Abstract
The most common canine tumour is mammary tumour, which resembles breast cancer in humans. Microenvironment is a crucial factor in the formation of breast cancers. In order to distinguish between benign and malignant canine mammary tumours, this study looked at the immunohistochemical expression of Na+/K+-ATPase and bone morphogenetic protein-2 (BMP-2) in tumour and microenvironmental cells. The aim of this study was to evaluate the expression of Na+/K+-ATPase and BMP-2 in canine mammary tumours and their relationship with malignancy. In this investigation, 10 normal breast tissues were used as controls, and 28 benign and 46 malignant mammary tumours were taken from the archives of the Department of Pathology. The findings showed that malignant tumours expressed more Na+/K+-ATPase and BMP-2 than did normal breast tissue. Both markers had a negative or slight expression in benign tumours, whereas they considerably increased in malignant tumours. Both tumour parenchymal and microenvironmental cells in malignancies expressed Na+/K+-ATPase and BMP-2. Na+/K+-ATPase expression was observed to be more prominent in cells when compared to BMP-2. These findings also suggest that Na+/K+-ATPase and BMP-2 could be employed in the future to help diagnose canine and possibly human breast cancers earlier or as possible targets for treatment.
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ACTA VETERINARIA HUNGARICA
Institute for Veterinary Medical Research
Centre for Agricultural Research
Hungarian Academy of Sciences
P.O. Box 18, H-1581 Budapest, Hungary
Phone: (36 1) 467 4081 (ed.-in-chief) or (36 1) 213 9793 (editor) Fax: (36 1) 467 4076 (ed.-in-chief) or (36 1) 213 9793
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| 2021 | |
|---|---|
| Web of Science | |
| Total Cites WoS |
1040 |
| Journal Impact Factor | 0,959 |
| Rank by Impact Factor | Veterinary Sciences 103/144 |
| Impact Factor without Journal Self Cites |
0,876 |
| 5 Year Impact Factor |
1,222 |
| Journal Citation Indicator | 0,48 |
| Rank by Journal Citation Indicator | Veterinary Sciences 106/168 |
| Scimago | |
| Scimago H-index |
36 |
| Scimago Journal Rank |
0,313 |
| Scimago Quartile Score | Veterinary (miscellaneous) (Q2) |
| Scopus | |
| Scopus Cite Score |
1,7 |
| Scopus CIte Score Rank |
General Veterinary 79/183 (Q2) |
| Scopus SNIP |
0,610 |
| 2020 | |
| Total Cites | 987 |
| WoS | |
| Journal Impact Factor |
0,955 |
| Rank by | Veterinary Sciences 101/146 (Q3) |
| Impact Factor | |
| Impact Factor | 0,920 |
| without | |
| Journal Self Cites | |
| 5 Year | 1,164 |
| Impact Factor | |
| Journal | 0,57 |
| Citation Indicator | |
| Rank by Journal | Veterinary Sciences 93/166 (Q3) |
| Citation Indicator | |
| Citable | 49 |
| Items | |
| Total | 49 |
| Articles | |
| Total | 0 |
| Reviews | |
| Scimago | 33 |
| H-index | |
| Scimago | 0,395 |
| Journal Rank | |
| Scimago | Veterinary (miscellaneous) Q2 |
| Quartile Score | |
| Scopus | 355/217=1,6 |
| Scite Score | |
| Scopus | General Veterinary 73/183 (Q2) |
| Scite Score Rank | |
| Scopus | 0,565 |
| SNIP | |
| Days from | 145 |
| submission | |
| to acceptance | |
| Days from | 150 |
| acceptance | |
| to publication | |
| Acceptance | 19% |
| Rate |
| 2019 | |
|---|---|
| Total Cites WoS |
798 |
| Impact Factor | 0,991 |
| Impact Factor without Journal Self Cites |
0,897 |
| 5 Year Impact Factor |
1,092 |
| Immediacy Index |
0,119 |
| Citable Items |
59 |
| Total Articles |
59 |
| Total Reviews |
0 |
| Cited Half-Life |
9,1 |
| Citing Half-Life |
9,2 |
| Eigenfactor Score |
0,00080 |
| Article Influence Score |
0,253 |
| % Articles in Citable Items |
100,00 |
| Normalized Eigenfactor |
0,09791 |
| Average IF Percentile |
42,606 |
| Scimago H-index |
32 |
| Scimago Journal Rank |
0,372 |
| Scopus Scite Score |
335/213=1,6 |
| Scopus Scite Score Rank |
General Veterinary 62/178 (Q2) |
| Scopus SNIP |
0,634 |
| Acceptance Rate |
18% |
| Acta Veterinaria Hungarica | |
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| Language | English |
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1951 |
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