This paper deals with a class of algebraic hyperstructures called ternary semihypergroups. In this paper, we introduce the notion of generalized quasi (bi)-hyperideals in ternary semihypergroups and study their structure. Some related properties of them are investigated. Several characterizations of ternary semihypergroups in terms of minimal generalized quasi(bi)-hyperideals are provided. Also, the n-left simple, m-right simple, (p, q)-lateral simple and (m, (p, q), n)-quasi-simple ternary semihypergroups are defined and investigated.