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Teréz Márián Please ask the editor of the journal.

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L. Balkay Please ask the editor of the journal.

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I. Fekete Please ask the editor of the journal.

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Zs. Lengyel Please ask the editor of the journal.

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G. Veress Please ask the editor of the journal.

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The effect of plasma glucose concentration on the cerebral uptake of [18 F]-fluorodeoxy-D-glucose (FDG) was studied in a broad concentration range in a rabbit brain model using dynamic FDG PET measure- ments. Hypoglycemic and hyperglycemic conditions were maintained by manipulating plasma glucose applying i.v. glucose or insulin load. FDG utilization (K) and cerebral glucose metabolic rate (CGMR) were evaluated in a plasma glucose concentration range between 0.5 mM and 26 mM from the kinetic constant k1, k2, k3 obtained by the Sokoloff model of FDG accumulation. A decreasing set of standard FDG uptake values found with increasing blood glucose concentration was explained by competition between the plasma glucose and the radiopharmacon FDG. A similar trend was observed for the forward kinetic constants k1, and k3 in the entire concentration range studied. The same decreasing tendency of k2 was of a smaller magnitude and was reverted at the lowest glucose concentrations where a pronounced decrease of this backward transport rate constant was detected. Our kinetic data indicate a modulation of the kinetics of carbohydrate metabolism by the blood glucose concentration and report on a special mechanism compensating for the low glucose supply under conditions of extremely low blood glucose level.

  • Shawver, L. K., Olson, S. A., White, M. K., Weber, M. J. (1987) Degradation and biosynthesis of the glucose transporter protein in chicken embryo fibroblasts transformed by the src oncogene. Mol. Cell Biol.7, 2112-2118.

    'Degradation and biosynthesis of the glucose transporter protein in chicken embryo fibroblasts transformed by the src oncogene ' () 7 Mol. Cell Biol. : 2112 -2118. .

    • Search Google Scholar
  • Sieber, J. E., Traystman, R. J. (1992) Special issues: Glucose and the brain. Critical Care Med.20, 104-114.

    'Special issues: Glucose and the brain ' () 20 Critical Care Med. : 104 -114. .

  • Sokoloff, L., Reivich, M., Kennedy, C., Des Rosiers, C., Patlak, H., Pettigrew, K., Sakurada, O., Shinohara, M. (1977) The [14C]deoxiglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J. Neurochem.28, 897-916.

    'The [14C]deoxiglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat ' () 28 J. Neurochem. : 897 -916. .

    • Search Google Scholar
  • Suds, S., Shinohara, M., Miyaoka, M., Lucignani, G., Kennedy, C., Sokoloff, L. (1990) The lumped constant of the deoxyglucose method in hypoglycemia: effects of moderate hypoglycemia on local cerebral glucose utilization in the rat. J. Cereb. Blood Flow Metab.10, 499-509.

    'The lumped constant of the deoxyglucose method in hypoglycemia: effects of moderate hypoglycemia on local cerebral glucose utilization in the rat ' () 10 J. Cereb. Blood Flow Metab. : 499 -509. .

    • Search Google Scholar
  • Torizuka, T., Clavo, A. C., Wahl, R. L. (1997) Effect of hyperglycemia on in vitro tumor uptake of tritiated FDG, thymidine, L-methionine and L-leucine, J. Nucl. Med.38, 382-386.

    'Effect of hyperglycemia on in vitro tumor uptake of tritiated FDG, thymidine, L-methionine and L-leucine, ' () 38 J. Nucl. Med : 382 -386. .

    • Search Google Scholar
  • Urabe, T., Hattori, N., Nagamatsu, S., Sawa, H., Mizuno, Y. (1996) Expression of glucose transporters in rat brain following transient focal ishemic injure. J. Neurochem.67, 265-271.

    'Expression of glucose transporters in rat brain following transient focal ishemic injure ' () 67 J. Neurochem. : 265 -271. .

    • Search Google Scholar
  • Vannucci, S. J., Seaman, L. B., Vannucci, R. C. (1996) Effect of hypoxia-ischemia on GLUTI and GLUT3 glucose transporters in immature rat brain. J. Cereb. Blood Flow Metab.16, 77-81.

    'Effect of hypoxia-ischemia on GLUTI and GLUT3 glucose transporters in immature rat brain ' () 16 J. Cereb. Blood Flow Metab. : 77 -81. .

    • Search Google Scholar
  • Wahl, R. L., Henry, C. A., Ethier, S. P. (1992) Serum glucose effects on tumor and normal tissue accumulation of [18F]fluoro-2-deoxy-D-glucose in rodents with mammary carcinoma. Radiology183, 643-647.

    'Serum glucose effects on tumor and normal tissue accumulation of [18]fluoro-2-deoxy-D-glucose in rodents with mammary carcinoma ' () 183 Radiology : 643 -647. .

    • Search Google Scholar
  • Wahl, L. R. (1996) Targeting glucose transporters for tumor imaging: "Sweet" idea, "Sour" result. J. Nucl. Med.37, 1038-104.

    'Targeting glucose transporters for tumor imaging: "Sweet" idea, "Sour" result ' () 37 J. Nucl. Med. : 1038 -104 .

    • Search Google Scholar
  • Walker, P. S., Donovans, J. A., Van Ness, B. G., Fellows, R. E., Pessin, J. E. (1988) Glucose-dependent regulation of the glucose transport activity, protein and mRNA in primary cultures of rat brain glial cells. J. Biol. Chem.263, 15594-15601.

    'Glucose-dependent regulation of the glucose transport activity, protein and mRNA in primary cultures of rat brain glial cells ' () 263 J. Biol. Chem. : 15594 -15601. .

    • Search Google Scholar
  • Aller, B. C., Ehmann, S., Gilman-Sachs, A., Snyder, K. A. (1997) Flow cytometric analysis of glucose transport by rat brain cells. Cytometry27, 262-268.

    'Flow cytometric analysis of glucose transport by rat brain cells ' () 27 Cytometry : 262 -268. .

    • Search Google Scholar
  • Dienel, G. A., Cruz, N. F., Mori, K., Holden, J., Sokoloff, L. (1991) Direct measurements of the γgM of the lumped constant of the deoxyglucose method in rat brain: determination of γgM and lumped constant from tissue glucose concentration or equilibrium tissue: plasma distribution ratio for methylglucose. J. Cereb. Blood Flow Metab.11, 25-34.

    'Direct measurements of the γgM of the lumped constant of the deoxyglucose method in rat brain: determination of γgM and lumped constant from tissue glucose concentration or equilibrium tissue: plasma distribution ratio for methylglucose ' () 11 J. Cereb. Blood Flow Metab. : 25 -34. .

    • Search Google Scholar
  • Eng, H. L., DeLapaz, R. L., Frankel, K. A., Poljak, A., Phillips, M. H., Brennan, K. M., Woodruff, K. H., Valk, P. E., Steinberg, G. K., Fabrikant, J. I. (1991) MRI and PET delayed heavy-ion radiation injury in the rabbit brain. J. Radiation Oncology Biol. Phys.20, 689-696.

    'MRI and PET delayed heavy-ion radiation injury in the rabbit brain ' () 20 J. Radiation Oncology Biol. Phys. : 689 -696. .

    • Search Google Scholar
  • Gamelli, R. L., Liu, H., He, L. K., Hoffmann, C. A. (1994) Alterations of glucose transporter mRNA and protein levels in brain following thermal injury and sepsis in mice. Shock1, 395-400.

    'Alterations of glucose transporter mRNA and protein levels in brain following thermal injury and sepsis in mice ' () 1 Shock : 395 -400. .

    • Search Google Scholar
  • Germinario, R. J., Michaelidou, A. (1986) Hexose transport after glucose refeeding of glucose-starved human fibroblasts: 1. The effects of tunicamycin and cycloheximide. 2. Insulin binding and action. Biochem Biophys Res. Commun140, 844-849.

    'Hexose transport after glucose refeeding of glucose-starved human fibroblasts: 1. The effects of tunicamycin and cycloheximide. 2. Insulin binding and action ' () 140 Biochem Biophys Res. Commun : 844 -849. .

    • Search Google Scholar
  • Hamacher, K., Coenen, H. H., StőoUcklin, G. (1986) Efficient stereospecific synthesis of no-carrier-added2-(18F)-Fluoro-2-Deoxy-D-Glucose using aminopolyether supported nucleophilic substitution. J. Nucl. Med.27, 235-238.

    'Efficient stereospecific synthesis of no-carrier-added2-(18F)-Fluoro-2-Deoxy-D-Glucose using aminopolyether supported nucleophilic substitution ' () 27 J. Nucl. Med. : 235 -238. .

    • Search Google Scholar
  • Hegedűus, K., Keresztes, T., Fekete, I., MolnàaAr, L. (1997) Effect of i.v. dipyridamol on cerebral blood flow, blood pressure, plasma adenosine and cAMP levels in rabbits. J. Neuro. Sci.148, 153-157.

    'Effect of i.v. dipyridamol on cerebral blood flow, blood pressure, plasma adenosine and cAMP levels in rabbits ' () 148 J. Neuro. Sci. : 153 -157 .

    • Search Google Scholar
  • Hoh, C. K., Dahlbom, M., Hawkins, R. A., Glaspy, J. A., Yao, W. J., Lee, S. J., Maddahi, J., Phelps, M. E. (1994) Basic principles of positron emission tomography in oncology: quantification and whole body techniques. Wien Klin. Wochenschr.106, 496-504.

    'Basic principles of positron emission tomography in oncology: quantification and whole body techniques ' () 106 Wien Klin. Wochenschr. : 496 -504. .

    • Search Google Scholar
  • Ishizu, K., Nishizawa, S., Yonekura, Y., Sadato, N., Magata, Y., Tamaki, N., Tsuchida, T., Okazawa, H., Miyatake, S., Ishikawa, M., Kikuchi, H., Konishi, J. (1994) Effects of hyperglycemia on FDG uptake in human brain and glioma. J. Nucl. Med.35, 1104-1109.

    'Effects of hyperglycemia on FDG uptake in human brain and glioma ' () 35 J. Nucl. Med. : 1104 -1109. .

    • Search Google Scholar
  • Ishiwata, K., Sakiyama, Y., Sakiyama, T., Shimada, J., Toyama, H., Oda, K., Suzuki, F., Senda, M. (1997) Myocardial adenosine A2a receptor imaging of rabbit by PET with [11C]KF17837. Ann. Nucl. Med. 3, 219-225.

    'Myocardial adenosine A2a receptor imaging of rabbit by PET with [11C]KF17837 ' () 3 Ann. Nucl. Med. : 219 -225. .

    • Search Google Scholar
  • Knuuti, J., Nuutila, P., Ruotsalainen, U., Saraste, M., Harkonen, R., Ahonen, A., Teras, M., Haaparanta, M., Wegelius, U., Haapanen, A. (1992) Euglicemic hyperinsulinemic clamp and oral glucose load in stimulating myocardial glucose utilization during positron emission tomography. J. Nucl. Med.33, 1255-1262.

    'Euglicemic hyperinsulinemic clamp and oral glucose load in stimulating myocardial glucose utilization during positron emission tomography ' () 33 J. Nucl. Med. : 1255 -1262. .

    • Search Google Scholar
  • Kubota, K., Kubota, R., Yamada, S., Tada, M., Takahashi, T., Iwata, R. (1996) Re-evalution of myocardial FDG uptake in hyperglycemia. J. Nucl. Med.37, 1713-1717.

    'Re-evalution of myocardial FDG uptake in hyperglycemia ' () 37 J. Nucl. Med. : 1713 -1717. .

    • Search Google Scholar
  • Lemmon, S. K., Sens, D. A., Buse, M. G. (1985) Insulin stimulation of glucose transport and metabolism in a human Wilms' tumor-derived myoblast-like cell line: modulation of hormone effects by glucose deprivation. J. Cell Physiol.125, 456-464.

    'Insulin stimulation of glucose transport and metabolism in a human Wilms' tumor-derived myoblast-like cell line: modulation of hormone effects by glucose deprivation ' () 125 J. Cell Physiol. : 456 -464. .

    • Search Google Scholar
  • Lindholm, P., Minn, H., Leskinen-Kallio, S., Bergman, J., Ruotsalainen, U., Joensuu, H. (1993) Influence of the blood glucose concentration on FDG uptake in cancer-A PET study. J. Nucl. Med.34, 1-6.

    'Influence of the blood glucose concentration on FDG uptake in cancer-A PET study ' () 34 J. Nucl. Med. : 1 -6. .

    • Search Google Scholar
  • Maher, F., Vannucci, S. J., Simpson, I. A. (1994) Glucose transporter proteins in brain. FASEB J.8, 1003-1011.

    'Glucose transporter proteins in brain ' () 8 FASEB J. : 1003 -1011. .

  • Phelps, M. E., Huang, S. C., Hoffman, E. J., Selin, C., Sokoloff, L., Kuhl, D. E. (1979) Tomographic measurement of local cerebral glucose metabolic rate in humans with 2-[F-18]fluoro-2-deoxy-D-glucose: validation of Method. Ann. Neurol.6, 371-388.

    'Tomographic measurement of local cerebral glucose metabolic rate in humans with 2-[F-18]fluoro-2-deoxy-D-glucose: validation of Method ' () 6 Ann. Neurol. : 371 -388. .

    • Search Google Scholar
  • Sadiq, F., Holtzclaw, L., Chundu, K., Muzzafar, A., Devaskar, S. (1990) The ontogeny of the rabbit brain glucose transporter. Endocrinology126, 2417-2424.

    'The ontogeny of the rabbit brain glucose transporter ' () 126 Endocrinology : 2417 -2424. .

    • Search Google Scholar
  • T. Nishioka, Y. Oda, Y. Seino, T. Yamamoto, N. Inagaki, H. Yano, H. Imura, R. Shigemoto, H. Kikuchi (1992) Distribution of the glucose transporters in human brain tumors. Cancer Research52, 3972-3979.

    'Distribution of the glucose transporters in human brain tumors ' () 52 Cancer Research : 3972 -3979. .

    • Search Google Scholar
  • Pelligrini, D. A., LaManna, J. C., Duckrow, R. B., Bryan, R. M. Jr., Harik, S. I. (1992) Hyperglycemia and blood-brain barrier glucose transport. J Cerebr. Blood Flow Metab.12, 887-899.

    'Hyperglycemia and blood-brain barrier glucose transport ' () 12 J Cerebr. Blood Flow Metab. : 887 -899. .

    • Search Google Scholar
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Editorial Board

    1. Csányi, Vilmos (Göd)
    1. Dudits, Dénes (Szeged)
    1. Falus, András (Budapest)
    1. Fischer, Ernő (Pécs)
    1. Gábriel, Róbert (Pécs)
    1. Gulya, Károly (Szeged)
    1. Gulyás, Balázs (Stockholm)
    1. Hajós, Ferenc (Budapest)
    1. Hámori, József (Budapest)
    1. Heszky, László (Gödöllő)
    1. Hideg, Éva (Szeged)
    1. E. Ito (Sanuki)
    1. Janda, Tibor (Martonvásár)
    1. Kavanaugh, Michael P. (Missoula)
    1. Kása, Péter (Szeged)
    1. Klein, Éva (Stockholm)
    1. Kovács, János (Budapest)
    1. Brigitte Mauch-Mani (Neuchâtel)
    1. Nässel, Dick R. (Stockholm)
    1. Nemcsók, János (Szeged)
    1. Péczely, Péter (Gödöllő)
    1. Roberts, D. F. (Newcastle-upon-Tyne)
    1. Sakharov, Dimitri A. (Moscow)
    1. Singh, Meharvan (Fort Worth)
    1. Sipiczky, Mátyás (Debrecen)
    1. Szeberényi, József (Pécs)
    1. Székely, György (Debrecen)
    1. Tari, Irma (Szeged)
    1. Vágvölgyi, Csaba (Szeged),
    1. L. Zaborszky (Newark)

 

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Acta Biologica Hungarica
Language English
Size  
Year of
Foundation
1950
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Programme
changed title
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Founder Magyar Tudományos Akadémia
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H-1051 Budapest, Hungary, Széchenyi István tér 9.
Publisher Akadémiai Kiadó
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H-1117 Budapest, Hungary 1516 Budapest, PO Box 245.
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Chief Executive Officer, Akadémiai Kiadó
ISSN 0236-5383 (Print)
ISSN 1588-256X (Online)