues
per Year
4
Founder Magyar Tudományos Akadémia
Founder's
Address
H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
Publisher's
Address
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
Responsible
Publisher
Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-6290 (Print)
ISSN 1588-2705 (Online)

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