Authors:
Sergio Villanueva-Saz Animal Pathology Department, Veterinary Faculty, Zaragoza University, Miguel Servet 177, 50013, Zaragoza, Spain
Clinical Immunology Laboratory, Veterinary Faculty, Zaragoza University, Miguel Servet 177, 50013, Zaragoza, Spain

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https://orcid.org/0000-0001-6209-4282
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Jacobo Giner Animal Pathology Department, Veterinary Faculty, Zaragoza University, Miguel Servet 177, 50013, Zaragoza, Spain
Clinical Immunology Laboratory, Veterinary Faculty, Zaragoza University, Miguel Servet 177, 50013, Zaragoza, Spain

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Antonio Fernández Animal Pathology Department, Veterinary Faculty, Zaragoza University, Miguel Servet 177, 50013, Zaragoza, Spain
Clinical Immunology Laboratory, Veterinary Faculty, Zaragoza University, Miguel Servet 177, 50013, Zaragoza, Spain

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María Magdalena Alcover Department de Biologia, Salut i Medi Ambient, Facultat de Farmacia, Universitat de Barcelona, Av. de Joan XXIII 27-31, 08028, Barcelona, Spain

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Cristina Riera Department de Biologia, Salut i Medi Ambient, Facultat de Farmacia, Universitat de Barcelona, Av. de Joan XXIII 27-31, 08028, Barcelona, Spain

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Roser Fisa Department de Biologia, Salut i Medi Ambient, Facultat de Farmacia, Universitat de Barcelona, Av. de Joan XXIII 27-31, 08028, Barcelona, Spain

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Andrés Yzuel Clinical Immunology Laboratory, Veterinary Faculty, Zaragoza University, Miguel Servet 177, 50013, Zaragoza, Spain

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Ana González Animal Pathology Department, Veterinary Faculty, Zaragoza University, Miguel Servet 177, 50013, Zaragoza, Spain
Clinical Immunology Laboratory, Veterinary Faculty, Zaragoza University, Miguel Servet 177, 50013, Zaragoza, Spain

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Diana Marteles Clinical Immunology Laboratory, Veterinary Faculty, Zaragoza University, Miguel Servet 177, 50013, Zaragoza, Spain

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Maite Verde Animal Pathology Department, Veterinary Faculty, Zaragoza University, Miguel Servet 177, 50013, Zaragoza, Spain
Clinical Immunology Laboratory, Veterinary Faculty, Zaragoza University, Miguel Servet 177, 50013, Zaragoza, Spain

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Abstract

The information about the clinical features of Leishmania infantum infection in cats is scarce. In this study, we evaluated the serum protein electrophoresis of samples from 19 infected but apparently healthy cats. To detect L. infantum infection, two serological tests, i.e. western blot (WB) and enzyme-linked immunosorbent assay (ELISA) as well as quantitative polymerase chain reaction (qPCR) on the blood samples were performed. Eventual infection by several selected bacterial and viral pathogens was also tested. All but one of the cats were found positive with WB. The WB-negative cat was positive by ELISA only. From the 18 WB-positive cats, only three were positive also by ELISA and eight with qPCR, including the only animal which was positive in all the three tests. No concomitant infections were detected in any of the cats. The main alteration of the proteinogram was characterised by an increase of the α-2 fraction. In the five cats with hypergammaglobulinaemia, the pattern detected was polyclonal. None of the cats were seropositive to any other pathogens tested. The presence of polyclonal gammopathy and elevation of the α-2 fraction could suggest the presence of active infection. In contrast, the only detection of an increase of the α-2 fraction alone with the presence of positive serological result could be associated by immune response activation against L. infantum.

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  • Basso, M. A. , Marques, C. , Santos, M. , Duarte, A. , Pissarra, H. , Carreira, L. M. , Gomes, L. , Valério-Bolas, A. , Tavares, L. , Santos-Gomes, G. and Pereira da Fonseca, I. (2016): Successful treatment of feline leishmaniosis using a combination of allopurinol and N-methyl-glucamine antimoniate. JFMS Open Rep. 2, 2055116916630002.

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  • Fernández-Gallego, A. , Feo-Bernabe, L. , Dalmau, A. , Esteban-Saltiveri, D. , Font, A. , Leiva, M. , Ortuñez-Navarro, A. , Peña, M. T. , Tabar, M. D. , Real-Sampietro, L. , Saló, F. , Lloret, A. and Bardagi, M. (2020): Feline leishmaniosis: diagnosis, treatment and outcome in 16 cats. J. Feline Med. Surg. 22, 9931007.

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  • Giner, J. , Basurco, A. , Alcover, M. M. , Riera, C. , Fisa, R. , Lopez, R. A. , Juan-Sallés, C. , Verde, M. T. , Fernández, A. , Yzuel, A. and Villanueva-Saz, S. (2020a): First report on natural infection with Leishmania infantum in a domestic ferret (Mustela putorius furo) in Spain. Vet. Parasitol. Reg. Stud. Rep. 19, 100369.

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  • Giner, J. , Villanueva-Saz, S. , Alcover, M. M. , Riera, C. , Fisa, R. , Basurco, A. , Yzuel, A. , Trotta, M. , Verde, M. T. and Fernández, A. (2020b): Treatment and follow-up of a domestic ferret (Mustela putorius furo) with clinical leishmaniosis caused by Leishmania infantum. Vet. Parasitol. Reg. Stud. Rep. 21, 100423.

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  • Giner, J. , Villanueva-Saz, S. , Alcover, M. M. , Riera, C. , Fisa, R. , Verde, M. , Fernández, A. and Yzuel, A. (2021): Clinical leishmaniosis in a domestic ferret (Mustela putorius furo) treated with miltefosine plus allopurinol: serological and clinical follow-up. Vet. Parasitol. Reg. Stud. Rep. 25, 100607.

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  • Giordano, A. and Paltrinieri, S. (2010): Interpretation of capillary zone electrophoresis compared with cellulose acetate and agarose gel electrophoresis: reference intervals and diagnostic efficiency in dogs and cats. Vet. Clin. Pathol. 39, 464473.

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  • Mary, C. , Faraut, F. , Lascombe, L. and Dumon, H. (2004): Quantification of Leishmania infantum DNA by a real-time PCR assay with high sensitivity. J. Clin. Microbiol. 42, 52495255.

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  • Paltrinieri, S. , Gradoni, L. , Roura, X. , Zatelli, A. and Zini, E. (2016): Laboratory tests for diagnosing and monitoring canine leishmaniasis. Vet. Clin. Pathol. 45, 552578.

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  • Pennisi, M. G. and Persichetti, M. F. (2018): Feline leishmaniosis: is the cat a small dog? Vet. Parasitol. 251, 131137.

  • Pennisi, M. G. , Cardoso, L. , Baneth, G. , Bourdeau, P. , Koutinas, A. , Miró, G. , Oliva, G. and Solano-Gallego, L. (2015): LeishVet update and recommendations on feline leishmaniosis. Parasites Vectors 8, 302.

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  • Pennisi, M. G. , Hartmann, K. , Lloret, A. , Addie, D. , Belák, S. , Boucraut-Baralon, C. , Egberink, H. , Frymus, T. , Gruffydd-Jones, T. , Hosie, M. J. , Lutz, H. , Marsilio, F. , Mostl, K. , Radford, A. D. , Thiry, T. , Truyen, U. and Horzinek, M. C. (2013): Leishmaniosis in cats: ABCD guidelines on prevention and management. J. Feline Med. Surg. 15, 638642.

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  • Pennisi, M. G. , Venza, M. , Reale, S. , Vitale, F. and Lo Giudice, S. (2004): Case report of leishmaniasis in four cats. Vet. Res. Commun. 28, 363366.

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  • Proverbio, D. , Spada, E. , Bagnagatti de Giorgi, G. , Perego, R. and Valena, E. (2014): Relationship between Leishmania IFAT titer and clinicopathological manifestations (clinical score) in dogs. BioMed Res. Int. 2014, 412808.

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  • Savioli, G. , Archer, J. , Brianti, E. , Benelli, G. , Schnyder, M. , Iatta, M. , Otranto, D. and Cantacessi, C. (2021): Serum amyloid A levels and alpha 2 and gamma globulins on serum protein electrophoresis in cats exposed to and infected with Leishmania infantum. Parasites Vectors 21, 217.

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  • Solano-Gallego, L. , Miró, G. , Koutinas, A. , Cardoso, L. , Pennisi, M. G. , Ferrer, L. , Bourdeau, P. , Oliva, G. and Baneth, G. (2011): LeishVet guidelines for the practical management of canine leishmaniosis. Parasites Vectors 4, 86.

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Editor-in-Chief: Ferenc BASKA

Editorial assistant: Szilvia PÁLINKÁS

 

Editorial Board

  • Mária BENKŐ (Acta Veterinaria Hungarica, Budapest, Hungary)
  • Gábor BODÓ (University of Veterinary Medicine, Budapest, Hungary)
  • Béla DÉNES (University of Veterinary Medicine, Budapest Hungary)
  • Edit ESZTERBAUER (Veterinary Medical Research Institute, Budapest, Hungary)
  • Hedvig FÉBEL (National Agricultural Innovation Centre, Herceghalom, Hungary)
  • László FODOR (University of Veterinary Medicine, Budapest, Hungary)
  • János GÁL (University of Veterinary Medicine, Budapest, Hungary)
  • Balázs HARRACH (Veterinary Medical Research Institute, Budapest, Hungary)
  • Peter MASSÁNYI (Slovak University of Agriculture in Nitra, Nitra, Slovak Republic)
  • Béla NAGY (Veterinary Medical Research Institute, Budapest, Hungary)
  • Tibor NÉMETH (University of Veterinary Medicine, Budapest, Hungary)
  • Zsuzsanna NEOGRÁDY (University of Veterinary Medicine, Budapest, Hungary)
  • Dušan PALIĆ (Ludwig Maximilian University, Munich, Germany)
  • Alessandra PELAGALLI (University of Naples Federico II, Naples, Italy)
  • Kurt PFISTER (Ludwig-Maximilians-University of Munich, Munich, Germany)
  • László SOLTI (University of Veterinary Medicine, Budapest, Hungary)
  • József SZABÓ (University of Veterinary Medicine, Budapest, Hungary)
  • Péter VAJDOVICH (University of Veterinary Medicine, Budapest, Hungary)
  • János VARGA (University of Veterinary Medicine, Budapest, Hungary)
  • Štefan VILČEK (University of Veterinary Medicine in Kosice, Kosice, Slovak Republic)
  • Károly VÖRÖS (University of Veterinary Medicine, Budapest, Hungary)
  • Herbert WEISSENBÖCK (University of Veterinary Medicine, Vienna, Austria)
  • Attila ZSARNOVSZKY (Szent István University, Gödöllő, Hungary)

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Acta Veterinaria Hungarica
Language English
Size A4
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1951
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Founder Magyar Tudományos Akadémia
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ISSN 0236-6290 (Print)
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