Abstract
The aim of this study was to demonstrate a relationship between the occurrence of clinical signs of brain involvement in dogs with babesiosis and the concentration of manganese (Mn) in their serum. The study included seven dogs with early babesiosis (Group 1), seven dogs with cerebral babesiosis (Group 2) and seven healthy dogs (Group 3). Haematological and biochemical blood tests were performed in all dogs, and the results were analysed statistically. The Mann–Whitney rank test was used to demonstrate the differences in Mn concentrations, as well as other haematological and biochemical parameters between groups. In dogs in Group 2 with cerebral babesiosis, as compared to dogs in Groups 1 and 3, a statistically significant increase in serum Mn concentration was shown (P = 0.002 and P = 0.029) that may have been associated with the development of anaemia and/or impairment of liver function. Given the well-established neurotoxic effects of Mn in humans, experimental rodents and primates, additional studies on the role of Mn in the pathogenesis of the cerebral form of canine babesiosis are warranted.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
Adaszek, Ł. and Winiarczyk, S. (2010): Application of the SYBR Green real-time HRM PCR technique in the differentiation of the Babesia canis canis protozoa isolated in areas of eastern Poland. Parasitol. Res. 106, 1253–1256.
-
Adaszek, Ł. and Winiarczyk, S. (2008): Molecular characterization of Babesia canis canis isolates from naturally infected dogs in Poland. Vet. Parasitol. 152, 235–241.
-
Adaszek, Ł., Górna, M., Klimiuk, P., Kalinowski, M. and Winiarczyk, S. (2012): A presumptive case of cerebral babesiosis in a dog in Poland caused by a virulent Babesia canis strain. Tierarztl. Prax. Ausg. K Kleintiere Heimtiere 40, 367–371.
-
Adaszek, Ł., Winiarczyk, S. and Skrzypczak, M. (2009): The clinical course of babesiosis in 76 dogs infected with Babesia canis canis protozoa parasites. Pol. J. Vet. Sci. 12, 81–87.
-
Aschner, J. L. and Aschner, M. (2005): Nutritional aspects of manganese homeostasis. Mol. Aspect. Med. 26, 353–362.
-
Boozer, A. L. and Macintire, D. K. (2003): Canine babesiosis. Vet. Clin. North Am. Small Anim. Pract. 33, 885–904.
-
Bourdoiseau, G. (2006): Canine babesiosis in France. Vet. Parasitol. 138, 118–125.
-
Brna, P., Gordon, K., Dooley, J. M. and Price, V. (2011): Manganese toxicity in a child with iron deficiency and polycythemia. J. Child Neurol. 26, 891–894.
-
Costa-Júnior, L. M., Ribeiro, M. F., Rembeck, K., Rabelo, E. M., Zahler-Rinder, M., Hirzmann, J., Pfister, K. and Passos, L. M. (2009): Canine babesiosis caused by Babesia canis vogeli in rural areas of the State of Minas Gerais, Brazil and factors associated with its seroprevalence. Res. Vet. Sci. 86, 257–260.
-
Cronin, R. E., Ferguson, E. R., Shannon, W. A. Jr. and Knochel, J. P. (1982): Skeletal muscle injury after magnesium depletion in the dog. Am. J. Physiol. 243, F113–F120.
-
Daste, T., Lucas, M. N. and Aumann, M. (2013): Cerebral babesiosis and acute respiratory distress syndrome in a dog. J. Vet. Emerg. Crit. Care (San Antonio) 23, 615–623.
-
De Vos, A. J., Imes, G. D. and Cullen, J. S. (1976): Cerebral babesiosis in a new-born calf. Onderstepoort J. Vet. Res. 43, 75–78.
-
Dodd, C. A. and Filipov, N. M. (2011): Manganese potentiates LPS-induced heme-oxygenase 1 in microglia but not dopaminergic cells: role in controlling microglial hydrogen peroxide and inflammatory cytokine output. Neurotoxicology 32, 683–692.
-
Esmaeilnejad, B., Tavassoli, M., Dalir-Naghadeh, B., Samiei, A., Rajabi, S., Mohammadi, V., Anassori, E. and Ehteshamfar, S. (2020): Status of oxidative stress, trace elements, sialic acid and cholinesterase activity in cattle naturally infected with Babesia bigemina. Comp. Immunol. Microbiol. Infect. Dis. 71, 101503. Epub 2020 May 30.
-
Ferreira, M. D. F., Aylor, A. E. A., Mellanby, R. J., Campbell, S. M. and Gow, A. G. (2017): Investigation of manganese homeostasis in dogs with anaemia and chronic enteropathy. Open Vet. J. 7, 360–366.
-
Herrero Hernandez, E., Discalzi, G., Valentini, C., Venturi, F., Chiò, A., Carmellino, C., Rossi, L., Sacchetti, A. and Pira, E. (2006): Follow-up of patients affected by manganese-induced Parkinsonism after treatment with CaNa2EDTA. Neurotoxicology 27, 333–339.
-
Irwin, P. J. (2009): Canine babesiosis: from molecular taxonomy to control. Parasit. Vectors 26, S4.
-
Jacobson, L. S. (2006): The South African form of severe and complicated canine babesiosis: clinical advances 1994–2004. Vet. Parasitol. 138, 126–139.
-
Keller, N., Jacobson, L. S., Nel, M., de Clerq, M., Thompson, P. N. and Schoeman, J. P. (2004): Prevalence and risk factors of hypoglycemia in virulent canine babesiosis. J. Vet. Intern. Med. 18, 265–270.
-
Kilpatrick, S., Jacinto, A., Foale, R. D., Tappin, S. W., Burton, C., Frowde, P. E., Elwood, C. M., Powell, R., Duncan, A., Mellanby, R. J. and Gow, A. G. (2014): Whole blood manganese concentrations in dogs with primary hepatitis. J. Small Anim. Pract. 55, 241–246.
-
Kjemtrup, A. M., Wainwright, K., Miller, M., Penzhorn, B. L. and Carreno, R. A. (2006): Babesia conradae, sp. nov., a small canine Babesia identified in California. Vet. Parasitol. 138, 103–111.
-
Kwik-Uribe, C. L., Golubt, M. S. and Keen, C. L. (1999): Behavioral consequences of marginal iron deficiency during development in a murine model. Neurotoxicol. Teratol. 21, 661–672.
-
Leisewitz, A. L., Goddard, A., Clift, S., Thompson, P. N., de Gier, J., van Engelshoven, J. M. A. J. A. J. and Schoeman, J. P. (2019): A clinical and pathological description of 320 cases of naturally acquired Babesia rossi infection in dogs. Vet.Parasitol. 271, 22–30.
-
Łyp, P., Adaszek, Ł., Furmaga, B. and Winiarczyk, S. (2015): Identification of new 18S rRNA strains of Babesia canis isolated from dogs with subclinical babesiosis. Pol. J. Vet. Sci. 18, 573–577.
-
Malherbe, D. (1956): The manifestations and diagnosis of Babesia infections. Ann. N. Y. Acad. Sci. 64, 128–146.
-
Máthé, Á., Vörös, K., Papp, L. and Reiczigel, J. (2006): Clinical manifestations of canine babesiosis in Hungary (63 cases). Acta Vet. Hung. 54, 367–385.
-
Meltzer, H. M., Brantsaeter, A. L., Borch-Iohnsen, B., Ellingsen, D. G., Alexander, J., Thomassen, Y., Stigum, H. and Ydersbond, T. A. (2010): Low iron stores are related to higher blood concentrations of manganese, cobalt and cadmium in non-smoking, Norwegian women in the HUNT 2 study. Environ. Res. 110, 497–504.
-
Okoh, A. E. (1978): A case of cerebral babesiosis in the dog. Bull. Anim. Health Prod. Afr. 26, 118–119.
-
Park, H. K., Kim, S. M., Choi, C. G., Lee, M. C. and Chung, S. J. (2008): Effect of trientine on manganese intoxication in a patient with acquired hepatocerebral degeneration. Mov. Disord. 23, 768–770.
-
Parsh, B. and Whitney, K. (2020): What is babesiosis? Nursing 50, 13–14.
-
Prakash, R. and Mullen, K. D. (2010): Mechanisms, diagnosis and management of hepatic encephalopathy. Nat. Rev. Gastroenterol. Hepatol. 7, 515–525.
-
Racette, B. A., Searles Nielsen, S., Criswell, S. R., Sheppard, L., Seixas, N., Warden, M. N. and Checkoway, H. (2017): Dose-dependent progression of parkinsonism in manganese-exposed welders. Neurology 88, 344–351.
-
Schetters, T. P. and Eling, W. M. (1999): Can Babesia infections be used as a model for cerebral malaria? Parasitol. Today 15, 492–497.
-
Shaw, S. E., Day, M. J., Birtles, R. J. and Breitschwerdt, E. B. (2001): Tick-borne infectious diseases of dogs. Trends Parasitol. 17, 74–80.
-
Smith, M. R., Fernandes, J., Go, Y. M. and Jones, D. P. (2017): Redox dynamics of manganese as a mitochondrial life-death switch. Biochem. Biophys. Res. Commun. 482, 388–398.
-
Torisu, S., Washizu, M., Hasegawa, D. and Orima, H. (2008): Measurement of brain trace elements in a dog with a portosystemic shunt: relation between hyperintensity on T1-weighted magnetic resonance images in lentiform nuclei and brain trace elements. J. Vet. Med. Sci. 70, 1391–1393.
-
Tuschl, K., Mills, P. B., Parsons, H., Malone, M., Fowler, D., Bitner-Glindzicz, M. and Clayton, P. T. (2008): Hepatic cirrhosis, dystonia, polycythaemia and hypermanganesaemia – a new metabolic disorder. J. Inherit. Metab. Dis. 31, 151–163.
-
Van de Maele, I., Savary-Bataille, K., Gielen, I. and Daminet, S. (2008): An unusual form of canine babesiosis. Can. Vet. J. 49, 283–286.
-
Vial, H. J. and Gorenflot, A. (2006): Chemotherapy against babesiosis. Vet. Parasitol. 138, 147–160.
-
Vitale, S., Hague, D. W., Foss, K., de Godoy, M. C. and Selmic, L. E. (2019): Comparison of serum trace nutrient concentrations in epileptics compared to healthy dogs. Front. Vet. Sci. 6, 467.
-
Yin, Z., Aschner, J. L., dos Santos, A. P and Aschner, M. (2008): Mitochondrial-dependent manganese neurotoxicity in rat primary astrocyte cultures. Brain Res. 1203, 1–11.
-
Zahler, M., Schein, E., Rinder, H. and Gothe, R. (1998): Characteristic genotypes discriminate between Babesia canis isolates of differing vector specificity and pathogenicity in dogs. Parasitol. Res. 84, 544–548.
Monthly Content Usage
| Abstract Views | Full Text Views | PDF Downloads | |
|---|---|---|---|
| Oct 2020 | 0 | 0 | 0 |
| Nov 2020 | 0 | 0 | 0 |
| Dec 2020 | 10 | 0 | 0 |
| Jan 2021 | 55 | 1 | 1 |
| Feb 2021 | 97 | 2 | 4 |
| Mar 2021 | 91 | 12 | 3 |
| Apr 2021 | 18 | 0 | 0 |
Copyright Akadémiai Kiadó
AKJournals is the trademark of Akadémiai Kiadó's journal publishing business branch.
Copyright Akadémiai Kiadó AKJournals is the trademark of Akadémiai Kiadó's journal publishing business branch.
Powered by PubFactory