Acta Veterinaria Hungarica
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Genetic distribution of polymorphisms in the shadow of prion protein (SPRN) gene in Jeju black cattle
Authors:
Thi-Thuy-Duong Nguyen Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of Korea
Department of Bioactive Material Sciences and Institute for Molecular Biology and Genetics, Jeonbuk National University, Jeonju 54896, Republic of Korea

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Da-In Choi Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of Korea
Department of Bioactive Material Sciences and Institute for Molecular Biology and Genetics, Jeonbuk National University, Jeonju 54896, Republic of Korea

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Kyoungtag Do Lab of Equine Science, Department of Animal Biotechnology, Faculty of Biotechnology, Jeju National University, Jeju 63243, Republic of Korea

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Nameun Kim Livestock and Life Sciences Research Institute, Jeju Special Self-Governing Province, Jeju 63078, Republic of Korea

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Byung-Hoon Jeong Korea Zoonosis Research Institute, Jeonbuk National University, Iksan 54531, Republic of Korea
Department of Bioactive Material Sciences and Institute for Molecular Biology and Genetics, Jeonbuk National University, Jeonju 54896, Republic of Korea

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https://orcid.org/0000-0002-4525-9994
Online Publication Date:
03 Mar 2025
Publication Date:
03 Mar 2025
Article Category:
Research Article
DOI:
https://doi.org/10.1556/004.2025.01138
Keywords:
SPRN gene; cattle; BSE; prion disease; genetic polymorphism
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Abstract

Bovine spongiform encephalopathy (BSE) is a progressive neurodegenerative disorder in cattle that poses risks to public health and has economic consequences. The shadow of prion protein encoded by the shadow of prion protein (SPRN) gene affects prion disease progression. A 12-base-pair indel polymorphism in the SPRN gene has been implicated in BSE susceptibility in Polish cattle. Building upon our previous research, we aimed to investigate the SPRN gene polymorphisms in Jeju black cattle — a Korean native breed with distinct genetic features and compared them with those in Hanwoo and Korean Holstein. Our findings reveal that the Jeju black cattle SPRN gene, with only two synonymous single nucleotide polymorphisms, has lower genetic diversity than that in Hanwoo and Korean Holstein. Moreover, we contrasted the distribution of c.199_210delGCCGCGGCGGGG (67_70delAAAG) polymorphisms in the SPRN gene between BSE-infected Polish cattle and Korean cattle to assess BSE susceptibility. The results suggest that Jeju black and Korean Holstein demonstrate a higher genetic potential for BSE resistance compared to the Hanwoo breed. To the best of our knowledge, this study provides the first report of the SPRN gene in Jeju black cattle, along with a comparative analysis of SPRN gene polymorphisms across three Korean cattle breeds.

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Cover Acta Veterinaria Hungarica
Acta Veterinaria Hungarica
Print ISSN:
0236-6290
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1588-2705

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  • Mária BENKŐ (Acta Veterinaria Hungarica, Budapest, Hungary)
  • Gábor BODÓ (University of Veterinary Medicine, Budapest, Hungary)
  • Béla DÉNES (University of Veterinary Medicine, Budapest Hungary)
  • Edit ESZTERBAUER (Veterinary Medical Research Institute, Budapest, Hungary)
  • Hedvig FÉBEL (University of Veterinary Medicine, Budapest, Hungary)
  • László FODOR (University of Veterinary Medicine, Budapest, Hungary)
  • János GÁL (University of Veterinary Medicine, Budapest, Hungary)
  • Balázs HARRACH (Veterinary Medical Research Institute, Budapest, Hungary)
  • Peter MASSÁNYI (Slovak University of Agriculture in Nitra, Nitra, Slovak Republic)
  • Béla NAGY (Veterinary Medical Research Institute, Budapest, Hungary)
  • Tibor NÉMETH (University of Veterinary Medicine, Budapest, Hungary)
  • Zsuzsanna NEOGRÁDY (University of Veterinary Medicine, Budapest, Hungary)
  • Dušan PALIĆ (Ludwig Maximilian University, Munich, Germany)
  • Alessandra PELAGALLI (University of Naples Federico II, Naples, Italy)
  • Kurt PFISTER (Ludwig-Maximilians-University of Munich, Munich, Germany)
  • László SOLTI (University of Veterinary Medicine, Budapest, Hungary)
  • József SZABÓ (University of Veterinary Medicine, Budapest, Hungary)
  • Péter VAJDOVICH (University of Veterinary Medicine, Budapest, Hungary)
  • János VARGA (University of Veterinary Medicine, Budapest, Hungary)
  • Štefan VILČEK (University of Veterinary Medicine in Kosice, Kosice, Slovak Republic)
  • Károly VÖRÖS (University of Veterinary Medicine, Budapest, Hungary)
  • Herbert WEISSENBÖCK (University of Veterinary Medicine, Vienna, Austria)
  • Attila ZSARNOVSZKY (Szent István University, Gödöllő, Hungary)

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Acta Veterinaria Hungarica
Language English
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Foundation		 1951
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ISSN 0236-6290 (Print)
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