Abstract
The aim of this study was to describe the histological effects of two high postnatal doses of the potent third-generation GnRH antagonist, acyline in the domestic cat testicle. Secondly, the physical, endocrine, and steroidogenic findings of this pharmaceutical protocol are also reported. Twelve postnatal littermate male kittens were administered acyline in a dose of 2.2 mg/100 g SC weekly for 2 weeks (ACY; n = 6), or placebo (PL; n = 6). All the animals were followed up until puberty when they were castrated. Serial faecal samples were collected until the age of 10 weeks for testosterone (T) measurement. The kittens achieved puberty without either age (236.5 ± 19.7 vs. 221.7 ± 23.7 days) or body weight (3.05 ± 0.15 vs. 2.78 ± 0.28 kg, P > 0.05) differences between ACY and PL, respectively. Acyline suppressed faecal T concentrations for 3 weeks (P < 0.01). From the fourth week on, both groups had low concentrations up to the end of the follow-up period (P > 0.05). Histological assessment of the testes showed that ACY cats presented a reduced height of the epithelium (P < 0.01) due to the diminished number of germinal cells accompanied by an enlarged luminal area (P < 0.01) with cellular debris (P < 0.01). The immunostaining of P450c17 also appeared partially diminished in ACY testes.
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ACTA VETERINARIA HUNGARICA
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| 2021 | |
|---|---|
| Web of Science | |
| Total Cites WoS |
1040 |
| Journal Impact Factor | 0,959 |
| Rank by Impact Factor | Veterinary Sciences 103/144 |
| Impact Factor without Journal Self Cites |
0,876 |
| 5 Year Impact Factor |
1,222 |
| Journal Citation Indicator | 0,48 |
| Rank by Journal Citation Indicator | Veterinary Sciences 106/168 |
| Scimago | |
| Scimago H-index |
36 |
| Scimago Journal Rank |
0,313 |
| Scimago Quartile Score | Veterinary (miscellaneous) (Q2) |
| Scopus | |
| Scopus Cite Score |
1,7 |
| Scopus CIte Score Rank |
General Veterinary 79/183 (Q2) |
| Scopus SNIP |
0,610 |
| 2020 | |
| Total Cites | 987 |
| WoS | |
| Journal Impact Factor |
0,955 |
| Rank by | Veterinary Sciences 101/146 (Q3) |
| Impact Factor | |
| Impact Factor | 0,920 |
| without | |
| Journal Self Cites | |
| 5 Year | 1,164 |
| Impact Factor | |
| Journal | 0,57 |
| Citation Indicator | |
| Rank by Journal | Veterinary Sciences 93/166 (Q3) |
| Citation Indicator | |
| Citable | 49 |
| Items | |
| Total | 49 |
| Articles | |
| Total | 0 |
| Reviews | |
| Scimago | 33 |
| H-index | |
| Scimago | 0,395 |
| Journal Rank | |
| Scimago | Veterinary (miscellaneous) Q2 |
| Quartile Score | |
| Scopus | 355/217=1,6 |
| Scite Score | |
| Scopus | General Veterinary 73/183 (Q2) |
| Scite Score Rank | |
| Scopus | 0,565 |
| SNIP | |
| Days from | 145 |
| submission | |
| to acceptance | |
| Days from | 150 |
| acceptance | |
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| Acceptance | 19% |
| Rate |
| 2019 | |
|---|---|
| Total Cites WoS |
798 |
| Impact Factor | 0,991 |
| Impact Factor without Journal Self Cites |
0,897 |
| 5 Year Impact Factor |
1,092 |
| Immediacy Index |
0,119 |
| Citable Items |
59 |
| Total Articles |
59 |
| Total Reviews |
0 |
| Cited Half-Life |
9,1 |
| Citing Half-Life |
9,2 |
| Eigenfactor Score |
0,00080 |
| Article Influence Score |
0,253 |
| % Articles in Citable Items |
100,00 |
| Normalized Eigenfactor |
0,09791 |
| Average IF Percentile |
42,606 |
| Scimago H-index |
32 |
| Scimago Journal Rank |
0,372 |
| Scopus Scite Score |
335/213=1,6 |
| Scopus Scite Score Rank |
General Veterinary 62/178 (Q2) |
| Scopus SNIP |
0,634 |
| Acceptance Rate |
18% |
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