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Mariela Grisolia-Romero
mgrisolia89@gmail.com
https://orcid.org/0000-0001-9197-6460
Mariela Grisolia-Romero
Faculty of Veterinary Sciences, National University of La Plata, Argentina
National Research Council, Argentina
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National Research Council, Argentina
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Marcela Faya
Marcela Faya
Catholic University of Cordoba, Argentina
National Research Council, Argentina
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National Research Council, Argentina
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Cynthia Marchetti
Cynthia Marchetti
Faculty of Veterinary Sciences, National University of La Plata, Argentina
National Research Council, Argentina
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National Research Council, Argentina
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Hanna Körber
Hanna Körber
Reproductive Unit of the Clinic - Clinic for Small Animals, University of Veterinary Medicine Hannover, Foundation, Hannover , Germany
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Sandra Goericke-Pesch
Sandra Goericke-Pesch
Reproductive Unit of the Clinic - Clinic for Small Animals, University of Veterinary Medicine Hannover, Foundation, Hannover , Germany
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Cristina Gobello
Cristina Gobello
Faculty of Veterinary Sciences, National University of La Plata, Argentina
National Research Council, Argentina
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National Research Council, Argentina
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Abstract
The aim of this study was to describe the histological effects of two high postnatal doses of the potent third-generation GnRH antagonist, acyline in the domestic cat testicle. Secondly, the physical, endocrine, and steroidogenic findings of this pharmaceutical protocol are also reported. Twelve postnatal littermate male kittens were administered acyline in a dose of 2.2 mg/100 g SC weekly for 2 weeks (ACY; n = 6), or placebo (PL; n = 6). All the animals were followed up until puberty when they were castrated. Serial faecal samples were collected until the age of 10 weeks for testosterone (T) measurement. The kittens achieved puberty without either age (236.5 ± 19.7 vs. 221.7 ± 23.7 days) or body weight (3.05 ± 0.15 vs. 2.78 ± 0.28 kg, P > 0.05) differences between ACY and PL, respectively. Acyline suppressed faecal T concentrations for 3 weeks (P < 0.01). From the fourth week on, both groups had low concentrations up to the end of the follow-up period (P > 0.05). Histological assessment of the testes showed that ACY cats presented a reduced height of the epithelium (P < 0.01) due to the diminished number of germinal cells accompanied by an enlarged luminal area (P < 0.01) with cellular debris (P < 0.01). The immunostaining of P450c17 also appeared partially diminished in ACY testes.
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