In this paper, we obtain generalized weighted Sobolev-Morrey estimates with weights from the Muckenhoupt class Ap by establishing boundedness of several important operators in harmonic analysis such as Hardy-Littlewood operators and Calderon-Zygmund singular integral operators in generalized weighted Morrey spaces. As a consequence, a priori estimates for the weak solutions Dirichlet boundary problem uniformly elliptic equations of higher order in generalized weighted Sobolev-Morrey spaces in a smooth bounded domain Ω ⊂ ℝn are obtained.