Search for other papers by Mehmet Akif Kilinc in
Current site
Google Scholar
PubMed
Search for other papers by Ali Risvanli in
Current site
Google Scholar
PubMed
Abstract
The aim of the present study was to determine asprosin levels in cows, the relationship of this hormone with postpartum disorders and β-hydroxybutyric acid, and also the potential of asprosin to be a marker for postpartum diseases. The study was designed as a two-stage trial. In the first stage, blood asprosin and β-hydroxybutyric acid levels of 20 healthy Simmental cows aged 3–4 years were measured at the time of calving, and on days 3, 6, 9, 12 and 15 postpartum. In the second stage, 200 cows were divided into two groups: (1) healthy (n = 100) and (2) diseased (placental retention, hypocalcaemia, metritis, lameness, abomasal displacement, mastitis; n = 100); asprosin and β-hydroxybutyric acid concentrations of the blood were assessed on day 15 postpartum. In conclusion, the asprosin level was found to be at measurable levels in cows, and a negative correlation with β-hydroxybutyric acid was found. According to these findings, the data obtained from this study could be used for the prevention, control and treatment of some postpartum disorders associated with ketosis and for developing novel hypotheses concerning the actions of this hormone. It was concluded that further studies are required to reveal the associations between asprosin and postpartum disorders.
-
Abdelli, A. , Raboisson, D. , Kaidi, R. , Ibrahim, B. , Kalem, A. and Iguer-Ouada, M. (2017): Elevated non-esterified fatty acid and β-hydroxybutyrate in transition dairy cows and their association with reproductive performance and disorders: a meta-analysis. Theriogenology 93 ,99–104.
-
Alan, M. , Gurlek, B. , Yilmaz, A. , Aksit, M. , Aslanipour, B. , Gulhan, I. , Mehmet, C. and Taner, C. E. (2019): Asprosin: a novel peptide hormone related to insulin resistance in women with polycystic ovary syndrome. Gynecol. Endocrinol. 35, 220–223.
-
Bach, K. D. , Heuwieser, W. and McArt, J. A. A. (2016): Technical note: comparison of 4 electronic handheld meters for diagnosing hyperketonemia in dairy cows. J. Dairy Sci. 99, 9136–9142.
-
Bastan, A. and Gürbulak, G. (2012): Metabolic disorders. In: Semacan, A. , Kaymaz, M. , Fındık, M. , Rişvanlı, A. and Köker, A. (eds) Farm Animal Obstetrics and Gynecology [in Turkish]. Medipres, Malatya. pp. 469–506.
-
Booth, A. , Magnuson, A. , Fouts, J. and Foster, M. T. (2016): Adipose tissue: an endocrine organ playing a role in metabolic regulation. Horm. Mol. Biol. Clin. Investig. 26 ,25–42.
-
Chapinal, N. , Carson, M. , Duffield, T. , Capel, M. , Godden, S. , Overton, M. , Santos, J. and LeBlanc, S. (2011): The association of serum metabolites with clinical disease during the transition period. J. Dairy Sci. 94 ,4897–4903.
-
Dohoo, I. R. and Martin, S. (1984): Subclinical ketosis: prevalence and associations with production and disease. Can. J. Comp. Med. 48 ,1.
-
Drackley, J. K. (1999): Biology of dairy cows during the transition period: The final frontier? J. Dairy Sci. 82 ,2259–2273.
-
Duerrschmid, C. , He, Y. , Wang, C. , Li, C. , Bournat, J. C. , Romere, C. , Saha, P. K. , Lee, M. E. , Phillips, K. J. and Jain, M. (2017): Asprosin is a centrally acting orexigenic hormone. Nat. Med. 23 ,1444.
-
Duffield, T. , Bagg, R. , DesCoteaux, L. , Bouchard, E. , Brodeur, M. , DuTremblay, D. , Keefe, G. , LeBlanc, S. and Dick, P. (2002): Prepartum monensin for the reduction of energy associated disease in postpartum dairy cows. J. Dairy Sci. 85 ,397–405.
-
Duffield, T. , Lissemore, K. , McBride, B. and Leslie, K. (2009): Impact of hyperketonemia in early lactation dairy cows on health and production. J. Dairy Sci. 92 ,571–580.
-
Fiorentin, E. L. , Tiecher, A. , Menegat, C. , Soares, C. , Aires, A. , Rocha, R. and Gonzalez, F. H. D. (2017): Accuracy of two hand-held electronic devices for determination of blood β-hydroxybutyrate in dairy cows. Rev. Bras. Saude Prod. Anim. 18 ,439–445.
-
Geishauser, T. , Leslie, K. , Kelton, D. and Duffield, T. (2001): Monitoring for subclinical ketosis in dairy herds. Compendium 23 ,65–71.
-
Grummer, R. R. (1995): Impact of changes in organic nutrient metabolism on feeding the transition dairy cow. J. Anim. Sci. 73 ,2820–2833.
-
Ingvartsen, K. L. (2006): Feeding- and management-related diseases in the transition cow: Physiological adaptations around calving and strategies to reduce feeding-related diseases. Anim. Feed Sci. Technol. 126 ,175–213.
-
Kaufmann, T. B. , Drillich, M. , Tenhagen, B. A. and Heuwieser, W. (2010): Correlations between periparturient serum concentrations of non-esterified fatty acids, beta-hydroxybutyric acid, bilirubin, and urea and the occurrence of clinical and subclinical postpartum bovine endometritis. BMC Vet. Res. 6 ,1–6.
-
Kremer, W. , Noordhuizen-Stassen, E. , Grommers, F. , Schukken, Y. , Heeringa, R. , Brand, A. and Burvenich, C. (1993): Severity of experimental Escherichia coli mastitis in ketonemic and nonketonemic dairy cows. J. Dairy Sci. 76 ,3428–3436.
-
Leal Yepes, F. A. , Nydam, D. V. , Heuwieser, W. and Mann, S. (2018): Technical note: Evaluation of the diagnostic accuracy of 2 point-of-care β-hydroxybutyrate devices in stored bovine plasma at room temperature and at 37 °C. J. Dairy Sci. 101 ,6455–6461.
-
LeBlanc, S. , Leslie, K. and Duffield, T. (2005): Metabolic predictors of displaced abomasum in dairy cattle. J. Dairy Sci. 88 ,159–170.
-
Maylem, E. R. S. , Spicer, L. J. , Batalha, I. and Schutz, L. F. (2021): Discovery of a possible role of asprosin in ovarian follicular function. J. Mol. Endocrinol. 66 ,35–44.
-
Ospina, P. , Nydam, D. , Stokol, T. and Overton, T. (2010): Association between the proportion of sampled transition cows with increased nonesterified fatty acids and β-hydroxybutyrate and disease incidence, pregnancy rate, and milk production at the herd level. J. Dairy Sci. 93 ,3595–3601.
-
Romere, C. , Duerrschmid, C. , Bournat, J. , Constable, P. , Jain, M. , Xia, F. , Saha, P. K. , Del Solar, M. , Zhu, B. and York, B. (2016): Asprosin, a fasting-induced glucogenic protein hormone. Cell 165 ,566–579.
-
Suthar, V. , Canelas-Raposo, J. , Deniz, A. and Heuwieser, W. (2013): Prevalence of subclinical ketosis and relationships with postpartum diseases in European dairy cows. J. Dairy Sci. 96 ,2925–2938.
-
Ugur, K. and Aydin, S. (2019): Saliva and blood asprosin hormone concentration associated with obesity. Int. J. Endocrinol. 2019 ,1–8.
-
Zhang, L. , Chen, C. , Zhou, N. , Fu, Y. and Cheng, X. (2019): Circulating asprosin concentrations are increased in type 2 diabetes mellitus and independently associated with fasting glucose and triglyceride. Clin. Chim. Acta 489 ,183–188.
ACTA VETERINARIA HUNGARICA
University of Veterinary Medicine,
H-1078 Budapest, István utca 2., Hungary
Phone: (36 20) 560 4183 (ed.-in-chief) or (36 1) 478 4100/8430 (editor)
E-mail: acta.veterinaria@univet.hu (ed.-in-chief)
Indexing and Abstracting Services:
- Biological Abstracts
- BIOSIS Previews
- CAB Abstracts
- Chemical Abstracts
- Current Contents: Agriculture, Biology and Environmental Sciences
- Elsevier Science Navigator
- Focus On: Veterinary Science and Medicine
- Global Health
- Index Medicus
- Index Veterinarius
- Medline
- Science Citation Index
- Science Citation Index Expanded (SciSearch)
- SCOPUS
- The ISI Alerting Services
- Zoological Abstracts
| 2023 | |
|---|---|
| Web of Science | |
| Journal Impact Factor | 0.7 |
| Rank by Impact Factor | Q3 (Veterinary Sciences) |
| Journal Citation Indicator | 0.4 |
| Scopus | |
| CiteScore | 1.8 |
| CiteScore rank | Q2 (General Veterinary) |
| SNIP | 0.39 |
| Scimago | |
| SJR index | 0.258 |
| SJR Q rank | Q3 |
| Acta Veterinaria Hungarica | |
|---|---|
| Publication Model | Hybrid |
| Submission Fee | none |
| Article Processing Charge | 1100 EUR/article |
| Printed Color Illustrations | 40 EUR (or 10 000 HUF) + VAT / piece |
| Regional discounts on country of the funding agency | World Bank Lower-middle-income economies: 50% World Bank Low-income economies: 100% |
| Further Discounts | Editorial Board / Advisory Board members: 50% Corresponding authors, affiliated to an EISZ member institution subscribing to the journal package of Akadémiai Kiadó: 100% |
| Subscription fee 2025 | Online subsscription: 832 EUR / 916 USD Print + online subscription: 960 EUR / 1054 USD |
| Subscription Information | Online subscribers are entitled access to all back issues published by Akadémiai Kiadó for each title for the duration of the subscription, as well as Online First content for the subscribed content. |
| Purchase per Title | Individual articles are sold on the displayed price. |
| Acta Veterinaria Hungarica | |
|---|---|
| Language | English |
| Size | A4 |
| Year of Foundation |
1951 |
| Volumes per Year |
1 |
| Issues per Year |
4 |
| Founder | Magyar Tudományos Akadémia |
| Founder's Address |
H-1051 Budapest, Hungary, Széchenyi István tér 9. |
| Publisher | Akadémiai Kiadó |
| Publisher's Address |
H-1117 Budapest, Hungary 1516 Budapest, PO Box 245. |
| Responsible Publisher |
Chief Executive Officer, Akadémiai Kiadó |
| ISSN | 0236-6290 (Print) |
| ISSN | 1588-2705 (Online) |
Monthly Content Usage
| Abstract Views | Full Text Views | PDF Downloads | |
|---|---|---|---|
| Oct 2024 | 137 | 1 | 1 |
| Nov 2024 | 69 | 0 | 0 |
| Dec 2024 | 43 | 0 | 0 |
| Jan 2025 | 59 | 0 | 0 |
| Feb 2025 | 79 | 0 | 0 |
| Mar 2025 | 78 | 0 | 0 |
| Apr 2025 | 0 | 0 | 0 |
Copyright Akadémiai Kiadó AKJournals is the trademark of Akadémiai Kiadó's journal publishing business branch.